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Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice
Loss of TMEM106B exacerbates Tau pathology and neurodegeneration in PS19 mice
TMEM106B, a gene encoding a lysosome membrane protein, is tightly associated with brain aging, hypomyelinating leukodystro...
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy
TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy
TMEM106B is a risk modifier of multiple neurological conditions, where a single coding variant and multiple non-coding SNP...
Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies
Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies
Neurodegenerative pathologies such as Alzheimer disease neuropathologic change (ADNC), Lewy body disease (LBD), limbic-pre...
Gene transcript fusions are associated with clinical outcomes and molecular groups of meningiomas
Gene transcript fusions are associated with clinical outcomes and molecular groups of meningiomas
Agnihotri S, Suppiah S, Tonge PD, Jalali S, Danesh A, Bruce JP et al (2017) Therapeutic radiation for childhood cancer dri...
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
Inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, ...
Role of GBA variants in Lewy body disease neuropathology
Role of GBA variants in Lewy body disease neuropathology
Rare and common GBA variants are risk factors for both Parkinson’s disease (PD) and dementia with Lewy bodies (DLB)....
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia
The stimulator of interferon genes (STING) pathway has been implicated in neurodegenerative diseases, including Parkinson&...
The prevalence and topography of spinal cord demyelination in multiple sclerosis: a retrospective study
The prevalence and topography of spinal cord demyelination in multiple sclerosis: a retrospective study
Spinal cord pathology is a major determinant of irreversible disability in progressive multiple sclerosis. The demyelinate...
Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease
Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease
Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are...
Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy
Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by recessive pathogenic variants affecting the survival o...
Myofiber-type-dependent ‘boulder’ or ‘multitudinous pebble’ formations across distinct amylopectinoses
Myofiber-type-dependent ‘boulder’ or ‘multitudinous pebble’ formations across distinct amylopectinoses
At least five enzymes including three E3 ubiquitin ligases are dedicated to glycogen’s spherical structure. Absence ...
Astroglial calcium signaling and homeostasis in tuberous sclerosis complex
Astroglial calcium signaling and homeostasis in tuberous sclerosis complex
Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized by the development of benign tumors in va...
Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE
Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive head impacts (RHI) and patholog...
MET receptor serves as a promising target in melanoma brain metastases
MET receptor serves as a promising target in melanoma brain metastases
The development of brain metastases hallmarks disease progression in 20–40% of melanoma patients and is a serious ob...
Aggressive human MenG C meningiomas have a molecular counterpart in canines
Aggressive human MenG C meningiomas have a molecular counterpart in canines
Bayley JC, Hadley CC, Harmanci AO, Harmanci AS, Klisch TJ, Patel AJ (2022) Multiple approaches converge on three biologica...
Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas
Canine meningiomas are comprised of 3 DNA methylation groups that resemble the molecular characteristics of human meningiomas
Abyzov A, Urban AE, Snyder M, Gerstein M (2011) CNVnator: an approach to discover, genotype, and characterize typical and ...
PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport
PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which currently lacks effective treatments. Mutat...
Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change
Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change
The amyloid cascade hypothesis states that Aβ aggregates induce pathological changes in tau, leading to neurofibrilla...
The niche matters: origin, function and fate of CNS-associated macrophages during health and disease
The niche matters: origin, function and fate of CNS-associated macrophages during health and disease
There are several cellular and acellular structural barriers associated with the brain interfaces, which include the dura,...
The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders
The contribution of β-amyloid, Tau and α-synuclein to blood–brain barrier damage in neurodegenerative disorders
Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (Aβ), hyperphosphorylated Tau...
Endothelial cells and macrophages as allies in the healthy and diseased brain
Endothelial cells and macrophages as allies in the healthy and diseased brain
Diseases of the central nervous system (CNS) are often associated with vascular disturbances or inflammation and frequentl...
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
Synapse loss correlates with cognitive decline in Alzheimer’s disease, and soluble oligomeric amyloid beta (Aβ)...
Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients
Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients
Biallelic loss of SPG11 function constitutes the most frequent cause of complicated autosomal recessive hereditary spastic...