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Metabolomic and genetic architecture of gestational diabetes subtypes
Metabolomic and genetic architecture of gestational diabetes subtypes
Physiological gestational diabetes mellitus (GDM) subtypes that may confer different risks for adverse pregnancy outcomes ...
Harnessing the power of proteomics in precision diabetes medicine
Harnessing the power of proteomics in precision diabetes medicine
Precision diabetes medicine (PDM) aims to reduce errors in prevention programmes, diagnosis thresholds, prognosis predicti...
Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease
Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease
Childhood overweight increases the risk of type 2 diabetes and cardiovascular disease in adulthood. However, the impact of...
Continuous glucose monitoring in adults with type 2 diabetes: a systematic review and meta-analysis
Continuous glucose monitoring in adults with type 2 diabetes: a systematic review and meta-analysis
Continuous glucose monitoring (CGM) is increasingly used in the treatment of type 2 diabetes, but the effects on glycaemic...
An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study
An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study
People with type 2 diabetes are heterogeneous in their disease trajectory, with some progressing more quickly to insulin i...
Glucose tolerance and insulin resistance/sensitivity associate with retinal layer characteristics: the LIFE-Adult-Study
Glucose tolerance and insulin resistance/sensitivity associate with retinal layer characteristics: the LIFE-Adult-Study
As the prevalence of insulin resistance and glucose intolerance is increasing throughout the world, diabetes-induced eye d...
Correction to: Dose–response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial
Correction to: Dose–response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
A novel subpopulation of monocytes with a strong interferon signature indicated by SIGLEC-1 is present in patients with in recent-onset type 1 diabetes
A novel subpopulation of monocytes with a strong interferon signature indicated by SIGLEC-1 is present in patients with in recent-onset type 1 diabetes
Type 1 diabetes is a T cell-mediated autoimmune disease characterised by pancreatic beta cell destruction. In this study, ...
Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study
Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study
The aim of this study was to explore whether diabetic retinopathy is associated with alterations of the circadian system, ...
Circulating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: analyses from the Hong Kong Diabetes Biobank
Circulating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: analyses from the Hong Kong Diabetes Biobank
The aim of this study was to describe the metabolome in diabetic kidney disease (DKD) and its association with incident CV...
Elevated ITGA1 levels in type 2 diabetes: implications for cardiac function impairment
Elevated ITGA1 levels in type 2 diabetes: implications for cardiac function impairment
Type 2 diabetes mellitus is known to contribute to the development of heart failure with preserved ejection fraction (HFpE...
Incidence trend of type 2 diabetes from 2012 to 2021 in Germany: an analysis of health claims data of 11 million statutorily insured people
Incidence trend of type 2 diabetes from 2012 to 2021 in Germany: an analysis of health claims data of 11 million statutorily insured people
The aim of the study is to describe the time trend of type 2 diabetes incidence in the largest state of Germany, Bavaria, ...
Interferons are key cytokines acting on pancreatic islets in type 1 diabetes
Interferons are key cytokines acting on pancreatic islets in type 1 diabetes
The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immu...
Low birthweight and overweight during childhood and young adulthood and the risk of type 2 diabetes in men: a population-based cohort study
Low birthweight and overweight during childhood and young adulthood and the risk of type 2 diabetes in men: a population-based cohort study
This study aimed to determine the relative contributions of low birthweight and overweight during childhood and young adul...
Diabetes and infection: review of the epidemiology, mechanisms and principles of treatment
Diabetes and infection: review of the epidemiology, mechanisms and principles of treatment
An association between diabetes and infection has been recognised for many years, with infection being an important cause ...
Hyperlipidaemia in diabetes: are there particular considerations for next-generation therapies?
Hyperlipidaemia in diabetes: are there particular considerations for next-generation therapies?
Dyslipidaemias are major cardiovascular risk factors, especially in people with diabetes. In this area, next-generation th...
Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial
Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial
Infection with coxsackie B viruses (CVBs) can cause diseases ranging from mild common cold-type symptoms to severe life-th...
A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life
A loss-of-function mutation in KCNJ11 causing sulfonylurea-sensitive diabetes in early adult life
The ATP-sensitive potassium (KATP) channel couples beta cell electrical activity to glucose-stimulated insulin secretion. ...
Feasibility of prevention of type 2 diabetes in low- and middle-income countries
Feasibility of prevention of type 2 diabetes in low- and middle-income countries
Type 2 diabetes is a leading cause of global mortality and morbidity. Nearly 80% of individuals with diabetes live in low-...
The insulin resistant brain: impact on whole-body metabolism and body fat distribution
The insulin resistant brain: impact on whole-body metabolism and body fat distribution
Insulin exerts its actions not only on peripheral organs but is also transported into the brain where it performs distinct...
Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be ...
Keeping pace: the primary cilium as the conducting baton of the islet
Keeping pace: the primary cilium as the conducting baton of the islet
Primary cilia are rod-like sensory organelles that protrude from the surface of most mammalian cells, including the cells ...
Surveillance of the liver in type 2 diabetes: important but unfeasible?
Surveillance of the liver in type 2 diabetes: important but unfeasible?
Fatty liver plays a pivotal role in the pathogenesis of the metabolic syndrome and type 2 diabetes. According to an update...
Epidemiology of heart failure in diabetes: a disease in disguise
Epidemiology of heart failure in diabetes: a disease in disguise
Left ventricular diastolic dysfunction (LVDD) without symptoms, and heart failure (HF) with preserved ejection fraction (H...
Cardiovascular and mortality outcomes with GLP-1 receptor agonists vs other glucose-lowering drugs in individuals with NAFLD and type 2 diabetes: a large population-based matched cohort study
Cardiovascular and mortality outcomes with GLP-1 receptor agonists vs other glucose-lowering drugs in individuals with NAFLD and type 2 diabetes: a large population-based matched cohort study
We aimed to determine whether the use of glucagon-like peptide-1 receptor agonists (GLP-1RA) in individuals with non-alcoh...
GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
Diabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeuti...
Dose–response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial
Dose–response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial
The aim of this study was to assess the dose–response effects of the subcutaneous glucagon receptor/glucagon-like pe...
Impact of remission from type 2 diabetes on long-term health outcomes: findings from the Look AHEAD study
Impact of remission from type 2 diabetes on long-term health outcomes: findings from the Look AHEAD study
We examined the association of attainment of diabetes remission in the context of a 12 year intensive lifestyle interventi...
Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research
Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research
The liver plays a crucial role in the control of glucose homeostasis and is therefore of great interest in the investigati...
Autoimmune comorbidity in type 1 diabetes and its association with metabolic control and mortality risk in young people: a population-based study
Autoimmune comorbidity in type 1 diabetes and its association with metabolic control and mortality risk in young people: a population-based study
This register-based study aimed to describe autoimmune comorbidity in children and young adults from type 1 diabetes onset...
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