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Ticagrelor Versus Clopidogrel in Acute Large-Vessel Ischemic Stroke: A Randomized Controlled Single-Blinded Trial
Ticagrelor Versus Clopidogrel in Acute Large-Vessel Ischemic Stroke: A Randomized Controlled Single-Blinded Trial
Large-vessel ischemic stroke represents about 25–40% of all ischemic strokes. Few clinical trials compared ticagrelo...
Longitudinal studies of bipolar patients and their families: translating findings to advance individualized risk prediction, treatment and research
Longitudinal studies of bipolar patients and their families: translating findings to advance individualized risk prediction, treatment and research
Bipolar disorder is a broad diagnostic construct associated with significant phenotypic and genetic heterogeneity challeng...
Social Isolation/loneliness and Mobility Disability Among Older Adults
Social Isolation/loneliness and Mobility Disability Among Older Adults
The purpose of this review was to investigate how mobility disabilities are related to the current problems of social isol...
Pain Management Considerations in the Geriatric ED Patient: Start Low, Go Slow, But Get Somewhere
Pain Management Considerations in the Geriatric ED Patient: Start Low, Go Slow, But Get Somewhere
Safely treating pain in older adults can be a daunting undertaking. The authors sought clarity in available analgesic choi...
The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases
The 37TrillionCells initiative for improving global healthcare via cell-based interception and precision medicine: focus on neurodegenerative diseases
One of the main burdens in the treatment of diseases is imputable to the delay between the appearance of molecular dysfunc...
Exemplar Hospital initiation trial to Enhance Treatment Engagement (EXHIT ENTRE): protocol for CTN-0098B a randomized implementation study to support hospitals in caring for patients with opioid use disorder
Exemplar Hospital initiation trial to Enhance Treatment Engagement (EXHIT ENTRE): protocol for CTN-0098B a randomized implementation study to support hospitals in caring for patients with opioid use disorder
Hospitalizations involving opioid use disorder (OUD) are increasing. Medications for opioid use disorder (MOUD) reduce mor...
Treating Obsessive Compulsive Disorder in Adolescents and Adults with Down Syndrome: Results from a Scoping Rapid Review
Treating Obsessive Compulsive Disorder in Adolescents and Adults with Down Syndrome: Results from a Scoping Rapid Review
Adolescents and adults with Down syndrome are noted to display symptoms and behaviors consistent with a diagnosis of Obses...
Dysregulations of amino acid metabolism and lipid metabolism in urine of children and adolescents with major depressive disorder: a case-control study
Dysregulations of amino acid metabolism and lipid metabolism in urine of children and adolescents with major depressive disorder: a case-control study
The mechanisms underlying major depressive disorder (MDD) in children and adolescents are unclear. Metabolomics has been u...
Pharmacogenomic study—A pilot study of the effect of pharmacogenomic phenotypes on the adequate dosing of verapamil for migraine prevention
Pharmacogenomic study—A pilot study of the effect of pharmacogenomic phenotypes on the adequate dosing of verapamil for migraine prevention
To investigate factors affecting the efficacy and tolerability of verapamil for migraine prevention using individual pharm...
Factors associated with the use of cannabis for self-medication by adults: data from the French TEMPO cohort study
Factors associated with the use of cannabis for self-medication by adults: data from the French TEMPO cohort study
Medical cannabis, legalized in many countries, remains illegal in France. Despite an experiment in the medical use of cann...
Population Neuroscience: Principles and Advances
Population Neuroscience: Principles and Advances
In population neuroscience, three disciplines come together to advance our knowledge of factors that shape the human brain...
The Functional-Cognitive and Sensory Treatment (F-CaST) to improve rehabilitation outcomes of individuals with substance use disorder: a study protocol for a mixed-method randomized controlled trial
The Functional-Cognitive and Sensory Treatment (F-CaST) to improve rehabilitation outcomes of individuals with substance use disorder: a study protocol for a mixed-method randomized controlled trial
Substance use disorder (SUD) is associated with executive function (EF) deficits and sensory modulation dysfunction (SMD)....
Cannabis use associated with lower mortality among hospitalized Covid-19 patients using the national inpatient sample: an epidemiological study
Cannabis use associated with lower mortality among hospitalized Covid-19 patients using the national inpatient sample: an epidemiological study
Prior reports indicate that modulation of the endocannabinoid system (ECS) may have a protective benefit for Covid-19 pati...
Synergism of Anti-CGRP Monoclonal Antibodies and OnabotulinumtoxinA in the Treatment of Chronic Migraine: A Real-World Retrospective Chart Review
Synergism of Anti-CGRP Monoclonal Antibodies and OnabotulinumtoxinA in the Treatment of Chronic Migraine: A Real-World Retrospective Chart Review
Many patients with chronic migraine do not achieve clinically meaningful improvement in their headache frequency with mono...
