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Exploring the molecular characterization of PANoptosis-related genes with features of immune dysregulation in Alzheimer’s disease based on bulk and single-nuclei RNA sequencing
Exploring the molecular characterization of PANoptosis-related genes with features of immune dysregulation in Alzheimer’s disease based on bulk and single-nuclei RNA sequencing
The immune system has emerged as a major factor in the pathogenesis of Alzheimer’s disease (AD). PANoptosis is a new...
Exploring the mechanism of Radix Bupleuri in the treatment of depression combined with SARS-CoV-2 infection through bioinformatics, network pharmacology, molecular docking, and molecular dynamic simulation
Exploring the mechanism of Radix Bupleuri in the treatment of depression combined with SARS-CoV-2 infection through bioinformatics, network pharmacology, molecular docking, and molecular dynamic simulation
Radix Bupleuri is commonly used in treating depression and acute respiratory diseases such as SARS-CoV-2 infection in Chin...
Integrating network pharmacology and experimental verification to reveal the ferroptosis-associated mechanism of Changpu-Yizhi-Wan in the treatment of Alzheimer's disease
Integrating network pharmacology and experimental verification to reveal the ferroptosis-associated mechanism of Changpu-Yizhi-Wan in the treatment of Alzheimer's disease
To explore the pharmacological mechanism of Changpu-Yizhi-Wan (CYW) in the treatment of Alzheimer’s disease (AD) fro...
L-carnitine protects against oxidative damage and neuroinflammation in cerebral cortex of rats submitted to chronic chemically-induced model of hyperphenylalaninemia
L-carnitine protects against oxidative damage and neuroinflammation in cerebral cortex of rats submitted to chronic chemically-induced model of hyperphenylalaninemia
Phenylketonuria is a genetic disorder characterized by high phenylalanine levels, the main toxic metabolite of the disease...
Lactulose use among patients with alcohol-related liver cirrhosis as a surrogate marker of hepatic encephalopathy: prevalence and association with mortality - a Danish nationwide cohort study
Lactulose use among patients with alcohol-related liver cirrhosis as a surrogate marker of hepatic encephalopathy: prevalence and association with mortality - a Danish nationwide cohort study
Background & aims: Hepatic encephalopathy (HE), one of the most serious prognostic factors for mortality in alcoho...
Emerging role of adaptive immunity in diabetes-induced cognitive impairment: from the periphery to the brain
Emerging role of adaptive immunity in diabetes-induced cognitive impairment: from the periphery to the brain
Diabetic cognitive impairment (DCI) is a central nervous system complication induced by peripheral metabolic dysfunction o...
Hepatic encephalopathy in non-cirrhotic portal hypertension
Hepatic encephalopathy in non-cirrhotic portal hypertension
Hepatic encephalopathy (HE) is traditionally associated with hepatic parenchymal diseases, such as acute liver failure and...
Drug delivery strategies for the treatment of relapse behavior in substance use disorder- A systematic review
Drug delivery strategies for the treatment of relapse behavior in substance use disorder- A systematic review
Substance use disorders (SUDs) pose a significant global health challenge, with relapse being a major obstacle in achievin...
Ammonia and beyond – biomarkers of hepatic encephalopathy
Ammonia and beyond – biomarkers of hepatic encephalopathy
Ammonia is a product of amino acid metabolism that accumulates in the blood of patients with liver cirrhosis, leading to n...
Mechanistic insight into neuroprotective effect of standardized ginger chemo varieties from Manipur, India in scopolamine induced learning and memory impaired mice
Mechanistic insight into neuroprotective effect of standardized ginger chemo varieties from Manipur, India in scopolamine induced learning and memory impaired mice
Alzheimer’s disease is a complex neurodegenerative disease characterized by progressive decline in cognitive functio...
TeMac™ ameliorates memory impairment and cholinergic dysfunction in rats induced by scopolamine
TeMac™ ameliorates memory impairment and cholinergic dysfunction in rats induced by scopolamine
Alzheimer’s disease (AD) is associated with cognitive impairments which are linked to a deficit in cholinergic funct...
LCN2 blockade mitigating metabolic dysregulation and redefining appetite control in type 2 diabetes
LCN2 blockade mitigating metabolic dysregulation and redefining appetite control in type 2 diabetes
LCN2 has an osteokine important for appetite regulation; in type 2 diabetes (T2D) it is not known whether appetite regulat...
The CD74 inhibitor DRhQ improves short-term memory and mitochondrial function in 5xFAD mouse model of Aβ accumulation
The CD74 inhibitor DRhQ improves short-term memory and mitochondrial function in 5xFAD mouse model of Aβ accumulation
Neuroinflammation and mitochondrial dysfunction are early events in Alzheimer’s disease (AD) and contribute to neuro...
Genistein-3'-sodium sulfonate suppresses NLRP3-mediated cell pyroptosis after cerebral ischemia
Genistein-3'-sodium sulfonate suppresses NLRP3-mediated cell pyroptosis after cerebral ischemia
Cerebral ischemia-induced pyroptosis contributes to the dissemination of neuroinflammation, and Nod-like receptor protein-...
Citrobacter rodentium promotes brain cognitive dysfunction of type 2 diabetes mice by activating FXR mediated gut barrier damage
Citrobacter rodentium promotes brain cognitive dysfunction of type 2 diabetes mice by activating FXR mediated gut barrier damage
Type 2 diabetes (T2D) is an important risk factor for brain cognitive impairment, but the specific mechanism is still uncl...
