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Palmitate potentiates the SMAD3-PAI-1 pathway by reducing nuclear GDF15 levels
Palmitate potentiates the SMAD3-PAI-1 pathway by reducing nuclear GDF15 levels
Nuclear growth differentiation factor 15 (GDF15) reduces the binding of the mothers’ against decapentaplegic homolog...
HIF-1 and HIF-2 in cancer: structure, regulation, and therapeutic prospects
HIF-1 and HIF-2 in cancer: structure, regulation, and therapeutic prospects
Hypoxia, or a state of low tissue oxygenation, has been characterized as an important feature of solid tumors that is rela...
N6-Methylandenosine-related lncRNAs as potential biomarkers for predicting prognosis and the immunotherapy response in pancreatic cancer
N6-Methylandenosine-related lncRNAs as potential biomarkers for predicting prognosis and the immunotherapy response in pancreatic cancer
Emerging evidence has shown that the N6-methyladenosine (m6A) modification of RNA plays key roles in tumorigenesis and the...
BRAT1 - a new therapeutic target for glioblastoma
BRAT1 - a new therapeutic target for glioblastoma
Glioblastoma (GBM), the most malignant primary brain tumor in adults, has poor prognosis irrespective of therapeutic advan...
Sirtuin 2 exacerbates renal tubule injury and inflammation in diabetic mice via deacetylation of c-Jun/c-Fos
Sirtuin 2 exacerbates renal tubule injury and inflammation in diabetic mice via deacetylation of c-Jun/c-Fos
Diabetic nephropathy (DN) is a serious complication of diabetes, and inflammation plays a crucial role. Sirtuin 2 (SIRT2),...
Glial-derived TNF/Eiger signaling promotes somatosensory neurite sculpting
Glial-derived TNF/Eiger signaling promotes somatosensory neurite sculpting
The selective elimination of inappropriate projections is essential for sculpting neural circuits during development. The ...
Activation and evasion of inflammasomes during viral and microbial infection
Activation and evasion of inflammasomes during viral and microbial infection
The inflammasome is a cytoplasmic multiprotein complex that induces the maturation of the proinflammatory cytokines interl...
Cytoophidium complexes resonate with cell fates
Cytoophidium complexes resonate with cell fates
Metabolism is a fundamental characteristic of life. In 2010, we discovered that the metabolic enzyme CTP synthase (CTPS) c...
Integration of CRISPR/dCas9-Based methylation editing with guide positioning sequencing identifies dynamic changes of mrDEGs in breast cancer progression
Integration of CRISPR/dCas9-Based methylation editing with guide positioning sequencing identifies dynamic changes of mrDEGs in breast cancer progression
Dynamic changes in DNA methylation are prevalent during the progression of breast cancer. However, critical alterations in...
BMP4 regulates differentiation of nestin-positive stem cells into melanocytes
BMP4 regulates differentiation of nestin-positive stem cells into melanocytes
Hair follicle (HF) development and pigmentation are complex processes governed by various signaling pathways, such as TGF-...
The interconnective role of the UPS and autophagy in the quality control of cancer mitochondria
The interconnective role of the UPS and autophagy in the quality control of cancer mitochondria
Uncontrollable cancer cell growth is characterized by the maintenance of cellular homeostasis through the continuous accum...
The protective effects of liraglutide in reducing lipid droplets accumulation and myocardial fibrosis in diabetic cardiomyopathy
The protective effects of liraglutide in reducing lipid droplets accumulation and myocardial fibrosis in diabetic cardiomyopathy
Diabetes is a primary contributor to diabetic cardiomyopathy (DbCM), which is marked by metabolic imbalances such as eleva...
SLC10A7 regulates O-GalNAc glycosylation and Ca2+ homeostasis in the secretory pathway: insights into SLC10A7-CDG
SLC10A7 regulates O-GalNAc glycosylation and Ca2+ homeostasis in the secretory pathway: insights into SLC10A7-CDG
Glycans are known to be fundamental for many cellular and physiological functions. Congenital disorders of glycosylation (...
DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells
DNA-damage orchestrates self-renewal and differentiation via reciprocal p53 family and Hippo/Wnt/TGF-β pathway activation in embryonic stem cells
The mechanism by which DNA-damage affects self-renewal and pluripotency remains unclear. DNA damage and repair mechanisms ...
Connexin 43 contributes to perioperative neurocognitive disorder by attenuating perineuronal net of hippocampus in aged mice
Connexin 43 contributes to perioperative neurocognitive disorder by attenuating perineuronal net of hippocampus in aged mice
Perioperative neurocognitive disorder (PND) is a prevalent form of cognitive impairment in elderly patients following anes...
