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Cyclase-associated protein (CAP) inhibits inverted formin 2 (INF2) to induce dendritic spine maturation
Cyclase-associated protein (CAP) inhibits inverted formin 2 (INF2) to induce dendritic spine maturation
The morphology of dendritic spines, the postsynaptic compartment of most excitatory synapses, decisively modulates the fun...
Iron-dependent KDM4D activity controls the quiescence-activity balance of MSCs via the PI3K-Akt-Foxo1 pathway
Iron-dependent KDM4D activity controls the quiescence-activity balance of MSCs via the PI3K-Akt-Foxo1 pathway
Iron deficiency is a prevalent nutritional deficit associated with organ damage and dysfunction. Recent research increasin...
An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb expression through distinct mechanisms in a sex-specific context
An i-motif-regulated enhancer, eRNA and adjacent lncRNA affect Lhb expression through distinct mechanisms in a sex-specific context
Genome-wide studies have demonstrated regulatory roles for diverse non-coding elements, but their precise and interrelated...
RetSat stabilizes mitotic chromosome segregation in pluripotent stem cells
RetSat stabilizes mitotic chromosome segregation in pluripotent stem cells
Chromosome stability is crucial for homeostasis of pluripotent stem cells (PSCs) and early-stage embryonic development. Ch...
ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation
ACAD10 and ACAD11 allow entry of 4-hydroxy fatty acids into β-oxidation
Hydroxylated fatty acids are important intermediates in lipid metabolism and signaling. Surprisingly, the metabolism of 4-...
Endothelial cell heterogeneity in colorectal cancer: tip cells drive angiogenesis
Endothelial cell heterogeneity in colorectal cancer: tip cells drive angiogenesis
This study aims to uncover the heterogeneity of endothelial cells (ECs) in colorectal cancer (CRC) and their crucial role ...
Comparative profiling of whole-cell and exosome samples reveals protein signatures that stratify breast cancer subtypes
Comparative profiling of whole-cell and exosome samples reveals protein signatures that stratify breast cancer subtypes
Identifying novel breast cancer biomarkers will improve patient stratification, enhance therapeutic outcomes, and help dev...
Innate immune signatures in the nasopharynx after SARS-CoV-2 infection and links with the clinical outcome of COVID-19 in Omicron-dominant period
Innate immune signatures in the nasopharynx after SARS-CoV-2 infection and links with the clinical outcome of COVID-19 in Omicron-dominant period
While severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is characterized by impaired induction of interferons (...
HiPSC-derived 3D neural models reveal neurodevelopmental pathomechanisms of the Cockayne Syndrome B
HiPSC-derived 3D neural models reveal neurodevelopmental pathomechanisms of the Cockayne Syndrome B
Cockayne Syndrome B (CSB) is a hereditary multiorgan syndrome which—through largely unknown mechanisms—can aff...
SLC30A9: an evolutionarily conserved mitochondrial zinc transporter essential for mammalian early embryonic development
SLC30A9: an evolutionarily conserved mitochondrial zinc transporter essential for mammalian early embryonic development
SLC30A9 (ZnT9) is a mitochondria-resident zinc transporter. Mutations in SLC30A9 have been reported in human patients with...
Uncovering key steps in FGF12 cellular release reveals a common mechanism for unconventional FGF protein secretion
Uncovering key steps in FGF12 cellular release reveals a common mechanism for unconventional FGF protein secretion
FGF12 belongs to a subfamily of FGF proteins called FGF homologous factors (FHFs), which until recently were thought to be...
PI3K couples long-term synaptic potentiation with cofilin recruitment and actin polymerization in dendritic spines via its regulatory subunit p85α
PI3K couples long-term synaptic potentiation with cofilin recruitment and actin polymerization in dendritic spines via its regulatory subunit p85α
Long-term synaptic plasticity is typically associated with morphological changes in synaptic connections. However, the mol...
RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy
RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy
Disease-modifying strategies for Parkinson disease (PD), the most common synucleinopathy, represent a critical unmet medic...
Novel CDKL5 targets identified in human iPSC-derived neurons
Novel CDKL5 targets identified in human iPSC-derived neurons
CDKL5 Deficiency Disorder (CDD) is a debilitating epileptic encephalopathy disorder affecting young children with no effec...
SARS-CoV2 infection in whole lung primarily targets macrophages that display subset-specific responses
SARS-CoV2 infection in whole lung primarily targets macrophages that display subset-specific responses
Deciphering the initial steps of SARS-CoV-2 infection, that influence COVID-19 outcomes, is challenging because animal mod...
