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Correction: Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion
Correction: Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion
Maria ShoykhetPresent address: Department of Otorhinolarynology, Technical University of Munich and University Hospital re...
Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM
Real-time heterogeneity of supramolecular assembly of amyloid precursor protein is modulated by an endocytic risk factor PICALM
Recently, the localization of amyloid precursor protein (APP) into reversible nanoscale supramolecular assembly or “...
Critical functions of extracellular matrix in brain metastasis seeding
Critical functions of extracellular matrix in brain metastasis seeding
Human brain is characterized by extremely sparse extracellular matrix (ECM). Despite its low abundance, the significance o...
Human CD34+-derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8+ T cell and NK cell responses in vitro and in vivo
Human CD34+-derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8+ T cell and NK cell responses in vitro and in vivo
Allogeneic stem cell transplantation (alloSCT) can be curative for hemato-oncology patients due to effective graft-versus-...
Plant-derived cell-penetrating microprotein α-astratide aM1 targets Akt signaling and alleviates insulin resistance
Plant-derived cell-penetrating microprotein α-astratide aM1 targets Akt signaling and alleviates insulin resistance
Insulin-resistant diabetes is a common metabolic disease with serious complications. Treatments directly addressing the un...
Reciprocal negative feedback regulation of ATF6α and PTEN promotes prostate cancer progression
Reciprocal negative feedback regulation of ATF6α and PTEN promotes prostate cancer progression
Phosphatase and tensin homolog (PTEN) loss tightly correlates with prostate cancer (PCa) progression and metastasis. Inact...
Correction: Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones
Correction: Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Lipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causati...
The origin of brain malignancies at the blood–brain barrier
The origin of brain malignancies at the blood–brain barrier
Despite improvements in extracranial therapy, survival rate for patients suffering from brain metastases remains very poor...
Why are neuromelanin-containing dopaminergic neurons lost in idiopathic Parkinson’s disease?
Why are neuromelanin-containing dopaminergic neurons lost in idiopathic Parkinson’s disease?
Gao X, Huang Z, Feng C, Guan C, Li R, Xie H, Chen J, Li M, Que R, Deng B, Cao P, Li M, Lu J, Huang Y, Li M, Yang W, Yang X...
Energetics and dynamics of the proton shuttle of carbonic anhydrase II
Energetics and dynamics of the proton shuttle of carbonic anhydrase II
Human carbonic anhydrase II catalyzes the reversible reaction of carbon dioxide and water to form bicarbonate and a proton...
Synapses do not facilitate prion-like transfer of alpha-synuclein: a quantitative study in reconstructed unidirectional neural networks
Synapses do not facilitate prion-like transfer of alpha-synuclein: a quantitative study in reconstructed unidirectional neural networks
Alpha-synuclein (aSyn) aggregation spreads between cells and underlies the progression of neuronal lesions in the brain of...
Metformin induces tolerogenicity of dendritic cells by promoting metabolic reprogramming
Metformin induces tolerogenicity of dendritic cells by promoting metabolic reprogramming
Dendritic cells (DCs) can mediate immune responses or immune tolerance depending on their immunophenotype and functional s...
Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus
Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus
Voltage-gated sodium (NaV) channels are transmembrane proteins that play a critical role in electrical signaling in the ne...
TGFβ signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells
TGFβ signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells
Environmental exposure to endocrine-disrupting chemicals (EDCs) is linked to the development of uterine fibroids (UFs) in ...
Functions of the RIP kinase family members in the skin
Functions of the RIP kinase family members in the skin
The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are involved in the integrat...
Upregulation of HDAC9 in hippocampal neurons mediates depression-like behaviours by inhibiting ANXA2 degradation
Upregulation of HDAC9 in hippocampal neurons mediates depression-like behaviours by inhibiting ANXA2 degradation
Major depressive disorder (MDD) is a pervasive and devastating mental disease. Broad spectrum histone deacetylase (HDAC) i...
The ubiquitin specific protease 7 stabilizes HPV16E7 to promote HPV-mediated carcinogenesis
The ubiquitin specific protease 7 stabilizes HPV16E7 to promote HPV-mediated carcinogenesis
Human papillomavirus (HPV) encoded E7 oncoprotein plays an important role in supporting the viral productive cycle and ind...
The proper interplay between the expression of Spo11 splice isoforms and the structure of the pseudoautosomal region promotes XY chromosomes recombination
The proper interplay between the expression of Spo11 splice isoforms and the structure of the pseudoautosomal region promotes XY chromosomes recombination
XY chromosome missegregation is relatively common in humans and can lead to sterility or the generation of aneuploid sperm...
Cyclin D1—Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors
Cyclin D1—Cdk4 regulates neuronal activity through phosphorylation of GABAA receptors
Nuclear Cyclin D1 (Ccnd1) is a main regulator of cell cycle progression and cell proliferation. Interestingly, Ccnd1 moves...
Correction: Autophagy protein 5 controls flow-dependent endothelial functions
Correction: Autophagy protein 5 controls flow-dependent endothelial functions
Pierre-Louis Tharaux and Olivia Lenoir have contributed equally to this work.Inserm, Université Paris Cité, PARCC, 56 Rue ...
Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells
Tensin-3 is involved in osteogenic versus adipogenic fate of human bone marrow stromal cells
The tightly controlled balance between osteogenic and adipogenic differentiation of human bone marrow-derived stromal cell...
Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted heart...
OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer
OSGIN1 is a novel TUBB3 regulator that promotes tumor progression and gefitinib resistance in non-small cell lung cancer
Oxidative stress induced growth inhibitor 1 (OSGIN1) regulates cell death. The role and underlying molecular mechanism of ...
ISG20L2: an RNA nuclease regulating T cell activation
ISG20L2: an RNA nuclease regulating T cell activation
ISG20L2, a 3′ to 5′ exoribonuclease previously associated with ribosome biogenesis, is identified here in acti...
Developmental reprogramming of myometrial stem cells by endocrine disruptor linking to risk of uterine fibroids
Developmental reprogramming of myometrial stem cells by endocrine disruptor linking to risk of uterine fibroids
The stage, when tissues and organs are growing, is very vulnerable to environmental influences, but it’s not clear h...
Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis
Chromogranin A and its derived peptides: potential regulators of cholesterol homeostasis
Chromogranin A (CHGA), a member of the granin family of proteins, has been an attractive therapeutic target and candidate ...
TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness
TRPM7 transactivates the FOSL1 gene through STAT3 and enhances glioma stemness
We previously reported that TRPM7 regulates glioma cells’ stemness through STAT3. In addition, we demonstrated that ...
Chaotic aging: intrinsically disordered proteins in aging-related processes
Chaotic aging: intrinsically disordered proteins in aging-related processes
The development of aging is associated with the disruption of key cellular processes manifested as well-established hallma...
Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies
Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies
Aortic valve degeneration (AVD) is a life-threatening condition that has no medical treatment and lacks individual therapi...
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