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Sugar binding of sodium–glucose cotransporters analyzed by voltage-clamp fluorometry
Sugar binding of sodium–glucose cotransporters analyzed by voltage-clamp fluorometry
Keywordsmembrane transportsugar transportstructure-functionsubstrate specificityvoltage-clamp fluorometrySGLTsubstrate rec...
Epstein-Barr virus suppresses N6-methyladenosine modification of TLR9 to promote immune evasion
Epstein-Barr virus suppresses N6-methyladenosine modification of TLR9 to promote immune evasion
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , , , , , , , Epstein-Barr virus (EBV) is a human ...
The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues
The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , , Cholesterol is essential for both normal cell ...
TRIM13 reduces cholesterol efflux and increases oxidized LDL uptake leading to foam cell formation and atherosclerosis
TRIM13 reduces cholesterol efflux and increases oxidized LDL uptake leading to foam cell formation and atherosclerosis
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , Impaired cholesterol efflux and/or uptake can in...
Minor electrostatic changes robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles
Minor electrostatic changes robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles
KeywordsEbola viruselectrostaticslipid–protein interactionsphosphatidylinositol-4,5-bisphosphatephosphatidylserineplasma m...
The LOV-domain blue-light receptor LreA of the fungus Alternaria alternata binds predominantly FAD as chromophore and acts as a light and temperature sensor
The LOV-domain blue-light receptor LreA of the fungus Alternaria alternata binds predominantly FAD as chromophore and acts as a light and temperature sensor
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , , Light and temperature sensing are important fe...
Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway
Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , , Tauopathies are neurodegenerative disorders ch...
Bacterial stigmasterol degradation involving radical flavin delta-24 desaturase and molybdenum-dependent C26 hydroxylase
Bacterial stigmasterol degradation involving radical flavin delta-24 desaturase and molybdenum-dependent C26 hydroxylase
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , , , , Sterols are ubiquitous membrane constituen...
Zinc utilization by microglia in Alzheimer’s disease
Zinc utilization by microglia in Alzheimer’s disease
Author links open overlay panel, , AbstractAlzheimer’s disease (AD) is the most common form of dementia defined by two key...
Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR
Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , , , , , , Ciliary neurotrophic factor (CNTF) act...
Deafness-associated tRNAPhe mutation impaired mitochondrial and cellular integrity
Deafness-associated tRNAPhe mutation impaired mitochondrial and cellular integrity
Keywordsdeafnessmitochondrial tRNA mutationmitochondrial dynamicsmitophagyapoptosisAbbreviationsBN-PAGEblue native polyacr...
Rapid HPLC method reveals dynamic shifts in coenzyme Q redox state
Rapid HPLC method reveals dynamic shifts in coenzyme Q redox state
Author links open overlay panel, , , , AbstractUbiquinol or coenzyme Q (CoQ) is a lipid-soluble electron carrier in the re...
LncRNA-SERB promotes vasculogenic mimicry (VM) formation and tumor metastasis in renal cell carcinoma
LncRNA-SERB promotes vasculogenic mimicry (VM) formation and tumor metastasis in renal cell carcinoma
A growing body of evidence shows that vasculogenic mimicry (VM) is closely related to the invasion and metastasis of many ...
Unity among the diverse RNA-guided CRISPR-Cas interference mechanisms
Unity among the diverse RNA-guided CRISPR-Cas interference mechanisms
Author links open overlay panel, , , , AbstractCRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISP...
ABCG2 and SLC1A5 functionally interact to rewire metabolism and confer a survival advantage to cancer cells under oxidative stress
ABCG2 and SLC1A5 functionally interact to rewire metabolism and confer a survival advantage to cancer cells under oxidative stress
Author links open overlay panel, , , AbstractABCG2, a member of the ABC transporter superfamily, is overexpressed in many ...
Critical Amino Acid Residues Regulating TRPA1 Zn2+ Response: A Comparative Study Across Species
Critical Amino Acid Residues Regulating TRPA1 Zn2+ Response: A Comparative Study Across Species
Cellular zinc ions (Zn2+) are crucial for signal transduction in various cell types. The transient receptor potential (TRP...
Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis
Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis
Integrin-mediated activation of the pro-fibrotic mediator transforming growth factor-β1 (TGF-β1), plays a critical role in...
The Multifaceted Role of Intracellular Glycosylation in Cytoprotection and Heart Disease
The Multifaceted Role of Intracellular Glycosylation in Cytoprotection and Heart Disease
Key wordsGlycoproteinER StressIntegrated Stress ResponseHeart FailureHypertrophyCardioprotectionCellular Stress ResponseCh...
Network switches and their role in circadian clocks
Network switches and their role in circadian clocks
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , Circadian rhythms are generated by complex inter...
Protein kinase A is a functional component of focal adhesions
Protein kinase A is a functional component of focal adhesions
Journal of Biological ChemistryAuthor links open overlay panel, , , , , , , Focal adhesions (FAs) form the junction betwee...
Structural insight into the ZFAND1–p97 interaction involved in stress granule clearance
Structural insight into the ZFAND1–p97 interaction involved in stress granule clearance
KeywordsZFAND1p97stress granuleubiquitin-proteasome systemzinc fingerubiquitin-like domainNMR spectroscopycryo-EMX-ray cry...
Emergence of two distinct spatial folds in a pair of plant virus proteins encoded by nested genes
Emergence of two distinct spatial folds in a pair of plant virus proteins encoded by nested genes
Keywordsgenome evolutionmovement proteinsoverlapping reading framesvirus genomesconvergent evolution of protein structuret...
The Michael addition of thiols to 13-oxo-octadecadienoate (13-oxo-ODE) with implications for LC-MS analysis of glutathione conjugation
The Michael addition of thiols to 13-oxo-octadecadienoate (13-oxo-ODE) with implications for LC-MS analysis of glutathione conjugation
Author links open overlay panel, , , , AbstractUnsaturated fatty acid ketones with αβ,γδ conjugation are susceptible to Mi...
Properties of the iron-sulfur cluster electron transfer relay in an [FeFe]-hydrogenase that is tuned for H2 oxidation catalysis
Properties of the iron-sulfur cluster electron transfer relay in an [FeFe]-hydrogenase that is tuned for H2 oxidation catalysis
Keywordscatalysisdirectionalelectronic couplingelectron paramagnetic resonance (EPR)electron transferenzyme mechanismiron-...
Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1 deficient mice
Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1 deficient mice
Author links open overlay panel, , , , , , , , , , , ABSTRACTMutations in the adiponectin receptor 1 gene (AdipoR1) lead t...
The structure of the rat vitamin B12 transporter TC and its complex with glutathionylcobalamin
The structure of the rat vitamin B12 transporter TC and its complex with glutathionylcobalamin
Author links open overlay panel, , , , , , , , , AbstractVitamin B12 (cobalamin or Cbl) functions as a cofactor in two imp...
Exenatide reduces atrial fibrillation susceptibility by inhibiting hKv1.5 and hNav1.5 channels
Exenatide reduces atrial fibrillation susceptibility by inhibiting hKv1.5 and hNav1.5 channels
Author links open overlay panel, , , , , , , , , , AbstractExenatide, a promising cardioprotective agent, protects against...
The Plasmodium vivax MSP1P-19 is involved in binding of reticulocytes through interactions with the membrane proteins band3 and CD71
The Plasmodium vivax MSP1P-19 is involved in binding of reticulocytes through interactions with the membrane proteins band3 and CD71
The parasite Plasmodium vivax preferentially invades human reticulocytes. Its merozoite surface protein 1 paralog (PvMSP1P...
Cyclic AMP binding to a universal stress protein in Mycobacterium tuberculosis is essential for viability.
Cyclic AMP binding to a universal stress protein in Mycobacterium tuberculosis is essential for viability.
Cyclic AMPMycobacterium tuberculosisMycobacterium smegmatissecond messengeruniversal stress protein (USP)protein secretion...
Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry
Proximity labeling of host factor ANXA3 in HCV infection reveals a novel LARP1 function in viral entry
Hepatitis C virus (HCV) infection is tightly connected to the lipid metabolism with lipid droplets (LDs) serving as assemb...
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