SCI时时刷

search
Therapeutics targeting the metastatic breast cancer bone microenvironment
mBCmetastatic breast cancerTMEtumor microenvironmentHER2human epidermal growth factor receptor 2BSEbreast self-examination...
Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most frequent neurodegenerative disorders. Despite their pat...
Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
ALSAmyotrophic lateral sclerosisAMPAα-amino-3-hydroxy-5-methyl-4- isoxazole propionateBDNFBrain derived neurotrophic facto...
Review of the application of Kirchhoff's Laws of series and parallel flows to pharmacology: Defining organ clearance
Dosing rate decisions for drugs and changes in dosing in a patient due to disease states, drug interactions and pharmacoge...
Future perspectives of anemia management in chronic kidney disease using hypoxia-inducible factor-prolyl hydroxylase inhibitors
For the past 3 decades, erythropoiesis-stimulating agents (ESA) in conjunction with iron supplementation has been the main...
Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends
CAFscancer-associated fibroblastsHANhigh-affinity neoantigensHCChepatocellular carcinomahHSChuman hematopoietic stem cells...
Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases
Dysbiosis is associated with various diseases. The composition and diversity of gut microbiota affect host physiology thro...
Emerging roles of Glucagon like peptide-1 in the management of autoimmune diseases and diabetes-associated comorbidities
Currently, gastrointestinal hormone glucagon like peptide-1 (GLP-1) has received significant attention in maintaining gluc...
Cholesterol crystals and atherosclerotic plaque instability: Therapeutic potential of Eicosapentaenoic acid
Atherosclerotic plaques associated with acute coronary syndromes (ACS), i.e. culprit lesions, frequently feature a rupture...
Monoclonal antibody therapeutics for infectious diseases: Beyond normal human immunoglobulin
Volume 240, December 2022, 108233AbstractAntibody therapy is effective for treating infectious diseases. Due to the corona...
Antibody drug conjugates: The dos and don'ts in clinical development
Available online 20 June 2022, 108235AbstractAntibody Drug Conjugates (ADCs) entered clinical trials in the mid 1990s to s...
Progressive massive fibrosis: An overview of the recent literature
Available online 19 June 2022, 108232AbstractThis review provides an overview of literature addressing progressive massive...
Targeting cancer-associated fibroblasts: Challenges, opportunities and future directions
Available online 17 June 2022, 108231AbstractCancer-associated fibroblasts (CAFs) are a common cell in the tumour microenv...
Development and clinical translation of P2X7 receptor antagonists: A potential therapeutic target in coronary artery disease?
Available online 16 June 2022, 108228AbstractThe purinoceptor 7 receptor (P2X7R) plays an important role in promoting infl...
Pharmacological treatment of cardiogenic shock – A state of the art review
Available online 10 June 2022, 108230AbstractCardiogenic shock is a clinical syndrome of impaired tissue perfusion caused ...
Targeting CDK7 in oncology: The avenue forward
Available online 11 June 2022, 108229AbstractCyclin-dependent kinase (CDK) 7 is best characterized for the ability to regu...
The roles of TGF-β and VEGF pathways in the suppression of antitumor immunity in melanoma and other solid tumors
Available online 14 May 2022, 108211AbstractImmune checkpoint blockade (ICB) has become well-known in cancer therapy, stre...
MicroRNAs in drug addiction: Current status and future perspectives
Available online 21 May 2022, 108215AbstractDrug addiction is a chronic and relapsing brain disorder characterized by comp...
Superconserved receptors expressed in the brain: Expression, function, motifs and evolution of an orphan receptor family
Available online 26 May 2022, 108217AbstractGPR27, GPR85 and GPR173 constitute a small family of G protein-coupled recepto...
CNS border-associated macrophages in the homeostatic and ischaemic brain
CNS border-associated macrophages (BAMs) are a small population of specialised macrophages localised in the choroid plexus...
Stress- and drug-induced neuroimmune signaling as a therapeutic target for comorbid anxiety and substance use disorders
Volume 239, November 2022, 108212AbstractStress and substance use disorders remain two of the most highly prevalent psychi...
Mitochondrial metabolism mediated macrophage polarization in chronic lung diseases
COPDchronic obstructive pulmonary diseaseIPFidiopathic pulmonary fibrosisOXPHOSoxidative phosphorylationROSreactive oxygen...
Cannabinoids and the endocannabinoid system in fibromyalgia: A review of preclinical and clinical research
Characterised by chronic widespread musculoskeletal pain, generalised hyperalgesia, and psychological distress, fibromyalg...
The role of drug-metabolizing enzymes in synthetic lethality of cancer
Volume 240, December 2022, 108219AbstractDrug-metabolizing enzymes (DMEs) have shown increasing importance in anticancer t...
Clinical implications of tristetraprolin (TTP) modulation in the treatment of inflammatory diseases
Available online 5 May 2022, 108198AbstractAbnormal regulation of pro-inflammatory cytokine and chemokine mediators can co...
The IL-18/IL-18R1 signalling axis: Diagnostic and therapeutic potential in hypertension and chronic kidney disease
ANCAAnti-neutrophil cytoplasmic antibodiesASCApoptosis-associated speck like protein containing a caspase recruitment doma...
The future of targeted kinase inhibitors in melanoma
KeywordsCancerMelanomaTargeted therapyKinase inhibitorsImmune checkpoint inhibitorsCombination therapyAbbreviationsADCsant...
Clinical advances in oncolytic virotherapy for pediatric brain tumors
Available online 26 April 2022, 108193AbstractMalignant brain tumors constitute nearly one-third of cancer diagnoses in ch...