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Congenital Hyperinsulinism: An Historical Perspective
Congenital Hyperinsulinism: An Historical Perspective
Congenital hyperinsulinism is the most common cause of persistent hypoglycemia in neonates, infants, and children. Since t...
The History of Obesity Research
The History of Obesity Research
Perhaps the most unexpected development in pediatric endocrinology in the past 50 years has been the recognition of obesit...
The Evolution of Adolescent Gender-Affirming Care: An Historical Perspective
The Evolution of Adolescent Gender-Affirming Care: An Historical Perspective
While individuals have demonstrated gender diversity throughout history, the use of medication and/or surgery to bring a p...
11-Oxygenated Androgen Metabolite Concentrations are Affected by Pubertal Progression and Obesity
11-Oxygenated Androgen Metabolite Concentrations are Affected by Pubertal Progression and Obesity
Introduction: 11-oxygenated C19 steroids (11-oxyandrogens) have been shown to rise during adrenarche and remain higher thr...
Long-Term Retention of Young Adult Study Participants with Youth-Onset Type 2 Diabetes: Results from the TODAY2 Study
Long-Term Retention of Young Adult Study Participants with Youth-Onset Type 2 Diabetes: Results from the TODAY2 Study
Introduction: The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial examined the effects of thr...
Prospective Test Performance of Nonfasting Biomarkers to Identify Dysglycemia in Children and Adolescents
Prospective Test Performance of Nonfasting Biomarkers to Identify Dysglycemia in Children and Adolescents
Introduction: Test performance screening measures for dysglycemia have not been evaluated prospectively in youth. This stu...
Impact of Stress on Health in Childhood and Adolescence
Impact of Stress on Health in Childhood and Adolescence
«We must avoid with our utmost endeavour and amputate with fire and sword and by all other means: from the body, sick...
10 years’ experience of a global and freely accessible e-Learning website for paediatric endocrinology and diabetes
10 years’ experience of a global and freely accessible e-Learning website for paediatric endocrinology and diabetes
The European Society for Paediatric Endocrinology (ESPE) interactive website https://www.espe-elearning.org was first publ...
Burosumab therapy in a paediatric patient with McCune-Albright Syndrome: A case report
Burosumab therapy in a paediatric patient with McCune-Albright Syndrome: A case report
Introduction McCune-Albright syndrome is characterised by the triad of fibrous dysplasia, café au lait skin pigmentat...
Sodium-glucose co-transporter-2 inhibitors in Type 1 Diabetes: A Scoping Review
Sodium-glucose co-transporter-2 inhibitors in Type 1 Diabetes: A Scoping Review
Background. With recent developments in diabetes technology, attaining adequate glucose control is more achievable than ev...
Glucocorticoid receptor expression pattern in very low-birth weight infants changes drastically within the first week of life
Glucocorticoid receptor expression pattern in very low-birth weight infants changes drastically within the first week of life
Introduction We herein examined changes in expression levels of the glucocorticoid receptor subtypes GRα and GRβ in very l...
Stress Management Methods in Children and Adolescents – Past, Present, and Future
Stress Management Methods in Children and Adolescents – Past, Present, and Future
Background: Stress is a natural automatic reaction of organisms to challenging or threatening stimuli. Prevalence rates re...
A case of peripheral precocious puberty may be caused by a diet containing phytosterols in a 20-month-old boy
A case of peripheral precocious puberty may be caused by a diet containing phytosterols in a 20-month-old boy
Introduction: Precocious puberty in boys generally remind an etiology. In addition to the causes of endogenous hormone cha...
Cell therapy for type 1 diabetes: from islet transplantation to stem cells
Cell therapy for type 1 diabetes: from islet transplantation to stem cells
Background. The field of cell therapy of type 1 diabetes is a particularly interesting example in the scenario of regenera...
Vitamin D toxicity from an unusual and unexpected source: a report of 2 cases
Vitamin D toxicity from an unusual and unexpected source: a report of 2 cases
Introduction: Hypervitaminosis D is a relatively uncommon etiology of hypercalcemia. Toxicity is usually caused by very hi...
Approaches to Identify Factors Associated with Pubertal Timing in Self-Limited Delayed Puberty
Approaches to Identify Factors Associated with Pubertal Timing in Self-Limited Delayed Puberty
Introduction: Children with self-limited delayed puberty (constitutional delay) enter puberty after variable waiting times...
Can GH-therapy worsen a clinically silent Chiari malformation? A case report and systematic literature review.
Can GH-therapy worsen a clinically silent Chiari malformation? A case report and systematic literature review.
Background: The link between the effects of recombinant human growth hormone (rhGH) therapy in patient with growth hormone...
Ethnic and National Differences in Congenital Adrenal Hyperplasia Incidence: A Systematic Review and Meta-analysis
Ethnic and National Differences in Congenital Adrenal Hyperplasia Incidence: A Systematic Review and Meta-analysis
Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive genetic disorder that causes defects in the adr...
Mosaic GLUD1 mutations associated with hyperinsulinism hyperammonemia syndrome
Mosaic GLUD1 mutations associated with hyperinsulinism hyperammonemia syndrome
Introduction: The hyperinsulinemia-hyperammonemia syndrome (HIHA) is the second most common cause of congenital hyperinsul...
The influence of body mass index on the growth hormone peak response regarding growth hormone stimulation tests in children
The influence of body mass index on the growth hormone peak response regarding growth hormone stimulation tests in children
Introduction: Several studies have analyzed the association between the maximal growth hormone serum level obtained during...
SLIT2 Rare Sequencing Variants Identified in Idiopathic Hypogonadotropic Hypogonadism
SLIT2 Rare Sequencing Variants Identified in Idiopathic Hypogonadotropic Hypogonadism
<b><i>Introduction:</i></b> Idiopathic hypogonadotropic hypogonadism (IHH) is a rare reproductive ...