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Characterising impaired awareness of hypoglycaemia and associated risks through HypoA-Q: findings from a T1D Exchange cohort
Characterising impaired awareness of hypoglycaemia and associated risks through HypoA-Q: findings from a T1D Exchange cohort
We aimed to: (1) externally validate the five-item Hypoglycaemia Awareness Questionnaire (HypoA-Q) impaired awareness subs...
Postprandial hypoglycaemia after gastric bypass in type 2 diabetes: pathophysiological mechanisms and clinical implications
Postprandial hypoglycaemia after gastric bypass in type 2 diabetes: pathophysiological mechanisms and clinical implications
Postprandial hypoglycaemia (PPHG) is a frequent late complication of Roux-en-Y gastric bypass (RYGB) in people without dia...
Autoimmune diseases and the risk and prognosis of latent autoimmune diabetes in adults
Autoimmune diseases and the risk and prognosis of latent autoimmune diabetes in adults
The aim of this study was to clarify the impact of autoimmune disease (AD) comorbidity on the risk and prognosis of latent...
Sugar-sweetened or artificially sweetened beverage consumption, physical activity and risk of type 2 diabetes in US adults
Sugar-sweetened or artificially sweetened beverage consumption, physical activity and risk of type 2 diabetes in US adults
A positive association between sugar-sweetened beverages (SSBs) and diabetes risk has been shown, with inconsistent eviden...
Eating disorders among people with and without type 1 diabetes: incidence and treatment in a nationwide population-based cohort
Eating disorders among people with and without type 1 diabetes: incidence and treatment in a nationwide population-based cohort
Eating disorders are over-represented in type 1 diabetes and are associated with an increased risk of complications, but i...
Intermittently scanned continuous glucose monitoring compared with blood glucose monitoring is associated with lower HbA1c and a reduced risk of hospitalisation for diabetes-related complications in adults with type 2 diabetes on insulin therapies
Intermittently scanned continuous glucose monitoring compared with blood glucose monitoring is associated with lower HbA1c and a reduced risk of hospitalisation for diabetes-related complications in adults with type 2 diabetes on insulin therapies
We assessed the impact of initiating intermittently scanned continuous glucose monitoring (isCGM) compared with capillary ...
The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium
The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium
Human molecular genetics has brought incredible insights into the variants that confer risk for the development of tissue-...
Exposure to antibiotics and risk of latent autoimmune diabetes in adults and type 2 diabetes: results from a Swedish case–control study (ESTRID) and the Norwegian HUNT study
Exposure to antibiotics and risk of latent autoimmune diabetes in adults and type 2 diabetes: results from a Swedish case–control study (ESTRID) and the Norwegian HUNT study
Some studies find an increased risk of type 1 diabetes in children exposed to antibiotics. We investigated if exposure to ...
Effect of fenofibrate on residual beta cell function in adults and adolescents with newly diagnosed type 1 diabetes: a randomised clinical trial
Effect of fenofibrate on residual beta cell function in adults and adolescents with newly diagnosed type 1 diabetes: a randomised clinical trial
Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, shows some promise in alleviating beta cell stres...
Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
Bereavement and type 1 diabetes in childhood: a register-based cohort study in Sweden
The potential impact of childhood bereavement—a severe psychological stressor—on childhood type 1 diabetes dev...
Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes
Leveraging artificial intelligence and machine learning to accelerate discovery of disease-modifying therapies in type 1 diabetes
Progress in developing therapies for the maintenance of endogenous insulin secretion in, or the prevention of, type 1 diab...
Single-cell RNA sequencing identifies endothelial-derived HBEGF as promoting pancreatic beta cell proliferation in mice via the EGFR–Kmt5a–H4K20me pathway
Single-cell RNA sequencing identifies endothelial-derived HBEGF as promoting pancreatic beta cell proliferation in mice via the EGFR–Kmt5a–H4K20me pathway
Pancreatic beta cell mass is dynamically regulated in response to increased physiological and pathological demands. Unders...
Dose-related effects of intraduodenal quinine on plasma glucose, glucoregulatory hormones and gastric emptying of a nutrient drink, and energy intake, in men with type 2 diabetes: a double-blind, randomised, crossover study
Dose-related effects of intraduodenal quinine on plasma glucose, glucoregulatory hormones and gastric emptying of a nutrient drink, and energy intake, in men with type 2 diabetes: a double-blind, randomised, crossover study
Quinine, when administered intraduodenally to activate bitter-taste receptors, in a dose of 600 mg, stimulates glucagon-li...
Gain of pancreatic beta cell-specific SCD1 improves glucose homeostasis by maintaining functional beta cell mass under metabolic stress
Gain of pancreatic beta cell-specific SCD1 improves glucose homeostasis by maintaining functional beta cell mass under metabolic stress
The key pancreatic beta cell transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homologue A (MafA) is cri...
