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Exploring sulforaphane as neurotherapeutic: targeting Nrf2-Keap & Nf-Kb pathway crosstalk in ASD
Exploring sulforaphane as neurotherapeutic: targeting Nrf2-Keap & Nf-Kb pathway crosstalk in ASD
Autism spectrum disorders (ASD) are a family of complex neurodevelopmental disorders, characterized mainly through deficit...
The role of astrocytes in the glymphatic network: a narrative review
The role of astrocytes in the glymphatic network: a narrative review
To date, treatment of Central Nervous System (CNS) pathology has largely focused on neuronal structure and function. Yet, ...
Nutritional strategies cause memory damage and alter biochemical parameters without causing neuroinflammation
Nutritional strategies cause memory damage and alter biochemical parameters without causing neuroinflammation
Obesity results from an energy imbalance and has been considered an epidemic due to its increasing rates worldwide. It is ...
Methylseleninic acid inhibits human glioma growth in vitro and in vivo by triggering ROS-dependent oxidative damage and apoptosis
Methylseleninic acid inhibits human glioma growth in vitro and in vivo by triggering ROS-dependent oxidative damage and apoptosis
Selenium-containing agents showed novel anticancer activity by triggering pro-oxidative mechanism. Studies confirmed that ...
Molecular and in silico investigation of a novel ECHS1 gene mutation in a consanguine family with short-chain enoyl-CoA hydratase deficiency and Mt-DNA depletion: effect on trimer assembly and catalytic activity
Molecular and in silico investigation of a novel ECHS1 gene mutation in a consanguine family with short-chain enoyl-CoA hydratase deficiency and Mt-DNA depletion: effect on trimer assembly and catalytic activity
Short-chain enoyl-CoA hydratase deficiency (ECHS1D) is a rare congenital metabolic disorder that follows an autosomal rece...
New curcumin-loaded nanocapsules as a therapeutic alternative in an amnesia model
New curcumin-loaded nanocapsules as a therapeutic alternative in an amnesia model
This study aimed to investigate the action of two different formulations of curcumin (Cur)-loaded nanocapsules (Nc) (Eudra...
Identification of metabolic pathways and key genes associated with atypical parkinsonism using a systems biology approach
Identification of metabolic pathways and key genes associated with atypical parkinsonism using a systems biology approach
Atypical parkinsonism (AP) is a group of complex neurodegenerative disorders with marked clinical and pathophysiological h...
Correction to: Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis
Correction to: Calorie restriction promotes remyelination in a Cuprizone-Induced demyelination mouse model of multiple sclerosis
Cite this articleMojaverrostami, S., Pasbakhsh, P., Madadi, S. et al. Correction to: Calorie restriction promotes remyelin...
Proteomics revealed an association between ribosome-associated proteins and amyloid beta deposition in Alzheimer's disease
Proteomics revealed an association between ribosome-associated proteins and amyloid beta deposition in Alzheimer's disease
Most scholars believe that amyloid-beta (Aβ) has the potential to induce apoptosis, stimulate an inflammatory cascade...
Etomidate inhibits tumor growth of glioblastoma by regulating M1 macrophage polarization
Etomidate inhibits tumor growth of glioblastoma by regulating M1 macrophage polarization
Glioblastoma (GBM) is a common primary central nervous system tumor. Although the multimodal integrated treatment for GBM ...
Therapeutic potentialities of green tea (Camellia sinensis) in ischemic stroke: biochemical and molecular evidence
Therapeutic potentialities of green tea (Camellia sinensis) in ischemic stroke: biochemical and molecular evidence
Ischemic stroke is a leading cause of disability and death in patients. Despite considerable recent advances in the treatm...
Alterations of the glutamatergic system in diabetes mellitus
Alterations of the glutamatergic system in diabetes mellitus
Diabetes mellitus (DM) is a chronic disease characterized by elevated blood glucose levels caused by a lack of insulin pro...
Nuclear translocation of STAT5 initiates iron overload in huntington’s disease by up-regulating IRP1 expression
Nuclear translocation of STAT5 initiates iron overload in huntington’s disease by up-regulating IRP1 expression
Mutant huntingtin (mHtt) proteins interact to form aggregates, disrupting cellular functions including transcriptional dys...
Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease
Network pharmacology-based approach to understand the effect and mechanism of chrysophanol against cognitive impairment in Wilson disease
Wilson disease (WD) is a rare hereditary copper metabolism disorder, wherein cognitive impairment is a common clinical sym...
