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Untargeted metabolomics unveils critical metabolic signatures in novel phenotypes of acute ischemic stroke
Untargeted metabolomics unveils critical metabolic signatures in novel phenotypes of acute ischemic stroke
This study aimed to identify metabolic footprints associated with distinct phenotypes of acute ischemic stroke (AIS) using...
Unlocking NAC’s potential ATF4 and m6A dynamics in rescuing cognitive impairments in PTSD
Unlocking NAC’s potential ATF4 and m6A dynamics in rescuing cognitive impairments in PTSD
In this study, we investigated the therapeutic potential of N-acetylcysteine (NAC) in a mouse model of post-traumatic stre...
A novel approach to metabolic profiling in case models of MECP2-related disorders
A novel approach to metabolic profiling in case models of MECP2-related disorders
Genetic abnormalities of the MECP2 gene cause several conditions grouped under the umbrella term of MECP2-related disorder...
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (St3gal4) deficiency reveals correlations among alkaline phosphatase activity, metabolic parameters, and fear-related behavior in mice
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (St3gal4) deficiency reveals correlations among alkaline phosphatase activity, metabolic parameters, and fear-related behavior in mice
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 (ST3GAL4) is a sialyltransferase involved in the bios...
Lights and shadows of clozapine on the immune system in schizophrenia: a narrative literature review
Lights and shadows of clozapine on the immune system in schizophrenia: a narrative literature review
Schizophrenia is a chronic mental disorder and one of the main causes of disability in the world. Approximately 1% of the ...
α-asarone activates mitophagy to relieve diabetic encephalopathy via inhibiting apoptosis and oxidative stress
α-asarone activates mitophagy to relieve diabetic encephalopathy via inhibiting apoptosis and oxidative stress
Diabetic encephalopathy (DE) is a common complication of diabetes that may result in cognitive impairment. Currently, ther...
Neuroprotective effects of L-carnitine towards oxidative stress and inflammatory processes: a review of its importance as a therapeutic drug in some disorders
Neuroprotective effects of L-carnitine towards oxidative stress and inflammatory processes: a review of its importance as a therapeutic drug in some disorders
L-carnitine (LC) is a natural compound crucial for transporting long-chain fatty acids into mitochondria for ATP productio...
Unraveling the role of Nrf2 in dopaminergic neurons: a review of oxidative stress and mitochondrial dysfunction in Parkinson’s disease
Unraveling the role of Nrf2 in dopaminergic neurons: a review of oxidative stress and mitochondrial dysfunction in Parkinson’s disease
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcriptional factor, involved in the regulation of c...
Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis
Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis
The gut microbiota plays a crucial role in the communication between the gut, liver, and brain through the production of s...
Sodium butyrate ameliorates mitochondrial oxidative stress and alterations in membrane-bound enzyme activities in pentylenetetrazole-induced kindling rat model
Sodium butyrate ameliorates mitochondrial oxidative stress and alterations in membrane-bound enzyme activities in pentylenetetrazole-induced kindling rat model
Epilepsy is a chronic neurological disorder manifested through repeatedly recurrent unprovoked seizures. It is a debilitat...
Glutamate/GABA/glutamine ratios in intact and ischemia reperfusion challenged rat brain subregions, the effect of ischemic preconditioning
Glutamate/GABA/glutamine ratios in intact and ischemia reperfusion challenged rat brain subregions, the effect of ischemic preconditioning
The proper function of the brain is entirely dependent on intact neurotransmission, where glutamate (Glu) and γ-amino...
TIPS and hepatic encephalopathy in patients with cirrhosis
TIPS and hepatic encephalopathy in patients with cirrhosis
Despite a better understanding in its prognosis and pathogenesis, hepatic encephalopathy (HE) remains one of the major com...
Altered gut microbiome and serum metabolome profiles associated with essential tremor
Altered gut microbiome and serum metabolome profiles associated with essential tremor
The genetic predisposition and environmental factors both trigger the complex neurological dyskinesia of essential tremor ...
Impact of neuroinflammation on brain glutamate and dopamine signalling in schizophrenia: an update
Impact of neuroinflammation on brain glutamate and dopamine signalling in schizophrenia: an update
Schizophrenia is one of the most severe and chronic psychiatric disorders. Over the years, numerous treatment options have...
The effects of ursodeoxycholic acid on Parkinson’s disease, a mechanistic review of the recent evidence
The effects of ursodeoxycholic acid on Parkinson’s disease, a mechanistic review of the recent evidence
Introduction. Parkinson`s disease stands as the second-most widespread neurodegenerative disorder. Parkinson`s disease is ...
Brain interleukins and Alzheimer’s disease
Brain interleukins and Alzheimer’s disease
The central nervous system (CNS) is immune-privileged by several immuno-modulators as interleukins (ILs). ILs are cytokine...
The protective efficacy of omega-3 polyunsaturated fatty acids on oxidative stress, inflammation, neurotransmitter perturbations, and apoptosis induced by monosodium glutamate in the brain of male rats
The protective efficacy of omega-3 polyunsaturated fatty acids on oxidative stress, inflammation, neurotransmitter perturbations, and apoptosis induced by monosodium glutamate in the brain of male rats
Exaggerated neuronal excitation by glutamate is a well-known cause of excitotoxicity, a key factor in numerous neurodegene...
