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Skin mutation burden drives adaptive immunity and response to immunotherapy
Numerous studies over the past century have reported an inverse correlation between lifetime solar ultraviolet radiation (...
Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors
IntroductionAdvancements in immunotherapy have significantly improved clinical outcomes for patients with various tumor ty...
Corticosteroid premedication on anti-tumor effect of immune checkpoint blockade in murine hepatocellular carcinoma models
We analyzed the states of tumor-infiltrating T cells following dICB with or without Dexa premedication using scRNA-seq, as...
Mimicry-based strategy between human and commensal antigens for the development of a new family of immune therapies for cancer
IntroductionImmune checkpoint inhibitors (ICIs) offer potentially curative cancer treatment by boosting anticancer T-cell ...
Ethanol inhibits the growth and metastasis of hepatocellular carcinoma by inducing immunogenic cell death
IntroductionHepatocellular carcinoma (HCC) is the sixth most common cancer worldwide.1 With the progress of drug developme...
Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway
IntroductionClofarabine (Clo) is an Food and Drug Administration-approved purine nucleoside analog that has been shown to ...
Single-chain variable fragment affinity tuning can optimize anti-AML CAR-NK cell functionality
BackgroundAcute myeloid leukemia (AML) is a hematological malignancy caused by uncontrolled clonal expansion of myeloid bl...
Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma
WHAT IS ALREADY KNOWN ON THIS TOPICIL-7 is a cytokine that is essential in the role of T-cell development, proliferation a...
Pembrolizumab hybrid dosing is non-inferior to flat dosing in advanced non-small cell lung cancer: a real-world, retrospective bicenter cohort study
IntroductionImmune checkpoint inhibitors (ICIs) have caused a paradigm shift in the treatment for patients with solid tumo...
Complete metabolic response as early predictor of long-term efficacy after adoptive T cell therapy using tumor-infiltrating lymphocytes
IntroductionSince the introduction of immune checkpoint inhibitors (ICIs) as standard of care for patients with metastatic...
Targeting IL-33 in patients with cancer under immune checkpoint inhibitors for a better antitumor response and prevent thromboembolism?
We read with great interest the article by Nan et al on the possibility of targeting interleukin (IL)-33 to obtain an impr...
Real-world outcomes with tisagenlecleucel in aggressive B-cell lymphoma: subgroup analyses from the CIBMTR registry
BackgroundApproximately one-third of patients with diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma (H...
TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial
BackgroundHarnessing the antitumor immune response is fundamental to cancer immunotherapy and both effector and memory T l...
Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors
BackgroundIncorporating sex and gender medicine and adopting sex-specific prevention or treatment strategies in oncology i...
Comment on "Role of CD47 Gene Expression in Colorectal Cancer: A Comprehensive Molecular Profiling Study"
The study by Arai et al1 provides significant insights into the role of CD47 gene expression in colorectal cancer (CRC) an...
Correction: Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma
McKenna MK, Ozcan A, Brenner D, et al. Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated st...
Pooled screening for CAR function identifies novel IL-13R{alpha}2-targeted CARs for treatment of glioblastoma
BackgroundGlioblastoma (GBM) is the most common form of primary malignant brain tumor and has a very poor prognosis, with ...
4-1BB agonist targeted to fibroblast activation protein {alpha} synergizes with radiotherapy to treat murine breast tumor models
IntroductionCancer-associated fibroblasts (CAFs) are recognized as one of the stromal cellular constituents of the tumor m...
CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors
CD4 depletion therapy but not ICB immunotherapy increased CAR T cell efficacy against B16F10 melanomaWe previously reporte...
CD56bright cytokine-induced memory-like NK cells and NK-cell engagers synergize against non-small cell lung cancer cancer-stem cells
BackgroundNon-small cell lung cancer (NSCLC) accounts for approximately 80% of all lung malignancies and is diagnosed at a...
Radiomic analysis of patient and interorgan heterogeneity in response to immunotherapies and BRAF-targeted therapy in metastatic melanoma
BackgroundDespite improvements with BRAF and immune-checkpoint inhibitors (ICI), at least half of patients with melanoma s...
Efficacy and safety of nivolumab plus ipilimumab in patients with metastatic variant histology (non-clear cell) renal cell carcinoma
IntroductionVariant histology renal cell carcinomas (vhRCC), more commonly referred to as non-clear cell RCC (non-ccRCC) m...
Acetyltransferase NAT10 inhibits T-cell immunity and promotes nasopharyngeal carcinoma progression through DDX5/HMGB1 axis
IntroductionNasopharyngeal carcinoma (NPC), a prototypical neoplastic tumor, is characterized by the infiltration of vario...
Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation
IntroductionImmunotherapy targeting programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) has revolutio...
Correction: Peritumoral administration of IFN{beta} upregulated mesenchymal stem cells inhibits tumor growth in an orthotopic, immunocompetent rat glioma model
Mao J, Cao M, Zhang F, et al. Peritumoral administration of IFNβ upregulated mesenchymal stem cells inhibits tumor growth ...
Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma
IntroductionCholangiocarcinoma, a malignancy arising from the biliary epithelium, presents therapeutic challenges because ...
Transient lymphocyte count decrease correlates with oncolytic adenovirus efficacy in humans: mechanistic and biomarker findings from TUNIMO phase I trial
WHAT IS ALREADY KNOWN ON THIS TOPICOncolytic viruses are a promising anticancer therapeutic, and multiple clinical trials ...
Combined PARP14 inhibition and PD-1 blockade promotes cytotoxic T cell quiescence and modulates macrophage polarization in relapsed melanoma
IntroductionImmune checkpoint inhibitors (ICI) antagonizing the programmed cell death 1 (PD-1) signaling axis by disruptin...
Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma
WHAT IS ALREADY KNOWN ON THIS TOPICPrevious experimental models and clinical trials in the setting of allogeneic transplan...
Plasma membrane-coated nanoparticles and membrane vesicles to orchestrate multimodal antitumor immunity
BackgroundSeveral cancer immunotherapies use antibodies to target specific molecules or cells. Antibodies are naturally sy...
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