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A Rab10–ACAP1–Arf6 GTPases cascade modulates M4 muscarinic acetylcholine receptor trafficking and signaling
A Rab10–ACAP1–Arf6 GTPases cascade modulates M4 muscarinic acetylcholine receptor trafficking and signaling
Membrane trafficking processes regulate the G protein-coupled receptor activity. The muscarinic acetylcholine receptors (m...
Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
Aggregation of the RNA-binding protein, TDP-43, is the unifying hallmark of amyotrophic lateral sclerosis and frontotempor...
Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer
Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer
Deep sequencing of human tumours has uncovered a previously unappreciated role for epigenetic regulators in tumorigenesis....
Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb
Endogenous but not sensory-driven activity controls migration, morphogenesis and survival of adult-born juxtaglomerular neurons in the mouse olfactory bulb
The development and survival of adult-born neurons are believed to be driven by sensory signaling. Here, in vivo analyses ...
lncRNA miR4458HG modulates hepatocellular carcinoma progression by activating m6A-dependent glycolysis and promoting the polarization of tumor-associated macrophages
lncRNA miR4458HG modulates hepatocellular carcinoma progression by activating m6A-dependent glycolysis and promoting the polarization of tumor-associated macrophages
Long non-coding RNAs (lncRNAs) play significant roles in different biological functions of cancers. However, their functio...
Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice
Pharmacological and mechanistic study of PS1, a Pdia4 inhibitor, in β-cell pathogenesis and diabetes in db/db mice
Pdia4 has been characterized as a key protein that positively regulates β-cell failure and diabetes via ROS regulatio...
Extracellular vesicles from hyperammonemic rats induce neuroinflammation in hippocampus and impair cognition in control rats
Extracellular vesicles from hyperammonemic rats induce neuroinflammation in hippocampus and impair cognition in control rats
Patients with liver cirrhosis show hyperammonemia and peripheral inflammation and may show hepatic encephalopathy with cog...
Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome
Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome
Vertebrate lonesome kinase (VLK) is the only known secreted tyrosine kinase and responsible for the phosphorylation of a b...
UBE2T resolves transcription-replication conflicts and protects common fragile sites in primordial germ cells
UBE2T resolves transcription-replication conflicts and protects common fragile sites in primordial germ cells
The proper development of primordial germ cells (PGCs) is an essential prerequisite for gametogenesis and mammalian fertil...
KIF13B mediates VEGFR2 recycling to modulate vascular permeability
KIF13B mediates VEGFR2 recycling to modulate vascular permeability
Excessive vascular endothelial growth factor-A (VEGF-A) signaling induces vascular leakage and angiogenesis in diseases. V...
Microstructured soft devices for the growth and analysis of populations of homogenous multicellular tumor spheroids
Microstructured soft devices for the growth and analysis of populations of homogenous multicellular tumor spheroids
Multicellular tumor spheroids are rapidly emerging as an improved in vitro model with respect to more traditional 2D cultu...
The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production
The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production
The processing of the amyloid precursor protein (APP) is one of the key events contributing to Alzheimer’s disease (...
Correction: CHIP induces ubiquitination and degradation of HMGB1 to regulate glycolysis in ovarian endometriosis
Correction: CHIP induces ubiquitination and degradation of HMGB1 to regulate glycolysis in ovarian endometriosis
Cite this articleSun, Y., Wang, Q., Wang, M. et al. Correction: CHIP induces ubiquitination and degradation of HMGB1 to re...
Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB
Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB
Monocyte-derived macrophages contribute to pathogenesis in inflammatory diseases and their effector functions greatly depe...
Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm
Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm
The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged proteins, cellular debris, and...
AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea
AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea
Mechanosensitive hair cells (HCs) in the cochlear sensory epithelium are critical for sound detection and transduction. Ma...
Correction: An oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies
Correction: An oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines
Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines
Neurotrypsin (NT) is a neuronal trypsin-like serine protease whose mutations cause severe mental retardation in humans. NT...
The TIMELESS effort for timely DNA replication and protection
The TIMELESS effort for timely DNA replication and protection
Accurate replication of the genome is fundamental to cellular survival and tumor prevention. The DNA replication fork is v...
Analysis of a rare progeria variant of Barrier-to-autointegration factor in Drosophila connects centromere function to tissue homeostasis
Analysis of a rare progeria variant of Barrier-to-autointegration factor in Drosophila connects centromere function to tissue homeostasis
Barrier-to-autointegration factor (BAF/BANF) is a nuclear lamina protein essential for nuclear integrity, chromatin struct...
A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment
A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment
Chemokines are pivotal players in instigation and perpetuation of synovitis through leukocytes egress from the blood circu...
Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer
Network-informed discovery of multidrug combinations for ERα+/HER2-/PI3Kα-mutant breast cancer
Breast cancer is a persistent threat to women worldwide. A large proportion of breast cancers are dependent on the estroge...
Correction: LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size
Correction: LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size
Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA...
On the assembly of the mitotic spindle, bistability and hysteresis
On the assembly of the mitotic spindle, bistability and hysteresis
During cell division, the transition from interphase to mitosis is dictated by activation of the cyclin B-cdk1 (Cdk1) comp...
Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines
Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines
Plasmodium falciparum and P. vivax are the major causes of human malaria, and P. knowlesi is an important additional cause...
MiR-422a promotes adipogenesis via MeCP2 downregulation in human bone marrow mesenchymal stem cells
MiR-422a promotes adipogenesis via MeCP2 downregulation in human bone marrow mesenchymal stem cells
Methyl-CpG binding protein 2 (MeCP2) is a ubiquitous transcriptional regulator. The study of this protein has been mainly ...
The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells
The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells
Invariant natural killer T (iNKT) cells correspond to a population of thymus-generated T cells with innate-like characteri...
ORP9 and ORP10 form a heterocomplex to transfer phosphatidylinositol 4-phosphate at ER-TGN contact sites
ORP9 and ORP10 form a heterocomplex to transfer phosphatidylinositol 4-phosphate at ER-TGN contact sites
Oxysterol-binding protein (OSBP) and its related proteins (ORPs) are a family of lipid transfer proteins (LTPs) that media...
Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells
Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells
Pulmonary neuroendocrine (NE) cells represent a small population in the airway epithelium, but despite this, hyperplasia o...
Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
Replication of viruses requires interaction with host cell factors and repression of innate immunity. Recent findings sugg...
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