Elevated risk of infection in individuals with hyperinsulinaemic type 2 diabetes: a Danish 12 year cohort study
Elevated risk of infection in individuals with hyperinsulinaemic type 2 diabetes: a Danish 12 year cohort study
A better understanding of the mechanisms underlying an elevated infection risk in individuals with type 2 diabetes is need...
Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes
Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes
Many studies of type 1 diabetes pathogenesis focus on individuals with high-risk HLA haplotypes. We tested the hypothesis ...
Genetic variation in the RETN promoter, accompanied by latent sarcopenic obesity, led to insulin resistance in a Japanese cohort: the Toon Genome Study
Genetic variation in the RETN promoter, accompanied by latent sarcopenic obesity, led to insulin resistance in a Japanese cohort: the Toon Genome Study
Resistin, inducing insulin resistance, is elevated in the sera of individuals with the G-A haplotype at c.-420 C>G ...
Sex differences in the efficacy of angiotensin receptor blockers on kidney and cardiovascular outcomes among individuals with type 2 diabetes and diabetic kidney disease: post hoc analyses of the RENAAL and IDNT trials
Sex differences in the efficacy of angiotensin receptor blockers on kidney and cardiovascular outcomes among individuals with type 2 diabetes and diabetic kidney disease: post hoc analyses of the RENAAL and IDNT trials
Our aim was to assess sex differences in the efficacy of angiotensin receptor blockers (i.e. losartan and irbesartan) on k...
The use of automated insulin delivery around physical activity and exercise in type 1 diabetes: a position statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD)
The use of automated insulin delivery around physical activity and exercise in type 1 diabetes: a position statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD)
Regular physical activity and exercise (PA) are cornerstones of diabetes care for individuals with type 1 diabetes. In rec...
Sex differences in response to the endothelin receptor antagonist atrasentan in individuals with type 2 diabetes and chronic kidney disease: a post hoc analysis of the SONAR trial
Sex differences in response to the endothelin receptor antagonist atrasentan in individuals with type 2 diabetes and chronic kidney disease: a post hoc analysis of the SONAR trial
In the Study Of diabetic Nephropathy with AtRasentan (SONAR), the endothelin receptor antagonist (ERA) atrasentan slowed p...
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
Immunotherapeutics targeting T cells are crucial for inhibiting autoimmune disease progression proximal to disease onset i...
Evidence on the effectiveness and equity of population-based policies to reduce the burden of type 2 diabetes: a narrative review
Evidence on the effectiveness and equity of population-based policies to reduce the burden of type 2 diabetes: a narrative review
There is increasing evidence for the effectiveness of population-based policies to reduce the burden of type 2 diabetes. Y...
Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline
Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline
This study aims to explore the association between plasma metabolites and chronic kidney disease progression in individual...
The effect of vitamin D3 supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial
The effect of vitamin D3 supplementation on the incidence of type 2 diabetes in healthy older adults not at high risk for diabetes (FIND): a randomised controlled trial
Vitamin D insufficiency is associated with an elevated risk of type 2 diabetes, but evidence from randomised trials on the...
A critique of measurement of defective insulin secretion and insulin sensitivity as a precision approach to gestational diabetes
A critique of measurement of defective insulin secretion and insulin sensitivity as a precision approach to gestational diabetes
Precision medicine approaches to gestational diabetes mellitus (GDM) have categorised patients according to disease pathop...
Diet-enhanced LRG1 expression promotes insulin hypersecretion and ER stress in pancreatic beta cells
Diet-enhanced LRG1 expression promotes insulin hypersecretion and ER stress in pancreatic beta cells
Upregulation of serum leucine-rich α-2-glycoprotein 1 (LRG1) has been implicated in diet-induced obesity and metaboli...
Correction: Quantifying beta cell function in the preclinical stages of type 1 diabetes
Correction: Quantifying beta cell function in the preclinical stages of type 1 diabetes
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular–kidney complications
A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular–kidney complications
Monogenic diabetes is caused by rare mutations in genes usually implicated in beta cell biology. Common variants of monoge...
Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab
Trajectory of beta cell function and insulin clearance in stage 2 type 1 diabetes: natural history and response to teplizumab
We aimed to analyse TrialNet Anti-CD3 Prevention (TN10) data using oral minimal model (OMM)-derived indices to characteris...
Simplified meal announcement study (SMASH) using hybrid closed-loop insulin delivery in youth and young adults with type 1 diabetes: a randomised controlled two-centre crossover trial
Simplified meal announcement study (SMASH) using hybrid closed-loop insulin delivery in youth and young adults with type 1 diabetes: a randomised controlled two-centre crossover trial
The majority of hybrid closed-loop systems still require carbohydrate counting (CC) but the evidence for its justification...
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