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Bile acid metabolism and signaling: Emerging pharmacological targets of dietary polyphenols
Bile acids (BAs) are a heterogeneous group of amphipathic steroidal acids that facilitate emulsification and absorption of...
Regulatory lipid vicinal diols counteract the biological activity of epoxy fatty acids and can act as biomarkers and mechanisms for disease progression
“Regulatory lipids”, also described as oxylipins, comprise a class of omega-3 (n-3) and − 6 (n-6) polyunsaturated fatty ac...
Inflammation, lipids, and pain in vulvar disease
Available online 5 June 2023, 108467Author links open overlay panel, , AbstractLocalized provoked vulvodynia (LPV) affects...
Potential neonatal toxicity of new psychoactive substances
Since their isolation in the early 19th century, certain compounds, such as cocaine and morphine, were used as psychoactiv...
Integrins in cancer: Emerging mechanisms and therapeutic opportunities
Volume 247, July 2023, 108458Author links open overlay panel, , , AbstractIntegrins are vital surface adhesion receptors t...
Resolution of inflammation in oral diseases
The oral microbiome modulates oral and systemic immune development that creates a sustainable balanced relationship with t...
Is there a role for specialized pro-resolving mediators in pulmonary fibrosis?
Pulmonary fibrotic diseases are characterized by proliferation of lung fibroblasts and myofibroblasts and excessive deposi...
Regulation of inflammation in cancer by dietary eicosanoids
Cancer is a worldwide major public health concern. In 2020, the American Cancer Society reported that more than 600,000 ca...
Terpenes: Modulating anti-inflammatory signaling in inflammatory bowel disease
Inflammatory Bowel Disease (IBD) are polygenic autoimmune disorders characterized by intestinal chronic inflammation. In 2...
Corrigendum to “Game of clones: Battles in the field of carcinogenesis” [Pharmacology & Therapeutics, volume 237, Pages 108–251]
Volume 247, July 2023, 108446Author links open overlay panelZahraa Rahal, Ansam Sinjab, Ignacio I. Wistuba, Humam KadaraSh...
Bacterial extracellular vesicles and their interplay with the immune system
Bacterial extracellular vesicles (bEV) are nanosized (~20–300 nm) membrane vesicles that are spontaneously released by bac...
Obesity, cancer, and response to immune checkpoint inhibitors: Could the gut microbiota be the mechanistic link?
The worldwide prevalence of obesity, defined by a body mass index (BMI) above 30 kg/m2, is continuously increasing, it is ...
Pulmonary vascular fibrosis in pulmonary hypertension – The role of the extracellular matrix as a therapeutic target
Pulmonary hypertension (PH) is a condition characterized by changes in the extracellular matrix (ECM) deposition and vascu...
Acidosis-related pain and its receptors as targets for chronic pain
Tissue acidosis is a pathophysiological phenomenon accompanying tissue injury, inflammation and ischemia. Environmental ac...
Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases
The Basic Law on Measures against Allergic Diseases in Japan was enforced on December 25, 2015. Six diseases are defined a...
Icosapent ethyl in cardiovascular prevention: Resolution of inflammation through the eicosapentaenoic acid - resolvin E1 - ChemR23 axis
CVOTcardiovascular outcome trialsCCTAcoronary computed tomographic angiographyFADSfatty acid desaturasesGPRG protein-coupl...
The essential role of docosahexaenoic acid and its derivatives for retinal integrity
The retina, together with the brain and testis, is highly enriched in omega-3 (n-3) long chain and very long chain polyuns...
Targeting mitochondrial function in macrophages: A novel treatment strategy for atherosclerotic cardiovascular disease?
Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide, accounting for 32% of all dea...
Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption
Docosahexaenoic acid (DHA) is a 22‑carbon omega-3 polyunsaturated fatty acid (n-3 PUFA) with six double bonds, commonly de...
Prolactin and pain of endometriosis
Endoscopic submucosal dissection (ESD) is an accepted treatment for early esophageal cancer and precancerous lesions, but ...
Targeting tumor endothelial cells with methyltransferase inhibitors: Mechanisms of action and the potential of combination therapy
Tumor endothelial cells (TECs) have distinct characteristics that differentiate them from ordinary endothelial cells. Thes...
Bayesian prediction-based individualized dosing of anti-methicillin-resistant Staphylococcus aureus treatment: Recent advancements and prospects in therapeutic drug monitoring
KeywordsTherapeutic drug monitoringModel-informed precision dosingAntimicrobialsBayesian forecastingPopulation pharmacokin...
Molecular and neuroimmune pharmacology of S1P receptor modulators and other disease-modifying therapies for multiple sclerosis
Neurological disorders are medically defined as diseases of the nervous system, including stroke, Alzheimer's disease and ...
Dysregulation of metabolic pathways in pulmonary fibrosis
KeywordsIdiopathic pulmonary fibrosisAmino acid metabolismLipid metabolismCarbohydrate metabolismTCA cycleTherapeutic targ...
The antidepressant actions of ketamine and its enantiomers
The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was first developed as a shorter-acting, less psychoactive a...
17β-hydroxysteroid dehydrogenases in the progression of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a liver disease characterized by steatosis and excessive lipid deposition in h...
Bioactive lipid regulation of platelet function, hemostasis, and thrombosis
Cardiovascular disease (CVD) is the leading cause of death globally, accounting for 1 in 4 deaths (Tsao et al., 2023). Car...
The tissue-specific transcriptional landscape underlines the involvement of endothelial cells in health and disease
In the past fifty years, research into vascular biology has dramatically changed the previously established perspectives o...
Lysophosphatidic acid, a simple phospholipid with myriad functions
Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate head group, glycerol moiety, and single fat...
Targeting the GBA1 pathway to slow Parkinson disease: Insights into clinical aspects, pathogenic mechanisms and new therapeutic avenues
The GBA1 gene encodes the lysosomal enzyme glucocerebrosidase (GCase), which is involved in sphingolipid metabolism. Biall...
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