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A Fab of trastuzumab to treat HER2 overexpressing breast cancer brain metastases
A Fab of trastuzumab to treat HER2 overexpressing breast cancer brain metastases
Despite major therapeutic advances for two decades, including the most recently approved anti-HER2 drugs, brain metastatic...
Pan-cancer transcriptional atlas of minimal residual disease links DUSP1 to chemotherapy persistence
Pan-cancer transcriptional atlas of minimal residual disease links DUSP1 to chemotherapy persistence
Chemotherapy is a commonly effective treatment for most types of cancer. However, many patients experience a relapse due t...
Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion
Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion
Paradoxically, tumor development and progression can be inhibited and promoted by the immune system. After three stages of...
Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review
Mechanistic insights and the clinical prospects of targeted therapies for glioblastoma: a comprehensive review
Glioblastoma (GBM) is a fatal brain tumour that is traditionally diagnosed based on histological features. Recent molecula...
TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma
TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma
Rhabdomyosarcoma (RMS), such as other childhood tumors, has witnessed treatment advancements in recent years. However, hig...
Novel insights into TCR-T cell therapy in solid neoplasms: optimizing adoptive immunotherapy
Novel insights into TCR-T cell therapy in solid neoplasms: optimizing adoptive immunotherapy
Adoptive immunotherapy in the T cell landscape exhibits efficacy in cancer treatment. Over the past few decades, genetical...
VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses
VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses
VISTA is a well-known immune checkpoint in T cell biology, but its role in innate immunity is less established. Here, we i...
Vaccination with a combination of STING agonist-loaded lipid nanoparticles and CpG-ODNs protects against lung metastasis via the induction of CD11bhighCD27low memory-like NK cells
Vaccination with a combination of STING agonist-loaded lipid nanoparticles and CpG-ODNs protects against lung metastasis via the induction of CD11bhighCD27low memory-like NK cells
Natural killer (NK) cells are effective in attacking tumor cells that escape T cell attack. Memory NK cells are believed t...
Cyclin dependent kinase 4/6 inhibitor palbociclib synergizes with BCL2 inhibitor venetoclax in experimental models of mantle cell lymphoma without RB1 deletion
Cyclin dependent kinase 4/6 inhibitor palbociclib synergizes with BCL2 inhibitor venetoclax in experimental models of mantle cell lymphoma without RB1 deletion
Mantle cell lymphoma (MCL) is a chronically relapsing malignancy with deregulated cell cycle progression. We analyzed effi...
Heat-killed Prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment
Heat-killed Prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment
Oral microbial dysbiosis contributes to the development of oral squamous cell carcinoma (OSCC). Our previous study showed ...
Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis
Ubiquitin ligase subunit FBXO9 inhibits V-ATPase assembly and impedes lung cancer metastasis
The evolutionarily conserved protein FBXO9 acts as a substrate receptor for the SKP1-cullin-1-RBX1 ubiquitin ligase and is...
Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects
Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects
Sarcoma is a malignant tumor that originates from mesenchymal tissue. The common treatment for sarcoma is surgery suppleme...
Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway
Suppression of A-to-I RNA-editing enzyme ADAR1 sensitizes hepatocellular carcinoma cells to oxidative stress through regulating Keap1/Nrf2 pathway
A-to-I RNA editing is an abundant post-transcriptional modification event in hepatocellular carcinoma (HCC). Evidence sugg...
MSCsDB: a database of single-cell transcriptomic profiles and in-depth comprehensive analyses of human mesenchymal stem cells
MSCsDB: a database of single-cell transcriptomic profiles and in-depth comprehensive analyses of human mesenchymal stem cells
Mesenchymal stem cells (MSCs) possess multipotent properties that make them promising candidates for immunomodulation and ...