Novel rat model of gaming disorder: assessment of social reward and sex differences in behavior and c-Fos brain activity
Novel rat model of gaming disorder: assessment of social reward and sex differences in behavior and c-Fos brain activity
In 2018, the International Classification of Diseases (ICD-11) classified Gaming Disorder (GD) as a mental disorder. GD ma...
Understanding Burnout among Parents of Children with Complex Care Needs: A Scoping Review Followed by a Stakeholder Consultation
Understanding Burnout among Parents of Children with Complex Care Needs: A Scoping Review Followed by a Stakeholder Consultation
The concept of parental burnout has been proposed to be helpful for describing and understanding the impact of parenting c...
CNS Viral Infections—What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches
CNS Viral Infections—What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches
Neurotropic viruses may cause meningitis, myelitis, encephalitis, or meningoencephalitis. These inflammatory conditions of...
Disruption of positive- and negative-feature morphine interoceptive occasion setters by dopamine receptor agonism and antagonism in male and female rats
Disruption of positive- and negative-feature morphine interoceptive occasion setters by dopamine receptor agonism and antagonism in male and female rats
Internally perceived stimuli evoked by morphine administration can form Pavlovian associations such that they can function...
Psychometric properties of the cannabis abuse screening test (CAST) in a sample of Moroccans with cannabis use
Psychometric properties of the cannabis abuse screening test (CAST) in a sample of Moroccans with cannabis use
The Cannabis Abuse Screening Test (CAST) is a widely used screening tool for identifying patterns of cannabis use that hav...
Managing Delirium in the Emergency Department: An Updated Narrative Review
Managing Delirium in the Emergency Department: An Updated Narrative Review
Emergency departments (EDs) are facing an epidemic of overcrowding and ED boarding, particularly of older adults who often...
Observation on the Analgesic Effect of Different Doses of a Combination of Esketamine and Dexmedetomidine Administered for Percutaneous Endoscopic Transforaminal Discectomy: A Randomized, Double-Blind Controlled Trial
Observation on the Analgesic Effect of Different Doses of a Combination of Esketamine and Dexmedetomidine Administered for Percutaneous Endoscopic Transforaminal Discectomy: A Randomized, Double-Blind Controlled Trial
Percutaneous endoscopic transforaminal discectomy (PETD) is an effective method for treating lumbar disc herniation, and i...
Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses
Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses
Synaptopodin (SP), an actin-associated protein found in telencephalic neurons, affects activity-dependant synaptic plastic...
Type of cycle, temperament and childhood trauma are associated with lithium response in patients with bipolar disorders
Type of cycle, temperament and childhood trauma are associated with lithium response in patients with bipolar disorders
Lithium stands as the gold standard in treating bipolar disorders (BD). Despite numerous clinical factors being associated...
Cost of start-up activities to implement a community-level opioid overdose reduction intervention in the HEALing Communities Study
Cost of start-up activities to implement a community-level opioid overdose reduction intervention in the HEALing Communities Study
Communities That HEAL (CTH) is a novel, data-driven community-engaged intervention designed to reduce opioid overdose deat...
Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study
Synergistic use of deep TMS therapy with IV ketamine infusions for major depressive disorder: a pilot study
Major Depressive Disorder (MDD) is a pervasive psychiatric condition effecting approximately 21 million adults in the U.S....
The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats
The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats
Ketamine produces dissociative, psychomimetic, anxiolytic, antidepressant, and anesthetic effects in a dose dependent mann...
Evaluation of dispensaries’ cannabis flowers for accuracy of labeling of cannabinoids content
Evaluation of dispensaries’ cannabis flowers for accuracy of labeling of cannabinoids content
Cannabis policies have changed drastically over the last few years with many states enacting medical cannabis laws, and so...
Prevention of suicidal behavior with lithium treatment in patients with recurrent mood disorders
Prevention of suicidal behavior with lithium treatment in patients with recurrent mood disorders
Suicidal behavior is more prevalent in bipolar disorders than in other psychiatric illnesses. In the last thirty years evi...
Polypharmacy in psychiatry and weight gain: longitudinal study of 832 patients hospitalized for depression or schizophrenia, along with data of 3180 students from Europe, the U.S., South America, and China
Polypharmacy in psychiatry and weight gain: longitudinal study of 832 patients hospitalized for depression or schizophrenia, along with data of 3180 students from Europe, the U.S., South America, and China
Epidemiologic data indicate that overweight and obesity are on the rise worldwide. Psychiatric patients are particularly v...
Magic mushroom and zebrafish: A new recipe?
Magic mushroom and zebrafish: A new recipe?
No, we are not talking about a new dish for dinner, but a study representing an emerging research field. Psilocybin resear...
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