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Novel mutation in patients with microcephalic osteodysplastic primordial dwarfism type II (MOPD II)
Novel mutation in patients with microcephalic osteodysplastic primordial dwarfism type II (MOPD II)
A rare type of autosomal recessive skeletal disorder, known as microcephalic osteodysplastic primordial dwarfism (MOPD) ty...
Development and validation a novel FEZF2 based fluorescent reporter for corticospinal motor neurons
Development and validation a novel FEZF2 based fluorescent reporter for corticospinal motor neurons
Corticospinal motor neurons (CSMNs), also named upper motor neurons, are the giant pyramidal neurons called Betz cells. In...
Astragalus polysaccharide treatment relieves cerebral ischemia‒reperfusion injury by promoting M2 polarization of microglia by enhancing O-GlcNAcylation
Astragalus polysaccharide treatment relieves cerebral ischemia‒reperfusion injury by promoting M2 polarization of microglia by enhancing O-GlcNAcylation
Cerebral ischemia‒reperfusion (I/R) injury seriously threatens the lives of patients. Astragalus polysaccharide (APS...
Hepatic encephalopathy as a result of ammonia-induced increase in GABAergic tone with secondary reduced brain energy metabolism
Hepatic encephalopathy as a result of ammonia-induced increase in GABAergic tone with secondary reduced brain energy metabolism
Hepatic encephalopathy (HE) is a neuropsychiatric syndrome caused by liver insufficiency and/or portosystemic shunting. HE...
Dynamic changes in the hippocampal memory index and biochemical indices in Sprague Dawley rats exposed to intrauterine kola nut
Dynamic changes in the hippocampal memory index and biochemical indices in Sprague Dawley rats exposed to intrauterine kola nut
Kola nut is commonly consumed by pregnant women to suppress symptoms of morning sickness. This study investigated the effe...
Depression, stress, and tryptophan metabolism through the kynurenine pathway: treatment strategies from the perspective of Chinese herbal medicine
Depression, stress, and tryptophan metabolism through the kynurenine pathway: treatment strategies from the perspective of Chinese herbal medicine
The pathogenesis of depression is complex, involving abnormalities in tryptophan (TRP) metabolism through the kynurenine p...
Neurodegenerative biomarkers and inflammation in patients with propionic and methylmalonic acidemias: effect of L-carnitine treatment
Neurodegenerative biomarkers and inflammation in patients with propionic and methylmalonic acidemias: effect of L-carnitine treatment
Propionic and methylmalonic acidemias (PAcidemia and MMAcidemia, respectively) are genetic disorders characterized by acut...
Untargeted metabolomics to detect and identify plasma metabolic signatures associated with intracranial aneurysm and its rupture
Untargeted metabolomics to detect and identify plasma metabolic signatures associated with intracranial aneurysm and its rupture
The biological basis for metabolic differences between unruptured and ruptured intracranial aneurysm (UIA and RIA) populat...
Individuals with SATB2-associated syndrome have impaired vitamin and energy metabolism pathways
Individuals with SATB2-associated syndrome have impaired vitamin and energy metabolism pathways
Special AT-rich sequence-binding protein 2 (SATB2) is a master regulator of gene expression. Mutations of the SATB2 gene r...
Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats dependent on NLRP3 activation
Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats dependent on NLRP3 activation
Postoperative cognitive dysfunction (POCD), a complication following procedures such as orthopedic surgery, is associated ...
Exercise rescues cognitive impairment through inhibiting the fibrinogen neuroinflammative pathway in diabetes
Exercise rescues cognitive impairment through inhibiting the fibrinogen neuroinflammative pathway in diabetes
Fibrinogen is a pivotal factor in the activation of neuroinflammation and cognitive impairment. While exercise, especifica...
Exploring the material basis and molecular targets of Changma Xifeng tablet in treating Tourette syndrome: an integrative approach of network pharmacology and miRNA analysis
Exploring the material basis and molecular targets of Changma Xifeng tablet in treating Tourette syndrome: an integrative approach of network pharmacology and miRNA analysis
This study was to investigate the mechanism of Changma Xifeng tablet, a traditional Chinese medicine in the treatment of T...
Effects of aerobic exercise on demyelination and brain morphology in the cuprizone rat model of multiple sclerosis
Effects of aerobic exercise on demyelination and brain morphology in the cuprizone rat model of multiple sclerosis
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) that led to brain atrophy. ...
ChangPu YuJin Tang improves Tourette disorder symptoms by modulating amino acid neurotransmitters in IDPN model rats
ChangPu YuJin Tang improves Tourette disorder symptoms by modulating amino acid neurotransmitters in IDPN model rats
Changpu Yujin Tang(CPYJT), a Chinese herbal compound, is an effective therapeutic strategy for pediatric patients with Tou...
Curcumin attenuated neuroinflammation via the TLR4/MyD88/NF-κB signaling way in the juvenile rat hippocampus following kainic acid-induced epileptic seizures
Curcumin attenuated neuroinflammation via the TLR4/MyD88/NF-κB signaling way in the juvenile rat hippocampus following kainic acid-induced epileptic seizures
The study examined curcumin’s impart on relieving neuroinflammation of juvenile rats in kainic acid (KA) induced epi...
