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Chronic traumatic encephalopathy (CTE) in the context of longstanding intimate partner violence
Chronic traumatic encephalopathy (CTE) in the context of longstanding intimate partner violence
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Proteolytic cell surface release (‘shedding’) of the prion protein (PrP), a broadly expressed GPI-anchored gly...
DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson’s disease, and progressive supranuclear palsy: a cross-comparative investigation
DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson’s disease, and progressive supranuclear palsy: a cross-comparative investigation
Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by neuronal loss and gliosis, with oligode...
Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma
Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma
In recent years, the classification of adult-type diffuse gliomas has undergone a revolution, wherein specific molecular f...
Anti-Ku + myositis: an acquired inflammatory protein-aggregate myopathy
Anti-Ku + myositis: an acquired inflammatory protein-aggregate myopathy
Myositis with anti-Ku-autoantibodies is a rare inflammatory myopathy associated with various connective tissue diseases. H...
Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator
Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator
Alzheimer’s disease (AD) is the most common cause of dementia, and disease mechanisms are still not fully understood...
Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury
Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury
We show that redox active iron can induce a regulated form of non-apoptotic cell death and tissue damage called ferroptosi...
Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease
Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurological condition characterized by impaired cognitive function and be...
Annexin A11 aggregation in FTLD–TDP type C and related neurodegenerative disease proteinopathies
Annexin A11 aggregation in FTLD–TDP type C and related neurodegenerative disease proteinopathies
TAR DNA-binding protein 43 (TDP-43) is an RNA binding protein found within ribonucleoprotein granules tethered to lysosome...
Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database
Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database
TDP-43 proteinopathy is a salient neuropathologic feature in a subset of frontotemporal lobar degeneration (FTLD-TDP), in ...
Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion
Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with average lifespan of 2–5 ...
Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease
Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer’s disease
Insoluble pathogenic proteins accumulate along blood vessels in conditions of cerebral amyloid angiopathy (CAA), exerting ...
Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis
Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis
Myasthenia gravis is a chronic antibody-mediated autoimmune disease disrupting neuromuscular synaptic transmission. Inform...
Correction to: Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs
Correction to: Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs
Department of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000, Leuven, BelgiumYingli Zhu, Katrien Neyri...
Early and selective localization of tau filaments to glutamatergic subcellular domains within the human anterodorsal thalamus
Early and selective localization of tau filaments to glutamatergic subcellular domains within the human anterodorsal thalamus
Widespread cortical accumulation of misfolded pathological tau proteins (ptau) in the form of paired helical filaments is ...
The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease
The necroptosis cell death pathway drives neurodegeneration in Alzheimer’s disease
Although apoptosis, pyroptosis, and ferroptosis have been implicated in AD, none fully explains the extensive neuronal los...
Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer’s disease
Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer’s disease
Β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) is a crucial protease in the production of amyloid- ...
Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations
Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations
The non-WNT/non-SHH (Grp3/Grp4) medulloblastomas (MBs) include eight second-generation subgroups (SGS; I–VIII) each ...
Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer’s disease pathology progression
Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer’s disease pathology progression
A recent large genome-wide association study has identified EGFR (encoding the epidermal growth factor EGFR) as a new gene...
Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy
Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease charac...
Neuropathological findings in Down syndrome, Alzheimer’s disease and control patients with and without SARS-COV-2: preliminary findings
Neuropathological findings in Down syndrome, Alzheimer’s disease and control patients with and without SARS-COV-2: preliminary findings
The SARS-CoV-2 virus that led to COVID-19 is associated with significant and long-lasting neurologic symptoms in many pati...
The influence of APOEε4 on the pTau interactome in sporadic Alzheimer’s disease
The influence of APOEε4 on the pTau interactome in sporadic Alzheimer’s disease
APOEε4 is the major genetic risk factor for sporadic Alzheimer’s disease (AD). Although APOEε4 is known to...
Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions
Disentangling the heterogeneity of multiple sclerosis through identification of independent neuropathological dimensions
Multiple sclerosis (MS) is a heterogeneous neurological disorder with regards to clinical presentation and pathophysiology...
Transmission experiments verify sporadic V2 prion in a patient with E200K mutation
Transmission experiments verify sporadic V2 prion in a patient with E200K mutation
Creutzfeldt-Jakob disease (CJD) is caused by abnormal pathogenic prion protein (PrPSc...
Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G
Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G
Dominantly inherited mutation D395G in the gene encoding valosin-containing protein causes vacuolar tauopathy, a type of b...
From metabolomics to proteomics: understanding the role of dopa decarboxylase in Parkinson’s disease. Scientific commentary on: “Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease”
From metabolomics to proteomics: understanding the role of dopa decarboxylase in Parkinson’s disease. Scientific commentary on: “Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease”
Al Mughram MH, Ghatge MS, Kellogg GE, Safo MK (2022) Elucidating the interaction between pyridoxine 5′-phosphate oxidase a...
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry
Antibodies are essential research tools whose performance directly impacts research conclusions and reproducibility. Owing...
Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes
Aberrant CHCHD2-associated mitochondriopathy in Kii ALS/PDC astrocytes
Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC), a rare and complex neurological disorder, is predom...
Genome-wide loss of heterozygosity predicts aggressive, treatment-refractory behavior in pituitary neuroendocrine tumors
Genome-wide loss of heterozygosity predicts aggressive, treatment-refractory behavior in pituitary neuroendocrine tumors
Pituitary neuroendocrine tumors (PitNETs) exhibiting aggressive, treatment-refractory behavior are the rare subset that pr...
Anaplastic histology and distinct molecular features in a small series of spinal cord ependymomas
Anaplastic histology and distinct molecular features in a small series of spinal cord ependymomas
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
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