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Glycaemic patterns during breastfeeding with postpartum use of closed-loop insulin delivery in women with type 1 diabetes
Glycaemic patterns during breastfeeding with postpartum use of closed-loop insulin delivery in women with type 1 diabetes
This study aimed to describe the relationship between breastfeeding episodes and maternal glucose levels, and to assess wh...
Technology in the management of diabetes in hospitalised adults
Technology in the management of diabetes in hospitalised adults
Suboptimal glycaemic management in hospitals has been associated with adverse clinical outcomes and increased financial co...
Transgender healthcare: metabolic outcomes and cardiovascular risk
Transgender healthcare: metabolic outcomes and cardiovascular risk
Transgender identity is often associated with gender dysphoria and minority stress. Gender-affirming hormone treatment (GA...
The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo
The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo
Strategies to augment functional beta cell mass include directed differentiation of stem cells towards a beta cell fate, w...
Technology advances in diabetes pregnancy: right technology, right person, right time
Technology advances in diabetes pregnancy: right technology, right person, right time
This review outlines some of the extraordinary recent advances in diabetes technology, which are transforming the manageme...
Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h
Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h
Disruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycaemia, b...
Trajectories of BMI before and after diagnosis of type 2 diabetes in a real-world population
Trajectories of BMI before and after diagnosis of type 2 diabetes in a real-world population
Few studies have examined the clinical characteristics associated with changes in weight before and after diagnosis of typ...
Higher fibre and lower carbohydrate intake are associated with favourable CGM metrics in a cross-sectional cohort of 470 individuals with type 1 diabetes
Higher fibre and lower carbohydrate intake are associated with favourable CGM metrics in a cross-sectional cohort of 470 individuals with type 1 diabetes
The aim of this work was to investigate the association between macronutrient intakes and continuous glucose monitoring (C...
tRNA-derived fragments in T lymphocyte–beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice
tRNA-derived fragments in T lymphocyte–beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice
tRNAs play a central role in protein synthesis. Besides this canonical function, they were recently found to generate non-...
Heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisation
Heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisation
Diabetic retinopathy is characterised by neuroinflammation that drives neuronal and vascular degenerative pathology, which...
Molecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte–endothelial interactions
Molecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte–endothelial interactions
Alterations in circadian rhythms increase the likelihood of developing type 2 diabetes and CVD. Circadian rhythms are cont...
Efficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes (PIONEER 11): a double-blind, Phase IIIa, randomised trial
Efficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes (PIONEER 11): a double-blind, Phase IIIa, randomised trial
The aim of this study was to evaluate the efficacy and safety of oral semaglutide monotherapy vs placebo in a predominantl...
Efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: PIONEER 12, a double-blind, Phase IIIa, randomised trial
Efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: PIONEER 12, a double-blind, Phase IIIa, randomised trial
The aim of this study was to assess the efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese ...
Advances in diabetes technology to improve the lives of people with cystic fibrosis
Advances in diabetes technology to improve the lives of people with cystic fibrosis
People with cystic fibrosis (CF) are at risk for dysglycaemia caused by progressive beta cell dysfunction and destruction ...
Ultra-processed food consumption and risk of diabetes: results from a population-based prospective cohort
Ultra-processed food consumption and risk of diabetes: results from a population-based prospective cohort
Understanding the impact of the overall construct of ultra-processed foods on diabetes risk can inform dietary approaches ...
Effectiveness and safety of empagliflozin: final results from the EMPRISE study
Effectiveness and safety of empagliflozin: final results from the EMPRISE study
Limited evidence exists on the comparative safety and effectiveness of empagliflozin against alternative glucose-lowering ...
Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial
Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial
The aim of this study was to evaluate the impact on metabolic control of periodic use of a 5-day fasting-mimicking diet (F...
Trajectories of clinical characteristics, complications and treatment choices in data-driven subgroups of type 2 diabetes
Trajectories of clinical characteristics, complications and treatment choices in data-driven subgroups of type 2 diabetes
This study aimed to explore the added value of subgroups that categorise individuals with type 2 diabetes by k-means clust...
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities
Diabetes mellitus is a significant risk factor for both ischaemic and haemorrhagic stroke, affecting up to a third of indi...
Gestational age at birth and type 1 diabetes in childhood and young adulthood: a nationwide register study in Finland, Norway and Sweden
Gestational age at birth and type 1 diabetes in childhood and young adulthood: a nationwide register study in Finland, Norway and Sweden
Children and adults born preterm have an increased risk of type 1 diabetes. However, there is limited information on risk ...
Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus
Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus
Non-adherence to medication is a frequent barrier in the treatment of patients with type 2 diabetes mellitus, potentially ...
Subcutaneously administered tirzepatide vs semaglutide for adults with type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials
Subcutaneously administered tirzepatide vs semaglutide for adults with type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials
We conducted a systematic review and network meta-analysis to compare the efficacy and safety of s.c. administered tirzepa...
CK2 activity is crucial for proper glucagon expression
CK2 activity is crucial for proper glucagon expression
Protein kinase CK2 acts as a negative regulator of insulin expression in pancreatic beta cells. This action is mainly medi...
Risk of diabetic retinopathy and diabetic macular oedema with sodium–glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in type 2 diabetes: a real-world data study from a global federated database
Risk of diabetic retinopathy and diabetic macular oedema with sodium–glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists in type 2 diabetes: a real-world data study from a global federated database
A protective role of sodium–glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonis...
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
Lactate accumulation is reported to be a biomarker for diabetic nephropathy progression. Lactate drives lysine lactylation...
Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes
Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes
Mutations in Isl1, encoding the insulin enhancer-binding protein islet-1 (ISL1), may contribute to attenuated insulin secr...
Caesarean section and risk of type 1 diabetes
Caesarean section and risk of type 1 diabetes
Delivery by Caesarean section continues to rise globally and has been associated with the risk of developing type 1 diabet...
Sex-dependent intra-islet structural rearrangements affecting alpha-to-beta cell interactions lead to adaptive enhancements of Ca2+ dynamics in prediabetic beta cells
Sex-dependent intra-islet structural rearrangements affecting alpha-to-beta cell interactions lead to adaptive enhancements of Ca2+ dynamics in prediabetic beta cells
Prediabetic pancreatic beta cells can adapt their function to maintain normoglycaemia for a limited period of time, after ...
Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes
Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes
Almost all beta cells contact one capillary and insulin granule fusion is targeted to this region. However, there are repo...
Identification and validation of gestational diabetes subgroups by data-driven cluster analysis
Identification and validation of gestational diabetes subgroups by data-driven cluster analysis
Gestational diabetes mellitus (GDM) is a heterogeneous condition. Given such variability among patients, the ability to re...
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