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Clinical and biological heterogeneity of Grade 2 digestive neuroendocrine neoplasms: prognostic significance of the 10% Ki-67 index cutoff and implications for treatment strategies. A longitudinal study
Clinical and biological heterogeneity of Grade 2 digestive neuroendocrine neoplasms: prognostic significance of the 10% Ki-67 index cutoff and implications for treatment strategies. A longitudinal study
Digestive neuroendocrine neoplasms (NENs) encompass a heterogeneous group of tumors with varying prognoses and clinical be...
Artificial intelligence in the management of metabolic disorders: a comprehensive review
Artificial intelligence in the management of metabolic disorders: a comprehensive review
This review explores the significant role of artificial intelligence (AI) in managing metabolic disorders like diabetes, o...
Extending curve matching with flexible hyperparameter selection to predict response to long-acting PEGylated growth hormone treatment in growth hormone deficiency children: method development and validation
Extending curve matching with flexible hyperparameter selection to predict response to long-acting PEGylated growth hormone treatment in growth hormone deficiency children: method development and validation
Curve matching can predict the height trajectories of children by analyzing longitudinal growth data. We extended the meth...
Evaluation of fluid status in patients with acromegaly through bioelectrical impedance vector analysis: a cross-sectional study
Evaluation of fluid status in patients with acromegaly through bioelectrical impedance vector analysis: a cross-sectional study
The acromegalic state is associated with an increase in total body water and sodium. The aim of our study was to assess th...
Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence
Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence
Long COVID is a multisystemic syndrome leading to significant morbidity. To date, a comprehensive characterization of unde...
Exploring the interplay of karyotype, hormones, sexuality, and body image perception in individuals with Turner syndrome
Exploring the interplay of karyotype, hormones, sexuality, and body image perception in individuals with Turner syndrome
Most patients with Turner Syndrome (TS) require Hormone Replacement Therapy (HRT). Androgen levels could be compromised du...
MiR-27a-5p inhibits malignant progression of differentiated thyroid cancer by directly affecting the miR-27a-5p/SREBP1 axis
MiR-27a-5p inhibits malignant progression of differentiated thyroid cancer by directly affecting the miR-27a-5p/SREBP1 axis
To detect the expression of miR-27a-5p in differentiated thyroid cancer (DTC) and to explore its correlation with SREBP1 e...
ccfDNA analysis for the classification of adrenocortical adenomas
ccfDNA analysis for the classification of adrenocortical adenomas
Somatic alterations are commonly observed in adrenocortical adenomas including cortisol-producing (CPA) [overt Cushing syn...
Growth hormone replacement therapy enhances humoral response to COVID-19 mRNA vaccination in patients with adult-onset growth hormone deficiency
Growth hormone replacement therapy enhances humoral response to COVID-19 mRNA vaccination in patients with adult-onset growth hormone deficiency
Given the established link between GH/insulin-like growth factor 1 (IGF-1) deficiency and severe COVID-19 outcomes, this r...
Thyroxine overuse and clinical indices guiding successful treatment withdrawal
Thyroxine overuse and clinical indices guiding successful treatment withdrawal
Levothyroxine (LT4) is commonly prescribed, but there is evidence strongly suggesting that a significant proportion of the...
Effects of acarbose and metformin on thyroid function and thyroid hormone sensitivity in type 2 diabetes patients: a post-hoc analysis of the MARCH study
Effects of acarbose and metformin on thyroid function and thyroid hormone sensitivity in type 2 diabetes patients: a post-hoc analysis of the MARCH study
While metformin is known to regulate thyroid stimulating hormone (TSH) levels, the effects of acarbose on thyroid function...
The role of TMEM163 protein in thyroid microcarcinoma: expression pattern and clinical implications
The role of TMEM163 protein in thyroid microcarcinoma: expression pattern and clinical implications
TMEM163 protein is a new zinc ion transporter whose regulatory role in tumors has yet to be discovered. This study aimed t...
A single bout of physical exercise improves 1-hour post-load plasma glucose in healthy young adults
A single bout of physical exercise improves 1-hour post-load plasma glucose in healthy young adults
Physical exercise is a key component in the treatment of type 2 diabetes and plays an important role in maintaining a heal...
Pannexin-1 regulation of ATP release promotes the invasion of pituitary adenoma
Pannexin-1 regulation of ATP release promotes the invasion of pituitary adenoma
Pannexin-1 (PANX1) channel participates in the development and progression of many tumor types, however, its role of PANX1...
Interleukin-5: an indicator of mild cognitive impairment in patients with type 2 diabetes mellitus - a comprehensive investigation ranging from bioinformatics analysis to clinical research
Interleukin-5: an indicator of mild cognitive impairment in patients with type 2 diabetes mellitus - a comprehensive investigation ranging from bioinformatics analysis to clinical research
Neuroinflammation constitutes an underlying mechanism for cognitive impairment. Here, we endeavor to scrutinize the potent...
