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Construction and characterization of chimeric FcγR T cells for universal T cell therapy
Construction and characterization of chimeric FcγR T cells for universal T cell therapy
Several approaches are being explored for engineering off-the-shelf chimeric antigen receptor (CAR) T cells. In this study...
Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications
Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications
Immune checkpoint therapies have spearheaded drug innovation over the last decade, propelling cancer treatments toward a n...
Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer
Radiotherapy is the primary treatment modality for most head and neck cancers (HNCs). Despite the addition of chemotherapy...
AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition
AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition
Cytoplasmic proliferating cell nuclear antigen (PCNA) is highly expressed in acute myeloid leukemia (AML) cells, supportin...
Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial
Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial
Due to the lack of effective treatment options, the prognosis of patients with relapsed/refractory acute myeloid leukemia ...
Disrupting Notch signaling related HES1 in myeloid cells reinvigorates antitumor T cell responses
Disrupting Notch signaling related HES1 in myeloid cells reinvigorates antitumor T cell responses
Tumor-associated macrophages (TAMs) are immunosuppressive cells within the tumor microenvironment (TME) that hinder anti-t...
Chimeric antigen receptor-T cell therapy for T cell-derived hematological malignancies
Chimeric antigen receptor-T cell therapy for T cell-derived hematological malignancies
Relapsed/refractory T cell-derived malignancies present with high heterogeneity and poor prognoses. Recently, chimeric ant...
CUL4A-DDB1-circRFWD2 E3 ligase complex mediates the ubiquitination of p27 to promote multiple myeloma proliferation
CUL4A-DDB1-circRFWD2 E3 ligase complex mediates the ubiquitination of p27 to promote multiple myeloma proliferation
Multiple myeloma (MM) is an incurable disease characterized by the abnormal expansion of plasma cells in the bone marrow (...
Natural killer cell biology and therapy in multiple myeloma: challenges and opportunities
Natural killer cell biology and therapy in multiple myeloma: challenges and opportunities
Despite therapeutic advancements, multiple myeloma (MM) remains incurable. NK cells have emerged as a promising option for...
High-throughput screening for optimizing adoptive T cell therapies
High-throughput screening for optimizing adoptive T cell therapies
Adoptive T cell therapy is a pivotal strategy in cancer immunotherapy, demonstrating potent clinical efficacy. However, it...
Targeting SPP1-orchestrated neutrophil extracellular traps-dominant pre-metastatic niche reduced HCC lung metastasis
Targeting SPP1-orchestrated neutrophil extracellular traps-dominant pre-metastatic niche reduced HCC lung metastasis
The mechanisms by which tumor-derived factors remodel the microenvironment of target organs to facilitate cancer metastasi...
New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies
New insights into CAR T-cell hematological toxicities: manifestations, mechanisms, and effective management strategies
Chimeric antigen receptor (CAR) T-cell therapy represents a highly efficacious treatment modality demonstrated to enhance ...
Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response
Nuclear porcupine mediates XRCC6/Ku70 S-palmitoylation in the DNA damage response
The activation of the DNA damage response (DDR) heavily relies on post-translational modifications (PTMs) of proteins, whi...
Advances in adoptive cellular immunotherapy and therapeutic breakthroughs in multiple myeloma
Advances in adoptive cellular immunotherapy and therapeutic breakthroughs in multiple myeloma
The basic idea of modulating the immune system to better recognize and fight tumor cells has led to the successful introdu...
Vertical targeting of the PI3K/AKT pathway at multiple points is synergistic and effective for non-Hodgkin lymphoma
Vertical targeting of the PI3K/AKT pathway at multiple points is synergistic and effective for non-Hodgkin lymphoma
The phosphatidylinositol 3‑kinase/protein kinase B (PI3K/AKT) signaling pathway is critically active in many cell ty...
Crosstalk between O-GlcNAcylation and ubiquitination: a novel strategy for overcoming cancer therapeutic resistance
Crosstalk between O-GlcNAcylation and ubiquitination: a novel strategy for overcoming cancer therapeutic resistance
Developing resistance to cancer treatments is a major challenge, often leading to disease recurrence and metastasis. Under...
Targeting CD5 chimeric antigen receptor-engineered natural killer cells against T-cell malignancies
Targeting CD5 chimeric antigen receptor-engineered natural killer cells against T-cell malignancies
Chimeric antigen receptor engineered T cells (CAR-T) have demonstrated promising clinical efficacy in B-cell malignancies,...
Spatial immunogenomic patterns associated with lymph node metastasis in lung adenocarcinoma
Spatial immunogenomic patterns associated with lymph node metastasis in lung adenocarcinoma
Lung adenocarcinoma (LUAD) with lymph node (LN) metastasis is linked to poor prognosis, yet the underlying mechanisms rema...
Natural killer cell-based cancer immunotherapy: from basics to clinical trials
Natural killer cell-based cancer immunotherapy: from basics to clinical trials
Cellular immunotherapy exploits the capacity of the human immune system in self-protection and surveillance to achieve the...