Plasma metabolomics reveals the intervention mechanism of different types of exercise on chronic unpredictable mild stress-induced depression rat model
Plasma metabolomics reveals the intervention mechanism of different types of exercise on chronic unpredictable mild stress-induced depression rat model
To study the effects of different types of exercise on the plasma metabolomics of chronic unpredictable mild stress (CUMS)...
Understanding the multifaceted role of miRNAs in Alzheimer’s disease pathology
Understanding the multifaceted role of miRNAs in Alzheimer’s disease pathology
Small non-coding RNAs (miRNAs) regulate gene expression by binding to mRNA and mediating its degradation or inhibiting tra...
Combination chemotherapy in rodents: a model for chemotherapy-induced neuropathic pain and pharmacological screening
Combination chemotherapy in rodents: a model for chemotherapy-induced neuropathic pain and pharmacological screening
Chemotherapy-induced neuropathic pain (CINP) remains a therapeutic challenge, with no US-FDA approved drugs or effective t...
A computational approach to analyzing the functional and structural impacts of Tripeptidyl-Peptidase 1 missense mutations in neuronal ceroid lipofuscinosis
A computational approach to analyzing the functional and structural impacts of Tripeptidyl-Peptidase 1 missense mutations in neuronal ceroid lipofuscinosis
Neuronal ceroid-lipofuscinosis (NCLs) are a group of severe neurodegenerative conditions, most likely present in infantile...
Therapeutic efficacy and pharmacological mechanism of Yindan Xinnaotong soft capsule on acute ischemic stroke: a meta-analysis and network pharmacology analysis
Therapeutic efficacy and pharmacological mechanism of Yindan Xinnaotong soft capsule on acute ischemic stroke: a meta-analysis and network pharmacology analysis
Yindan Xinnaotong soft capsule (YDXNT), a traditional Chinese medicine preparation, has shown a promising effect in the tr...
Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions
Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by altered brain connectivity and f...
Echinacea purpurea extract intervention for counteracting neurochemical and behavioral changes induced by bifenthrin
Echinacea purpurea extract intervention for counteracting neurochemical and behavioral changes induced by bifenthrin
This study was conducted to elucidate the possible protective efficiency of Echinacea purpurea hydroethanolic extract (Ech...
Molecular dynamics exploration of Lupenone: therapeutic implications for glioblastoma multiforme and alzheimer's amyloid beta pathogenesis
Molecular dynamics exploration of Lupenone: therapeutic implications for glioblastoma multiforme and alzheimer's amyloid beta pathogenesis
Neuro-oncological and neurodegenerative disorders, represented paradigmatically by glioblastoma and Alzheimer's diseas...
Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats
Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats
Chlorpyrifos (CPF), considered one of the most potent organophosphates, causes a variety of human disorders including neur...
Considerations for Chinese tolerable upper intake level for selenium
Considerations for Chinese tolerable upper intake level for selenium
Bai YZ, Zhang SQ (2023a) Do selenium-enriched foods provide cognitive benefit? Metab Brain Dis 38:1501–1502. https://doi.o...
NMR based Serum metabolomics revealed metabolic signatures associated with oxidative stress and mitochondrial damage in brain stroke
NMR based Serum metabolomics revealed metabolic signatures associated with oxidative stress and mitochondrial damage in brain stroke
Brain stroke (BS, also known as a cerebrovascular accident), represents a serious global health crisis. ...
Development of novel treatments for amyotrophic lateral sclerosis
Development of novel treatments for amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that causes paralysis whose etiology and pathogenesis h...
Chitosan/PLA-loaded Magnesium oxide nanocomposite to attenuate oxidative stress, neuroinflammation and neurotoxicity in rat models of Alzheimer's disease
Chitosan/PLA-loaded Magnesium oxide nanocomposite to attenuate oxidative stress, neuroinflammation and neurotoxicity in rat models of Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid-beta (Aβ) aggregation, neuroinfl...
Circ_0027446 promotes malignant development of glioblastoma by interacting with miR-346 to up-regulate PGK1
Circ_0027446 promotes malignant development of glioblastoma by interacting with miR-346 to up-regulate PGK1
Circular RNAs (circRNAs) can play essential roles in tumor development, including glioblastoma (GBM). The current study wa...
Sestrin2 can alleviate endoplasmic reticulum stress to improve traumatic brain injury by activating AMPK/mTORC1 signaling pathway
Sestrin2 can alleviate endoplasmic reticulum stress to improve traumatic brain injury by activating AMPK/mTORC1 signaling pathway
Traumatic brain injury (TBI), as a serious central nervous system disease, can result in severe neurological dysfunction o...
Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets
Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets
Intracerebral hemorrhage is a common neurological disease, and its pathological mechanism is complex. As the first recruit...
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