Intermittent fasting alerts neurotransmitters and oxidant/antioxidant status in the brain of rats
Intermittent fasting alerts neurotransmitters and oxidant/antioxidant status in the brain of rats
Several recent studies have attempted to understand how fasting has benefits for body health, especially the nervous syste...
Effects of prolonged escitalopram administration on long-term potentiation within the hippocampal CA1 area in rats under predictable and unpredictable chronic mild stress
Effects of prolonged escitalopram administration on long-term potentiation within the hippocampal CA1 area in rats under predictable and unpredictable chronic mild stress
Exposure to chronic stress impairs memory. Also, escitalopram’s impact on memory remains paradoxical. Therefore, thi...
Infection, inflammation and hepatic encephalopathy from a clinical perspective
Infection, inflammation and hepatic encephalopathy from a clinical perspective
Hepatic encephalopathy (HE) is a syndrome that is associated with both acute and chronic liver injury. It manifests as a w...
Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology
Advances and challenges in serine in the central nervous system: physicochemistry, physiology, and pharmacology
Neurological disorders are the primary cause of human disability and mortality globally, however, current medications slig...
Involvement of oncomiRs miR-23, miR-24, and miR-27 in the regulation of alternative polyadenylation in glioblastoma via CFIm25 cleavage factor
Involvement of oncomiRs miR-23, miR-24, and miR-27 in the regulation of alternative polyadenylation in glioblastoma via CFIm25 cleavage factor
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. The cleavage factor Im 25 (CFIm25)...
Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist
Neurological recovery in rats with portocaval anastomosis-induced hepatic encephalopathy treated with leuprolide acetate, a GnRH agonist
Hepatic encephalopathy (HE) is a neuropsychiatric complication of acute liver failure or chronic liver injury. Liver dysfu...
Role of peripheral inflammation in minimal hepatic encephalopathy
Role of peripheral inflammation in minimal hepatic encephalopathy
Many patients with liver cirrhosis show minimal hepatic encephalopathy (MHE) with mild cognitive impairment (MCI) and moto...
Genomic, epigenomic and transcriptomic landscape of glioblastoma
Genomic, epigenomic and transcriptomic landscape of glioblastoma
The mostly aggressive and extremely malignant type of central nervous system is Glioblastoma (GBM), which is characterized...
Peganum harmala L. seed extract attenuates anxiety and depression in rats by reducing neuroinflammation and restoring the BDNF/TrkB signaling pathway and monoamines after exposure to chronic unpredictable mild stress
Peganum harmala L. seed extract attenuates anxiety and depression in rats by reducing neuroinflammation and restoring the BDNF/TrkB signaling pathway and monoamines after exposure to chronic unpredictable mild stress
Depression is a mental disorder characterised by persistent low mood, anhedonia and cognitive impairment that affects an e...
Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats
Morin attenuated the global cerebral ischemia via antioxidant, anti-inflammatory, and antiapoptotic mechanisms in rats
Global cerebral ischemia is one of the major causes of memory and cognitive impairment. Hyperactivation of acetylcholine e...
Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer’s disease
Integrative analysis reveals key lysosomal genes as potential therapeutic targets in Alzheimer’s disease
Alzheimer's disease (AD) is a neurodegenerative disorder with early autophagy deficits. Our study probed the role of l...
Treatment response of venlafaxine induced alterations of gut microbiota and metabolites in a mouse model of depression
Treatment response of venlafaxine induced alterations of gut microbiota and metabolites in a mouse model of depression
Antidepressants remain the first-line treatment for depression. However, the factors influencing medication response are s...
Neuroprotective role of chlorogenic acid against hippocampal neuroinflammation, oxidative stress, and apoptosis following acute seizures induced by pentylenetetrazole
Neuroprotective role of chlorogenic acid against hippocampal neuroinflammation, oxidative stress, and apoptosis following acute seizures induced by pentylenetetrazole
This study investigated the neuroprotective effect of chlorogenic acid (CGA) on pentylenetetrazole (PTZ)-induced acute epi...
Exploring the molecular mechanisms underlying neuroprotective effect of ellagic acid in okadaic acid-induced Alzheimer’s phenotype
Exploring the molecular mechanisms underlying neuroprotective effect of ellagic acid in okadaic acid-induced Alzheimer’s phenotype
Pomegranate polyphenol ellagic acid has medicinal potential in neurodegenerative disorders. The advantageous effect of thi...
Bulk-RNA and single-nuclei RNA seq analyses reveal the role of lactate metabolism-related genes in Alzheimer’s disease
Bulk-RNA and single-nuclei RNA seq analyses reveal the role of lactate metabolism-related genes in Alzheimer’s disease
Dysfunctional lactate metabolism in the brain has been implicated in neuroinflammation, Aβ deposition, and cell distu...
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