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TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury
TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury
Nerve injury causes neuropathic pain and multilevel nerve barrier disruption. Nerve barriers consist of perineurial, endot...
Amyloid-β oligomers increase the binding and internalization of tau oligomers in human synapses
Amyloid-β oligomers increase the binding and internalization of tau oligomers in human synapses
In Alzheimer’s disease (AD), the propagation and spreading of CNS tau pathology closely correlates with cognitive de...
Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts
Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts
Neurodegeneration is a seminal feature of many neurological disorders. Chronic traumatic encephalopathy (CTE) is caused by...
Single-cell transcriptomic and neuropathologic analysis reveals dysregulation of the integrated stress response in progressive supranuclear palsy
Single-cell transcriptomic and neuropathologic analysis reveals dysregulation of the integrated stress response in progressive supranuclear palsy
Progressive supranuclear palsy (PSP) is a sporadic neurodegenerative tauopathy variably affecting brainstem and cortical s...
Identification of isoAsp7-Aβ as a major Aβ variant in Alzheimer’s disease, dementia with Lewy bodies and vascular dementia
Identification of isoAsp7-Aβ as a major Aβ variant in Alzheimer’s disease, dementia with Lewy bodies and vascular dementia
The formation of amyloid-β (Aβ) aggregates in brain is a neuropathological hallmark of Alzheimer’s disease...
MN1 immunohistochemistry is a sensitive diagnostic biomarker for primitive CNS tumors with MN1 fusion
MN1 immunohistochemistry is a sensitive diagnostic biomarker for primitive CNS tumors with MN1 fusion
Cuoco JA, Williams S, Klein BJ, Borowicz VM, Ho H, Stump MS et al (2024) Astroblastoma with a novel YAP1::BEND2 fusion: a ...
Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction
Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction
Aberrant activity of the retrotransposable element long interspersed nuclear element-1 (LINE-1) has been hypothesized to c...
Functional profiling of murine glioma models highlights targetable immune evasion phenotypes
Functional profiling of murine glioma models highlights targetable immune evasion phenotypes
Cancer-intrinsic immune evasion mechanisms and pleiotropy are a barrier to cancer immunotherapy. This is apparent in certa...
Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history
Raphe and ventrolateral medulla proteomics in sudden unexplained death in childhood with febrile seizure history
Sudden unexplained death in childhood (SUDC) is death of a child ≥ 12 months old that is unexpl...
BAG3’s dual roles in Parkinson’s disease and cardiomyopathy: benefit or liability?
BAG3’s dual roles in Parkinson’s disease and cardiomyopathy: benefit or liability?
Antoku K, Maser RS, Scully WJ, Delach SM, Johnson DE (2001) Isolation of Bcl-2 binding proteins that exhibit homology with...
SMOC1 colocalizes with Alzheimer’s disease neuropathology and delays Aβ aggregation
SMOC1 colocalizes with Alzheimer’s disease neuropathology and delays Aβ aggregation
SMOC1 has emerged as one of the most significant and consistent new biomarkers of early Alzheimer’s disease (AD). Re...
Lipid storage myopathy associated with sertraline treatment is an acquired mitochondrial disorder with respiratory chain deficiency
Lipid storage myopathy associated with sertraline treatment is an acquired mitochondrial disorder with respiratory chain deficiency
Lipid storage myopathies are considered inborn errors of metabolism affecting the fatty acid metabolism and leading to acc...
Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors
Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors
Aggressive pituitary neuroendocrine tumors (PitNETs)/adenomas are characterized by progressive growth despite surgery and ...
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies
Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies
Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear pal...
Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer’s disease
Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer’s disease
Plasma glial fibrillary acidic protein (GFAP) is an emerging biomarker of Alzheimer’s disease (AD), with higher bloo...
Unsuccessful transmissions of atypical genetic Creutzfeldt–Jakob disease (PRNP p.T183A-129M) in transgenic mice
Unsuccessful transmissions of atypical genetic Creutzfeldt–Jakob disease (PRNP p.T183A-129M) in transgenic mice
Aguilar-Calvo P, Callender JA, Sigurdson CJ (2021) Short and sweet: How glycans impact prion conversion, cofactor interact...
No sex difference in the extent of acute mechanical blood–brain barrier disruption after experimental concussion
No sex difference in the extent of acute mechanical blood–brain barrier disruption after experimental concussion
Authors and AffiliationsDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 S...
The microglial translocator protein (TSPO) in Alzheimer’s disease reflects a phagocytic phenotype
The microglial translocator protein (TSPO) in Alzheimer’s disease reflects a phagocytic phenotype
Translocator protein (TSPO) is a mitochondrial protein expressed by microglia, ligands for which are used as a marker of n...
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia
Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mu...
Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer’s pathologies
Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer’s pathologies
Pure limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (pure LATE-NC) is a term used to describ...
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells
Biondi bodies are filamentous amyloid inclusions of unknown composition in ependymal cells of the choroid plexuses, ependy...
Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
Mesial temporal lobe epilepsy (mTLE) is a debilitating disease characterized by recurrent seizures originating from tempor...
Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer’s-type dementia
Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer’s-type dementia
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Besides neurofibrillary tangles and amyloid bet...
Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
Chronic wasting disease (CWD) is a widely distributed prion disease of cervids with implications for wildlife conservation...
Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease
Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease
microRNAs (miRNAs) have a broad influence on gene expression; however, we have limited insights into their contribution to...
Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation
Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation
Synaptic dysfunction and loss are central to neurodegenerative diseases and correlate with cognitive decline. Synaptic Ves...
MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes
MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes
Astrocytomas that harbor recurrent genomic alterations in MYB or MYBL1 are a group of Pediatric-type diffuse low-grade gli...
Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer’s disease
Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer’s disease
The profile of autoantibodies is dysregulated in patients with Alzheimer’s disease (AD). Autoantibodies to beta-site...
Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy
Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy
Anti-IgLON5 disease is a unique condition that bridges autoimmunity and neurodegeneration. Since its initial description 1...
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway
Growing evidence supports that early- or middle-life traumatic brain injury (TBI) is a risk factor for developing Alzheime...
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