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Dodecyl creatine ester therapy: from promise to reality
Dodecyl creatine ester therapy: from promise to reality
Pathogenic variants in SLC6A8, the gene which encodes creatine transporter SLC6A8, prevent creatine uptake in the brain an...
RUNX transcription factors are essential in maintaining epididymal epithelial differentiation
RUNX transcription factors are essential in maintaining epididymal epithelial differentiation
Apart from the androgen receptor, transcription factors (TFs) that are required for the development and formation of the d...
The impact of nanomaterials on autophagy across health and disease conditions
The impact of nanomaterials on autophagy across health and disease conditions
Autophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress c...
When DNA-damage responses meet innate and adaptive immunity
When DNA-damage responses meet innate and adaptive immunity
When cells proliferate, stress on DNA replication or exposure to endogenous or external insults frequently results in DNA ...
The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation
The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation
Intercellular communication via gap junctions has a fundamental role in regulating cell growth and tissue homeostasis, and...
Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia
Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia
Aberrant remodeling of uterine spiral arteries (SPA) is strongly associated with the pathogenesis of early-onset preeclamp...
Functional myelin in cognition and neurodevelopmental disorders
Functional myelin in cognition and neurodevelopmental disorders
In vertebrates, oligodendrocytes (OLs) are glial cells of the central nervous system (CNS) responsible for the formation o...
Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo
Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo
Stem cell therapy is a promising therapeutic strategy. In a previous study, we evaluated tumorigenicity ...
Sex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis
Sex differences in DNA methylation across gestation: a large scale, cross-cohort, multi-tissue analysis
Biological sex is a key variable influencing many physiological systems. Disease prevalence as well as treatment success c...
Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1α axis in head and neck squamous cell carcinoma
Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1α axis in head and neck squamous cell carcinoma
Extracellular vesicles (EVs) have recently received increasing attention as essential mediators of communication between t...
Epigenomic insights into common human disease pathology
Epigenomic insights into common human disease pathology
The epigenome—the chemical modifications and chromatin-related packaging of the genome—enables the same geneti...
PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling
PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling
Heterozygous mutations in any of three major genes, BRCA1, BRCA2 and PALB2, are associated with high-risk hereditary breas...
A novel fatty acid analogue triggers CD36–GPR120 interaction and exerts anti-inflammatory action in endotoxemia
A novel fatty acid analogue triggers CD36–GPR120 interaction and exerts anti-inflammatory action in endotoxemia
Inflammation is a mediator of a number of chronic pathologies. We synthesized the diethyl (9Z,12Z)-octadeca-9,12-dien-1-yl...
LncRNA CARMN inhibits abdominal aortic aneurysm formation and vascular smooth muscle cell phenotypic transformation by interacting with SRF
LncRNA CARMN inhibits abdominal aortic aneurysm formation and vascular smooth muscle cell phenotypic transformation by interacting with SRF
Phenotypic transformation of vascular smooth muscle cells (VSMCs) plays a crucial role in abdominal aortic aneurysm (AAA) ...
Metabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm
Metabolic profiling identifies Qrich2 as a novel glutamine sensor that regulates microtubule glutamylation and mitochondrial function in mouse sperm
In our prior investigation, we discerned loss-of-function variants within the gene encoding glutamine-rich protein 2 (QRIC...
Bioengineered MSCCxcr2 transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound
Bioengineered MSCCxcr2 transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound
Skin regeneration is severely compromised in diabetic foot ulcers. Allogeneic mesenchymal stem cell (MSC) transplantation ...
CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice
CCDC28A deficiency causes sperm head defects, reduced sperm motility and male infertility in mice
Mature spermatozoa with normal morphology and motility are essential for male reproduction. The epididymis has an importan...
Unearthing FLVCR1a: tracing the path to a vital cellular transporter
Unearthing FLVCR1a: tracing the path to a vital cellular transporter
The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a member of the SLC49 Major Facilitator Superfamily of trans...
Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis
Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis
Kinesin family member 3A (KIF3A) is a microtubule-oriented motor protein that belongs to the kinesin-2 family for regulati...
Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression
Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression
Rhes (Ras homolog enriched in the striatum), a multifunctional protein that regulates striatal functions associated with m...
Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation
Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation
The susceptibility to autoimmune diseases is conditioned by the association of modest genetic alterations which altogether...
Phosphorylation of the compartmentalized PKA substrate TAF15 regulates RNA–protein interactions
Phosphorylation of the compartmentalized PKA substrate TAF15 regulates RNA–protein interactions
Spatiotemporal-controlled second messengers alter molecular interactions of central signaling nodes for ensuring physiolog...
iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I
iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I
Proteolytic release of transmembrane proteins from the cell surface, the so called ectodomain shedding, is a key process i...
Aberrant splicing of CaV1.2 calcium channel induced by decreased Rbfox1 enhances arterial constriction during diabetic hyperglycemia
Aberrant splicing of CaV1.2 calcium channel induced by decreased Rbfox1 enhances arterial constriction during diabetic hyperglycemia
Diabetic hyperglycemia induces dysfunctions of arterial smooth muscle, leading to diabetic vascular complications. The CaV...
CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes
CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes
The DNA methylation is gradually acquired during oogenesis, a process sustained by successful follicle development. Howeve...
NFKBIZ regulates NFκB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16
NFKBIZ regulates NFκB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16
Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence and mortality rates. NFKBIZ, a member of the nucle...
EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
The androgen receptor (AR) is a primary target for treating prostate cancer (PCa), forming the bedrock of its clinical man...
Regulation and function of transposable elements in cancer genomes
Regulation and function of transposable elements in cancer genomes
Over half of human genomic DNA is composed of repetitive sequences generated throughout evolution by prolific mobile genet...
A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration
A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration
Mutations in cysteine and glycine-rich protein 3 (CSRP3)/muscle LIM protein (MLP), a key regulator of striated muscle func...
Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis
Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis
Both EphB2- and EphB3-deficient mice exhibit profound histological alterations in the thymic epithelial network but few ch...
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