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In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been a...
Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation
Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation
Lung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) play crucial roles in the synthesis, recycling and catabolis...
DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2
DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2
DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid li...
Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy
Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy
Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation...
Truncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation
Truncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation
The autophagy-lysosomal pathway plays a critical role in the clearance of tau protein aggregates that deposit in the brain...
PHLDA1-PRDM1 mediates the effect of lentiviral vectors on fate-determination of human retinal progenitor cells
PHLDA1-PRDM1 mediates the effect of lentiviral vectors on fate-determination of human retinal progenitor cells
Lentiviral vectors have markedly enhanced gene therapy efficiency in treating congenital diseases, but their long-term saf...
Cryopreservation of human kidney organoids
Cryopreservation of human kidney organoids
Recent advances in stem cell research have led to the creation of organoids, miniature replicas of human organs, offering ...
Unconventional posttranslational modification in innate immunity
Unconventional posttranslational modification in innate immunity
Pattern recognition receptors (PRRs) play a crucial role in innate immunity, and a complex network tightly controls their ...
Plakophilin 4 controls the spatio-temporal activity of RhoA at adherens junctions to promote cortical actin ring formation and tissue tension
Plakophilin 4 controls the spatio-temporal activity of RhoA at adherens junctions to promote cortical actin ring formation and tissue tension
Plakophilin 4 (PKP4) is a component of cell–cell junctions that regulates intercellular adhesion and Rho-signaling d...
Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis
Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis
Congenital human cytomegalovirus (HCMV) infection is a major cause of abnormalities and disorders in the central nervous s...
Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer
Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer
Cisplatin resistance is a major challenge for systemic therapy against advanced bladder cancer (BC). Little information is...
Short-chain fatty acids suppresses astrocyte activation by amplifying Trp-AhR-AQP4 signaling in experimental autoimmune encephalomyelitis mice
Short-chain fatty acids suppresses astrocyte activation by amplifying Trp-AhR-AQP4 signaling in experimental autoimmune encephalomyelitis mice
The function of astrocytes in response to gut microbiota-derived signals has an important role in the pathophysiological p...
The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2
The Toxoplasma secreted effector TgWIP modulates dendritic cell motility by activating host tyrosine phosphatases Shp1 and Shp2
The obligate intracellular parasite Toxoplasma gondii causes life-threatening toxoplasmosis to immunocompromised individua...
Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis
Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte pyroptosis
Nod-like receptor family pyrin-containing protein 3 (NLRP3) inflammasome plays a pathologic role in metabolic dysfunction-...
Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation
Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation
In spite of its essential role in culture media, the precise influence of lactate on early mouse embryonic development rem...
CD74 is a functional MIF receptor on activated CD4+ T cells
CD74 is a functional MIF receptor on activated CD4+ T cells
Next to its classical role in MHC II-mediated antigen presentation, CD74 was identified as a high-affinity receptor for ma...
Human post-implantation blastocyst-like characteristics of Muse cells isolated from human umbilical cord
Human post-implantation blastocyst-like characteristics of Muse cells isolated from human umbilical cord
Muse cells, identified as cells positive for the pluripotent surface marker SSEA-3, are pluripotent-like endogenous stem c...
GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress
GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress
Acetaminophen (APAP) overdose is a significant contributor to drug-induced liver injury worldwide. G-protein–coupled...
Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis
Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis
Age-associated impairments in innate immunity are believed to be a causative factor responsible for severe pathogenesis of...
A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels
A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels
Voltage-gated K+ (KV) channels govern K+ ion flux across cell membranes in response to changes in membrane potential...
EphB2 activation in neural stem cells in the basolateral amygdala facilitates neurogenesis and enhances long-term memory
EphB2 activation in neural stem cells in the basolateral amygdala facilitates neurogenesis and enhances long-term memory
Many brain diseases lead to a reduction in the number of functional neurons and it would be of value to be able to increas...
AIM2 enhances Candida albicans infection through promoting macrophage apoptosis via AKT signaling
AIM2 enhances Candida albicans infection through promoting macrophage apoptosis via AKT signaling
Candida albicans is among the most prevalent invasive fungal pathogens for immunocompromised individuals and novel therape...
EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma
EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma
Ephrin receptor A2 (EphA2), a member of the Ephrin receptor family, is closely related to the progression of oral squamous...
INF2 formin variants linked to human inherited kidney disease reprogram the transcriptome, causing mitotic chaos and cell death
INF2 formin variants linked to human inherited kidney disease reprogram the transcriptome, causing mitotic chaos and cell death
Mutations in the human INF2 gene cause autosomal dominant focal segmental glomerulosclerosis (FSGS)—a condition char...
WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells
WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells
N6-methyladenosine (m6A) is one of the most prevalent and conserved RNA modifications. It controls several biological proc...
Combination of tumor antigen drainage and immune activation to promote a cancer-immunity cycle against glioblastoma
Combination of tumor antigen drainage and immune activation to promote a cancer-immunity cycle against glioblastoma
While conventional cancer modalities, such as chemotherapy and radiotherapy, act through direct killing of tumor cells, ca...
Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements
Hidden secrets of the cancer genome: unlocking the impact of non-coding mutations in gene regulatory elements
Discoveries in the field of genomics have revealed that non-coding genomic regions are not merely "junk DNA", bu...
Direct GPCR-EGFR interaction enables synergistic membrane-to-nucleus information transfer
Direct GPCR-EGFR interaction enables synergistic membrane-to-nucleus information transfer
We addressed the heteromerization of the epidermal growth factor receptor (EGFR) with G-protein coupled receptors (GPCR) o...
Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2
Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2
Long-term memory formation requires de novo RNA and protein synthesis. Using differential display PCR, we found that the N...
Targeting ubiquitination machinery in cystic fibrosis: Where do we stand?
Targeting ubiquitination machinery in cystic fibrosis: Where do we stand?
Cystic Fibrosis (CF) is a genetic disease caused by mutations in CFTR gene expressing the anion selective channel CFTR loc...
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