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Cross-regulation of RNA methylation modifications and R-loops: from molecular mechanisms to clinical implications
Cross-regulation of RNA methylation modifications and R-loops: from molecular mechanisms to clinical implications
R-loops, RNA–DNA hybrid structures, are integral to key cellular processes such as transcriptional regulation, DNA r...
BRG1 improves reprogramming efficiency by enhancing glycolytic metabolism
BRG1 improves reprogramming efficiency by enhancing glycolytic metabolism
BRG1 has been found to promote the generation of induced pluripotent stem cells (iPSCs) by regulating epigenetic modificat...
The orphan nuclear receptor Nr4a1 contributes to interstitial cardiac fibrosis via modulation of cardiac fibroblast and macrophage phenotype
The orphan nuclear receptor Nr4a1 contributes to interstitial cardiac fibrosis via modulation of cardiac fibroblast and macrophage phenotype
The orphan nuclear receptor Nr4a1 has complex biological functions and has been implicated in numerous diseases, including...
Epigenetic regulation of mitochondrial fission and cardiac fibrosis via sFRP3 promoter methylation
Epigenetic regulation of mitochondrial fission and cardiac fibrosis via sFRP3 promoter methylation
In the process of cardiac fibrosis, the balance between the Wnt/β-catenin signalling pathway and Wnt inhibitory facto...
The glycogene alterations and potential effects in esophageal squamous cell carcinoma
The glycogene alterations and potential effects in esophageal squamous cell carcinoma
Aberrant glycosylation is one of the hallmarks of cancer. The profile of glycoprotein expression caused by abnormal glycos...
Gut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis
Gut microbiota regulates oxidative stress and inflammation: a double-edged sword in renal fibrosis
Gut microbiota is a complex and dynamic system that plays critical roles in human health and various disease. Progressive ...
FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases
FGF receptor kinase inhibitors exhibit broad antiviral activity by targeting Src family kinases
The development of antiviral strategies is a key task of biomedical research, but broad-spectrum virus inhibitors are scar...
Potential compensatory mechanisms preserving cardiac function in myotubular myopathy
Potential compensatory mechanisms preserving cardiac function in myotubular myopathy
X-Linked myotubular myopathy (XLMTM) is characterized by severe skeletal muscle weakness and reduced life expectancy. The ...
YTHDF2-dependent m6A modification of FOXO3 mRNA mediates TIMP1 expression and contributes to intervertebral disc degeneration following ROS stimulation
YTHDF2-dependent m6A modification of FOXO3 mRNA mediates TIMP1 expression and contributes to intervertebral disc degeneration following ROS stimulation
The accumulation of reactive oxygen species (ROS) significantly contributes to intervertebral disc degeneration (IDD), but...
Shared and distinct changes in the molecular cargo of extracellular vesicles in different neurodegenerative diseases
Shared and distinct changes in the molecular cargo of extracellular vesicles in different neurodegenerative diseases
Neurodegenerative disorders such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson̵...
MTSS1: beyond the integration of actin and membrane dynamics
MTSS1: beyond the integration of actin and membrane dynamics
MTSS1 is a ubiquitously expressed intracellular protein known mainly for its involvement in basic cellular processes, such...
Altered ACE2 and interferon landscape in the COVID-19 microenvironment correlate with the anti-PD-1 response in solid tumors
Altered ACE2 and interferon landscape in the COVID-19 microenvironment correlate with the anti-PD-1 response in solid tumors
Angiotensensin-converting enzyme-2 (ACE2) is a receptor for SARS-CoV-2, allowing the virus to enter cells. Although tumor ...
The concealed side of caspases: beyond a killer of cells
The concealed side of caspases: beyond a killer of cells
Since the late 20th century, researchers have known that caspases are a pillar of cell death, particularly apoptosis. Howe...
Heterogeneous neutrophils in lung transplantation and proteolytic CXCL8 activation in COVID-19, influenza and lung transplant patient lungs
Heterogeneous neutrophils in lung transplantation and proteolytic CXCL8 activation in COVID-19, influenza and lung transplant patient lungs
Elevated neutrophil counts in broncho-alveolar lavage (BAL) fluids of lung transplant (LTx) patients with chronic lung all...
