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rTM reprograms macrophages via the HIF-1α/METTL3/PFKM axis to protect mice against sepsis
rTM reprograms macrophages via the HIF-1α/METTL3/PFKM axis to protect mice against sepsis
The metabolic reprogramming of macrophages is a potential therapeutic strategy for sepsis treatment, but the mechanism und...
Neutrophil-centric analysis of gastric cancer: prognostic modeling and molecular insights
Neutrophil-centric analysis of gastric cancer: prognostic modeling and molecular insights
Gastric cancer remains a significant global health concern with poor prognosis. This study investigates the role of neutro...
SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death
SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death
RIPK1/RIPK3-MLKL signaling molecules are fundamental in initiating necroptotic cell death, but their roles in the developm...
Correction: Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling
Correction: Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Helicobacter pylori promotes gastric cancer progression by activating the TGF-β/Smad2/EMT pathway through HKDC1
Helicobacter pylori promotes gastric cancer progression by activating the TGF-β/Smad2/EMT pathway through HKDC1
Helicobacter pylori (H. pylori) infection is widely acknowledged as the primary risk factor for gastric cancer, facilitati...
αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injury
αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injury
Contrast-induced acute kidney injury (CI-AKI) is one of the main causes of hospital-acquired renal failure, and still lack...
The phospholamban R14del generates pathogenic aggregates by impairing autophagosome-lysosome fusion
The phospholamban R14del generates pathogenic aggregates by impairing autophagosome-lysosome fusion
Phospholamban (PLN) plays a crucial role in regulating sarcoplasmic reticulum (SR) Ca2+ cycling and cardiac contractility....
Dapagliflozin targets SGLT2/SIRT1 signaling to attenuate the osteogenic transdifferentiation of vascular smooth muscle cells
Dapagliflozin targets SGLT2/SIRT1 signaling to attenuate the osteogenic transdifferentiation of vascular smooth muscle cells
Vascular calcification is a complication that is frequently encountered in patients affected by atherosclerosis, diabetes,...
The lemur tail kinase family in neuronal function and disfunction in neurodegenerative diseases
The lemur tail kinase family in neuronal function and disfunction in neurodegenerative diseases
The complex neuronal architecture and the long distance of synapses from the cell body require precisely orchestrated axon...
BCAS2 and hnRNPH1 orchestrate alternative splicing for DNA double-strand break repair and synapsis in meiotic prophase I
BCAS2 and hnRNPH1 orchestrate alternative splicing for DNA double-strand break repair and synapsis in meiotic prophase I
Understanding the intricacies of homologous recombination during meiosis is crucial for reproductive biology. However, the...
Ythdf2 facilitates precursor miR-378/miR-378-5p maturation to support myogenic differentiation
Ythdf2 facilitates precursor miR-378/miR-378-5p maturation to support myogenic differentiation
Ythdf2 is known to mediate mRNA degradation in an m6A-dependent manner, and it has been shown to play a role in skeletal m...
PARylation of GCN5 by PARP1 mediates its recruitment to DSBs and facilitates both HR and NHEJ Repair
PARylation of GCN5 by PARP1 mediates its recruitment to DSBs and facilitates both HR and NHEJ Repair
Efficient DNA double strand break (DSB) repair is necessary for genomic stability and determines efficacy of DNA damaging ...
Selective regulation of aspartyl intramembrane protease activity by calnexin
Selective regulation of aspartyl intramembrane protease activity by calnexin
Signal peptide peptidase-like 2c (SPPL2c) is a testis-specific aspartyl intramembrane protease that contributes to male ga...
Transcriptomic alterations in APP/PS1 mice astrocytes lead to early postnatal axon initial segment structural changes
Transcriptomic alterations in APP/PS1 mice astrocytes lead to early postnatal axon initial segment structural changes
Alzheimer´s disease (AD) is characterized by neuronal function loss and degeneration. The integrity of the axon initi...
The interplay of gut microbiota, obesity, and depression: insights and interventions
The interplay of gut microbiota, obesity, and depression: insights and interventions
The gut microbiome, body weight, and related comorbidities are intricately linked through a complex interaction of microbi...
Human TRPV1 is an efficient thermogenetic actuator for chronic neuromodulation
Human TRPV1 is an efficient thermogenetic actuator for chronic neuromodulation
Thermogenetics is a promising neuromodulation technique based on the use of heat-sensitive ion channels. However, on the w...
