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ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer
Metastasis is a crucial aspect of disease progression leading to death in patients with prostate cancer (PCa). However, it...
The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury
The gut microbiota as a booster for radiotherapy: novel insights into radio-protection and radiation injury
Approximately 60–80% of cancer patients treated with abdominopelvic radiotherapy suffer post-radiotherapy toxicities...
Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis
Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis
Drug resistance and poor treatment response are major obstacles to the effective treatment of acute myeloid leukemia (AML)...
Metastatic clear-cell renal cell carcinoma: a frequent NOTCH1 mutation predictive of response to anti-NOTCH1 CB-103 treatment
Metastatic clear-cell renal cell carcinoma: a frequent NOTCH1 mutation predictive of response to anti-NOTCH1 CB-103 treatment
Clear-cell renal cell carcinomas (ccRCCs) are malignant tumors with high metastatic potential and resistance to treatments...
Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing
Identification of potential resistance mechanisms and therapeutic targets for the relapse of BCMA CAR-T therapy in relapsed/refractory multiple myeloma through single-cell sequencing
BCMA CAR-T is highly effective for relapsed/refractory multiple myeloma(R/R-MM) and significantly improves the survival of...
Venetoclax combined with daunorubicin and cytarabine (2 + 6) as induction treatment in adults with newly diagnosed acute myeloid leukemia: a phase 2, multicenter, single-arm trial
Venetoclax combined with daunorubicin and cytarabine (2 + 6) as induction treatment in adults with newly diagnosed acute myeloid leukemia: a phase 2, multicenter, single-arm trial
Venetoclax (Ven) combined with intensive chemotherapy was proven effective in the management of acute myeloid leukemia (AM...
ANXA6/TRPV2 axis promotes lymphatic metastasis in head and neck squamous cell carcinoma by inducing autophagy
ANXA6/TRPV2 axis promotes lymphatic metastasis in head and neck squamous cell carcinoma by inducing autophagy
Head and neck squamous cell carcinoma (HNSCC) is highly aggressive with a significant tropism of lymph nodes, which restri...
New approaches to idiopathic neutropenia in the era of clonal hematopoiesis
New approaches to idiopathic neutropenia in the era of clonal hematopoiesis
Isolated chronic idiopathic neutropenia (CIN) is a rare disease with multiple contributing etiologies that must be ruled o...
Bispecific antibodies as monotherapy or in combinations for non-hodgkin B-cell lymphoma: latest updates from the American society of hematology 2022 annual meeting
Bispecific antibodies as monotherapy or in combinations for non-hodgkin B-cell lymphoma: latest updates from the American society of hematology 2022 annual meeting
Recent evidence suggests that bispecific antibodies (BsAbs) exhibit promising efficacy and low toxicity even in heavily tr...
“Major pathologic response” in lymph nodes: a modified nodal classification for non-small cell lung cancer patients treated with neoadjuvant immunochemotherapy
“Major pathologic response” in lymph nodes: a modified nodal classification for non-small cell lung cancer patients treated with neoadjuvant immunochemotherapy
We aim to examine the prognostic value of major pathologic response in metastatic lymph nodes (mLN-MPR) after immunochemot...
Wdr5 is essential for fetal erythropoiesis and hematopoiesis
Wdr5 is essential for fetal erythropoiesis and hematopoiesis
WDR5 is a highly conserved protein that performs multiple scaffolding functions in the context of chromatin. However, effo...
ASAP2 interrupts c-MET-CIN85 interaction to sustain HGF/c-MET-induced malignant potentials in hepatocellular carcinoma
ASAP2 interrupts c-MET-CIN85 interaction to sustain HGF/c-MET-induced malignant potentials in hepatocellular carcinoma
Sustained activation of hepatocyte growth factor (HGF)/c-MET signaling is a major driver of hepatocellular carcinoma (HCC)...
Comparison of local ablative therapies, including radiofrequency ablation, microwave ablation, stereotactic ablative radiotherapy, and particle radiotherapy, for inoperable hepatocellular carcinoma: a systematic review and meta-analysis
Comparison of local ablative therapies, including radiofrequency ablation, microwave ablation, stereotactic ablative radiotherapy, and particle radiotherapy, for inoperable hepatocellular carcinoma: a systematic review and meta-analysis
Surgical intervention is the first-line treatment in well-selected hepatocellular carcinoma (HCC) patients. However, only ...
Decitabine in combination with fludarabine and cyclophosphamide as a lymphodepletion regimen followed by CD19/CD22 bispecific targeted CAR T-cell therapy significantly improves survival in relapsed/refractory B-ALL patients
Decitabine in combination with fludarabine and cyclophosphamide as a lymphodepletion regimen followed by CD19/CD22 bispecific targeted CAR T-cell therapy significantly improves survival in relapsed/refractory B-ALL patients
Relapse is a major limitation of chimeric antigen receptor (CAR) T-cell therapy. Here, we speculated that decitabine (DAC)...
