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Unsuccessful transmissions of atypical genetic Creutzfeldt–Jakob disease (PRNP p.T183A-129M) in transgenic mice
Unsuccessful transmissions of atypical genetic Creutzfeldt–Jakob disease (PRNP p.T183A-129M) in transgenic mice
Aguilar-Calvo P, Callender JA, Sigurdson CJ (2021) Short and sweet: How glycans impact prion conversion, cofactor interact...
No sex difference in the extent of acute mechanical blood–brain barrier disruption after experimental concussion
No sex difference in the extent of acute mechanical blood–brain barrier disruption after experimental concussion
Authors and AffiliationsDepartment of Neurosurgery, Center for Brain Injury and Repair, University of Pennsylvania, 3320 S...
The microglial translocator protein (TSPO) in Alzheimer’s disease reflects a phagocytic phenotype
The microglial translocator protein (TSPO) in Alzheimer’s disease reflects a phagocytic phenotype
Translocator protein (TSPO) is a mitochondrial protein expressed by microglia, ligands for which are used as a marker of n...
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia
Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mu...
Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer’s pathologies
Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer’s pathologies
Pure limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (pure LATE-NC) is a term used to describ...
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells
TMEM106B amyloid filaments in the Biondi bodies of ependymal cells
Biondi bodies are filamentous amyloid inclusions of unknown composition in ependymal cells of the choroid plexuses, ependy...
Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
Compartment-specific small non-coding RNA changes and nucleolar defects in human mesial temporal lobe epilepsy
Mesial temporal lobe epilepsy (mTLE) is a debilitating disease characterized by recurrent seizures originating from tempor...
Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer’s-type dementia
Hypothesis-based investigation of known AD risk variants reveals the genetic underpinnings of neuropathological lesions observed in Alzheimer’s-type dementia
Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Besides neurofibrillary tangles and amyloid bet...
Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
Cryo-EM structure of a natural prion: chronic wasting disease fibrils from deer
Chronic wasting disease (CWD) is a widely distributed prion disease of cervids with implications for wildlife conservation...
Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease
Effects of brain microRNAs in cognitive trajectory and Alzheimer’s disease
microRNAs (miRNAs) have a broad influence on gene expression; however, we have limited insights into their contribution to...
Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation
Comprehensive mapping of synaptic vesicle protein 2A (SV2A) in health and neurodegenerative diseases: a comparative analysis with synaptophysin and ground truth for PET-imaging interpretation
Synaptic dysfunction and loss are central to neurodegenerative diseases and correlate with cognitive decline. Synaptic Ves...
MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes
MYB/MYBL1-altered gliomas frequently harbor truncations and non-productive fusions in the MYB and MYBL1 genes
Astrocytomas that harbor recurrent genomic alterations in MYB or MYBL1 are a group of Pediatric-type diffuse low-grade gli...
Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer’s disease
Autoantibodies to BACE1 promote Aβ accumulation and neurodegeneration in Alzheimer’s disease
The profile of autoantibodies is dysregulated in patients with Alzheimer’s disease (AD). Autoantibodies to beta-site...
Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy
Neuropathological spectrum of anti-IgLON5 disease and stages of brainstem tau pathology: updated neuropathological research criteria of the disease-related tauopathy
Anti-IgLON5 disease is a unique condition that bridges autoimmunity and neurodegeneration. Since its initial description 1...
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway
Growing evidence supports that early- or middle-life traumatic brain injury (TBI) is a risk factor for developing Alzheime...
Microangiopathy in temporal lobe epilepsy with diffusion MRI alterations and cognitive decline
Microangiopathy in temporal lobe epilepsy with diffusion MRI alterations and cognitive decline
White matter microvascular alterations in temporal lobe epilepsy (TLE) may be relevant to acquired neurodegenerative proce...
Targeted whole-viral genome sequencing from formalin-fixed paraffin-embedded neuropathology specimens
Targeted whole-viral genome sequencing from formalin-fixed paraffin-embedded neuropathology specimens
Viral infections of the central nervous system (CNS) can be severe and potentially life-threatening diseases [4]. Precise ...
Epigenetic landscape reorganisation and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma
Epigenetic landscape reorganisation and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma
Accurate grading of IDH-mutant gliomas defines patient prognosis and guides the treatment path. Histological grading is ch...
Correction to: Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
Correction to: Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians University Munich, Schillerstr. 44, 80336, Munich, GermanyKohj...
Regulated cell death in neurodegeneration: pathways and therapeutic horizons
Regulated cell death in neurodegeneration: pathways and therapeutic horizons
Conflict of interest DRT receives research grants from FWO ...
Tau accumulation is cleared by the induced expression of VCP via autophagy
Tau accumulation is cleared by the induced expression of VCP via autophagy
Tauopathy, including frontotemporal lobar dementia and Alzheimer’s disease, describes a class of neurodegenerative d...
TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition
TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition
Amyotrophic lateral sclerosis (ALS) is an adult-onset motor neuron disease with a mean survival time of three years. The 9...
Association of in vivo retention of [18f] flortaucipir pet with tau neuropathology in corresponding brain regions
Association of in vivo retention of [18f] flortaucipir pet with tau neuropathology in corresponding brain regions
[18F]Flortaucipir is an FDA-approved tau-PET tracer that is increasingly utilized in clinical settings for the diagnosis o...
Autophagy–lysosomal-associated neuronal death in neurodegenerative disease
Autophagy–lysosomal-associated neuronal death in neurodegenerative disease
Autophagy, the major lysosomal pathway for degrading damaged or obsolete constituents, protects neurons by eliminating tox...
HOXD12 defines an age-related aggressive subtype of oligodendroglioma
HOXD12 defines an age-related aggressive subtype of oligodendroglioma
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted has highly variable outcomes that are strongly influenced by patient ag...
Glioblastoma, IDH-wildtype with primarily leptomeningeal localization diagnosed by nanopore sequencing of cell-free DNA from cerebrospinal fluid
Glioblastoma, IDH-wildtype with primarily leptomeningeal localization diagnosed by nanopore sequencing of cell-free DNA from cerebrospinal fluid
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Rapid brain lymphoma diagnostics through nanopore sequencing of cytology-negative cerebrospinal fluid
Rapid brain lymphoma diagnostics through nanopore sequencing of cytology-negative cerebrospinal fluid
Adult patients with molecularly confirmed glioblastoma, IDH wildtype (GB-IDHwt), with radiological and clinical differenti...
Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer’s disease continuum
Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer’s disease continuum
The medial temporal lobe (MTL) is a hotspot for neuropathology, and measurements of MTL atrophy are often used as a biomar...
Novel mutation of SMPX-related scapuloperoneal myopathy and myofibrillar myopathy
Novel mutation of SMPX-related scapuloperoneal myopathy and myofibrillar myopathy
Department of Neurology, Peking University First Hospital, 8 Xishiku st, Xicheng District, Beijing, 100034, People’s Repub...
Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance
Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance
H3 K27M-altered diffuse midline gliomas (DMGs) are highly malignant tumours that arise in the midline structures of the CN...
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