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4
In patients with sepsis, neutrophil apoptosis tends to be inversely proportional to the severity of sepsis, but its mechan...
The NIPBL-gene mutation of a Cornelia de Lange Syndrome patient causes deficits in the hepatocyte differentiation of induced Pluripotent Stem Cells via altered chromatin-accessibility
The NIPBL-gene mutation of a Cornelia de Lange Syndrome patient causes deficits in the hepatocyte differentiation of induced Pluripotent Stem Cells via altered chromatin-accessibility
The Cornelia de Lange syndrome (CdLS) is a rare genetic disease, which is characterized by a cohesinopathy. Mutations of t...
Stromal softness confines pancreatic cancer growth through lysosomal-cathepsin mediated YAP1 degradation
Stromal softness confines pancreatic cancer growth through lysosomal-cathepsin mediated YAP1 degradation
The progression and malignancy of many tumors are associated with increased tissue stiffness. Conversely, the oncogenicall...
The pluripotent-to-totipotent state transition in mESCs activates the intrinsic apoptotic pathway through DUX-induced DNA replication stress
The pluripotent-to-totipotent state transition in mESCs activates the intrinsic apoptotic pathway through DUX-induced DNA replication stress
The pluripotent mouse embryonic stem cell (mESCs) can transit into the totipotent-like state, and the transcription factor...
Alpha-hemolysin promotes internalization of Staphylococcus aureus into human lung epithelial cells via caveolin-1- and cholesterol-rich lipid rafts
Alpha-hemolysin promotes internalization of Staphylococcus aureus into human lung epithelial cells via caveolin-1- and cholesterol-rich lipid rafts
Staphylococcus aureus is a pathogen associated with severe respiratory infections. The ability of S. aureus to internalize...
N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4
N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4
The ligamentum flavum (LF) is an important anatomical structure of the spine. Ossification of the LF (OLF) has become the ...
Long noncoding RNA AK144717 exacerbates pathological cardiac hypertrophy through modulating the cellular distribution of HMGB1 and subsequent DNA damage response
Long noncoding RNA AK144717 exacerbates pathological cardiac hypertrophy through modulating the cellular distribution of HMGB1 and subsequent DNA damage response
DNA damage induced by oxidative stress during cardiac hypertrophy activates the ataxia telangiectasia mutated (ATM)-mediat...
Pharmacologically increasing cGMP improves proteostasis and reduces neuropathy in mouse models of CMT1
Pharmacologically increasing cGMP improves proteostasis and reduces neuropathy in mouse models of CMT1
Increasing cyclic GMP activates 26S proteasomes via phosphorylation by Protein Kinase G and stimulates the intracellular d...
MERS-CoV-nsp5 expression in human epithelial BEAS 2b cells attenuates type I interferon production by inhibiting IRF3 nuclear translocation
MERS-CoV-nsp5 expression in human epithelial BEAS 2b cells attenuates type I interferon production by inhibiting IRF3 nuclear translocation
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an enveloped, positive-sense RNA virus that emerged in 2012, ca...
Regulation of Cx36 trafficking through the early secretory pathway by COPII cargo receptors and Grasp55
Regulation of Cx36 trafficking through the early secretory pathway by COPII cargo receptors and Grasp55
Gap junctions formed by the major neuronal connexin Cx36 function as electrical synapses in the nervous system and provide...
Myosin-5a facilitates stress granule formation by interacting with G3BP1
Myosin-5a facilitates stress granule formation by interacting with G3BP1
Stress granules (SGs) are non-membranous organelles composed of mRNA and proteins that assemble in the cytosol when the ce...
Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver
Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver
The mammalian imprinted Dlk1-Dio3 domain contains multiple lncRNAs, mRNAs, the largest miRNA cluster in the genome and fou...
Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation
Novel gain-of-function mutants identify a critical region within CFTR membrane-spanning domain 2 controlling cAMP-dependent and ATP-independent channel activation
CFTR is an anion channel that has evolved from the mold of an ABC transporter. It possesses specific structural features, ...
Functional diversification process of opsin genes for teleost visual and pineal photoreceptions
Functional diversification process of opsin genes for teleost visual and pineal photoreceptions
Most vertebrates have a rhodopsin gene with a five-exon structure for visual photoreception. By contrast, teleost fishes h...
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