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Malignant pleural effusion facilitates the establishment and maintenance of tumor organoid biobank with multiple patient-derived lung tumor cell sources
Malignant pleural effusion facilitates the establishment and maintenance of tumor organoid biobank with multiple patient-derived lung tumor cell sources
The Patient-Derived Organoids (PDOs) has demonstrated significant potential in personalized medicine. However, the initial...
Prospective pharmacotyping of urothelial carcinoma organoids for drug sensitivity prediction – feasibility and real world experience
Prospective pharmacotyping of urothelial carcinoma organoids for drug sensitivity prediction – feasibility and real world experience
Urothelial carcinoma (UC) of the urinary bladder has significant challenges in treatment due to its diverse genetic landsc...
Natural killer cell biology and therapy in multiple myeloma: challenges and opportunities
Natural killer cell biology and therapy in multiple myeloma: challenges and opportunities
Despite therapeutic advancements, multiple myeloma (MM) remains incurable. NK cells have emerged as a promising option for...
High-throughput screening for optimizing adoptive T cell therapies
High-throughput screening for optimizing adoptive T cell therapies
Adoptive T cell therapy is a pivotal strategy in cancer immunotherapy, demonstrating potent clinical efficacy. However, it...
Targeting SPP1-orchestrated neutrophil extracellular traps-dominant pre-metastatic niche reduced HCC lung metastasis
Targeting SPP1-orchestrated neutrophil extracellular traps-dominant pre-metastatic niche reduced HCC lung metastasis
The mechanisms by which tumor-derived factors remodel the microenvironment of target organs to facilitate cancer metastasi...
New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies
New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies
Chimeric antigen receptor (CAR) T-cell therapy represents a highly efficacious treatment modality demonstrated to enhance ...
Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response
Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response
The activation of the DNA damage response (DDR) heavily relies on post-translational modifications (PTMs) of proteins, whi...
Advances in adoptive cellular immunotherapy and therapeutic breakthroughs in multiple myeloma
Advances in adoptive cellular immunotherapy and therapeutic breakthroughs in multiple myeloma
The basic idea of modulating the immune system to better recognize and fight tumor cells has led to the successful introdu...
Vertical targeting of the PI3K/AKT pathway at multiple points is synergistic and effective for non-Hodgkin lymphoma
Vertical targeting of the PI3K/AKT pathway at multiple points is synergistic and effective for non-Hodgkin lymphoma
The phosphatidylinositol 3‑kinase/protein kinase B (PI3K/AKT) signaling pathway is critically active in many cell ty...
Crosstalk between O-GlcNAcylation and ubiquitination: a novel strategy for overcoming cancer therapeutic resistance
Crosstalk between O-GlcNAcylation and ubiquitination: a novel strategy for overcoming cancer therapeutic resistance
Developing resistance to cancer treatments is a major challenge, often leading to disease recurrence and metastasis. Under...
Targeting CD5 chimeric antigen receptor-engineered natural killer cells against T-cell malignancies
Targeting CD5 chimeric antigen receptor-engineered natural killer cells against T-cell malignancies
Chimeric antigen receptor engineered T cells (CAR-T) have demonstrated promising clinical efficacy in B-cell malignancies,...
Spatial immunogenomic patterns associated with lymph node metastasis in lung adenocarcinoma
Spatial immunogenomic patterns associated with lymph node metastasis in lung adenocarcinoma
Lung adenocarcinoma (LUAD) with lymph node (LN) metastasis is linked to poor prognosis, yet the underlying mechanisms rema...
CRISPR/Cas9 technology for advancements in cancer immunotherapy: from uncovering regulatory mechanisms to therapeutic applications
CRISPR/Cas9 technology for advancements in cancer immunotherapy: from uncovering regulatory mechanisms to therapeutic applications
In recent years, immunotherapy has developed rapidly as a new field of tumour therapy. However, the efficacy of tumour imm...
Optimizing CD8+ T cell-based immunotherapy via metabolic interventions: a comprehensive review of intrinsic and extrinsic modulators
Optimizing CD8+ T cell-based immunotherapy via metabolic interventions: a comprehensive review of intrinsic and extrinsic modulators
CD8+ T cells are integral to the effective management of cancer and infectious diseases due to their cytotoxic functions. ...
Natural killer cell-based cancer immunotherapy: from basics to clinical trials
Natural killer cell-based cancer immunotherapy: from basics to clinical trials
Cellular immunotherapy exploits the capacity of the human immune system in self-protection and surveillance to achieve the...
