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The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy
The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy
Myocardial ischemia/reperfusion (I/R)-induced cell death, such as autophagy and ferroptosis, is a major contributor to car...
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise
HFpEF is a prevalent and complex type of heart failure. The concurrent presence of conditions such as obesity, hypertensio...
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease
Phosphatidylinositol-3 kinases (PI3Ks) play a critical role in maintaining cardiovascular health and the development of ca...
p16INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance
p16INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance
Severe sepsis can promote myocardial injury and cardiac dysfunction, but role of p16 in sepsis-induced myocardial injury r...
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis
CHI3L1 is strongly associated with atherosclerosis, but its role in macrophages remains unknown. In this study, we observe...
Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension
Development and Internal Validation of an AI-Enabled Cuff-less, Non-invasive Continuous Blood Pressure Monitor Across All Classes of Hypertension
Non-invasive, continuous blood pressure monitoring technologies require additional validation beyond standard cuff-based m...
CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis
CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis
CRISPR-Cas9 gene editing technology, as an innovative biomedical tool, holds significant potential in the prevention and t...
Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training
Long Non-Coding RNAs in Diabetic Cardiomyopathy: Potential Function as Biomarkers and Therapeutic Targets of Exercise Training
Recent studies emphasize the beneficial effects of exercise on diabetic cardiomyopathy (DCM), adding to the growing body o...
Senescence-related Genes as Prognostic Markers for STEMI Patients: LASSO Regression-Based Bioinformatics and External Validation
Senescence-related Genes as Prognostic Markers for STEMI Patients: LASSO Regression-Based Bioinformatics and External Validation
The prognostic value of differentially expressed senescence-related genes(DESRGs) in ST-segment elevation myocardial infar...
Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome
Diagnostic Value and Short-Term Prognosis Assessment of Copeptin in Non-ST-Elevation Acute Coronary Syndrome
This study explored the early diagnosis and prognostic value of copeptin in non-ST-segment elevation acute coronary syndro...
Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway
Bufalin Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Macrophage Pyroptosis via P62 Pathway
Bufalin, which is isolated from toad venom, exerts positive effects on hearts under pathological circumstance. We aimed to...
Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery
Machine Learning Model for Risk Prediction of Prolonged Intensive Care Unit in Patients Receiving Intra-aortic Balloon Pump Therapy during Coronary Artery Bypass Graft Surgery
This study aimed to construct machine learning models and predict prolonged intensive care units (ICU) stay in patients re...
NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9
NAT10 Modulates Atherosclerosis Progression Mediated by Macrophage Polarization Through Regulating ac4C Modification of TLR9
Atherosclerosis (AS) is an inflammatory disease affected by macrophage polarization. N4-acetylcytosine (ac4C) modification...
Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort
Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort
Circulating lipids play a crucial role in the development of coronary artery disease (CAD). However, it is unclear whether...
Endothelial Cell-Derived Extracellular Vesicles Allow to Differentiate Between Various Endotypes of INOCA: A Multicentre, Prospective, Cohort Study
Endothelial Cell-Derived Extracellular Vesicles Allow to Differentiate Between Various Endotypes of INOCA: A Multicentre, Prospective, Cohort Study
Ischemia and non-obstructive coronary artery disease (INOCA) might be due to coronary microvascular dysfunction (CMD), vas...
Prediction of Major Adverse Limb Events in Females with Peripheral Artery Disease using Blood-Based Biomarkers and Clinical Features
Prediction of Major Adverse Limb Events in Females with Peripheral Artery Disease using Blood-Based Biomarkers and Clinical Features
The objective of this study was to identify a female-specific prognostic biomarker for peripheral artery disease ...
Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study
Hyperspectral Imaging for Microcirculatory Assessment of Patients undergoing Transcatheter and Surgical Aortic Valve Replacement-a Prospective Observational Pilot Study
This prospective, observational study evaluated Hyperspectral Imaging (HSI) to assess the effects of cardiac surgery and c...
β-Hydroxybutyrate and Citrate Synthase as Potential Diagnostic Biomarkers in Aging-Related Atrial Fibrillation
β-Hydroxybutyrate and Citrate Synthase as Potential Diagnostic Biomarkers in Aging-Related Atrial Fibrillation
The incidence of atrial fibrillation (AF) increases with age; however, the precise mechanisms by which aging elevates AF r...
Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction
Mechanical and Geometric Characterization of a Novel 2-Ply Vacuum-Pressed Biological Scaffold Patch Design for Posterior Mitral Valve Reconstruction
To assess the mechanical properties of small intestinal submucosal extracellular matrix (SIS-ECM) iterations and choose th...
Shorter Leukocyte Telomere Length Is Associated with Increased Major Adverse Cardiovascular Events or Mortality in Patients with Essential Hypertension
Shorter Leukocyte Telomere Length Is Associated with Increased Major Adverse Cardiovascular Events or Mortality in Patients with Essential Hypertension
The association between leukocyte telomere length (LTL) alteration and major adverse cardiovascular events (MACE) or morta...
Adaptation of Aortic Bioprosthetic Valves for Pulmonary Position: Comparative Analysis of Transcatheter and Surgical Valves
Adaptation of Aortic Bioprosthetic Valves for Pulmonary Position: Comparative Analysis of Transcatheter and Surgical Valves
Pulmonary valve dysfunction is common in congenital heart disease, often leading to interventions like right ventricular o...
Apolipoprotein A-I Mimetic Peptide Restores VEGF-induced Angiogenesis in Hypercholesterolemic Ischemic Heart by Reducing HDL Proinflammatory Properties
Apolipoprotein A-I Mimetic Peptide Restores VEGF-induced Angiogenesis in Hypercholesterolemic Ischemic Heart by Reducing HDL Proinflammatory Properties
VEGF-induced angiogenesis is impaired in hypercholesterolemia. Previous studies showed that an apolipoprotein A-I(ApoA-I) ...
Targeting Canonical Wnt-signaling Through GSK-3β in Arrhythmogenic Cardiomyopathy: Conservative or Progressive?
Targeting Canonical Wnt-signaling Through GSK-3β in Arrhythmogenic Cardiomyopathy: Conservative or Progressive?
Arrhythmogenic cardiomyopathy is a primary myocardial disease and a major cause of sudden death in all populations of the ...
Circulating Extracellular Vesicles from Heart Failure Patients Inhibit Human Cardiomyocyte Activities
Circulating Extracellular Vesicles from Heart Failure Patients Inhibit Human Cardiomyocyte Activities
Extracellular vesicles (EVs) have been implicated in cardiac remodeling during heart failure (HF). However, the role of ci...
Machine Learning Model for Predicting Risk Factors of Prolonged Length of Hospital Stay in Patients with Aortic Dissection: a Retrospective Clinical Study
Machine Learning Model for Predicting Risk Factors of Prolonged Length of Hospital Stay in Patients with Aortic Dissection: a Retrospective Clinical Study
The length of hospital stay (LOS) is crucial for assessing medical service quality. This study aimed to develop machine le...
Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission
Drp1 Promotes Macrophage M1 Polarization and Inflammatory Response in Autoimmune Myocarditis by Driving Mitochondrial Fission
Autoimmune myocarditis (AM) is characterized by an intricate inflammatory response within the myocardium. Dynamin-related ...
Induction of Controllable Vortical Flow in a Dual-Stenosis Aorta Model: A Replication of Disordered Eddies Flow in Aneurysms
Induction of Controllable Vortical Flow in a Dual-Stenosis Aorta Model: A Replication of Disordered Eddies Flow in Aneurysms
This paper presents a two-stenosis aorta model mimicking vortical flow in vascular aneurysms. More specifically, we propos...
Past Trends and Future Directions of Cardiac Regenerative Medicine – A Systematic Analysis of Clinical Trial Registries
Past Trends and Future Directions of Cardiac Regenerative Medicine – A Systematic Analysis of Clinical Trial Registries
Cell therapy, gene therapy, and tissue engineering have been explored as potential strategies to repair or regenerate dama...
4D-Flow MRI and Vector Ultrasound in the In-Vitro Evaluation of Surgical Aortic Heart Valves – a Pilot Study
4D-Flow MRI and Vector Ultrasound in the In-Vitro Evaluation of Surgical Aortic Heart Valves – a Pilot Study
Introduction: The aim of this study was the initial investigation of 4D-Flow MRI and Vector Ultrasound as novel imaging te...
CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases?
CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases?
The heart requires a substantial amount of energy to function, utilising various substrates including lipids, glucose and ...
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