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Embracing complexity: making sense of diet, nutrition, obesity and type 2 diabetes
Embracing complexity: making sense of diet, nutrition, obesity and type 2 diabetes
Nutrition therapy has been emphasised for decades for people with type 2 diabetes, and the vital importance of diet and nu...
Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation
Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation
The mitochondrial chaperonin heat shock protein (HSP) 60 is indispensable in protein folding and the mitochondrial stress ...
Islet Autoantibody Standardization Program: interlaboratory comparison of insulin autoantibody assay performance in 2018 and 2020 workshops
Islet Autoantibody Standardization Program: interlaboratory comparison of insulin autoantibody assay performance in 2018 and 2020 workshops
The Islet Autoantibody Standardization Program (IASP) aims to improve the performance of immunoassays measuring autoantibo...
Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
Diabetes and its complications cause a heavy disease burden globally. Identifying exposures, risk factors and molecular pr...
Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice
Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice
Non-alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes may more easily progress towards severe forms of...
Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study
Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study
Type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) are prevalent diseases of metabolic origin. We examined the ...
Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling
Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling
Glucagon-stimulated hepatic gluconeogenesis contributes to endogenous glucose production during fasting. Recent studies su...
Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice
Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice
N6-methyladenosine (m6A) mRNA methylation and m6A-related proteins (methyltransferase-like 3 [METTL3], methyltransferase-l...
Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice
Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice
Beta cells control glucose homeostasis via regulated production and secretion of insulin. This function arises from a high...
The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes
The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes
Insulitis is not present in all islets, and it is elusive in humans. Although earlier studies focused on islets that fulfi...
Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells
Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells
Transcriptome analyses revealed insulin-gene-derived transcripts in non-beta endocrine islet cells. We studied alternative...
Referees 2022
Referees 2022
We thank those who have given their time to referee for Diabetologia, all of whom are listed ...
The ‘scientist’, the ‘analyst’ and the ‘novelist’: science or metrics?
The ‘scientist’, the ‘analyst’ and the ‘novelist’: science or metrics?
An overwhelming number of meta-analyses and reviews are published by scientific journals. In part this may reflect some pr...
Inequalities in cancer mortality trends in people with type 2 diabetes: 20 year population-based study in England
Inequalities in cancer mortality trends in people with type 2 diabetes: 20 year population-based study in England
The aim of this study was to describe the long-term trends in cancer mortality rates in people with type 2 diabetes based ...
Missing the forest-plot for the trees
Missing the forest-plot for the trees
Systematic reviews and meta-analyses are methods increasingly used in biomedical research since their introduction in the ...
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset
Islet autoantibodies (AAbs) are detected in >90% of individuals with clinically suspected type 1 diabetes at diseas...
Empagliflozin protects mice against diet-induced obesity, insulin resistance and hepatic steatosis
Empagliflozin protects mice against diet-induced obesity, insulin resistance and hepatic steatosis
Sodium–glucose cotransporter 2 (SGLT2) inhibitors are widely used in the treatment of type 2 diabetes, heart failure...
Advanced glycation end-products, cardiac function and heart failure in the general population: The Rotterdam Study
Advanced glycation end-products, cardiac function and heart failure in the general population: The Rotterdam Study
The aim of this work was to assess the association of advanced glycation end-products (AGEs), measured by skin autofluores...
Stratifying risk for onset of type 1 diabetes using islet autoantibody trajectory clustering
Stratifying risk for onset of type 1 diabetes using islet autoantibody trajectory clustering
Islet autoantibodies can be detected prior to the onset of type 1 diabetes and are important tools for aetiologic studies,...
The changing landscape of scientific communication at EASD
The changing landscape of scientific communication at EASD
The saying ‘truth is stranger than fiction’ very much applies to scientific research and how ...