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Serum neurofilament light chain: a novel biomarker for early diabetic sensorimotor polyneuropathy
Serum neurofilament light chain: a novel biomarker for early diabetic sensorimotor polyneuropathy
No established blood-based biomarker exists to monitor diabetic sensorimotor polyneuropathy (DSPN) and evaluate treatment ...
The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes
The effect of age on longitudinal measures of beta cell function and insulin sensitivity during the progression of early stage type 1 diabetes
The risk of progressing from autoantibody positivity to type 1 diabetes is inversely related to age. Separately, whether a...
Pathophysiology of type 2 diabetes in sub-Saharan Africans
Pathophysiology of type 2 diabetes in sub-Saharan Africans
Sub-Saharan Africa (SSA) is the region with the highest projected rates of increase in type 2 diabetes (129% by 2045), whi...
Normal and disordered gastric emptying in diabetes: recent insights into (patho)physiology, management and impact on glycaemic control
Normal and disordered gastric emptying in diabetes: recent insights into (patho)physiology, management and impact on glycaemic control
Gastric emptying is a major determinant of postprandial blood glucose, accounting for ~35% of variance in peak glucose in ...
Associations between parental type 2 diabetes risk and offspring birthweight and placental weight: a survival analysis using the Walker cohort
Associations between parental type 2 diabetes risk and offspring birthweight and placental weight: a survival analysis using the Walker cohort
Low birthweight (BW) is associated with the development of type 2 diabetes. Genome-wide analyses have identified a strong ...
Timing of physical activity in relation to liver fat content and insulin resistance
Timing of physical activity in relation to liver fat content and insulin resistance
We hypothesised that the insulin-sensitising effect of physical activity depends on the timing of the activity. Here, we e...
Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants
Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants
TCF7L2 variants are the strongest genetic risk factor for type 2 diabetes. In individuals with type 1 diabetes, these vari...
Secular trend for increasing birthweight in offspring of pregnant women with type 1 diabetes: is improved placentation the reason?
Secular trend for increasing birthweight in offspring of pregnant women with type 1 diabetes: is improved placentation the reason?
Despite enormous progress in managing blood glucose levels, pregnancy in women with type 1 diabetes still carries risks fo...
The incidence of childhood-onset type 1 diabetes, time trends and association with the population composition in Sweden: a 40 year follow-up
The incidence of childhood-onset type 1 diabetes, time trends and association with the population composition in Sweden: a 40 year follow-up
During the 1980s and 1990s, the incidence of childhood-onset type 1 diabetes more than doubled in Sweden, followed by a pl...
MicroRNA biomarkers of type 2 diabetes: evidence synthesis from meta-analyses and pathway modelling
MicroRNA biomarkers of type 2 diabetes: evidence synthesis from meta-analyses and pathway modelling
MicroRNAs are being sought as biomarkers for the early identification of type 2 diabetes. This study aimed to synthesise t...
Investigating mortality in the association between depression and diabetes
Investigating mortality in the association between depression and diabetes
Authors’ relationships and activities The authors declare that there are no relationships or ...
Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes
Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes
Antibodies specific to oxidative post-translational modifications (oxPTM) of insulin (oxPTM-INS) are present in most indiv...
Do gene–environment interactions have implications for the precision prevention of type 2 diabetes?
Do gene–environment interactions have implications for the precision prevention of type 2 diabetes?
The past decades have seen a rapid global rise in the incidence of type 2 diabetes. This surge has been driven by diabetog...
Precision medicine in type 1 diabetes
Precision medicine in type 1 diabetes
First envisioned by early diabetes clinicians, a person-centred approach to care was an aspirational goal that aimed to ma...
Achievements, prospects and challenges in precision care for monogenic insulin-deficient and insulin-resistant diabetes
Achievements, prospects and challenges in precision care for monogenic insulin-deficient and insulin-resistant diabetes
Integration of genomic and other data has begun to stratify type 2 diabetes in prognostically meaningful ways, but this ha...
Pinpointing precision medicine for diabetes mellitus
Pinpointing precision medicine for diabetes mellitus
As the medical field has embraced the omics era, and big data have provided novel insights in...
Precision nutrition in diabetes: when population-based dietary advice gets personal
Precision nutrition in diabetes: when population-based dietary advice gets personal
Diet plays a fundamental role in maintaining long-term health, with healthful diets being endorsed by current dietary guid...
Retinal microvascular associations with cardiometabolic risk factors differ by diabetes status: results from the UK Biobank
Retinal microvascular associations with cardiometabolic risk factors differ by diabetes status: results from the UK Biobank
The aim of the study was to examine the association of retinal vessel morphometry with BP, body composition and biochemist...
ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes
ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes
Induction of intercellular adhesion molecule-1 (ICAM-1) has been implicated in the development of macrovascular and microv...
Urban–rural disparities in diabetes-related mortality in the USA 1999–2019
Urban–rural disparities in diabetes-related mortality in the USA 1999–2019
Our study aimed to examine the trends in diabetes-related mortality in urban and rural areas in the USA over the past two ...