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Brain and spinal cord arteriolosclerosis and its associations with cerebrovascular disease risk factors in community-dwelling older adults
Brain and spinal cord arteriolosclerosis and its associations with cerebrovascular disease risk factors in community-dwelling older adults
Arteriolosclerosis is common in older brains and related to cognitive and motor impairment. We compared the severity of ar...
Tuberous sclerosis complex is associated with a novel human tauopathy
Tuberous sclerosis complex is associated with a novel human tauopathy
Tuberous sclerosis complex (TSC) is a neurogenetic disorder leading to epilepsy, developmental delay, and neurobehavioral ...
Correction to: Adaptive structural changes in the motor cortex and white matter in Parkinson’s disease
Correction to: Adaptive structural changes in the motor cortex and white matter in Parkinson’s disease
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which ...
Widespread CNS pathology in amyotrophic lateral sclerosis homozygous for the D90A SOD1 mutation
Widespread CNS pathology in amyotrophic lateral sclerosis homozygous for the D90A SOD1 mutation
Mutations in the gene encoding the ubiquitously expressed free radical scavenging enzyme superoxide dismutase-1 (SOD1) are...
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation
Epitranscriptomic regulation adds a layer of post-transcriptional control to brain function during development and adultho...
NTRK rearrangements in a subset of NF1-related malignant peripheral nerve sheath tumors as novel actionable target
NTRK rearrangements in a subset of NF1-related malignant peripheral nerve sheath tumors as novel actionable target
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which ...
The continuing legacy of John
The continuing legacy of John
This issue of Acta Neuropathologica includes a cluster of four manuscripts that bear the impr...
Professor Charles Duyckaerts (1951–2022)
Professor Charles Duyckaerts (1951–2022)
Charles Duyckaerts passed away on August 6, after several years of struggle against cancer. D...
Loss of function variants in DNAJB4 cause a myopathy with early respiratory failure
Loss of function variants in DNAJB4 cause a myopathy with early respiratory failure
DNAJ/HSP40 co-chaperones are integral to the chaperone network, bind client proteins and recruit them to HSP70 for folding...
Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions
Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, M...
Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas
Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas
This study aimed to re-evaluate the prognostic impact of TP53 mutations and to identify specific chromosomal aberrations a...
Assessment of PABPN1 nuclear inclusions on a large cohort of patients and in a human xenograft model of oculopharyngeal muscular dystrophy
Assessment of PABPN1 nuclear inclusions on a large cohort of patients and in a human xenograft model of oculopharyngeal muscular dystrophy
Oculopharyngeal muscular dystrophy (OPMD) is a rare muscle disease characterized by an onset of weakness in the pharyngeal...
Neuropathology of central nervous system involvement in TTR amyloidosis
Neuropathology of central nervous system involvement in TTR amyloidosis
Hereditary transthyretin amyloidosis (ATTRv) is a systemic disease caused by the accumulation of misfolded transthyretin (...
Correction to: Flow blockage disrupts cilia-driven fluid transport in the epileptic brain
Correction to: Flow blockage disrupts cilia-driven fluid transport in the epileptic brain
In this article the funding from LouLou Foundation was omitted. The complete Funding section is given here.Funding Univers...
The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers
The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers
Glioblastoma (GBM) is characterized by extensive cellular and genetic heterogeneity. Its initial presentation as primary d...
Genetic and epigenetic profiling identifies two distinct classes of spinal meningiomas
Genetic and epigenetic profiling identifies two distinct classes of spinal meningiomas
Spinal meningiomas account for 1.2–12% of all meningiomas and 25–45% of all spinal tumors. About 20% of intracranial menin...
Expanding the spectrum of amyloid-β plaque pathology: the Down syndrome associated ‘bird-nest plaque’
Expanding the spectrum of amyloid-β plaque pathology: the Down syndrome associated ‘bird-nest plaque’
Boon BDC, Bulk M, Jonker AJ et al (2020) The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s ...
In memoriam, Roy Weller (1938–2022)
In memoriam, Roy Weller (1938–2022)
On 23rd August 2022, Roy Weller BSc MD PhD FRCPath, Emeritus Professor of Neuropathology in t...
PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD
PolyGA targets the ER stress-adaptive response by impairing GRP75 function at the MAM in C9ORF72-ALS/FTD
ER stress signaling is linked to the pathophysiological and clinical disease manifestations in amyotrophic lateral scleros...
Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
The predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to misfolding and aggregation in...
TREM2 risk variants are associated with atypical Alzheimer’s disease
TREM2 risk variants are associated with atypical Alzheimer’s disease
Alzheimer’s disease (AD) has multiple clinically and pathologically defined subtypes where the underlying causes of ...