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione protects against MPP+-induced neurotoxicity by ameliorating oxidative stress, apoptosis and autophagy in SH-SY5Y cells
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione protects against MPP+-induced neurotoxicity by ameliorating oxidative stress, apoptosis and autophagy in SH-SY5Y cells
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione (DMDD) is a cyclohexanedione compound extracted from the roots of Averrho...
The potential of alphapinene as a therapeutic agent for maternal hypoxia-induced cognitive impairments: a study on HO-1 and Nrf2 gene expression in rats
The potential of alphapinene as a therapeutic agent for maternal hypoxia-induced cognitive impairments: a study on HO-1 and Nrf2 gene expression in rats
This research seeks to address the gap in past studies by examining the role of the Nrf2 (nuclear factor erythroid 2-relat...
Acute lipid droplet accumulation induced by the inhibition of the phospholipase DDHD2 does not affect the level, solubility, or phosphoserine-129 status of α-synuclein
Acute lipid droplet accumulation induced by the inhibition of the phospholipase DDHD2 does not affect the level, solubility, or phosphoserine-129 status of α-synuclein
α-Synuclein (αS) is a 140 amino-acid neuronal protein highly enriched in presynaptic nerve terminals. Its progre...
Attenuating hyperammonemia preserves protein synthesis and muscle mass via restoration of perturbed metabolic pathways in bile duct-ligated rats
Attenuating hyperammonemia preserves protein synthesis and muscle mass via restoration of perturbed metabolic pathways in bile duct-ligated rats
Sarcopenia and hepatic encephalopathy (HE) are complications of chronic liver disease (CLD), which negatively impact clini...
Exploring the molecular characterization of PANoptosis-related genes with features of immune dysregulation in Alzheimer’s disease based on bulk and single-nuclei RNA sequencing
Exploring the molecular characterization of PANoptosis-related genes with features of immune dysregulation in Alzheimer’s disease based on bulk and single-nuclei RNA sequencing
The immune system has emerged as a major factor in the pathogenesis of Alzheimer’s disease (AD). PANoptosis is a new...
Exploring the mechanism of Radix Bupleuri in the treatment of depression combined with SARS-CoV-2 infection through bioinformatics, network pharmacology, molecular docking, and molecular dynamic simulation
Exploring the mechanism of Radix Bupleuri in the treatment of depression combined with SARS-CoV-2 infection through bioinformatics, network pharmacology, molecular docking, and molecular dynamic simulation
Radix Bupleuri is commonly used in treating depression and acute respiratory diseases such as SARS-CoV-2 infection in Chin...
Integrating network pharmacology and experimental verification to reveal the ferroptosis-associated mechanism of Changpu-Yizhi-Wan in the treatment of Alzheimer's disease
Integrating network pharmacology and experimental verification to reveal the ferroptosis-associated mechanism of Changpu-Yizhi-Wan in the treatment of Alzheimer's disease
To explore the pharmacological mechanism of Changpu-Yizhi-Wan (CYW) in the treatment of Alzheimer’s disease (AD) fro...
L-carnitine protects against oxidative damage and neuroinflammation in cerebral cortex of rats submitted to chronic chemically-induced model of hyperphenylalaninemia
L-carnitine protects against oxidative damage and neuroinflammation in cerebral cortex of rats submitted to chronic chemically-induced model of hyperphenylalaninemia
Phenylketonuria is a genetic disorder characterized by high phenylalanine levels, the main toxic metabolite of the disease...
Lactulose use among patients with alcohol-related liver cirrhosis as a surrogate marker of hepatic encephalopathy: prevalence and association with mortality - a Danish nationwide cohort study
Lactulose use among patients with alcohol-related liver cirrhosis as a surrogate marker of hepatic encephalopathy: prevalence and association with mortality - a Danish nationwide cohort study
Background & aims: Hepatic encephalopathy (HE), one of the most serious prognostic factors for mortality in alcoho...
Emerging role of adaptive immunity in diabetes-induced cognitive impairment: from the periphery to the brain
Emerging role of adaptive immunity in diabetes-induced cognitive impairment: from the periphery to the brain
Diabetic cognitive impairment (DCI) is a central nervous system complication induced by peripheral metabolic dysfunction o...
Hepatic encephalopathy in non-cirrhotic portal hypertension
Hepatic encephalopathy in non-cirrhotic portal hypertension
Hepatic encephalopathy (HE) is traditionally associated with hepatic parenchymal diseases, such as acute liver failure and...
Drug delivery strategies for the treatment of relapse behavior in substance use disorder- A systematic review
Drug delivery strategies for the treatment of relapse behavior in substance use disorder- A systematic review
Substance use disorders (SUDs) pose a significant global health challenge, with relapse being a major obstacle in achievin...
Ammonia and beyond – biomarkers of hepatic encephalopathy
Ammonia and beyond – biomarkers of hepatic encephalopathy
Ammonia is a product of amino acid metabolism that accumulates in the blood of patients with liver cirrhosis, leading to n...
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