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Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study
Sex differences in body composition in people with prediabetes and type 2 diabetes as compared with people with normal glucose metabolism: the Maastricht Study
Obesity is a major risk factor for type 2 diabetes. However, body composition differs between women and men. In this study...
Embracing complexity: making sense of diet, nutrition, obesity and type 2 diabetes
Embracing complexity: making sense of diet, nutrition, obesity and type 2 diabetes
Nutrition therapy has been emphasised for decades for people with type 2 diabetes, and the vital importance of diet and nu...
Separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and perfusion in people with type 2 diabetes: a randomised trial
Separate and combined effects of semaglutide and empagliflozin on kidney oxygenation and perfusion in people with type 2 diabetes: a randomised trial
Glucagon-like peptide-1 receptor agonists (GLP-1ras) and sodium–glucose cotransporter 2 inhibitors (SGLT2is) have sh...
Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation
Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation
The mitochondrial chaperonin heat shock protein (HSP) 60 is indispensable in protein folding and the mitochondrial stress ...
Islet Autoantibody Standardization Program: interlaboratory comparison of insulin autoantibody assay performance in 2018 and 2020 workshops
Islet Autoantibody Standardization Program: interlaboratory comparison of insulin autoantibody assay performance in 2018 and 2020 workshops
The Islet Autoantibody Standardization Program (IASP) aims to improve the performance of immunoassays measuring autoantibo...
Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
Diabetes and its complications cause a heavy disease burden globally. Identifying exposures, risk factors and molecular pr...
Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice
Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice
Non-alcoholic fatty liver disease (NAFLD) associated with type 2 diabetes may more easily progress towards severe forms of...
Long-term cost-effectiveness of implementing a lifestyle intervention during pregnancy to reduce the incidence of gestational diabetes and type 2 diabetes
Long-term cost-effectiveness of implementing a lifestyle intervention during pregnancy to reduce the incidence of gestational diabetes and type 2 diabetes
The aim of this study was to determine the long-term cost-effectiveness and return on investment of implementing a structu...
Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study
Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study
Type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) are prevalent diseases of metabolic origin. We examined the ...
Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling
Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling
Glucagon-stimulated hepatic gluconeogenesis contributes to endogenous glucose production during fasting. Recent studies su...
Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice
Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice
N6-methyladenosine (m6A) mRNA methylation and m6A-related proteins (methyltransferase-like 3 [METTL3], methyltransferase-l...
Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes
Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes
We previously demonstrated that N-glycosylation of plasma proteins and IgGs is different in children with recent-onset typ...
Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice
Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice
Beta cells control glucose homeostasis via regulated production and secretion of insulin. This function arises from a high...
Drug target Mendelian randomisation: are we really instrumenting drug use? Reply to Anderson EL, Williams DM [letter]
Drug target Mendelian randomisation: are we really instrumenting drug use? Reply to Anderson EL, Williams DM [letter]
To the Editor: We appreciate the opportunity to respond to the letter by Anderson and William...
The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes
The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes
Insulitis is not present in all islets, and it is elusive in humans. Although earlier studies focused on islets that fulfi...
Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells
Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells
Transcriptome analyses revealed insulin-gene-derived transcripts in non-beta endocrine islet cells. We studied alternative...
The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population
The utility of a type 2 diabetes polygenic score in addition to clinical variables for prediction of type 2 diabetes incidence in birth, youth and adult cohorts in an Indigenous study population
There is limited information on how polygenic scores (PSs), based on variants from genome-wide association studies (GWASs)...
Referees 2022
Referees 2022
We thank those who have given their time to referee for Diabetologia, all of whom are listed ...
Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice
Single-cell RNA sequencing combined with single-cell proteomics identifies the metabolic adaptation of islet cell subpopulations to high-fat diet in mice
Islets have complex heterogeneity and subpopulations. Cell surface markers representing alpha, beta and delta cell subpopu...
Projecting the incidence and costs of major cardiovascular and kidney complications of type 2 diabetes with widespread SGLT2i and GLP-1 RA use: a cost-effectiveness analysis
Projecting the incidence and costs of major cardiovascular and kidney complications of type 2 diabetes with widespread SGLT2i and GLP-1 RA use: a cost-effectiveness analysis
Whether sodium–glucose co-transporter 2 inhibitors (SGLT2is) or glucagon-like peptide-1 receptor agonists (GLP-1 RAs...
Changes in attitudes to awareness of hypoglycaemia during a hypoglycaemia awareness restoration programme are associated with avoidance of further severe hypoglycaemia episodes within 24 months: the A2A in HypoCOMPaSS study
Changes in attitudes to awareness of hypoglycaemia during a hypoglycaemia awareness restoration programme are associated with avoidance of further severe hypoglycaemia episodes within 24 months: the A2A in HypoCOMPaSS study
The aims of this study were to assess cognitions relating to hypoglycaemia in adults with type 1 diabetes and impaired awa...
Environmental exposures are important for type 2 diabetes pathophysiology in sub-Saharan African populations. Reply to Christensen D, Hjort L, Mpagama S et al [letter]
Environmental exposures are important for type 2 diabetes pathophysiology in sub-Saharan African populations. Reply to Christensen D, Hjort L, Mpagama S et al [letter]
Christensen DL, Hjort L, Mpagama SG, Ramayaiya KL (2022) Environmental exposures are important for type 2 diabetes pathoph...
The ‘scientist’, the ‘analyst’ and the ‘novelist’: science or metrics?
The ‘scientist’, the ‘analyst’ and the ‘novelist’: science or metrics?
An overwhelming number of meta-analyses and reviews are published by scientific journals. In part this may reflect some pr...
Inequalities in cancer mortality trends in people with type 2 diabetes: 20 year population-based study in England
Inequalities in cancer mortality trends in people with type 2 diabetes: 20 year population-based study in England
The aim of this study was to describe the long-term trends in cancer mortality rates in people with type 2 diabetes based ...
Missing the forest-plot for the trees
Missing the forest-plot for the trees
Systematic reviews and meta-analyses are methods increasingly used in biomedical research since their introduction in the ...
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset
Genetic determinants of type 1 diabetes in individuals with weak evidence of islet autoimmunity at disease onset
Islet autoantibodies (AAbs) are detected in >90% of individuals with clinically suspected type 1 diabetes at diseas...
Empagliflozin protects mice against diet-induced obesity, insulin resistance and hepatic steatosis
Empagliflozin protects mice against diet-induced obesity, insulin resistance and hepatic steatosis
Sodium–glucose cotransporter 2 (SGLT2) inhibitors are widely used in the treatment of type 2 diabetes, heart failure...
Advanced glycation end-products, cardiac function and heart failure in the general population: The Rotterdam Study
Advanced glycation end-products, cardiac function and heart failure in the general population: The Rotterdam Study
The aim of this work was to assess the association of advanced glycation end-products (AGEs), measured by skin autofluores...
Stratifying risk for onset of type 1 diabetes using islet autoantibody trajectory clustering
Stratifying risk for onset of type 1 diabetes using islet autoantibody trajectory clustering
Islet autoantibodies can be detected prior to the onset of type 1 diabetes and are important tools for aetiologic studies,...
The changing landscape of scientific communication at EASD
The changing landscape of scientific communication at EASD
The saying ‘truth is stranger than fiction’ very much applies to scientific research and how ...
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