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Tribuli Fructus alleviates 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease by suppressing neuroinflammation via JNK signaling
Tribuli Fructus alleviates 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease by suppressing neuroinflammation via JNK signaling
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons. In partic...
HMG-CoA reductase inhibitor simvastatin ameliorates trimethyltin neurotoxicity and cognitive impairment through reversal of Alzheimer’s-associated markers
HMG-CoA reductase inhibitor simvastatin ameliorates trimethyltin neurotoxicity and cognitive impairment through reversal of Alzheimer’s-associated markers
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder in elderly. The neurotoxicant trimethyltin (TMT) ...
Increased ROS levels, antioxidant defense disturbances and bioenergetic disruption induced by thiosulfate administration in the brain of neonatal rats
Increased ROS levels, antioxidant defense disturbances and bioenergetic disruption induced by thiosulfate administration in the brain of neonatal rats
Sulfite oxidase deficiencies, either caused by deficiency of the apoenzyme or the molybdenum cofactor, and ethylmalonic en...
Lactobacillus fermentum MCC2760 attenuates neurobehavioral alterations induced by oxidized oils in rats
Lactobacillus fermentum MCC2760 attenuates neurobehavioral alterations induced by oxidized oils in rats
The common practice of reusing deep-fried oil may derange the ability of the brain to counter free radicals and inflammato...
Insights into risk factors and outcomes of post-stroke seizures in Saudi Arabia: a multicenter analysis
Insights into risk factors and outcomes of post-stroke seizures in Saudi Arabia: a multicenter analysis
Post-stroke seizures present a global challenge, yet its frequency and factors associated with its incidence are poorly do...
Emerging role of Nrf2 in Parkinson’s disease therapy: a critical reassessment
Emerging role of Nrf2 in Parkinson’s disease therapy: a critical reassessment
Parkinson’s disease (PD) is the neurodegenerative disorder characterized by the progressive degeneration of nigrostr...
Pyridoxine supplementation before puberty ameliorates MAM-induced cognitive and sensorimotor gating impairments
Pyridoxine supplementation before puberty ameliorates MAM-induced cognitive and sensorimotor gating impairments
Schizophrenia is a kind of neurodevelopmental mental disorder in which patients begin to experience changes early in their...
Energy restriction inhibits β-catenin ubiquitination to improve ischemic stroke injury via USP18/SKP2 axis
Energy restriction inhibits β-catenin ubiquitination to improve ischemic stroke injury via USP18/SKP2 axis
Ischemic stroke (IS) remains a global health issue because of its great disability and mortality. Energy restriction (ER) ...
Ketogenic diet as a therapeutic approach in autism spectrum disorder: a narrative review
Ketogenic diet as a therapeutic approach in autism spectrum disorder: a narrative review
The ketogenic diet (KD) originated in the 1920s. It is a dietary model that is low in carbohydrates, adequate in protein, ...
Assessment of blood-brain barrier injury in hypertensive CSVD by 11.7TMR T1mapping and microvascular pathologic changes
Assessment of blood-brain barrier injury in hypertensive CSVD by 11.7TMR T1mapping and microvascular pathologic changes
We used spontaneously hypertensive rats (SHR) as a hypertensive cerebral small vessel disease (CSVD) model to quantify blo...
Therapeutic potential of the extract of giant millipede Telodeinopus Canaliculatus on epileptogenesis and associated anxiety-like behavior
Therapeutic potential of the extract of giant millipede Telodeinopus Canaliculatus on epileptogenesis and associated anxiety-like behavior
The secretions of Telodeinopus canaliculatus, a giant millipede, are used in traditional medicine to treat epileptic seizu...
Macaiba palm pulp (Acrocomia intumescens Drude) improves memory and induces anxiolytic-like behavior in dyslipidemic rats
Macaiba palm pulp (Acrocomia intumescens Drude) improves memory and induces anxiolytic-like behavior in dyslipidemic rats
Macaiba pulp is a source of bioactive compounds. This study aimed to evaluate the effects of macaiba pulp on anxiety behav...
Regulation of the blood-brain barrier function by peripheral cues in health and disease
Regulation of the blood-brain barrier function by peripheral cues in health and disease
The blood-brain barrier (BBB) is formed by microvascular endothelial cells which are ensembled with pericytes, astrocytes,...
Exploring role of citrus fruits in comorbid neurodegenerative disorders associated with psoriasis
Exploring role of citrus fruits in comorbid neurodegenerative disorders associated with psoriasis
A neurodegenerative illness is a disorder in which the brain and/or spinal cord’s neurons, or nerve cells, gradually...
Intricate mechanism of anxiety disorder, recognizing the potential role of gut microbiota and therapeutic interventions
Intricate mechanism of anxiety disorder, recognizing the potential role of gut microbiota and therapeutic interventions
Anxiety is a widespread psychological disorder affecting both humans and animals. It is a typical stress reaction; however...
