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iPSC-derived healthy human astrocytes selectively load miRNAs targeting neuronal genes into extracellular vesicles
iPSC-derived healthy human astrocytes selectively load miRNAs targeting neuronal genes into extracellular vesicles
Astrocytes participate in synapse formation and neuron maturation during development and maintain brain homeostasis during...
Systemic inflammation activates coagulation and immune cell infiltration pathways in brains with propagating α-synuclein fibril aggregates
Systemic inflammation activates coagulation and immune cell infiltration pathways in brains with propagating α-synuclein fibril aggregates
Atp1a2ATPase Na+/K+ transporting subunit Alpha2Atp1b2ATPase Na+/K+ transporting subunit Beta2DlatMitochondrial dehydrogena...
Cdc42 activation is necessary for heterosynaptic cooperation and competition
Cdc42 activation is necessary for heterosynaptic cooperation and competition
Synapses change their weights in response to neuronal activity and in turn, neuronal networks alter their response propert...
Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation
Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation
Proper circuit function in the mammalian brain relies upon cell-cell communication through two main types of chemical syna...
Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease
Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease
Volume 128, March 2024, 103919Author links open overlay panel, , , , , , Highlights•Patient specific midbrain organoids mo...
A neural mass model for disturbance of alpha rhythm in the minimal hepatic encephalopathy
A neural mass model for disturbance of alpha rhythm in the minimal hepatic encephalopathy
Hepatic encephalopathy (HE) is a spectrum of neuropsychiatric abnormalities associated with liver dysfunction, which is a ...
Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Amyloid-β deposits in human astrocytes contain truncated and highly resistant proteoforms
Alzheimer's disease (AD) is a neurodegenerative disorder that develops over decades. Glial cells, including astrocytes are...
TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges
TREM2 in Alzheimer's disease: Structure, function, therapeutic prospects, and activation challenges
Available online 19 January 2024, 103917Author links open overlay panelAbstractTriggering receptor expressed on myeloid ce...
Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin
Role and mechanism of EphB3 in epileptic seizures and epileptogenesis through Kalirin
Epilepsy, a prevalent chronic neurological disorder, transcends age, racial, and socioeconomic boundaries. Defined by the ...
The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ
The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ
Axon terminals are highly specialized cellular regions where targeted vesicle fusion is vital for a variety of critical sy...
Suppression of BMP signaling restores mitral cell development impaired by FGF signaling deficits in mouse olfactory bulb
Suppression of BMP signaling restores mitral cell development impaired by FGF signaling deficits in mouse olfactory bulb
The olfactory bulb (OB) is found in all vertebrates and is the first relay station of the olfactory information in the bra...
Neuron navigators: A novel frontier with physiological and pathological implications
Neuron navigators: A novel frontier with physiological and pathological implications
The last couple of decades have witnessed a tremendous growth in the field of medical research associated with overall hea...
The elastin-derived peptide (VGVAPG) activates autophagy in neuroblastoma (SH-SY5Y) cells via peroxisome proliferator-activated receptor gamma (PPARγ)
The elastin-derived peptide (VGVAPG) activates autophagy in neuroblastoma (SH-SY5Y) cells via peroxisome proliferator-activated receptor gamma (PPARγ)
Autophagy is a self-degradative process important for balancing the sources of energy and involved in the development of A...
Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation
Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation
Amyotrophic lateral sclerosis (ALS) affects millions of people worldwide, and till now there is no cure for this disease. ...
Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair
Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair
AbbreviationsADAMA disintegrin and metalloproteaseAICDAPP intracellular domainAPPamyloid-β precursor proteinDAPTN-[N-(3,5-...
The NIDA Avenir award in genetics or epigenetics of substance use disorders
The NIDA Avenir award in genetics or epigenetics of substance use disorders
NIDA's Avenir Program in the Genetics or Epigenetics of Substance Use Disorders (SUDs) was launched to support early stage...