Regulation of neuronal fate specification and connectivity of the thalamic reticular nucleus by the Ascl1-Isl1 transcriptional cascade
Regulation of neuronal fate specification and connectivity of the thalamic reticular nucleus by the Ascl1-Isl1 transcriptional cascade
The thalamic reticular nucleus (TRN) is an anatomical and functional hub that modulates the flow of information between th...
GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells
GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells
The use of incretin agonists for managing metabolic dysfunction-associated steatohepatitis (MASH) is currently experiencin...
Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma
Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma
OC2 knockout promotes apoptosis in HCC cells. OC2 knockout significantly inhibits tumor growth. OC2 promotes SKP2 transcri...
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease
Krüppel-like factor 4 (KLF4), a transcription factor, is involved in various biological processes. However, the role ...
β’-COP mediated loading of PPARγ into trophoblast-derived extracellular vesicles
β’-COP mediated loading of PPARγ into trophoblast-derived extracellular vesicles
Fetal growth restriction (FGR) is characterized by impaired fetal growth and dysregulated lipid metabolism. Extracellular ...
CLIP170 enhancing FOSL1 expression via attenuating ubiquitin-mediated degradation of β-catenin drives renal cell carcinoma progression
CLIP170 enhancing FOSL1 expression via attenuating ubiquitin-mediated degradation of β-catenin drives renal cell carcinoma progression
Protein interactions are fundamental for all cellular metabolic activities. Cytoplasmic linker protein 170 (CLIP170) plays...
Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide
Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide
Potassium channels encoded by human Ether-à-go-go-Related Gene (hERG) are inhibited by diverse cardiac and non-cardia...
Regulation of formin INF2 and its alteration in INF2-linked inherited disorders
Regulation of formin INF2 and its alteration in INF2-linked inherited disorders
Formins are proteins that catalyze the formation of linear filaments made of actin. INF2, a formin, is crucial for correct...
IQGAP1 promotes early B cell development, is essential for the development of marginal zone (MZ) B cells, and is critical for both T-dependent and T-independent antibody responses
IQGAP1 promotes early B cell development, is essential for the development of marginal zone (MZ) B cells, and is critical for both T-dependent and T-independent antibody responses
IQGAP1 is a multi-functional scaffold protein. However, its role in B cell development and function is unknown. Here, we s...
NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency
NFκB and JNK pathways mediate metabolic adaptation upon ESCRT-I deficiency
Endosomal Sorting Complexes Required for Transport (ESCRTs) are crucial for delivering membrane receptors or intracellular...
MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2
MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2
Breast carcinoma exhibits the highest incidence among various cancers and is the foremost cause of mortality in women. Inc...
Regulation of yeast polarized exocytosis by phosphoinositide lipids
Regulation of yeast polarized exocytosis by phosphoinositide lipids
Phosphoinositides help steer membrane trafficking routes within eukaryotic cells. In polarized exocytosis, which targets v...
Lactate promotes H3K18 lactylation in human neuroectoderm differentiation
Lactate promotes H3K18 lactylation in human neuroectoderm differentiation
In mammals, early embryonic gastrulation process is high energy demanding. Previous studies showed that, unlike endoderm a...
rTM reprograms macrophages via the HIF-1α/METTL3/PFKM axis to protect mice against sepsis
rTM reprograms macrophages via the HIF-1α/METTL3/PFKM axis to protect mice against sepsis
The metabolic reprogramming of macrophages is a potential therapeutic strategy for sepsis treatment, but the mechanism und...
Neutrophil-centric analysis of gastric cancer: prognostic modeling and molecular insights
Neutrophil-centric analysis of gastric cancer: prognostic modeling and molecular insights
Gastric cancer remains a significant global health concern with poor prognosis. This study investigates the role of neutro...
SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death
SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death
RIPK1/RIPK3-MLKL signaling molecules are fundamental in initiating necroptotic cell death, but their roles in the developm...
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