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Open-capsule budesonide for the treatment of immune-related enteritis from checkpoint inhibitors
IntroductionImmune checkpoint inhibitors (ICIs) targeting key checkpoint receptors responsible for immune system downregul...
Proteomic and phenotypic characteristics of memory-like natural killer cells for cancer immunotherapy
IntroductionNatural killer (NK) cells mediate defenses against pathogens and cancer cells.1 During the past two decades, w...
Biomarker development for PD-(L)1 axis inhibition: a consensus view from the SITC Biomarkers Committee
Defining PD-(L)1 inhibitor resistanceWhile many patients treated with programmed death-ligand 1 (PD-(L)1) inhibitors achie...
Osteoporotic fractures: an unrecognized adverse event of immune checkpoint inhibitors?
The development of immunotherapy caused a paradigm shift in treating different types of metastatic cancers. Immune checkpo...
Cantharidin overcomes IL-2R{alpha} signaling-mediated vorinostat resistance in cutaneous T-cell lymphoma through reactive oxygen species
IntroductionCutaneous T-cell lymphoma (CTCL), a rare non-Hodgkin’s lymphoma derived from T cell, can be divided into the m...
Novel insights into paclitaxels role on tumor-associated macrophages in enhancing PD-1 blockade in breast cancer treatment
BackgroundTriple-negative breast cancer (TNBC) is identified by the lack of estrogen, progesterone, and HER2 receptors, ma...
Assessing the implications of sentinel lymph node removal in cervical cancer: an immunogenetic perspective - a SENTICOL ancillary study
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSWe applied the nCounter PanCancer Immune Profiling panel on 36 SLN ...
Pretreatment CT-based machine learning radiomics model predicts response in unresectable hepatocellular carcinoma treated with lenvatinib plus PD-1 inhibitors and interventional therapy
IntroductionHepatocellular carcinoma (HCC) as the primary form of liver cancer, accounting for 75%–85%, represents the six...
Generation of non-genetically modified, CAR-like, NK cells
IntroductionNatural killer (NK) cell therapy using ex vivo expanded allogeneic NK cells is an established anticancer strat...
A crisis in clinical research
IntroductionA patient with cancer in their 70s was diagnosed with chemotherapy and immune checkpoint inhibitor (ICI)-refra...
Plasma metabolomics of immune-related adverse events for patients with lung cancer treated with PD-1/PD-L1 inhibitors
IntroductionLung cancer remains to have the highest incidence among cancers in men and leading cause of cancer-related dea...
Correction: ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3
Ao Y, Gao J, Jin C, et al. ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing...
Hypothesis: the generation of T cells directed against neoepitopes employing immune-mediating agents other than neoepitope vaccines
The development of vaccines directed against neoepitopes of solid tumors has recently been and continues to be an active a...
Harnessing lipid metabolism modulation for improved immunotherapy outcomes in lung adenocarcinoma
BackgroundDespite significant advancements in treatment, lung cancer continues to be the leading cause of cancer-related d...
Genetically engineering glycolysis in T cells increases their antitumor function
BackgroundA large body of studies in humans and mice has established that CD8+ T cells can control tumor progression.1 Dif...
Chronic immune-related adverse events arising from immune checkpoint inhibitors: an update
IntroductionImmune checkpoint inhibitors (ICIs) are now approved for at least 17 different cancer types, and have resulted...
Impact of isotype on the mechanism of action of agonist anti-OX40 antibodies in cancer: implications for therapeutic combinations
IntroductionAntibody immunotherapy now benefits a proportion of patients with cancer, most notably after checkpoint blocka...
Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin
IntroductionImmunotherapy strategies such as immune checkpoint blockades and adoptive immune cell transfer (ACT) that aim ...
Hypoxia inhibits the iMo/cDC2/CD8+ TRMs immune axis in the tumor microenvironment of human esophageal cancer
BackgroundDespite advances in the management and treatment of esophageal cancer (ESCA), the overall prognosis for patients...
Unique immune characteristics and differential anti-PD-1-mediated reinvigoration potential of CD8+ TILs based on BRCA1/2 mutation status in epithelial ovarian cancers
IntroductionEpithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, causing the deaths of over 152,00...
Infliximab in steroid-refractory immune-related hepatitis does not demonstrate hepatotoxicity and may shorten time on steroids
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYBackgroundImmune checkpoint inh...
TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response
BackgroundImmunotherapy has emerged as a groundbreaking approach in cancer treatment, notably exemplified in the context o...
Tethered IL15-IL15R{alpha} augments antitumor activity of CD19 CAR-T cells but displays long-term toxicity in an immunocompetent lymphoma mouse model
IntroductionChimeric antigen receptor T cell (CAR-T) therapy has emerged as one of the most innovative and promising advan...
Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSCancer vaccines can synergize with rationally selected CPIs to succ...
Extensive-stage small-cell lung cancer in patients receiving atezolizumab plus carboplatin-etoposide: stratification of outcome based on a composite score that combines gene expression profiling and immune characterization of microenvironment
IntroductionSmall-cell lung cancer (SCLC) is an aggressive disease with poor prognosis, accounting for approximately 15% o...
Bendamustine is a safe and effective lymphodepletion agent for axicabtagene ciloleucel in patients with refractory or relapsed large B-cell lymphoma
IntroductionChimeric antigen receptor T (CAR T) cell therapies have significantly improved the outcomes of patients with r...
Immune predictors of response to immune checkpoint inhibitors in mismatch repair-deficient endometrial cancer
IntroductionEndometrial cancer (EC) represents the sixth most frequently diagnosed cancer in women, with an incidence of 4...
IFN{gamma} mediates the resistance of tumor cells to distinct NK cell subsets
IntroductionNatural killer (NK) cells are cytotoxic innate lymphocytes that play a crucial role in eliminating tumor or vi...
Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer
IntroductionGastric cancer (GC) is a leading cause of cancer-related death,1 mainly because the disease is often detected ...
Exploring the predictive potential of programmed death ligand 1 expression in healthy organs and lymph nodes as measured by 18F-BMS-986192 PET: pooled analysis of data from four solid tumor types
IntroductionImmune checkpoint inhibitors (ICIs) can reinvigorate anticancer immunity and have been shown to improve overal...
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