Differentiation and regulation of CD4+ T cell subsets in Parkinson’s disease
Differentiation and regulation of CD4+ T cell subsets in Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and its hallmark pathological features...
Lys-63-specific deubiquitinase BRCC36 enhances the sensitivity of multiple myeloma cells to lenalidomide by inhibiting lysosomal degradation of cereblon
Lys-63-specific deubiquitinase BRCC36 enhances the sensitivity of multiple myeloma cells to lenalidomide by inhibiting lysosomal degradation of cereblon
Multiple myeloma (MM) is the second most common hematological tumor in adults. Immunomodulatory drugs (IMiDs), such as tha...
Rhythms in lipid droplet content driven by a metabolic oscillator are conserved throughout evolution
Rhythms in lipid droplet content driven by a metabolic oscillator are conserved throughout evolution
The biological clock in eukaryotes controls daily rhythms in physiology and behavior. It displays a complex organization t...
The extracellular heparan sulfatase SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis
The extracellular heparan sulfatase SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis
Heparan sulfate (HS) proteoglycans are important regulators of cellular responses to soluble mediators such as chemokines,...
S100A8/A9-activated IFNγ+ NK cells trigger β-cell necroptosis in hepatitis B virus-associated liver cirrhosis
S100A8/A9-activated IFNγ+ NK cells trigger β-cell necroptosis in hepatitis B virus-associated liver cirrhosis
Hepatitis B virus (HBV)-associated liver cirrhosis (LC), a common condition with high incidence and mortality rates, is of...
Low intensity repetitive transcranial magnetic stimulation enhances remyelination by newborn and surviving oligodendrocytes in the cuprizone model of toxic demyelination
Low intensity repetitive transcranial magnetic stimulation enhances remyelination by newborn and surviving oligodendrocytes in the cuprizone model of toxic demyelination
In people with multiple sclerosis (MS), newborn and surviving oligodendrocytes (OLs) can contribute to remyelination, howe...
Exosomes derived from BMSCs in osteogenic differentiation promote type H blood vessel angiogenesis through miR-150-5p mediated metabolic reprogramming of endothelial cells
Exosomes derived from BMSCs in osteogenic differentiation promote type H blood vessel angiogenesis through miR-150-5p mediated metabolic reprogramming of endothelial cells
Osteogenesis is tightly coupled with angiogenesis spatiotemporally. Previous studies have demonstrated that type H blood v...
Alx3 deficiency disrupts energy homeostasis, alters body composition, and impairs hypothalamic regulation of food intake
Alx3 deficiency disrupts energy homeostasis, alters body composition, and impairs hypothalamic regulation of food intake
The coordination of food intake, energy storage, and expenditure involves complex interactions between hypothalamic neuron...
PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis
PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis
The rising incidences of atherosclerosis have necessitated efforts to identify novel targets for therapeutic interventions...
Novel interplay between agonist and calcium binding sites modulates drug potentiation of α7 acetylcholine receptor
Novel interplay between agonist and calcium binding sites modulates drug potentiation of α7 acetylcholine receptor
Drug modulation of the α7 acetylcholine receptor has emerged as a therapeutic strategy for neurological, neurodegener...
Neuroprotection by ADAM10 inhibition requires TrkB signaling in the Huntington’s disease hippocampus
Neuroprotection by ADAM10 inhibition requires TrkB signaling in the Huntington’s disease hippocampus
Synaptic dysfunction is an early pathogenic event leading to cognitive decline in Huntington’s disease (HD). We prev...
IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport
IER3IP1-mutations cause microcephaly by selective inhibition of ER-Golgi transport
Mutations in the IER3IP1 (Immediate Early Response-3 Interacting Protein 1) gene can give rise to MEDS1 (Microcephaly with...
Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia
Overexpression of long noncoding RNA DUXAP8 inhibits ER-phagy through activating AKT/mTOR signaling and contributes to preeclampsia
Preeclampsia (PE) is a life-threatening pregnancy-specific complication with controversial mechanisms and no effective tre...
The battle between host antiviral innate immunity and immune evasion by cytomegalovirus
The battle between host antiviral innate immunity and immune evasion by cytomegalovirus
Cytomegalovirus (CMV) has successfully established a long-lasting latent infection in humans due to its ability to counter...
The AP-1 adaptor complex is essential for intracellular trafficking of the ORF2 capsid protein and assembly of Hepatitis E virus
The AP-1 adaptor complex is essential for intracellular trafficking of the ORF2 capsid protein and assembly of Hepatitis E virus
Although the Hepatitis E virus (HEV) is an emerging global health burden, little is known about its interaction with the h...
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