CD47 signaling induces hepatic cell death and microglia activation during hepatic encephalopathy
CD47 signaling induces hepatic cell death and microglia activation during hepatic encephalopathy
Acute liver failure results from severe hepatic injury and can lead to neurological dysfunction known as hepatic encephalo...
Value of systemic inflammation markers for the detection of minimal and prediction of overt hepatic encephalopathy after TIPS insertion
Value of systemic inflammation markers for the detection of minimal and prediction of overt hepatic encephalopathy after TIPS insertion
Development of overt hepatic encephalopathy (oHE) is a particularly feared complication when considering treatment with tr...
Effects of ginger root extract on cognitive impairment and the Nrf2/GPX4/SLC7A11 signaling pathway in aluminum-exposed rats
Effects of ginger root extract on cognitive impairment and the Nrf2/GPX4/SLC7A11 signaling pathway in aluminum-exposed rats
Aluminum exposure has been widely demonstrated to cause cognitive impairment and neuronal damage, which are significant fa...
New alternative approaches to stroke treatment: the blood cell–derived secretome shows promise in individuals with obesity
New alternative approaches to stroke treatment: the blood cell–derived secretome shows promise in individuals with obesity
Ischaemic tolerance induced by remote ischaemic conditioning (RIC) has been extensively demonstrated in several preclinica...
Altered spontaneous brain activity in patients with progressive-stage and end-stage chronic kidney disease: insights from dALFF analysis
Altered spontaneous brain activity in patients with progressive-stage and end-stage chronic kidney disease: insights from dALFF analysis
Chronic kidney disease (CKD) is a worldwide public health problem. Its association with cognitive impairment has attracted...
12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial
12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial
Multiple sclerosis (MS) can induce cardiac autonomic dysfunction identified by a decreased heart rate variability (HRV) wh...
Bile duct ligation-induced cirrhosis does not alter the blood-brain barrier permeability to sucrose in rats
Bile duct ligation-induced cirrhosis does not alter the blood-brain barrier permeability to sucrose in rats
Contradictory results have been reported about the effects of liver diseases on the blood-brain barrier (BBB) permeability...
Effects of chronic empathic stress on synaptic efficacy, as well as short-term and long-term plasticity at the Schaffer collateral/commissural– CA1 synapses in the dorsal hippocampus of rats
Effects of chronic empathic stress on synaptic efficacy, as well as short-term and long-term plasticity at the Schaffer collateral/commissural– CA1 synapses in the dorsal hippocampus of rats
Empathy, the ability to comprehend and share others’ emotional states, impacts brain functions. This in viv...
Down the road towards hepatic encephalopathy. Urea synthesis - the liver workhorse of nitrogen metabolism
Down the road towards hepatic encephalopathy. Urea synthesis - the liver workhorse of nitrogen metabolism
Urea synthesis is an irreversible, essential for maintenance of health and life, and highly regulated liver function with ...
Down the road towards hepatic encephalopathy. The elusive ammonia– what determines the arterial concentration?
Down the road towards hepatic encephalopathy. The elusive ammonia– what determines the arterial concentration?
Elevated arterial ammonia is associated with several complications of liver disease as it predicts mortality for in-patien...
Systems of care that improve outcomes for people with hepatic encephalopathy
Systems of care that improve outcomes for people with hepatic encephalopathy
Hepatic encephalopathy (HE) is a critical neuropsychiatric complication of liver cirrhosis with a significant impact on pa...
Ganoderic acid a alleviates Aβ25−35-induced HT22 cell apoptosis through the ERK/MAPK pathway: a system pharmacology and in vitro experimental validation
Ganoderic acid a alleviates Aβ25−35-induced HT22 cell apoptosis through the ERK/MAPK pathway: a system pharmacology and in vitro experimental validation
Alzheimer’s disease (AD) is a neurodegenerative disorder that occurs with aging. Ganoderma lucidum (Curtis.) P. Kars...
Blood-based microRNAs as the potential biomarkers for Alzheimer’s disease: evidence from a systematic review
Blood-based microRNAs as the potential biomarkers for Alzheimer’s disease: evidence from a systematic review
Alzheimer’s disease (AD) is a neurodegenerative disorder that progresses over time and is identified by the developm...
Integrated colon microbiome and metabolomics to elucidate the antidepressant mechanisms of the Radix Bupleuri-Radix Paeoniae Alba herb pair
Integrated colon microbiome and metabolomics to elucidate the antidepressant mechanisms of the Radix Bupleuri-Radix Paeoniae Alba herb pair
Radix Bupleuri-Radix Paeoniae Alba herb pair (RB-RPA) is the fundamental medication combination of many classic antidepres...
Hyperammonaemic encephalopathy due to non-functioning urea cycle as a complication to gastric bypass surgery
Hyperammonaemic encephalopathy due to non-functioning urea cycle as a complication to gastric bypass surgery
Hyperammonaemic encephalopathy in the absence of liver failure is a major diagnostic challenge. A rare cause is as a compl...
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