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Amyloid-independent pathogenesis for Alzheimer’s disease: implications for drug design
Amyloid-independent pathogenesis for Alzheimer’s disease: implications for drug design
Alzheimer’s disease (AD) is characterized pathologically by cerebral deposits of the amyloid β-peptide (Aβ...
Sulfur (VI) fluoride exchange (SuFEx): a versatile tool to profile protein-biomolecule interactions for therapeutic development
Sulfur (VI) fluoride exchange (SuFEx): a versatile tool to profile protein-biomolecule interactions for therapeutic development
Sulfur (VI) fluoride exchange (SuFEx), a new generation of click chemistry, enables the creation of a stable covalent link...
Advances in anticancer applications of platinum(II) complexes of dithiocarbamates
Advances in anticancer applications of platinum(II) complexes of dithiocarbamates
This review presents an overview of the antitumor properties of various platinum(II) complexes of dithiocarbamates. It has...
Reversible in-situ assembly of PROTACs using iminoboronate conjugation
Reversible in-situ assembly of PROTACs using iminoboronate conjugation
Proteolysis targeting chimeras (PROTACs) offer a promising degradation-based alternative to classical inhibition-based the...
In silico drug discovery: a machine learning-driven systematic review
In silico drug discovery: a machine learning-driven systematic review
This systematic review, which was carried out between 2018 and 2022 in accordance with PRISMA principles, assesses how mac...
Development of novel fluoro-substituted rivastigmine derivatives as selective AChE inhibitors for the treatment of AD
Development of novel fluoro-substituted rivastigmine derivatives as selective AChE inhibitors for the treatment of AD
The classic cholinergic hypothesis was considered as the successful hypothesis due to the marketed drugs (donepezil, rivas...
Pharmacological assessment of disulfide–triazine hybrids: synthesis, enzyme inhibition, and molecular docking study
Pharmacological assessment of disulfide–triazine hybrids: synthesis, enzyme inhibition, and molecular docking study
Acetylcholinesterase (AChE) is indispensable for neurotransmission, while glutathione S-transferase (GST) plays a crucial ...
Revolutionizing drug discovery: an AI-powered transformation of molecular docking
Revolutionizing drug discovery: an AI-powered transformation of molecular docking
AI-based molecular docking, a computational technique fueled by artificial intelligence (AI) algorithms, is transforming t...
New sirtuin modulators: their uncovering, pharmacophore, and implications in drug discovery
New sirtuin modulators: their uncovering, pharmacophore, and implications in drug discovery
Sirtuins are a group of enzymes known as class III histone deacetylases that catalyze the deacetylation reaction and are p...
Discovering cholinesterase inhibitors from Chinese herbal medicine with deep learning models
Discovering cholinesterase inhibitors from Chinese herbal medicine with deep learning models
Traditional Chinese medicine (TCM) holds distinctive advantages in the management of Alzheimer’s disease. Nonetheles...
Position switch of phenylthiazoles: novel compounds with promising anti-MRSA USA300
Position switch of phenylthiazoles: novel compounds with promising anti-MRSA USA300
The discovery of novel antibacterial agents holds promise in mitigating the escalating threat of antimicrobial resistance ...
Glutathione transporter as a target for brain drug delivery
Glutathione transporter as a target for brain drug delivery
Inability to achieve therapeutic concentrations of a medication in the brain due to the blood brain barrier (BBB) is the m...
Synthesis and antiviral property of polysulfate-grafted maleimide-based enediynes
Synthesis and antiviral property of polysulfate-grafted maleimide-based enediynes
Human coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pose a serious threat to ...
Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments
Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments
FXIa has emerged as a promising therapeutic target for treating thrombotic diseases. With the aim to replace the aniline m...
Exploring nucleoside analogs: key targets in the viral life cycle - advancing strategies against SARS-CoV-2
Exploring nucleoside analogs: key targets in the viral life cycle - advancing strategies against SARS-CoV-2
The COVID-19 pandemic has been a major reason behind the increased research aimed at the identification of effective antiv...
Design and synthesis of benzo[d]imidazo-6,7-dihydrobenzo[d] imidazo[2,1-b]thiazol-8(5H)-ones as potent anti-infective agents
Design and synthesis of benzo[d]imidazo-6,7-dihydrobenzo[d] imidazo[2,1-b]thiazol-8(5H)-ones as potent anti-infective agents
In this study, we present a series of 2-(5-chlorothiophen-2-yl)-1H-benzo-[d]-imidazol-2-yl)-6,7-dihydrobenzo-[d]-imidazo[2...
Design and synthesis of indole-based elipticine analogues as topoisomerase IIβ inhibitors
Design and synthesis of indole-based elipticine analogues as topoisomerase IIβ inhibitors
New ellipticine analogs with indole cores were synthesized. and evaluated for their anticancer activity. A new compound, s...
A study of alkene disulfonoxylation
A study of alkene disulfonoxylation
We have developed convenient protocols for alkene disulfonoxylation, which involve stirring alkene substrate with a commer...
Discovery of HNPC-A188: a novel acaricide containing trifluoroethyl thioether and pyrimidin-4-amine
Discovery of HNPC-A188: a novel acaricide containing trifluoroethyl thioether and pyrimidin-4-amine
Pyrimidifen is an excellent commercial acaricide, but it is not low toxic to mammals. Trifluoroethyl thioether derivatives...
Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents
Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents
Kinetoplastids are a group of flagellated protozoans including medically important parasites of the genus Trypanosoma and ...
Morpholinated curcuminoids against urinary bladder cancer cells: synthesis and anticancer evaluation
Morpholinated curcuminoids against urinary bladder cancer cells: synthesis and anticancer evaluation
Cancers present a significant medical problem despite the development of medical and pharmaceutical sciences leading to a ...