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The challenges of identifying and studying type 1 diabetes in adults
The challenges of identifying and studying type 1 diabetes in adults
Diagnosing type 1 diabetes in adults is difficult since type 2 diabetes is the predominant diabetes type, particularly wit...
Using race as a social construct when looking at differences in racial associations between non-alcoholic fatty liver disease and type 2 diabetes
Using race as a social construct when looking at differences in racial associations between non-alcoholic fatty liver disease and type 2 diabetes
Funding This research received no specific grant from any funding agency in the ...
Retinal inflammation in murine models of type 1 and type 2 diabetes with diabetic retinopathy
Retinal inflammation in murine models of type 1 and type 2 diabetes with diabetic retinopathy
The loss of pericytes surrounding the retinal vasculature in early diabetic retinopathy underlies changes to the neurovasc...
Incretin hormones and type 2 diabetes
Incretin hormones and type 2 diabetes
Incretin hormones (glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide-1 [GLP-1]) play a role in ...
Genetic associations vary across the spectrum of fasting serum insulin: results from the European IDEFICS/I.Family children’s cohort
Genetic associations vary across the spectrum of fasting serum insulin: results from the European IDEFICS/I.Family children’s cohort
There is increasing evidence for the existence of shared genetic predictors of metabolic traits and neurodegenerative dise...
Strength training is more effective than aerobic exercise for improving glycaemic control and body composition in people with normal-weight type 2 diabetes: a randomised controlled trial
Strength training is more effective than aerobic exercise for improving glycaemic control and body composition in people with normal-weight type 2 diabetes: a randomised controlled trial
Type 2 diabetes in people in the healthy weight BMI category (<25 kg/m2), herein defined as ‘normal-weight ty...
Daniel Porte Jr, 13 August 1931–13 May 2023
Daniel Porte Jr, 13 August 1931–13 May 2023
Daniel Porte Jr passed away peacefully at the age of 91, ...
SGLT2i and GLP-1 RA therapy in type 1 diabetes and reno-vascular outcomes: a real-world study
SGLT2i and GLP-1 RA therapy in type 1 diabetes and reno-vascular outcomes: a real-world study
Insulin is the primary treatment for type 1 diabetes. However, alternative glucose-lowering therapies are used adjunctivel...
Gut hormone-based pharmacology: novel formulations and future possibilities for metabolic disease therapy
Gut hormone-based pharmacology: novel formulations and future possibilities for metabolic disease therapy
Glucagon-like peptide-1 (GLP-1) receptor agonists are established pharmaceutical therapies for the treatment of type 2 dia...
The future of incretins in the treatment of obesity and non-alcoholic fatty liver disease
The future of incretins in the treatment of obesity and non-alcoholic fatty liver disease
In the last few decades, glucagon-like peptide-1 receptor (GLP-1R) agonists have changed current guidelines and improved o...
Metformin for the prevention of diabetes among people with HIV and either impaired fasting glucose or impaired glucose tolerance (prediabetes) in Tanzania: a Phase II randomised placebo-controlled trial
Metformin for the prevention of diabetes among people with HIV and either impaired fasting glucose or impaired glucose tolerance (prediabetes) in Tanzania: a Phase II randomised placebo-controlled trial
In sub-Saharan Africa (SSA), 5% of adults are living with type 2 diabetes and this is rising sharply, with a greater incre...
Socioeconomic aspects of incretin-based therapy
Socioeconomic aspects of incretin-based therapy
Incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1 RAs), have demonstrated cardiovasc...
Glycaemic control, risk of hypoglycaemia and all-cause mortality in new users of second-generation basal insulin with type 2 diabetes and chronic kidney disease: a nationwide register-based cohort study
Glycaemic control, risk of hypoglycaemia and all-cause mortality in new users of second-generation basal insulin with type 2 diabetes and chronic kidney disease: a nationwide register-based cohort study
The aim of this study was to compare the performance of the second-generation basal insulins, insulin degludec 100 U/ml (D...
Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells
Reversal of dual epigenetic repression of non-canonical Wnt-5a normalises diabetic corneal epithelial wound healing and stem cells
Diabetes is associated with epigenetic modifications including DNA methylation and miRNA changes. Diabetic complications i...
Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production
Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production
Hyperglycaemia is associated with alpha cell dysfunction, leading to dysregulated glucagon secretion in type 1 and type 2 ...
The expanding incretin universe: from basic biology to clinical translation
The expanding incretin universe: from basic biology to clinical translation
Incretin hormones, principally glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(GLP-1), pote...
Cystine/glutamate antiporter System xc- deficiency impairs insulin secretion in mice
Cystine/glutamate antiporter System xc- deficiency impairs insulin secretion in mice
Glutamate-induced cytotoxicity (excitotoxicity) has been detected in pancreatic beta cells. The cystine/glutamate antiport...
Incretins and microvascular complications of diabetes: neuropathy, nephropathy, retinopathy and microangiopathy
Incretins and microvascular complications of diabetes: neuropathy, nephropathy, retinopathy and microangiopathy
Glucagon-like peptide-1 receptor agonists (GLP-1RAs, incretin mimetics) and dipeptidyl peptidase-4 inhibitors (DPP-4is, in...
Incretins: turning the venom into the antidote
Incretins: turning the venom into the antidote
There is currently significant media attention surrounding glucose-lowering drugs bas...
(Pre)diabetes and a higher level of glycaemic measures are continuously associated with corneal neurodegeneration assessed by corneal confocal microscopy: the Maastricht Study
(Pre)diabetes and a higher level of glycaemic measures are continuously associated with corneal neurodegeneration assessed by corneal confocal microscopy: the Maastricht Study
To assess the associations between glucose metabolism status and a range of continuous measures of glycaemia with corneal ...
Targeting BCAA metabolism to potentiate metformin’s therapeutic efficacy in the treatment of diabetes in mice
Targeting BCAA metabolism to potentiate metformin’s therapeutic efficacy in the treatment of diabetes in mice
An increasing body of evidence has shown that the catabolism of branched-chain amino acids (BCAAs; leucine, isoleucine and...
Incretins beyond type 2 diabetes
Incretins beyond type 2 diabetes
Incretin-based therapies, in particular glucagon-like peptide-1 (GLP-1) receptor agonists, have been evaluated in other fo...
Incretins and cardiovascular disease: to the heart of type 2 diabetes?
Incretins and cardiovascular disease: to the heart of type 2 diabetes?
Major cardiovascular outcome trials and real-life observations have proven that glucagon-like peptide-1 (GLP-1) receptor a...
Retraction Note: Calcium-dependent transcriptional changes in human pancreatic islet cells reveal functional diversity in islet cell subtypes
Retraction Note: Calcium-dependent transcriptional changes in human pancreatic islet cells reveal functional diversity in islet cell subtypes
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Potential preventive properties of GLP-1 receptor agonists against prostate cancer: a nationwide cohort study
Potential preventive properties of GLP-1 receptor agonists against prostate cancer: a nationwide cohort study
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have been suggested to possess antineoplastic properties against pros...
Genetics of diabetes-associated microvascular complications
Genetics of diabetes-associated microvascular complications
Diabetes is associated with excess morbidity and mortality due to both micro- and macrovascular complications, as well as ...
Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes
Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes
Low birthweight is a risk factor for type 2 diabetes but it is unknown whether low birthweight is associated with distinct...
Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition
Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition
Low birthweight is a risk factor for type 2 diabetes. Most previous studies are based on cross-sectional prevalence data, ...
Not all very-low-carbohydrate diets are created equal. Reply to Conte C, Camajani E, Lai A, Caprio M [letter]
Not all very-low-carbohydrate diets are created equal. Reply to Conte C, Camajani E, Lai A, Caprio M [letter]
Authors’ relationships and activities The authors declare that there are n...
Occurrence of corneal sub-epithelial microneuromas and axonal swelling in people with diabetes with and without (painful) diabetic neuropathy
Occurrence of corneal sub-epithelial microneuromas and axonal swelling in people with diabetes with and without (painful) diabetic neuropathy
Non-invasive in vivo corneal confocal microscopy is gaining ground as an alternative to skin punch biopsy to evaluate smal...
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