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Effectiveness and safety of empagliflozin: final results from the EMPRISE study
Effectiveness and safety of empagliflozin: final results from the EMPRISE study
Limited evidence exists on the comparative safety and effectiveness of empagliflozin against alternative glucose-lowering ...
Trajectories of clinical characteristics, complications and treatment choices in data-driven subgroups of type 2 diabetes
Trajectories of clinical characteristics, complications and treatment choices in data-driven subgroups of type 2 diabetes
This study aimed to explore the added value of subgroups that categorise individuals with type 2 diabetes by k-means clust...
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities
Prevention and treatment of ischaemic and haemorrhagic stroke in people with diabetes mellitus: a focus on glucose control and comorbidities
Diabetes mellitus is a significant risk factor for both ischaemic and haemorrhagic stroke, affecting up to a third of indi...
Gestational age at birth and type 1 diabetes in childhood and young adulthood: a nationwide register study in Finland, Norway and Sweden
Gestational age at birth and type 1 diabetes in childhood and young adulthood: a nationwide register study in Finland, Norway and Sweden
Children and adults born preterm have an increased risk of type 1 diabetes. However, there is limited information on risk ...
CK2 activity is crucial for proper glucagon expression
CK2 activity is crucial for proper glucagon expression
Protein kinase CK2 acts as a negative regulator of insulin expression in pancreatic beta cells. This action is mainly medi...
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
ACSF2 and lysine lactylation contribute to renal tubule injury in diabetes
Lactate accumulation is reported to be a biomarker for diabetic nephropathy progression. Lactate drives lysine lactylation...
Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes
Missense mutation of ISL1 (E283D) is associated with the development of type 2 diabetes
Mutations in Isl1, encoding the insulin enhancer-binding protein islet-1 (ISL1), may contribute to attenuated insulin secr...
Caesarean section and risk of type 1 diabetes
Caesarean section and risk of type 1 diabetes
Delivery by Caesarean section continues to rise globally and has been associated with the risk of developing type 1 diabet...
Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes
Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes
Almost all beta cells contact one capillary and insulin granule fusion is targeted to this region. However, there are repo...
Identification and validation of gestational diabetes subgroups by data-driven cluster analysis
Identification and validation of gestational diabetes subgroups by data-driven cluster analysis
Gestational diabetes mellitus (GDM) is a heterogeneous condition. Given such variability among patients, the ability to re...
Risk factors and prediction of hypoglycaemia using the Hypo-RESOLVE cohort: a secondary analysis of pooled data from insulin clinical trials
Risk factors and prediction of hypoglycaemia using the Hypo-RESOLVE cohort: a secondary analysis of pooled data from insulin clinical trials
The objective of the Hypoglycaemia REdefining SOLutions for better liVES (Hypo-RESOLVE) project is to use a dataset of poo...
Heterogeneity of glycaemic phenotypes in type 1 diabetes
Heterogeneity of glycaemic phenotypes in type 1 diabetes
Our study aims to uncover glycaemic phenotype heterogeneity in type 1 diabetes. In the Study of the French-speaking Societ...
Coeliac disease and type 2 diabetes risk: a nationwide matched cohort and Mendelian randomisation study
Coeliac disease and type 2 diabetes risk: a nationwide matched cohort and Mendelian randomisation study
While the association between coeliac disease and type 1 diabetes is well documented, the association of coeliac disease w...
2024: The year to take European action on diabetes to the next level
2024: The year to take European action on diabetes to the next level
Acknowledgements EUDF board: Chantal Mathieu (EASD), Stefano Del Prato (EFSD), A...
Bone metabolism in diabetes: a clinician’s guide to understanding the bone–glucose interplay
Bone metabolism in diabetes: a clinician’s guide to understanding the bone–glucose interplay
Skeletal fragility is an increasingly recognised, but poorly understood, complication of both type 1 and type 2 diabetes. ...
RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
Regulatory factor X 6 (RFX6) is crucial for pancreatic endocrine development and differentiation. The RFX6 variant p.His29...
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Glucagon and glucagon-like peptide-1 (GLP-1) are derived from the same precursor; proglucagon, and dual agonists of their ...
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make dis...
A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation
A 3D atlas of the human developing pancreas to explore progenitor proliferation and differentiation
Rodent pancreas development has been described in great detail. On the other hand, there are still gaps in our understandi...
Cardiovascular risk management among individuals with type 2 diabetes and severe mental illness: a cohort study
Cardiovascular risk management among individuals with type 2 diabetes and severe mental illness: a cohort study
The aim of this study was to compare cardiovascular risk management among people with type 2 diabetes according to severe ...
The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults
The INNODIA Type 1 Diabetes Natural History Study: a European cohort of newly diagnosed children, adolescents and adults
Type 1 diabetes is an heterogenous condition. Characterising factors explaining differences in an individual’s clini...
A ketone monoester drink reduces postprandial blood glucose concentrations in adults with type 2 diabetes: a randomised controlled trial
A ketone monoester drink reduces postprandial blood glucose concentrations in adults with type 2 diabetes: a randomised controlled trial
The aim of the present study was to conduct a randomised, placebo-controlled, double-blind, crossover trial to determine w...