The Npc2Gt(LST105)BygNya mouse signifies pathological changes comparable to human Niemann-Pick type C2 disease
The Npc2Gt(LST105)BygNya mouse signifies pathological changes comparable to human Niemann-Pick type C2 disease
Niemann-Pick type C disease (NP-C) is an autosomal recessive lysosomal storage disease caused by a deficiency in either th...
Satellite glial cell-secreted exosomes after in-vitro oxaliplatin treatment presents a pro-nociceptive effect for dorsal root ganglion neurons and induce mechanical hypersensitivity in naïve mice
Satellite glial cell-secreted exosomes after in-vitro oxaliplatin treatment presents a pro-nociceptive effect for dorsal root ganglion neurons and induce mechanical hypersensitivity in naïve mice
Chemotherapy-induced neuropathic pain (CINP) is a severe side effect of commonly used chemotherapeutics, such as oxaliplat...
CRMP2 conditional knockout changes axonal function and ultrastructure of axons in mice corpus callosum
CRMP2 conditional knockout changes axonal function and ultrastructure of axons in mice corpus callosum
Collapsin response mediator protein 2 (CRMP2) is a member of a protein family, which is highly involved in neurodevelopmen...
The molecular neural mechanism underlying the acceleration of brain aging due to Dcf1 deficiency
The molecular neural mechanism underlying the acceleration of brain aging due to Dcf1 deficiency
Aging is a major risk factor for various types of functional loss as well as highly prevalent chronic or fatal diseases (N...
Recovery of motor function is associated with rescue of glutamate biomarkers in the striatum and motor cortex following treatment with Mucuna pruriens in a murine model of Parkinsons disease
Recovery of motor function is associated with rescue of glutamate biomarkers in the striatum and motor cortex following treatment with Mucuna pruriens in a murine model of Parkinsons disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by symptoms that include bradykinesia, ...
Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila
Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila
Unusual expansion of polyQ repeats in certain proteins causes a group of progressive neurodegenerative diseases and Huntin...
Consequences of oxygen deprivation on myelination and sex-dependent alterations
Consequences of oxygen deprivation on myelination and sex-dependent alterations
There is a critical window of neurodevelopment in the perinatal period, when multiple important events take place in brain...
Glutamine metabolism in diseases associated with mitochondrial dysfunction
Glutamine metabolism in diseases associated with mitochondrial dysfunction
Mitochondrial dysfunction can arise from genetic defects or environmental exposures and impact a wide range of biological ...
The long-loop recycling (LLR) of synaptic components as a question of economics
The long-loop recycling (LLR) of synaptic components as a question of economics
The pre- and post-synaptic compartments contain a variety of molecules that are known to recycle between the plasma membra...
Epigenomic profiling of mouse nucleus accumbens at single-cell resolution
Epigenomic profiling of mouse nucleus accumbens at single-cell resolution
Volume 126, September 2023, 103857Author links open overlay panel, , , , Highlights•Single-nucleus ATAC-seq of male mouse ...
Effect of germ-free status on transcriptional profiles in the nucleus accumbens and transcriptomic response to chronic morphine
Effect of germ-free status on transcriptional profiles in the nucleus accumbens and transcriptomic response to chronic morphine
Opioid use disorder (OUD) is a chronic psychiatric condition marked by increasing and out of control drug intake despite n...
Paternal morphine exposure in rats reduces social play in adolescent male progeny without affecting drug-taking behavior in juvenile males or female offspring
Paternal morphine exposure in rats reduces social play in adolescent male progeny without affecting drug-taking behavior in juvenile males or female offspring
The ongoing opioid addiction crisis necessitates the identification of novel risk factors to improve prevention and treatm...
Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters
Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters
Transcriptomic responses to neurotransmitters contribute to the complex processes driving memory and addiction. Advances i...
Experience-dependent Tip60 nucleocytoplasmic transport is regulated by its NLS/NES sequences for neuroplasticity gene control
Experience-dependent Tip60 nucleocytoplasmic transport is regulated by its NLS/NES sequences for neuroplasticity gene control
The human brain consists of a dense network of neurons that can modify the efficacy and strength of their synaptic connect...
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