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Disruption of Ephx2 in cardiomyocytes but not endothelial cells improves functional recovery after ischemia-reperfusion in isolated mouse hearts
Journal of Biological ChemistryVolume 299, Issue 4, April 2023, 103049Author links open overlay panel, , , , , , , Cytochr...
Differentiation-linked changes in the biosynthesis and turnover of sphingomyelins in rat male germ cells: Genes involved and effects of testosterone
In rodents, sphingomyelins (SMs) species with very-long-chain polyunsaturated fatty acid (VLCPUFA) are required for normal...
Selective PPARγ modulator diosmin improves insulin sensitivity and promotes browning of white fat
Keywordsdiosminselective PPARγ modulatorPPARγ phosphorylationinsulin sensitivitybrowning of white fat tissueAbbreviationsC...
Nucleotide metabolism is linked to cysteine availability
Journal of Biological ChemistryVolume 299, Issue 4, April 2023, 103039Author links open overlay panel, , , , The small mol...
The CTP-binding domain is disengaged from the DNA-binding domain in a cocrystal structure of Bacillus subtilis Noc–DNA complex
Journal of Biological ChemistryVolume 299, Issue 4, April 2023, 103063Author links open overlay panel, , , , , In Bacillus...
EZH2 W113C is a gain-of-function mutation in B-cell lymphoma enabling both PRC2 methyltransferase activation and tazemetostat resistance
Journal of Biological ChemistryVolume 299, Issue 4, April 2023, 103073Author links open overlay panel, , , , , , Polycomb ...
Molecular dynamics simulations reveal the importance of amyloid-beta oligomer β-sheet edge conformations in membrane permeabilization
Journal of Biological ChemistryVolume 299, Issue 4, April 2023, 103034Author links open overlay panel, Oligomeric aggregat...
Design, synthesis, and mechanism of action of novel μ-conotoxin KIIIA analogues for inhibition of the voltage-gated sodium channel Nav1.7
Keywordsμ-conotoxinvoltage-gated sodium ion channelanalgesiastructure optimizationpeptide synthesisKIIIAAbbreviationsDabL-...
Reciprocal regulatory balance within the CLEC16A–RNF41 mitophagy complex depends on an intrinsically disordered protein region
Journal of Biological ChemistryVolume 299, Issue 4, April 2023, 103057Author links open overlay panel, , , , , , , , , , C...
s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons
Journal of Biological ChemistryVolume 299, Issue 4, April 2023, 103040Author links open overlay panel, , , , , , , , , , ,...
The function of the phytoplasma effector SWP12 depends on the properties of two key amino acids
Journal of Biological ChemistryVolume 299, Issue 4, April 2023, 103052Author links open overlay panel, , , , , , Phytoplas...
Burst kinetics and CNNM binding are evolutionarily conserved properties of phosphatases of regenerating liver
Keywordscell signalingprotein phosphatasedual-specificity phosphoprotein phosphataseX-ray crystallographyanalytical ultrac...
Mutation of a distal gating residue modulates NADH binding in NADH:Quinone oxidoreductase from Pseudomonas aeruginosa PAO1
Research Article Collection: EnzymologyMutation of a distal gating residue modulates NADH binding in NADH:Quinone oxidored...
Interaction of the bacterial division regulator MinE with lipid bicelles studied by NMR spectroscopy
Research Article Collection: Protein Structure and FoldingInteraction of the bacterial division regulator MinE with lipid ...
UHMK1 is a novel splicing regulatory kinase
The U2AF Homology Motif Kinase 1 (UHMK1) is the only kinase that contains the U2AF homology motif, a common protein intera...
Crosstalk between protein kinase C α and transforming growth factor β signaling mediated by Runx2 in intestinal epithelial cells
Journal of Biological ChemistryVolume 299, Issue 4, April 2023, 103017Author links open overlay panel, , , , , Tight coord...
Gβγ subunits colocalize with RNA polymerase II and regulate transcription in cardiac fibroblasts
Journal of Biological ChemistryVolume 299, Issue 4, April 2023, 103064Author links open overlay panel, , , , , , , , , , ,...
Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b by interacting with its RVEP motif-containing ciliary targeting sequence
Arl13b, an ARF/Arl-family GTPase, is highly enriched in the cilium. Recent studies have established Arl13b as one of the m...
Atypical histone targets of PHD fingers
Author links open overlay panel, AbstractPlant homeodomain (PHD) fingers are structurally conserved zinc fingers that sele...
Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine-ceramides
Author links open overlay panel, , , , , , , AbstractPhytosphingosine (PHS) is a sphingolipid component present mainly in ...
A bivalent β-carboline derivative inhibits macropinocytosis-dependent entry of pseudorabies virus by targeting the kinase DYRK1A
Pseudorabies virus (PRV) has become a “new life-threatening zoonosis” since the human-originated PRV strain was first isol...
Glycolipid transfer protein knockout disrupts vesicle trafficking to the plasma membrane
Endoplasmic reticulum (ER)Golgigene silencingglycerosphingolipidglycolipidintracellular traffickinglipid transportVAP-AVSV...
Mechanism and linkage specificities of the dual retaining β-Kdo glycosyltransferase modules of KpsC from bacterial capsule biosynthesis
Escherichia colicell surfacecapsular polysaccharideglycolipidbiosynthesis3-deoxy-β-D-manno-oct-2-ulosonic acidglycosyltran...
Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products
Author links open overlay panel, , , , , , , , AbstractL1 is a dizinc subclass B3 metallo-β-lactamase (MBL) that hydrolyze...
Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches
Author links open overlay panel, , , , ABSTRACTRapid and accurate translation is essential in all organisms to produce pro...
A short-chain acyl-CoA synthetase that supports branched-chain fatty acid synthesis in Staphylococcus aureus
KeywordsStaphylococcus aureusacyl-CoA synthetasebranched-chain ketoacid dehydrogenasefatty acid synthesisphospholipidmembr...
p38 MAPK and MKP-1 control the glycolytic program via the bifunctional glycolysis regulator PFKFB3 during sepsis
Keywordsinfectionp38 MAPKc-Jun N-terminal kinasedual-specificity phosphoprotein phosphataseglycolysissepsisAbbreviationsBM...
Molecular Determinants for Differential Activation of the Bile Acid Receptor from the Pathogen Vibrio parahaemolyticus
Bile acids are important for digestion of food and for antimicrobial activity. Pathogenic Vibrio parahaemolyticus senses b...
Mismatch repair operates at the replication fork in direct competition with mismatch extension by DNA polymerase δ
Author links open overlay panel, , , , AbstractDNA mismatch repair (MMR) in eukaryotes is believed to occur post-replicati...
Differential role for rapid proteostasis in Rho GTPase-mediated control of quiescent endothelial integrity
Author links open overlay panel, , , , , SummaryEndothelial monolayer permeability is regulated by actin dynamics and vesi...
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