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Disease-free survival landmark analysis: a potential critical endpoint in triple-negative breast cancer
Disease-free survival landmark analysis: a potential critical endpoint in triple-negative breast cancer
Taxanes plus carboplatin (TP) regimen may be an acceptable alternative adjuvant chemotherapy strategy in patients with tri...
Polyclonal evolution of Fanconi anemia to MDS and AML revealed at single cell resolution
Polyclonal evolution of Fanconi anemia to MDS and AML revealed at single cell resolution
Fanconi anemia (FA) is a rare disease of bone marrow failure. FA patients are prone to develop myelodysplastic syndrome (M...
Chimeric antigen receptor T-cell therapy for relapsed and refractory thyroid cancer
Chimeric antigen receptor T-cell therapy for relapsed and refractory thyroid cancer
The prognosis of most thyroid cancer patients is excellent, but for those with advanced or metastatic thyroid cancer, effe...
Novel cellular immunotherapies for hematological malignancies: recent updates from the 2021 ASH annual meeting
Novel cellular immunotherapies for hematological malignancies: recent updates from the 2021 ASH annual meeting
Cellular immunotherapy, including the chimeric antigen receptor T (CAR-T) cell therapy and CAR- natural killer (CAR-NK) ce...
Bruton tyrosine kinase inhibitors in B-cell lymphoma: beyond the antitumour effect
Bruton tyrosine kinase inhibitors in B-cell lymphoma: beyond the antitumour effect
Targeting B-cell receptor signalling using Bruton tyrosine kinase (BTK) inhibitors (BTKis) has become a highly successful ...
A pan-cancer analysis of the oncogenic role of leucine zipper protein 2 in human cancer
A pan-cancer analysis of the oncogenic role of leucine zipper protein 2 in human cancer
In this study, we aimed to perform a pan-cancer analysis of leucine zipper protein 2 (LUZP2). A standardized TCGA pan-canc...
Association between abnormal lipid profile and inflammation and progression of myelodysplastic syndrome to acute leukemia
Association between abnormal lipid profile and inflammation and progression of myelodysplastic syndrome to acute leukemia
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with a small risk of developing hematologic malignanc...
Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia
Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia
Activating G protein-coupled estrogen receptor 1 (GPER1) is an attractive therapeutic strategy for treating a variety of h...
The putative mechanistic insights on how SARS-CoV-2 might influence the outcomes in cancer patients
The putative mechanistic insights on how SARS-CoV-2 might influence the outcomes in cancer patients
Early evidence indicated that cancer patients are at increased risk of adverse outcomes and mortality after severe acute r...
Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma
Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma
Cancer cells are well-known for their capacity to adapt their metabolism to their increasing energy demands which is neces...
The genomic analysis brings a new piece to the molecular jigsaw of idiopathic erythrocytosis
The genomic analysis brings a new piece to the molecular jigsaw of idiopathic erythrocytosis
Erythrocytosis is a clinical condition characterized by increased red cell mass, hemoglobin, and hematocrit values. A sign...
Serologic response and safety of COVID-19 vaccination in HSCT or CAR T-cell recipients: a systematic review and meta-analysis
Serologic response and safety of COVID-19 vaccination in HSCT or CAR T-cell recipients: a systematic review and meta-analysis
Patients receiving hematopoietic stem cell transplantation (HSCT) or chimeric antigen receptor T cell (CAR T-cell) therapy...
Role of m6A writers, erasers and readers in cancer
Role of m6A writers, erasers and readers in cancer
The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasi...
Current insight into the regulation of PD-L1 in cancer
Current insight into the regulation of PD-L1 in cancer
The molecular mechanisms underlying cancer immune escape are a core topic in cancer immunology research. Cancer cells can ...
Myeloid-derived suppressor cells in hematologic malignancies: two sides of the same coin
Myeloid-derived suppressor cells in hematologic malignancies: two sides of the same coin
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of bone marrow cells originating from immature mye...
JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression
JOSD2 regulates PKM2 nuclear translocation and reduces acute myeloid leukemia progression
Pyruvate kinase M2 (PKM2) plays an important role in the metabolism and proliferation of leukemia cells. Here, we show tha...
A novel E-cadherin/SOX9 axis regulates cancer stem cells in multiple myeloma by activating Akt and MAPK pathways
A novel E-cadherin/SOX9 axis regulates cancer stem cells in multiple myeloma by activating Akt and MAPK pathways
Cancer stem cells (CSCs) have been identified in multiple myeloma (MM) and are widely regarded as a key driver of MM initi...
A sumoylation program is essential for maintaining the mitotic fidelity in proliferating mantle cell lymphoma cells
A sumoylation program is essential for maintaining the mitotic fidelity in proliferating mantle cell lymphoma cells
Mantle cell lymphoma (MCL) is a rare, highly heterogeneous type of B-cell non-Hodgkin’s lymphoma. The sumoylation pa...
Targeting metabolic reprogramming in chronic lymphocytic leukemia
Targeting metabolic reprogramming in chronic lymphocytic leukemia
Metabolic reprogramming, fundamentally pivotal in carcinogenesis and progression of cancer, is considered as a promising t...
TCR engineered T cells for solid tumor immunotherapy
TCR engineered T cells for solid tumor immunotherapy
T cell immunotherapy remains an attractive approach for cancer immunotherapy. T cell immunotherapy mainly employs chimeric...
Spliceosome inhibitor induces human hematopoietic progenitor cell reprogramming toward stemness
Spliceosome inhibitor induces human hematopoietic progenitor cell reprogramming toward stemness
The application of hematopoietic stem cells (HSCs) has been restricted due to limited cell sources and conventional method...
IL-39 promotes chronic graft-versus-host disease by increasing T and B Cell pathogenicity
IL-39 promotes chronic graft-versus-host disease by increasing T and B Cell pathogenicity
Chronic graft-versus-host disease (cGVHD) remains a major complication during the late phase of allogeneic hematopoietic s...
Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer
Transfer RNA-derived small RNA: an emerging small non-coding RNA with key roles in cancer
Transfer RNAs (tRNAs) promote protein translation by binding to the corresponding amino acids and transporting them to the...