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Soat2 ties cholesterol metabolism to β‐oxidation and glucose tolerance in male mice
Soat2 ties cholesterol metabolism to β‐oxidation and glucose tolerance in male mice
Abstract Background Sterol O-Acyltransferase 2 (Soat2) encodes acyl-Coenzyme A:cholesterol acyltransferase 2 (ACAT2), whic...
Glucagon‐like peptide‐1 (GLP‐1) – are its roles as endogenous hormone and therapeutic wizard congruent?
Glucagon‐like peptide‐1 (GLP‐1) – are its roles as endogenous hormone and therapeutic wizard congruent?
Abstract GLP-1 is a peptide derived from differential processing of the precursor for the hormone glucagon. It is secreted...
Gender‐affirming hormone therapy: An updated literature review with an eye on the future
Gender‐affirming hormone therapy: An updated literature review with an eye on the future
Abstract In line with increasing numbers of transgender (trans) and gender non-binary people requesting hormone treatment,...
Apolipoprotein A‐IV concentrations and clinical outcomes in a large chronic kidney disease cohort: Results from the GCKD study
Apolipoprotein A‐IV concentrations and clinical outcomes in a large chronic kidney disease cohort: Results from the GCKD study
Abstract Background Chronic kidney disease (CKD) represents a chronic proinflammatory state and is associated with very hi...
The step count conundrum
The step count conundrum
For many years, the physical activity field has grappled with the important issue of dose–response—that is, the amount of ...
Neuroimaging phenotypes of CSF1R‐related leukoencephalopathy: Systematic review, meta‐analysis, and imaging recommendations
Neuroimaging phenotypes of CSF1R‐related leukoencephalopathy: Systematic review, meta‐analysis, and imaging recommendations
Abstract Colony-stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy is a rare but fatal microgliopathy. The ...
Can we cure diabetic kidney disease? Present and future perspectives from a nephrologist's point of view
Can we cure diabetic kidney disease? Present and future perspectives from a nephrologist's point of view
Abstract Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease (CKD) worldwide, contributing to a g...
Liver damage promotes pro‐inflammatory T‐cell responses against apolipoprotein B‐100
Liver damage promotes pro‐inflammatory T‐cell responses against apolipoprotein B‐100
Abstract Objectives Liver-derived apolipoprotein B-100 (ApoB100) is an autoantigen that is recognized by atherogenic CD4+ ...
Neuroimaging phenotypes of CSF1R‐related leukoencephalopathy: A systematic review, meta‐analysis, and imaging recommendations
Neuroimaging phenotypes of CSF1R‐related leukoencephalopathy: A systematic review, meta‐analysis, and imaging recommendations
Abstract Colony-stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy is a rare but fatal microgliopathy. The ...
Towards precision medicine in lymphoid malignancies
Towards precision medicine in lymphoid malignancies
Abstract Careful histopathologic examination remains the cornerstone in the diagnosis of the clinically and biologically h...
Food allergy and hypersensitivity reactions in children and adults ‐ a review
Food allergy and hypersensitivity reactions in children and adults ‐ a review
Abstract Adverse reactions after food intake are commonly reported and a cause of concern and anxiety that can lead to a v...
Incidence and survival of haemophagocytic lymphohistiocytosis: A population‐based cohort study from England
Incidence and survival of haemophagocytic lymphohistiocytosis: A population‐based cohort study from England
Abstract Background: Haemophagocytic Lymphohistiocytosis (HLH) is a rare hyper-inflammatory condition with poor outcomes. ...
Humoral response to two doses of BNT162b2 vaccination in people with HIV
Humoral response to two doses of BNT162b2 vaccination in people with HIV
Abstract Background People with HIV (PWH) are at increased risk of severe COVID-19. We aimed to determine humoral response...
Gastrointestinal function in diabetes is affected regardless of asymptomatic appearance
Gastrointestinal function in diabetes is affected regardless of asymptomatic appearance
Abstract Background Gastrointestinal dysmotility may exist without concomitant symptoms. We hypothesise that asymptomatic ...
Antiphospholipid antibodies in patients with myocardial infarction with and without obstructive coronary arteries
Antiphospholipid antibodies in patients with myocardial infarction with and without obstructive coronary arteries
Abstract Background Recent studies demonstrate that prothrombotic antiphospholipid antibodies (aPL) are overrepresented in...
Hospital at home for acute medical illness: The 21st century acute medical unit for a changing population
Hospital at home for acute medical illness: The 21st century acute medical unit for a changing population
Abstract Recent trends across Europe show a year-on-year increase in the number of patients with acute medical illnesses p...
Apolipoprotein C‐III predicts cardiovascular events and mortality in individuals with type 1 diabetes and albuminuria
Apolipoprotein C‐III predicts cardiovascular events and mortality in individuals with type 1 diabetes and albuminuria
Abstract Objectives We studied apolipoprotein C-III (apoC-III) in relation to diabetic kidney disease (DKD), cardiovascula...
4D flow MRI hemodynamic biomarkers for cerebrovascular diseases
4D flow MRI hemodynamic biomarkers for cerebrovascular diseases
Abstract Alterations in cerebral blood flow are common in several neurological diseases among the elderly including stroke...
Prognostic implications of ischemia with nonobstructive coronary arteries (INOCA): Understanding risks for improving treatment
Prognostic implications of ischemia with nonobstructive coronary arteries (INOCA): Understanding risks for improving treatment
Myocardial ischemia commonly manifests as angina pectoris and is generally ascribed to atherosclerotic narrowing of epicar...