CD19/CD22 CAR-T-cell cocktail therapy following autologous transplantation is an optimizing strategy for treating relapsed/refractory central nervous system lymphoma
CD19/CD22 CAR-T-cell cocktail therapy following autologous transplantation is an optimizing strategy for treating relapsed/refractory central nervous system lymphoma
Relapsed/refractory (R/R) primary and secondary central nervous system lymphomas (PCNSL, SCNSL) are associated with short ...
AXL as immune regulator and therapeutic target in Acute Myeloid Leukemia: from current progress to novel strategies
AXL as immune regulator and therapeutic target in Acute Myeloid Leukemia: from current progress to novel strategies
Until recently, treatment options for patients diagnosed with Acute Myeloid Leukemia (AML) were limited and predominantly ...
Preclinical investigations and a first-in-human phase 1a trial of JS007, a novel anti-CTLA-4 antibody, in patients with advanced solid tumors
Preclinical investigations and a first-in-human phase 1a trial of JS007, a novel anti-CTLA-4 antibody, in patients with advanced solid tumors
Blocking cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) shows substantial antitumor efficacy. Here, we report the pr...
Combined inhibition of MET and VEGF enhances therapeutic efficacy of EGFR TKIs in EGFR-mutant non-small cell lung cancer with concomitant aberrant MET activation
Combined inhibition of MET and VEGF enhances therapeutic efficacy of EGFR TKIs in EGFR-mutant non-small cell lung cancer with concomitant aberrant MET activation
Aberrant activation of mesenchymal epithelial transition (MET) has been considered to mediate primary and acquired resista...
Therapeutic targets of armored chimeric antigen receptor T cells navigating the tumor microenvironment
Therapeutic targets of armored chimeric antigen receptor T cells navigating the tumor microenvironment
Chimeric antigen receptor (CAR) T cell therapy, which targets tumors with high specificity through the recognition of part...
Targeting hepcidin in colorectal cancer triggers a TNF-dependent-gasdermin E-driven immunogenic cell death response
Targeting hepcidin in colorectal cancer triggers a TNF-dependent-gasdermin E-driven immunogenic cell death response
Interactions between colorectal cancer (CRC) cells and the noncancerous cells in the tumor microenvironment (TME) induce m...
Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers
Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers
Precision medicine has drastically changed cancer treatment strategies including KRAS-mutant cancers which have been undru...
Identifying ADGRG1 as a specific marker for tumor-reactive T cells in acute myeloid leukemia
Identifying ADGRG1 as a specific marker for tumor-reactive T cells in acute myeloid leukemia
Besides chemotherapy and hematopoietic stem cell transplantation (HSCT), autologous T cells can also serve as a new treatm...
Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets
Ubiquitin modification in the regulation of tumor immunotherapy resistance mechanisms and potential therapeutic targets
Although immune checkpoint-based cancer immunotherapy has shown significant efficacy in various cancers, resistance still ...
Genetic factors, risk prediction and AI application of thrombotic diseases
Genetic factors, risk prediction and AI application of thrombotic diseases
In thrombotic diseases, coagulation, anticoagulation, and fibrinolysis are three key physiological processes that interact...
Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironment
Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironment
Peritoneal metastases frequently occur in epithelial ovarian cancer (EOC), resulting in poor prognosis and survival rates....
Epigenetic alterations of TP53INP1 by EHMT2 regulate the cell cycle in gastric cancer
Epigenetic alterations of TP53INP1 by EHMT2 regulate the cell cycle in gastric cancer
Gastric cancer (GC) is a type of cancer with high incidence and mortality rates. Although various chemical interventions a...
Efficacy of NKG2D CAR-T cells with IL-15/IL-15Rα signaling for treating Epstein-Barr virus-associated lymphoproliferative disorder
Efficacy of NKG2D CAR-T cells with IL-15/IL-15Rα signaling for treating Epstein-Barr virus-associated lymphoproliferative disorder
Epstein-Barr virus (EBV) related post-transplant lymphoproliferative disorder (EBV-PTLD) is a life-threatening complicatio...
Application patterns and outcomes of hematopoietic stem cell transplantation in peripheral T-cell lymphoma patients: a multicenter real-world study in China
Application patterns and outcomes of hematopoietic stem cell transplantation in peripheral T-cell lymphoma patients: a multicenter real-world study in China
The optimal timing and type of hematopoietic stem cell transplantation (HSCT) for treating peripheral T-cell lymphoma (PTC...
Enhanced depletion of MLL-fusion proteins in acute leukemia: potential for improved therapeutic outcomes
Enhanced depletion of MLL-fusion proteins in acute leukemia: potential for improved therapeutic outcomes
Rearrangements of the MLL (KMT2A) locus are associated with aggressive leukaemia of both myeloid and lymphoid lineages, th...
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