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SUMOylation indirectly suppresses activity of the HIF-1α pathway in intestinal epithelial cells
SUMOylation indirectly suppresses activity of the HIF-1α pathway in intestinal epithelial cells
Keywordshypoxiahypoxia‐inducible factor (HIF)small ubiquitin‐like modifier (SUMO)sumoylationintestinal epitheliumAbbreviat...
Structural insights into Rad18 targeting by the SLF1 BRCT domains
Structural insights into Rad18 targeting by the SLF1 BRCT domains
KeywordsDNA damage responseprotein complexprotein-protein interactionphosphorylationX-ray crystallographyRad18SLF1SMC5/6 c...
Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription
Hypoxic regulation of hypoxia inducible factor 1 alpha via antisense transcription
Impaired oxygen homeostasis is a frequently encountered pathophysiological factor in multiple complex diseases, including ...
The endoplasmic reticulum–localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins
The endoplasmic reticulum–localized enzyme zDHHC6 mediates S-acylation of short transmembrane constructs from multiple type I and II membrane proteins
Journal of Biological ChemistryVolume 299, Issue 10, October 2023, 105201Author links open overlay panel, , In this study,...
Golgi α-mannosidases regulate cell surface N-glycan type and ectodomain shedding of the transmembrane protease corin
Golgi α-mannosidases regulate cell surface N-glycan type and ectodomain shedding of the transmembrane protease corin
Journal of Biological ChemistryVolume 299, Issue 10, October 2023, 105211Author links open overlay panel, , , , , , , , Co...
Biochemical investigation of the tryptophan biosynthetic enzyme anthranilate phosphoribosyltransferase in plants
Biochemical investigation of the tryptophan biosynthetic enzyme anthranilate phosphoribosyltransferase in plants
While mammals require the essential amino acid tryptophan (Trp) in their diet, plants and microorganisms synthesize Trp de...
The biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype
The biased M3 mAChR ligand PD 102807 mediates qualitatively distinct signaling to regulate airway smooth muscle phenotype
Keywordsasthmaairwayairway smooth muscleG protein-coupled receptorbiased receptor pharmacologyAbbreviationsACCacetyl-CoA c...
G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions
G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions
KeywordsGPR35G protein–coupled receptor kinasesarrestinsphosphorylationphospho-site–specific antiseraAbbreviationsBRETbiol...
Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina
Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina
Keywordsretinaretinal pigment epitheliumnitrogenammoniumglutamineaspartatealanineleucinetransaminaseAbbreviationRPEretinal...
A Real-Time Analysis of Protein Transport via the Twin Arginine Translocation Pathway in Response to Different Components of the Protonmotive Force
A Real-Time Analysis of Protein Transport via the Twin Arginine Translocation Pathway in Response to Different Components of the Protonmotive Force
Research Article Collection: BioenergeticsA Real-Time Analysis of Protein Transport via the Twin Arginine Translocation Pa...
A novel phosphorylation site involved in dissociating RAF kinase from the scaffolding protein 14-3-3 and disrupting RAF dimerization
A novel phosphorylation site involved in dissociating RAF kinase from the scaffolding protein 14-3-3 and disrupting RAF dimerization
KeywordsphosphorylationRAF kinase14-3-3scaffolding proteincancerdimerizationATP-competitive inhibitorparadoxical activatio...
The nexus between reactive oxygen species and the mechanism of action of herbicides
The nexus between reactive oxygen species and the mechanism of action of herbicides
reactive oxygen species (ROS)antioxidanthydrogen peroxidelipid peroxidationoxidative stresssuperoxide ionoxygen radicalspl...
Respiratory syncytial virus (RSV)-approved monoclonal antibody Palivizumab as ligand for anti-idiotype nanobody-based synthetic cytokine receptors
Respiratory syncytial virus (RSV)-approved monoclonal antibody Palivizumab as ligand for anti-idiotype nanobody-based synthetic cytokine receptors
Author links open overlay panelJulia Ettich 1 †, Christoph Wittich 1 †, Jens M. Moll 1 2, Kristina Behnke 1, Doreen M. Flo...
Dysregulation of the Progranulin-driven Autophagy-lysosomal Pathway Mediates Secretion of the Nuclear Protein TDP-43
Dysregulation of the Progranulin-driven Autophagy-lysosomal Pathway Mediates Secretion of the Nuclear Protein TDP-43
Keywordsautophagyextracellular vesiclesTAR DNA‐binding protein 43 (TDP‐43)frontotemporal lobar degeneration (FTLD)amyotrop...