Surface TREM2 on circulating M-MDSCs as a novel prognostic factor for adults with treatment-naïve diffuse large B-cell lymphoma
Surface TREM2 on circulating M-MDSCs as a novel prognostic factor for adults with treatment-naïve diffuse large B-cell lymphoma
Circulating monocytic myeloid-derived suppressive cells (M-MDSCs) are implicated as a poor prognostic factor and cause CAR...
Exploiting E3 ubiquitin ligases to reeducate the tumor microenvironment for cancer therapy
Exploiting E3 ubiquitin ligases to reeducate the tumor microenvironment for cancer therapy
Tumor development relies on a complex and aberrant tissue environment in which cancer cells receive the necessary nutrient...
The clinical impact of IKZF1 mutation in acute myeloid leukemia
The clinical impact of IKZF1 mutation in acute myeloid leukemia
Genetic heterogeneity poses a great challenge to the understanding and management of acute myeloid leukemia (AML). Knowled...
Targeted treatment of T-cell acute lymphoblastic leukemia: latest updates from the 2022 ASH Annual Meeting
Targeted treatment of T-cell acute lymphoblastic leukemia: latest updates from the 2022 ASH Annual Meeting
T-cell acute lymphoblastic leukemia (T-ALL) occurs in approximately 25–30% of adult ALL. Currently, treatment approa...
Secretogranin II influences the assembly and function of MHC class I in melanoma
Secretogranin II influences the assembly and function of MHC class I in melanoma
Melanoma is the deadliest form of skin cancer showing rising incidence over the past years. New insights into the mechanis...
PD-L1+ macrophages are associated with favorable features in primary mediastinal (thymic) large B-cell lymphoma
PD-L1+ macrophages are associated with favorable features in primary mediastinal (thymic) large B-cell lymphoma
Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a rare, aggressive subtype of non-Hodgkin lymphoma and has a...
LINP1 represses unfolded protein response by directly inhibiting eIF2α phosphorylation to promote cutaneous squamous cell carcinoma
LINP1 represses unfolded protein response by directly inhibiting eIF2α phosphorylation to promote cutaneous squamous cell carcinoma
Endoplasmic reticulum stress (ER stress) may destroy endoplasmic reticulum homeostasis (ER homeostasis) and leads to progr...
Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer development
Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer development
As significant posttranslational modifications, ubiquitination and deubiquitination, whose balance is modulated by ubiquit...
Characterization of bone marrow heterogeneity in NK-AML (M4/M5) based on single-cell RNA sequencing
Characterization of bone marrow heterogeneity in NK-AML (M4/M5) based on single-cell RNA sequencing
Normal karyotype acute myeloid leukemia (NK-AML) is a heterogeneous hematological malignancy that contains a minor populat...
Detection of myeloma cell-derived microvesicles: a tool to monitor multiple myeloma load
Detection of myeloma cell-derived microvesicles: a tool to monitor multiple myeloma load
The persistence of tumor load in multiple myeloma (MM) lead to relapse in patients achieving complete remission (CR). Appr...
Age-related accumulation of B-1 cell progenitors in mice reflects changes in miR15a/16-1 expression and radioresistance capacity
Age-related accumulation of B-1 cell progenitors in mice reflects changes in miR15a/16-1 expression and radioresistance capacity
Hyperproliferative diseases such as Chronic Lymphocytic Leukemia (CLL) and Systemic Lupus Erythematosus (SLE) are potentia...
p53 directly downregulates the expression of CDC20 to exert anti-tumor activity in mantle cell lymphoma
p53 directly downregulates the expression of CDC20 to exert anti-tumor activity in mantle cell lymphoma
Cell cycle dysregulation characterized by cyclin D1 overexpression is common in mantle cell lymphoma (MCL), while mitotic ...
Complement-related molecular classification and a gene signature for lung adenocarcinoma
Complement-related molecular classification and a gene signature for lung adenocarcinoma
Lung adenocarcinoma (LUAD) is a major cause of cancer-related death worldwide, and the roles of complement-related genes i...
Emerging roles of m6A RNA modification in cancer therapeutic resistance
Emerging roles of m6A RNA modification in cancer therapeutic resistance
Marvelous advancements have been made in cancer therapies to improve clinical outcomes over the years. However, therapeuti...
Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia
Synergistic effect of HDAC inhibitor Chidamide with Cladribine on cell cycle arrest and apoptosis by targeting HDAC2/c-Myc/RCC1 axis in acute myeloid leukemia
More effective targeted therapy and new combination regimens are needed for Acute myeloid leukemia (AML), owing to the uns...
Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene
Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a refractory and recurrent subtype of B-cell AL...
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