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LPG 18:0 is a general biomarker of asthma and inhibits the differentiation and function of regulatory T-cells
LPG 18:0 is a general biomarker of asthma and inhibits the differentiation and function of regulatory T-cells
IntroductionBronchial asthma, affecting more than 260 million people worldwide, is a critical chronic airway disease with ...
Airway-derived emphysema-specific alveolar type II cells exhibit impaired regenerative potential in COPD
Airway-derived emphysema-specific alveolar type II cells exhibit impaired regenerative potential in COPD
IntroductionCOPD is a leading cause of morbidity and mortality worldwide [1]. One major phenotype of COPD is emphysema, wh...
Airway tapering in COPD
Airway tapering in COPD
BackgroundLuminal narrowing is a hallmark feature of airway remodelling in COPD, but current measures focus on airway wall...
Clinical response and on-treatment clinical remission with tezepelumab in a broad population of patients with severe, uncontrolled asthma: results over 2 years from the NAVIGATOR and DESTINATION studies
Clinical response and on-treatment clinical remission with tezepelumab in a broad population of patients with severe, uncontrolled asthma: results over 2 years from the NAVIGATOR and DESTINATION studies
IntroductionGlobally, ∼262 million people are affected by asthma [1], resulting in a significant healthcare and economic b...
Global Lung Function Initiative reference values for multiple breath washout indices
Global Lung Function Initiative reference values for multiple breath washout indices
IntroductionStandard pulmonary function tests measure a range of indices that inform clinicians about different aspects of...
Integrating hot topics and implementation of treatable traits in asthma
Integrating hot topics and implementation of treatable traits in asthma
IntroductionAsthma is a common and recognisable chronic inflammatory disease of the airways. Despite major therapeutic adv...
A novel in vitro tubular model to recapitulate features of distal airways: the bronchioid
A novel in vitro tubular model to recapitulate features of distal airways: the bronchioid
IntroductionChronic obstructive diseases such as COPD and asthma are major public health challenges characterised by airfl...
Deep brain stimulation of the motor thalamus relieves experimentally induced air hunger
Deep brain stimulation of the motor thalamus relieves experimentally induced air hunger
IntroductionDyspnoea, defined as “a subjective experience of breathing discomfort” that is prevalent across multiple condi...
Eosinophils, mucus plugs and clinical outcomes: findings from two COPD cohorts
Eosinophils, mucus plugs and clinical outcomes: findings from two COPD cohorts
Type 2 inflammation (Th2i) – indicated by blood eosinophil counts – and airway-occluding mucus plugs (MPs) on computed tom...
A breath of the future: a novel human model for COPD and beyond
A breath of the future: a novel human model for COPD and beyond
We have cured chronic lung diseases, including COPD, in mice many times. However, translation to clinical application has ...
Glycerolipids disrupt regulatory T-cells in asthma
Glycerolipids disrupt regulatory T-cells in asthma
Asthma is a chronic inflammatory disease that arises due to an exacerbated immune response causing narrowing and hypersens...
Identification of an emphysema-specific ATII cell: a step towards understanding impaired lung regeneration in COPD?
Identification of an emphysema-specific ATII cell: a step towards understanding impaired lung regeneration in COPD?
The ability to rejuvenate lung tissue and restore function is currently an ideal goal for those working in respiratory sci...
Comment on the European Respiratory Society pulmonary alveolar proteinosis guidelines
Comment on the European Respiratory Society pulmonary alveolar proteinosis guidelines
We read with great interest the European Respiratory Society (ERS) guidelines for pulmonary alveolar proteinosis (PAP) by ...
Uncovering early COPD? The T-slope as a novel CT biomarker for evaluating airway narrowing
Uncovering early COPD? The T-slope as a novel CT biomarker for evaluating airway narrowing
From the tracheobronchial tree structure models described by Weibel [1], Horsfield and Cumming [2], and others [3, 4], we ...
Relieving dyspnoea through the brain
Relieving dyspnoea through the brain
Dyspnoea is defined as a symptom conveying an upsetting or distressing experience of breathing awareness, which can vary i...
Is asthma remission an important clinical outcome in asthma management?
Is asthma remission an important clinical outcome in asthma management?
ExtractIn recent years, with the introduction of biologic therapies for the treatment of severe asthma, there has been a s...