The Capsaicin Binding Affinity of Wild-Type and Mutant TRPV1 Ion Channels
The Capsaicin Binding Affinity of Wild-Type and Mutant TRPV1 Ion Channels
Author links open overlay panel, AbstractVanilloids such as capsaicin and resiniferatoxin (RTX) are highly selective and p...
CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions.
CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions.
Author links open overlay panel, , , AbstractPrenylation is an irreversible post-translational modification that supports ...
Myeloid-derived suppressor cells and tolerogenic dendritic cells are distinctively induced by PI3K and Wnt signaling pathways
Myeloid-derived suppressor cells and tolerogenic dendritic cells are distinctively induced by PI3K and Wnt signaling pathways
Author links open overlay panel, , , , , , , , , , , , , , AbstractImbalanced immune responses are a prominent hallmark of...
Retardation of Aβ42 fibril formation by apolipoprotein A-I and recombinant HDL particles
Retardation of Aβ42 fibril formation by apolipoprotein A-I and recombinant HDL particles
Author links open overlay panel, , AbstractThe double nucleation mechanism of amyloid β (Aβ) peptide aggregation is retain...
Diversity in Connexin Biology
Diversity in Connexin Biology
Over 35 years ago the cell biology community was introduced to connexins as the subunit employed to assemble semi-crystall...
Mechanistic characterization of disulfide bond reduction of an ERAD substrate mediated by cooperation between ERdj5 and BiP
Mechanistic characterization of disulfide bond reduction of an ERAD substrate mediated by cooperation between ERdj5 and BiP
Endoplasmic reticulum (ER)-associated degradation (ERAD) is a protein quality control process that eliminates misfolded pr...
Protein interaction network analysis of mTOR signaling reveals modular organization
Protein interaction network analysis of mTOR signaling reveals modular organization
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that acts as a central mediator of translation, and ...
NFIB–MLL1 complex is required for the stemness and Dlx5-dependent osteogenic differentiation of C3H10T1/2 mesenchymal stem cells
NFIB–MLL1 complex is required for the stemness and Dlx5-dependent osteogenic differentiation of C3H10T1/2 mesenchymal stem cells
Keywordsmesenchymal stem cellsosteogenic differentiationNFIBMLL1Dlx5stem cell maintenancebivalent chromatin domainAbbrevia...
Synergistic computational and experimental studies of a phosphoglycosyl transferase membrane/ligand ensemble
Synergistic computational and experimental studies of a phosphoglycosyl transferase membrane/ligand ensemble
Keywordspolyprenol phosphateglycoconjugate biosynthesismembrane proteinmolecular dynamicsprotein dynamicsAbbreviationsDDMn...
An Essential Signaling Function of Cytoplasmic NELFB is Independent of RNA Polymerase II Pausing
An Essential Signaling Function of Cytoplasmic NELFB is Independent of RNA Polymerase II Pausing
Author links open overlay panel, , , , , , , , Highlights•An integral NELF complex is not required for NELFBdependent cell...
Phenotypic analysis with trans-recombination-based genetic mosaic models
Phenotypic analysis with trans-recombination-based genetic mosaic models
Author links open overlay panel, , AbstractMosaicism refers to the presence of genetically distinct cell populations in an...
Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate
Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate
aspartate (aspartic acid)beta cell (β‐cell)Type 1 diabetesautoimmune diseasemass spectrometry (MS)chromatographyinsulin C-...
Both chloride-binding sites are required for KCC2-mediated transport
Both chloride-binding sites are required for KCC2-mediated transport
Keywordsstructuresite-directed mutagenesisprotein conformationcation chloride cotransportercell culturechloride-binding si...
Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages
Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages
KeywordsRab32Rab38osteoclastmacrophagelysosome-related organellesAbbreviationsLamp1lysosomal associated membrane protein 1...
Modulation of aggregation and structural polymorphisms of β-amyloid fibrils in cellular environments by pyroglutamate-3 variant cross-seeding
Modulation of aggregation and structural polymorphisms of β-amyloid fibrils in cellular environments by pyroglutamate-3 variant cross-seeding
Keywordsβ-amyloid fibrilsposttranslational modificationneuroblastoma cell linescross-seedingstructural polymorphismsin-cel...
The kinesin-14 family motor protein KIFC2 promotes prostate cancer progression by regulating p65
The kinesin-14 family motor protein KIFC2 promotes prostate cancer progression by regulating p65
KeywordsProstate cancerKIFC2Tumor progressionChemotherapeutic resistanceNF-κB pathwayAbbreviationsCRPCCastration-resistanc...
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