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RBM24 controls cardiac QT interval through CaMKIIδ splicing
RBM24 controls cardiac QT interval through CaMKIIδ splicing
Calcium/calmodulin-dependent kinase II delta (CaMKIIδ) is the predominant cardiac isoform and it is alternatively spl...
Cellular interactions in the pituitary stem cell niche
Cellular interactions in the pituitary stem cell niche
Stem cells in the anterior pituitary gland can give rise to all resident endocrine cells and are integral components for t...
Seven classes of antiviral agents
Seven classes of antiviral agents
The viral epidemics and pandemics have stimulated the development of known and the discovery of novel antiviral agents. Ab...
Mechanisms of colorectal liver metastasis development
Mechanisms of colorectal liver metastasis development
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, largely due to the development of colorectal...
Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation
Peptide-based LDH5 inhibitors enter cancer cells and impair proliferation
Lactate dehydrogenase 5 (LDH5) is overexpressed in many cancers and is a potential target for anticancer therapy due to it...
Hydrogen sulfide as a therapeutic option for the treatment of Duchenne muscular dystrophy and other muscle-related diseases
Hydrogen sulfide as a therapeutic option for the treatment of Duchenne muscular dystrophy and other muscle-related diseases
Hydrogen sulfide (H2S) has been known for years as a poisoning gas and until recently evoked mostly negative associations....
New human ATM variants are able to regain ATM functions in ataxia telangiectasia disease
New human ATM variants are able to regain ATM functions in ataxia telangiectasia disease
Ataxia telangiectasia is a rare neurodegenerative disease caused by biallelic mutations in the ataxia telangiectasia mutat...
Activin A and CCR2 regulate macrophage function in testicular fibrosis caused by experimental autoimmune orchitis
Activin A and CCR2 regulate macrophage function in testicular fibrosis caused by experimental autoimmune orchitis
Experimental autoimmune-orchitis (EAO), a rodent model of chronic testicular inflammation and fibrosis, replicates pathoge...
ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response
ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response
Ataxia telangiectasia mutated (ATM) is a serine–threonine protein kinase and important regulator of the DNA damage r...
Accessing the human trophoblast stem cell state from pluripotent and somatic cells
Accessing the human trophoblast stem cell state from pluripotent and somatic cells
Trophoblasts are specialized epithelial cells that perform critical functions during blastocyst implantation and mediate m...
The role of tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis
The role of tyrosine hydroxylase–dopamine pathway in Parkinson’s disease pathogenesis
Parkinson’s disease (PD) is characterized by selective and progressive dopamine (DA) neuron loss in the substantia n...
Ca2+ binding to synapsin I regulates resting Ca2+ and recovery from synaptic depression in nerve terminals
Ca2+ binding to synapsin I regulates resting Ca2+ and recovery from synaptic depression in nerve terminals
Synapsin I (SynI) is a synaptic vesicle (SV)-associated phosphoprotein that modulates neurotransmission by controlling SV ...
Rho family GTPase signaling through type II p21-activated kinases
Rho family GTPase signaling through type II p21-activated kinases
Signaling from the Rho family small GTPases controls a wide range of signaling outcomes. Key among the downstream effector...
Inhibition of KDM5A attenuates cisplatin-induced hearing loss via regulation of the MAPK/AKT pathway
Inhibition of KDM5A attenuates cisplatin-induced hearing loss via regulation of the MAPK/AKT pathway
The study aimed to investigate the potential role of lysine-specific demethylase 5A (KDM5A) in cisplatin-induced ototoxici...
A circular RNA, circPTPN14, increases MYC transcription by interacting with FUBP1 and exacerbates renal fibrosis
A circular RNA, circPTPN14, increases MYC transcription by interacting with FUBP1 and exacerbates renal fibrosis
Fibrosis is a relentlessly progressive and irreversible cause of organ damage, as in chronic kidney disease (CKD), but its...
PI3K signalling at the intersection of cardio-oncology networks: cardiac safety in the era of AI
PI3K signalling at the intersection of cardio-oncology networks: cardiac safety in the era of AI
Class I phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases. They are super elevated in many human cancer typ...
CFTR modulates aquaporin-mediated glycerol permeability in mouse Sertoli cells
CFTR modulates aquaporin-mediated glycerol permeability in mouse Sertoli cells
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that is crucial for fluid homeodynamics...
Rnf20 inhibition enhances immunotherapy by improving regulatory T cell generation
Rnf20 inhibition enhances immunotherapy by improving regulatory T cell generation
Allergic disorders are common all over the world. The pathogenesis of allergy is unclear. Therapies for allergic disorders...
Piezo1-expressing vocal fold epithelia modulate remodeling via effects on self-renewal and cytokeratin differentiation
Piezo1-expressing vocal fold epithelia modulate remodeling via effects on self-renewal and cytokeratin differentiation
Mechanoreceptors are implicated as functional afferents within mucosa of the airways and the recent discovery of mechanose...
Functional diversity: update of the posttranslational modification of Epstein–Barr virus coding proteins
Functional diversity: update of the posttranslational modification of Epstein–Barr virus coding proteins
Epstein–Barr virus (EBV), a human oncogenic herpesvirus with a typical life cycle consisting of latent phase and lyt...
Omics-based biomarkers discovery for Alzheimer's disease
Omics-based biomarkers discovery for Alzheimer's disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorders presenting with the pathological hallmarks o...
Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure
Wnt/planar cell polarity signaling controls morphogenetic movements of gastrulation and neural tube closure
Gastrulation and neurulation are successive morphogenetic processes that play key roles in shaping the basic embryonic bod...