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The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment
The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment
Pyroptosis, an inflammatory programmed cell death, distinguishes itself from apoptosis and necroptosis and has drawn incre...
Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms
Antitumor effect of a small-molecule inhibitor of KRASG12D in xenograft models of mucinous appendicular neoplasms
Pseudomyxoma peritonei (PMP) is a rare disease characterized by a massive accumulation of mucus in the peritoneal...
A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease
A bile-based microRNA signature for differentiating malignant from benign pancreaticobiliary disease
Differentiating between pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA) is crucial for the appropriat...
Upregulated PARP1 confers breast cancer resistance to CDK4/6 inhibitors via YB-1 phosphorylation
Upregulated PARP1 confers breast cancer resistance to CDK4/6 inhibitors via YB-1 phosphorylation
Cyclic-dependent kinase (CDK) 4/6 kinases, as the critical drivers of the cell cycle, are involved in the tumor progressio...
Immune checkpoint inhibitors for multiple myeloma immunotherapy
Immune checkpoint inhibitors for multiple myeloma immunotherapy
Multiple myeloma (MM) is related to immune disorders, recent studys have revealed that immunotherapy can greatly benefit M...
Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
Molecular characterization of the CXCR4 / CXCR7 axis in germ cell tumors and its targetability using nanobody-drug-conjugates
Being stimulated by the chemokine CXCL12, the CXCR4 / CXCR7 cascade is involved in tumor proliferation, ...
Single VHH-directed BCMA CAR-NK cells for multiple myeloma
Single VHH-directed BCMA CAR-NK cells for multiple myeloma
Natural killer (NK) cells are promising alternatives for the production of “off-the-shelf” CAR products, posin...
Deciphering tumor-infiltrating dendritic cells in the single-cell era
Deciphering tumor-infiltrating dendritic cells in the single-cell era
Dendritic cells (DCs) serve as a pivotal link connecting innate and adaptive immunity by processing tumor-derived antigens...
The current landscape of using direct inhibitors to target KRASG12C-mutated NSCLC
The current landscape of using direct inhibitors to target KRASG12C-mutated NSCLC
Mutation in KRAS protooncogene represents one of the most common genetic alterations in NSCLC and has posed a great therap...
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling
Downregulation of pro-surfactant protein B contributes to the recurrence of early-stage non-small cell lung cancer by activating PGK1-mediated Akt signaling
Recurrence is one of the main causes of treatment failure in early-stage non-small cell lung cancer (NSCLC). However, ther...
CRISPR/Cas9 system: recent applications in immuno-oncology and cancer immunotherapy
CRISPR/Cas9 system: recent applications in immuno-oncology and cancer immunotherapy
Clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) is essentially an a...
Chinese expert consensus on Bruton tyrosine kinase inhibitors in the treatment of B-cell malignancies
Chinese expert consensus on Bruton tyrosine kinase inhibitors in the treatment of B-cell malignancies
Targeted therapy with Bruton tyrosine kinase (BTK) inhibitors have revolutionized the treatment of patients with various B...
New insight into circRNAs: characterization, strategies, and biomedical applications
New insight into circRNAs: characterization, strategies, and biomedical applications
Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most circRNAs are derived from exonic or int...
Targeting CD22 for B-cell hematologic malignancies
Targeting CD22 for B-cell hematologic malignancies
CD19-targeted chimeric receptor antigen (CAR)-T cell therapy has shown remarkable clinical efficacy in the treatment of re...
CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro
CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro
CAR T cell therapy has been successfully used in the treatment of hematological malignancies, and the strategy that deleti...
Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia
Regulatory T cells contribute to the immunosuppressive phenotype of neutrophils in a mouse model of chronic lymphocytic leukemia
Impaired neutrophil activity is an important issue in chronic lymphocytic leukemia (CLL), as it contributes to a dysfuncti...
Correction to: Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting
Correction to: Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Identification of a novel NPM1 mutation in acute myeloid leukemia
Identification of a novel NPM1 mutation in acute myeloid leukemia
Nucleophosmin (NPM1) is a widely expressed nucleocytoplasmic shuttling protein with prominent nucleolar localization. It i...
Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain
Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain
Immunosuppression induced by programmed cell death protein 1 (PD1) presents a significant constraint on the effectiveness ...
Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target
Role of gut microbiome in cancer immunotherapy: from predictive biomarker to therapeutic target
Immunotherapy has emerged as an effective treatment for various types of cancers. Recent studies have highlighted a signif...
Focal adhesion kinase: from biological functions to therapeutic strategies
Focal adhesion kinase: from biological functions to therapeutic strategies
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital participant in primary cellular functio...
The PTX3/TLR4 autocrine loop as a novel therapeutic target in triple negative breast cancer
The PTX3/TLR4 autocrine loop as a novel therapeutic target in triple negative breast cancer
The pattern recognition receptor long pentraxin-3 (PTX3) plays conflicting roles in cancer by acting as an oncosuppressor ...
A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models
A novel CAR-T cell product targeting CD74 is an effective therapeutic approach in preclinical mantle cell lymphoma models
Mantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma subtype which remains incurable despite multimodal approa...
Recent advances and future perspectives in the therapeutics of prostate cancer
Recent advances and future perspectives in the therapeutics of prostate cancer
Prostate cancer (PC) is one of the most common cancers in males and the fifth leading reason of death. Age, ethnicity, fam...
Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia
Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia
In KMT2A-rearranged acute lymphoblastic leukemia (ALL), an aggressive malignancy, oncogenic KMT2A-fusion proteins inapprop...
Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma
Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma
Leiomyosarcoma (LMS) is a rare soft tissue sarcoma (STS) that begins in smooth muscle tissue and most often initiates in t...
CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression
CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression
UTX (encoded by KDM6A), a histone demethylase for H3K27me2/3, is frequently mutated in human cancers. However, its functio...
Targeting NOTCH1 in combination with antimetabolite drugs prolongs life span in relapsed pediatric and adult T-acute lymphoblastic leukemia xenografts
Targeting NOTCH1 in combination with antimetabolite drugs prolongs life span in relapsed pediatric and adult T-acute lymphoblastic leukemia xenografts
T-cell acute lymphoblastic leukemia (T-ALL) is a hematologic tumor, characterized by several genetic alterations, that con...
Elevated expression of the RNA-binding protein IGF2BP1 enhances the mRNA stability of INHBA to promote the invasion and migration of esophageal squamous cancer cells
Elevated expression of the RNA-binding protein IGF2BP1 enhances the mRNA stability of INHBA to promote the invasion and migration of esophageal squamous cancer cells
The mechanisms underlying the occurrence and development of esophageal squamous cell carcinoma (ESCC) remains to be elucid...
Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting
Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting
Bispecific antibodies (BsAbs) and dual-targeted chimeric antigen receptor T (CAR T) cells have been employed in relapsed/r...
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