New insights on the regulators and inhibitors of RhoA-ROCK signalling in Parkinson’s disease
New insights on the regulators and inhibitors of RhoA-ROCK signalling in Parkinson’s disease
A multifaceted and widely prevalent neurodegenerative disease, Parkinson's disease (PD) is typified by the loss of dop...
Aerobic exercise and metformin attenuate the cognitive impairment in an experimental model of type 2 diabetes mellitus: focus on neuroinflammation and adult hippocampal neurogenesis
Aerobic exercise and metformin attenuate the cognitive impairment in an experimental model of type 2 diabetes mellitus: focus on neuroinflammation and adult hippocampal neurogenesis
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that increases the prevalence of cognitive impairment in t...
Ginkgo biloba extract mediates HT22 cell proliferation and migration after oxygen–glucose deprivation/reoxygenation via regulating RhoA-ROCK2 signalling pathway
Ginkgo biloba extract mediates HT22 cell proliferation and migration after oxygen–glucose deprivation/reoxygenation via regulating RhoA-ROCK2 signalling pathway
Vascular dementia (VD) is a neurocognitive disorder resulting from cerebral vascular disorders, leading to the demise of n...
Metabolic disorders after traumatic brain injury: a narrative review of systemic consequences
Metabolic disorders after traumatic brain injury: a narrative review of systemic consequences
Traumatic brain injury (TBI) is characterized as a heterogeneous and pathological remodeling of brain physiology because o...
Metabolomics analyses and comparative insight to neuroprotective potential of unripe fruits and leaves of Citrus aurantium ethanolic extracts against cadmium-induced rat brain dysfunction: involvement of oxidative stress and akt-mediated CREB/BDNF and GSK3β/NF-κB signaling pathways
Metabolomics analyses and comparative insight to neuroprotective potential of unripe fruits and leaves of Citrus aurantium ethanolic extracts against cadmium-induced rat brain dysfunction: involvement of oxidative stress and akt-mediated CREB/BDNF and GSK3β/NF-κB signaling pathways
Serious neurological disorders were associated with cadmium toxicity. Hence, this research aimed to investigate the potent...
Resilience mechanisms underlying Alzheimer’s disease
Resilience mechanisms underlying Alzheimer’s disease
Alzheimer’s disease (AD) consists of two main pathologies, which are the deposition of amyloid plaque as well as tau...
Jaranol alleviates cognitive impairment in db/db mice through the PI3K/AKT pathway
Jaranol alleviates cognitive impairment in db/db mice through the PI3K/AKT pathway
The widely used Radix Astragali (RA) has significant therapeutic effects on cognitive impairment (CI) caused by type 2 dia...
Eugenol attenuates aluminium-induced neurotoxicity in rats by inhibiting the activation of STAT3 and NF-кB
Eugenol attenuates aluminium-induced neurotoxicity in rats by inhibiting the activation of STAT3 and NF-кB
Aluminium is a common metallic toxicant that easily penetrates the brain and exerts severe pathological effects e.g., oxid...
Associations between stress hyperglycemia and outcomes in patients with ischemic stroke and TIA: the data comes from the Third China National Stroke Registry (CNSR-III).
Associations between stress hyperglycemia and outcomes in patients with ischemic stroke and TIA: the data comes from the Third China National Stroke Registry (CNSR-III).
In the acute stage of stroke, stress hyperglycemia is common in both diabetic and nondiabetic patients. The associations b...
Exosomes and non-coding RNAs: bridging the gap in Alzheimer’s pathogenesis and therapeutics
Exosomes and non-coding RNAs: bridging the gap in Alzheimer’s pathogenesis and therapeutics
Alzheimer’s disease (AD) is a neurodegenerative disease that primarily affects the elderly population and is the lea...
Alzheimer’s disease and diabetes-associated cognitive dysfunction: the microglia link?
Alzheimer’s disease and diabetes-associated cognitive dysfunction: the microglia link?
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) plaques and the aggregatio...
Exploring SERPINA3 as a neuroinflammatory modulator in Alzheimer’s disease with sex and regional brain variations
Exploring SERPINA3 as a neuroinflammatory modulator in Alzheimer’s disease with sex and regional brain variations
SERPINA3, a serine protease inhibitor, is strongly associated with neuroinflammation, a typical condition of AD. Its expre...
Cerebral oxygen saturation in cirrhotic patients with gastro-intestinal bleeding, a near infrared spectroscopy study
Cerebral oxygen saturation in cirrhotic patients with gastro-intestinal bleeding, a near infrared spectroscopy study
Near Infrared Spectroscopy (NIRS) is a non-invasive optical technique allowing a continuous measurement of brain’s h...
Selective diagnostics of Amyotrophic Lateral Sclerosis, Alzheimer’s and Parkinson’s Diseases with machine learning and miRNA
Selective diagnostics of Amyotrophic Lateral Sclerosis, Alzheimer’s and Parkinson’s Diseases with machine learning and miRNA
The diagnosis of neurological diseases can be expensive, invasive, and inaccurate, as it is often difficult to distinguish...
Chitosan lactate improves repeated closed head injury-generated motor and neurological dysfunctions in mice by impacting microbiota gut-brain axis
Chitosan lactate improves repeated closed head injury-generated motor and neurological dysfunctions in mice by impacting microbiota gut-brain axis
The negative impact of repeated-mild traumatic brain injury (rmTBI) is profoundly seen in circadian-disrupted individuals....
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