Downregulation of FcRn promotes ferroptosis in herpes simplex virus-1-induced lung injury
Downregulation of FcRn promotes ferroptosis in herpes simplex virus-1-induced lung injury
Herpes simplex virus type I (HSV-1) infection is associated with lung injury; however, no specific treatment is currently ...
ALG5 downregulation inhibits osteogenesis and promotes adipogenesis by regulating the N-glycosylation of SLC6A9 in osteoporosis
ALG5 downregulation inhibits osteogenesis and promotes adipogenesis by regulating the N-glycosylation of SLC6A9 in osteoporosis
Osteoporosis is characterized by decreased bone mass and accumulation of adipocytes in the bone marrow. The mechanism unde...
18 kDa TSPO targeting drives polarized human microglia towards a protective and restorative neurosteroidome profile
18 kDa TSPO targeting drives polarized human microglia towards a protective and restorative neurosteroidome profile
An aberrant pro-inflammatory microglia response has been associated with most neurodegenerative disorders. Identifying mic...
Establishment of nasal and olfactory epithelium organoids for unveiling mechanism of tissue regeneration and pathogenesis of nasal diseases
Establishment of nasal and olfactory epithelium organoids for unveiling mechanism of tissue regeneration and pathogenesis of nasal diseases
Organoid is an ideal in vitro model with cellular heterogeneity and genetic stability when passaging. Currently, organoids...
Microtubule acetylation and PERK activation facilitate eribulin-induced mitochondrial calcium accumulation and cell death
Microtubule acetylation and PERK activation facilitate eribulin-induced mitochondrial calcium accumulation and cell death
Over the past few decades, microtubules have been targeted by various anticancer drugs, including paclitaxel and eribulin....
Retinoic acid drives surface epithelium fate determination through the TCF7-MSX2 axis
Retinoic acid drives surface epithelium fate determination through the TCF7-MSX2 axis
Understanding how embryonic progenitors decode extrinsic signals and transform into lineage-specific regulatory networks t...
Characterisation and hierarchy of the spermatogonial stem cell compartment in human spermatogenesis by spectral cytometry using a 16-colors panel
Characterisation and hierarchy of the spermatogonial stem cell compartment in human spermatogenesis by spectral cytometry using a 16-colors panel
About one in six couples experience fertility problems, and male infertility accounts for about half of these cases. Sperm...
Gram-negative bacteria-driven increase of cytosolic phospholipase A2 leads to activation of Kupffer cells
Gram-negative bacteria-driven increase of cytosolic phospholipase A2 leads to activation of Kupffer cells
Bacterial infections are prevalent and the major cause of morbidity and mortality in cirrhosis. Activation of human Kupffe...
E3 ubiquitin ligase TRIM2 identified as a novel suppressor of CYP11B2 and aldosterone production
E3 ubiquitin ligase TRIM2 identified as a novel suppressor of CYP11B2 and aldosterone production
Aldosterone-producing adenoma (APA) is a leading cause of primary aldosteronism (PA), a condition marked by excessive aldo...
Genetic modeling of degenerative diseases and mechanisms of neuronal regeneration in the zebrafish cerebellum
Genetic modeling of degenerative diseases and mechanisms of neuronal regeneration in the zebrafish cerebellum
The cerebellum is a highly conserved brain compartment of vertebrates. Genetic diseases of the human cerebellum often lead...
Exogenous acetate attenuates inflammatory responses through HIF-1α-dependent glycolysis regulation in macrophage
Exogenous acetate attenuates inflammatory responses through HIF-1α-dependent glycolysis regulation in macrophage
Cytokine storm is a hallmark for acute systemic inflammatory disease like sepsis. Intrinsic microbiome-derived short-chain...
Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment
Adaptive remodeling of rat adrenomedullary stimulus-secretion coupling in a chronic hypertensive environment
Chronic elevated blood pressure impinges on the functioning of multiple organs and therefore harms body homeostasis. Eluci...
Amiloride sensitizes prostate cancer cells to the reversible tyrosine kinase inhibitor lapatinib by modulating Erbb3 subcellular localization
Amiloride sensitizes prostate cancer cells to the reversible tyrosine kinase inhibitor lapatinib by modulating Erbb3 subcellular localization
Neoadjuvant therapy (NAT) has been studied in clinically localized prostate cancer (PCa) to improve the outcomes from radi...
Endothelial CD38-induced endothelial-to-mesenchymal transition is a pivotal driver in pulmonary fibrosis
Endothelial CD38-induced endothelial-to-mesenchymal transition is a pivotal driver in pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a prevalent interstitial lung disease with high mortality. CD38 is a main enzyme fo...
VZV IE4 downregulates cellular surface MHC-I via sequestering it to the Golgi complex
VZV IE4 downregulates cellular surface MHC-I via sequestering it to the Golgi complex
Varicella-zoster virus (VZV) infection downregulates surface major histocompatibility complex class I (MHC-I) expression a...
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