Shepherd with goiter in the late-Renaissance Nativity scene of the Canonica di San Salvatore in Barzanò
Shepherd with goiter in the late-Renaissance Nativity scene of the Canonica di San Salvatore in Barzanò
Conflict of interest None. ...
Leukocytosis in Cushing’s syndrome persists post-surgical remission and could predict a lower remission prognosis in patients with Cushing’s disease
Leukocytosis in Cushing’s syndrome persists post-surgical remission and could predict a lower remission prognosis in patients with Cushing’s disease
Leukocytosis frequently noted in Cushing’s syndrome (CS), along with other blood cell changes caused by direct and i...
Fasting plasma methylglyoxal concentrations are associated with higher numbers of circulating intermediate and non-classical monocytes but with lower activation of intermediate monocytes: the Maastricht Study
Fasting plasma methylglyoxal concentrations are associated with higher numbers of circulating intermediate and non-classical monocytes but with lower activation of intermediate monocytes: the Maastricht Study
Elevated methylglyoxal (MGO) levels and altered immune cell responses are observed in diabetes. MGO is thought to modulate...
The paradoxical GH response at OGTT does not predict Pasireotide efficacy but matters for glucose metabolism
The paradoxical GH response at OGTT does not predict Pasireotide efficacy but matters for glucose metabolism
A paradoxical increase in GH after oral glucose load (GH-Par) characterizes about one-third of acromegaly patients and is ...
Delphi consensus on the diagnostic criteria of polycystic ovary syndrome
Delphi consensus on the diagnostic criteria of polycystic ovary syndrome
To gather the current opinion among Italian gynecologists and endocrinologists regarding the definition, diagnosis, and tr...
Screening of primary aldosteronism and pheochromocytoma among patients with hypertension: an Italian nationwide survey
Screening of primary aldosteronism and pheochromocytoma among patients with hypertension: an Italian nationwide survey
The delayed or missed diagnosis of secondary hypertension contributes to the poor blood pressure control worldwide. This s...
Primary ovarian insufficiency in Classic Galactosemia: a systematic review
Primary ovarian insufficiency in Classic Galactosemia: a systematic review
Galactosemia is a rare inborn error of galactose metabolism. There are several forms, the most severe being classic galact...
The thyroid hormone activating enzyme, DIO2, is a potential pan-cancer biomarker and immunotherapy target
The thyroid hormone activating enzyme, DIO2, is a potential pan-cancer biomarker and immunotherapy target
Type 2 deiodinase (D2), encoded by DIO2 gene, catalyzes the activation of the prohormone thyroxine (T4) into the bioactive...
Bromocriptine sensitivity in bromocriptine-induced drug-resistant prolactinomas is restored by inhibiting FGF19/FGFR4/PRL
Bromocriptine sensitivity in bromocriptine-induced drug-resistant prolactinomas is restored by inhibiting FGF19/FGFR4/PRL
At present, various treatment strategies are available for pituitary adenomas, including medications, surgery and radiatio...
Vitamin D supplementation in primary hyperparathyroidism: effects on 1,25(OH)2 vitamin D and FGF23 levels
Vitamin D supplementation in primary hyperparathyroidism: effects on 1,25(OH)2 vitamin D and FGF23 levels
In patients with Primary Hyperparathyroidism (PHPT) vitamin D deficiency has been associated with more severe presentation...
Current drawbacks and future perspectives in the diagnosis and treatment of male factor infertility, with a focus on FSH treatment: an expert opinion
Current drawbacks and future perspectives in the diagnosis and treatment of male factor infertility, with a focus on FSH treatment: an expert opinion
Infertility is defined as the inability to conceive after 1 year of unprotected intercourse, affecting approximat...
SP1 activates AKT3 to facilitate the development of diabetic nephropathy
SP1 activates AKT3 to facilitate the development of diabetic nephropathy
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus and has the complex pathogenesis. The previous stu...
Long noncoding RNA FAM111A-DT promotes aggressiveness of papillary thyroid cancer via activating NF-κB signaling
Long noncoding RNA FAM111A-DT promotes aggressiveness of papillary thyroid cancer via activating NF-κB signaling
Long noncoding RNAs (lncRNAs) play crucial regulatory roles in the tumorigenesis and progression of various cancers. Howev...
Emperor Leo I “the Thracian”: a possible case of Graves’ orbitopathy
Emperor Leo I “the Thracian”: a possible case of Graves’ orbitopathy
Representation of exophthalmos in ancient artworks is reported by several authors. In the present paper we analyze a sculp...
Aetiology, diagnosis and treatment of thalassemia-associated osteoporosis of the adult
Aetiology, diagnosis and treatment of thalassemia-associated osteoporosis of the adult
This review aims to overview factors contributing to TAO development and addresses the targeted diagnostic work-up and tre...
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