"Chronic thromboembolic pulmonary hypertension is an uncommon complication of COVID-19: UK national surveillance and observational screening cohort studies." S.A. Reddy, J. Newman, O.C. Leavy, et al. Eur Respir J 2024; 64: 2301742.
"Chronic thromboembolic pulmonary hypertension is an uncommon complication of COVID-19: UK national surveillance and observational screening cohort studies." S.A. Reddy, J. Newman, O.C. Leavy, et al. Eur Respir J 2024; 64: 2301742.
Adriana S. Leme William J. Janssen Maria C. Basil Corrine R. Kliment ...
Resolution of tuberculosis blood RNA signatures fails to discriminate persistent sputum culture positivity after 8 weeks of anti-tuberculous treatment
Resolution of tuberculosis blood RNA signatures fails to discriminate persistent sputum culture positivity after 8 weeks of anti-tuberculous treatment
Adriana S. Leme William J. Janssen Maria C. Basil Corrine R. Kliment ...
Blood RNA signatures for 8-week sputum tuberculosis culture sterilisation: how close are we?
Blood RNA signatures for 8-week sputum tuberculosis culture sterilisation: how close are we?
Adriana S. Leme William J. Janssen Maria C. Basil Corrine R. Kliment ...
Radiomultiomics: pioneering precision medicine for severe asthma
Radiomultiomics: pioneering precision medicine for severe asthma
Adriana S. Leme William J. Janssen Maria C. Basil Corrine R. Kliment ...
Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics
Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics
Adriana S. Leme William J. Janssen Maria C. Basil Corrine R. Kliment ...
RUNX2 is stabilised by TAZ and drives pulmonary artery calcification and lung vascular remodelling in pulmonary hypertension due to left heart disease
RUNX2 is stabilised by TAZ and drives pulmonary artery calcification and lung vascular remodelling in pulmonary hypertension due to left heart disease
Onno W. Akkerman G. B. Migliori Alberto L. Garcia-Basteiro European Respiratory ...
ERJ advances: epigenetic ageing and leveraging DNA methylation in chronic respiratory diseases
ERJ advances: epigenetic ageing and leveraging DNA methylation in chronic respiratory diseases
Onno W. Akkerman G. B. Migliori Alberto L. Garcia-Basteiro European Respiratory ...
Going astray with a smoking Traviata?
Going astray with a smoking Traviata?
Onno W. Akkerman G. B. Migliori Alberto L. Garcia-Basteiro European Respiratory ...
Inhaled soluble guanylate cyclase stimulator for the treatment of pulmonary arterial hypertension: struggling to breathe easy
Inhaled soluble guanylate cyclase stimulator for the treatment of pulmonary arterial hypertension: struggling to breathe easy
Onno W. Akkerman G. B. Migliori Alberto L. Garcia-Basteiro European Respiratory ...
Determination of loss of chromosome Y in peripheral blood cells in males with idiopathic pulmonary fibrosis
Determination of loss of chromosome Y in peripheral blood cells in males with idiopathic pulmonary fibrosis
Onno W. Akkerman G. B. Migliori Alberto L. Garcia-Basteiro European Respiratory ...
European Respiratory Society guidelines for the diagnosis and management of pulmonary alveolar proteinosis
European Respiratory Society guidelines for the diagnosis and management of pulmonary alveolar proteinosis
Onno W. Akkerman G. B. Migliori Alberto L. Garcia-Basteiro European Respiratory ...
MK-5475, an inhaled soluble guanylate cyclase stimulator, for treatment of pulmonary arterial hypertension: the INSIGNIA-PAH study
MK-5475, an inhaled soluble guanylate cyclase stimulator, for treatment of pulmonary arterial hypertension: the INSIGNIA-PAH study
Onno W. Akkerman G. B. Migliori Alberto L. Garcia-Basteiro European Respiratory ...
TAZ and RUNX2 awareness in pulmonary hypertension due to left heart disease
TAZ and RUNX2 awareness in pulmonary hypertension due to left heart disease
Onno W. Akkerman G. B. Migliori Alberto L. Garcia-Basteiro European Respiratory ...
Until it's done for everyone: the role of CFTR modulator label expansion
Until it's done for everyone: the role of CFTR modulator label expansion
Onno W. Akkerman G. B. Migliori Alberto L. Garcia-Basteiro European Respiratory ...
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