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MicroRNA-9 promotes axon regeneration of mauthner-cell in zebrafish via her6/ calcium activity pathway
MicroRNA-9 promotes axon regeneration of mauthner-cell in zebrafish via her6/ calcium activity pathway
MicroRNA (miRNA), functioning as a post-transcriptional regulatory element, plays a significant role in numerous regulator...
BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response
BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response
Abnormal autophagy is one of the vital features in polycystic ovary syndrome (PCOS). However, the underlying molecular mec...
The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease
The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease
VPS35 plays a key role in neurodegenerative processes in Alzheimer’s disease and Parkinson’s disease (PD). Man...
RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1
RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1
Proneural genes play a crucial role in neuronal differentiation. However, our understanding of the regulatory mechanisms g...
Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis
Role of chromosomal cohesion and separation in aneuploidy and tumorigenesis
Cell division is a crucial process, and one of its essential steps involves copying the genetic material, which is organiz...
Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?
Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?
Recent findings show that single, non-neuronal cells are also able to learn signalling responses developing cellular memor...
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway
Activation of hepatic stellate cells (HSCs) has been demonstrated to play a pivotal role in the process of liver fibrogene...
Emerging role of complement in COVID-19 and other respiratory virus diseases
Emerging role of complement in COVID-19 and other respiratory virus diseases
The complement system, a key component of innate immunity, provides the first line of defense against bacterial infection;...
RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo
RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo
The maintenance of genome integrity in the germline is crucial for mammalian development. Long interspersed element type 1...
WNT5A regulates the proliferation, apoptosis and stemness of human stem Leydig cells via the β-catenin signaling pathway
WNT5A regulates the proliferation, apoptosis and stemness of human stem Leydig cells via the β-catenin signaling pathway
Stem Leydig cells (SLCs) are essential for maintaining normal spermatogenesis as the significant component of testis micro...
FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1 intracellular domain and accelerating degradation
FBP1 inhibits NSCLC stemness by promoting ubiquitination of Notch1 intracellular domain and accelerating degradation
The existence of cancer stem cells is widely acknowledged as the underlying cause for the challenging curability and high ...
KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes
KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes
Glucose-stimulated insulin secretion (GSIS) in pancreatic islet β-cells primarily relies on electrophysiological proc...
Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling
Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and recent epidemiological studies suggested ...
Role of Sam68 as an adaptor protein in inflammatory signaling
Role of Sam68 as an adaptor protein in inflammatory signaling
Sam68 is a ubiquitously expressed KH-domain containing RNA-binding protein highly studied for its involvement in regulatin...
CircYthdc2 generates polypeptides through two translation strategies to facilitate virus escape
CircYthdc2 generates polypeptides through two translation strategies to facilitate virus escape
It is known that about 10 circular RNAs (circRNAs) can encode functional polypeptides in higher mammals. However, it is no...
Platelet C3G: a key player in vesicle exocytosis, spreading and clot retraction
Platelet C3G: a key player in vesicle exocytosis, spreading and clot retraction
C3G is a Rap1 GEF that plays a pivotal role in platelet-mediated processes such as angiogenesis, tumor growth, and metasta...
BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma
BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma
Interaction between programmed death-1 (PD-1) ligand 1 (PD-L1) on tumor cells and PD-1 on T cells allows tumor cells to ev...
The human OPA1delTTAG mutation induces adult onset and progressive auditory neuropathy in mice
The human OPA1delTTAG mutation induces adult onset and progressive auditory neuropathy in mice
Dominant optic atrophy (DOA) is one of the most prevalent forms of hereditary optic neuropathies and is mainly caused by h...
METTL16 inhibits papillary thyroid cancer tumorigenicity through m6A/YTHDC2/SCD1-regulated lipid metabolism
METTL16 inhibits papillary thyroid cancer tumorigenicity through m6A/YTHDC2/SCD1-regulated lipid metabolism
Papillary thyroid carcinoma (PTC) stands as the leading cancer type among endocrine malignancies, and there exists a stron...
Exploring the nexus of nuclear receptors in hematological malignancies
Exploring the nexus of nuclear receptors in hematological malignancies
Hematological malignancies (HM) represent a subset of neoplasms affecting the blood, bone marrow, and lymphatic systems, c...
Wnt/β-catenin-driven EMT regulation in human cancers
Wnt/β-catenin-driven EMT regulation in human cancers
Metastasis accounts for 90% of cancer-related deaths among the patients. The transformation of epithelial cells into mesen...
A glimpse into novel acylations and their emerging role in regulating cancer metastasis
A glimpse into novel acylations and their emerging role in regulating cancer metastasis
Metastatic cancer is a major cause of cancer-related mortality; however, the complex regulation process remains to be furt...
LRP10 and α-synuclein transmission in Lewy body diseases
LRP10 and α-synuclein transmission in Lewy body diseases
Autosomal dominant variants in LRP10 have been identified in patients with Lewy body diseases (LBDs), including Parkinson&...