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Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration
IntroductionA substantial number of cancer immunotherapy strategies rely on adaptive immune responses against antigens pre...
Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages
IntroductionThe receptor tyrosine kinases (RTKs) are transmembrane receptors whose critical roles have been extensively ch...
GPC2 antibody-drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies
BackgroundSurvival outcomes for patients with high-risk neuroblastoma remain dismal despite use of intense multimodal ther...
Targeting CD89 on tumor-associated macrophages overcomes resistance to immune checkpoint blockade
BackgroundOver the past several years, antibodies targeting the co-inhibitory immune checkpoints have demonstrated marked ...
T cells of colorectal cancer patients stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells
BackgroundImmunotherapeutic agents and strategies are most promising, adding to the armamentarium for effectively treating...
In situ vaccination with cowpea mosaic virus elicits systemic antitumor immunity and potentiates immune checkpoint blockade
WHAT IS ALREADY KNOWN ON THIS TOPICIn situ vaccination with cowpea mosaic virus (CPMV) has potent antitumor efficacy at lo...
Dasatinib for treatment of CAR T-cell therapy-related complications
Chimeric antigen receptor T-cell (CAR T) therapy is an established and effective option in the treatment of lymphoid malig...
Z-DNA enhances immunotherapy by triggering death of inflammatory cancer-associated fibroblasts
HighlightsInflammatory cancer-associated fibroblasts (iCAFs) portend poor patient survival.iCAFs can be selectively target...
Ensuring equity in the era of HLA-restricted cancer therapeutics
Biologic agents based on the human T cell receptor (TCR) represent an emerging class of immunotherapies that mimic the ada...
Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
IntroductionCD4+ and CD8+ effector T lymphocytes have the potential to inhibit tumor cells. However, tumor cells can evade...
Imaging endpoints for clinical trial use: a RECIST perspective
IntroductionTwenty years after its initial publication, Response Evaluation Criteria in Solid Tumors (RECIST) remains a un...
Correction: First report of CART treatment in AL Amyloidosis and relapsed/refractory multiple myeloma
Oliver-Caldes A, Jiménez R, Español-Rego M, et al. First report of CART treatment in AL amyloidosis and relapsed/refractor...
Correction: MRI techniques for immunotherapy monitoring
Lau D, Corrie PG, Gallagher FAMRI techniques for immunotherapy monitoring. J Immunother Cancer 2022;10:e004708. doi: 10.11...
Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition
WHAT IS ALREADY KNOWN IN THIS TOPICWHAT THIS STUDY ADDSIn this study, it was discovered that metformin increases HNC NK ce...
FRACTION-RCC: nivolumab plus ipilimumab for advanced renal cell carcinoma after progression on immuno-oncology therapy
WHAT IS ALREADY KNOWN ON THIS TOPICImmuno-oncology (IO) options, including immune checkpoint inhibitor (ICI) monotherapy a...