The multi-CDK inhibitor dinaciclib reverses bromo- and extra-terminal domain (BET) inhibitor resistance in acute myeloid leukemia via inhibition of Wnt/β-catenin signaling
The multi-CDK inhibitor dinaciclib reverses bromo- and extra-terminal domain (BET) inhibitor resistance in acute myeloid leukemia via inhibition of Wnt/β-catenin signaling
Acute myeloid leukemia (AML) is a highly aggressive hematologic cancer with poor survival across a broad range of molecula...
Cytokine-based models for efficient differentiation between infection and cytokine release syndrome in patients with hematological malignancies
Cytokine-based models for efficient differentiation between infection and cytokine release syndrome in patients with hematological malignancies
Although the efficacy of chimeric antigen receptor (CAR)-T cell therapy has been widely demonstrated, its clinical applica...
Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice
Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice
A drug conjugate consists of a cytotoxic drug bound via a linker to a targeted ligand, allowing the targeted delivery of t...
The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice
The abundance of the short GATA1 isoform affects megakaryocyte differentiation and leukemic predisposition in mice
Transcription factor GATA1 controls the delicate balance between proliferation, differentiation and apoptosis in both the ...
Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency
Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency
GATA1 plays a critical role in differentiation, proliferation, and apoptosis during erythropoiesis. We developed a Gata1 k...
Cirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinoma
Cirrhotic-extracellular matrix attenuates aPD-1 treatment response by initiating immunosuppressive neutrophil extracellular traps formation in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is closely associatedwith chronic liver diseases, particularly liver cirrhosis, which has a...
Challenges and strategies associated with CAR-T cell therapy in blood malignancies
Challenges and strategies associated with CAR-T cell therapy in blood malignancies
Cellular immunotherapy, particularly CAR-T cells, has shown potential in the improvement of outcomes in patients with refr...
Targeting natural killer cells: from basic biology to clinical application in hematologic malignancies
Targeting natural killer cells: from basic biology to clinical application in hematologic malignancies
Natural killer (NK) cell belongs to innate lymphoid cell family that contributes to host immunosurveillance and defense wi...
Blockade of the lncRNA-DOT1L-LAMP5 axis enhances autophagy and promotes degradation of MLL fusion proteins
Blockade of the lncRNA-DOT1L-LAMP5 axis enhances autophagy and promotes degradation of MLL fusion proteins
Mixed-lineage leukemia (MLL) fusion gene caused by chromosomal rearrangement is a dominant oncogenic driver in leukemia. D...
Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Low-dose hypomethylating agents cooperate with ferroptosis inducers to enhance ferroptosis by regulating the DNA methylation-mediated MAGEA6-AMPK-SLC7A11-GPX4 signaling pathway in acute myeloid leukemia
Ferroptosis is a new form of nonapoptotic and iron-dependent type of cell death. Glutathione peroxidase-4 (GPX4) plays an ...
Outcomes of acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: validation, comparison and improvement of 2022 ELN genetic risk system
Outcomes of acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: validation, comparison and improvement of 2022 ELN genetic risk system
The 2022 European LeukemiaNet (ELN) updated the previous risk classification published in 2017 but the prognostic signific...
Revealing the role of the gut microbiota in enhancing targeted therapy efficacy for lung adenocarcinoma
Revealing the role of the gut microbiota in enhancing targeted therapy efficacy for lung adenocarcinoma
Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death globally. Although the gut microbiota's role i...
The HSP90-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma
The HSP90-MYC-CDK9 network drives therapeutic resistance in mantle cell lymphoma
Brexucabtagene autoleucel CAR-T therapy is highly efficacious in overcoming resistance to Bruton’s tyrosine kinase i...
GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
Glioblastoma multiforme (GBM) stands as a formidable challenge in oncology because of its aggressive nature and severely l...
Cancer metabolism and carcinogenesis
Cancer metabolism and carcinogenesis
Metabolic reprogramming is an emerging hallmark of cancer cells, enabling them to meet increased nutrient and energy deman...
Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistance
Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistance
Leukemias are refractory hematological malignancies, characterized by marked intrinsic heterogeneity which poses significa...
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