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Design, synthesis, and biological evaluation of 2, 4-dichlorophenoxyacetamide chalcone hybrids as potential c-Met kinase inhibitors
Design, synthesis, and biological evaluation of 2, 4-dichlorophenoxyacetamide chalcone hybrids as potential c-Met kinase inhibitors
c-Met is involved in cellular processes that lead to the development and progression of cancer. A series of 2, 4-dichlorop...
Synthesis, antimicrobial, and antioxidant activities of disubstituted 1,2,3-triazoles with amide-hydroxyl functionality
Synthesis, antimicrobial, and antioxidant activities of disubstituted 1,2,3-triazoles with amide-hydroxyl functionality
A series of 1,4-disubstituted 1,2,3-triazoles with amide-hydroxyl functionality (5a–5t) was synthesized from aliphat...
Design, synthesis and anticancer activity studies of novel indole derivatives as Bcl-2/Mcl-1 dual inhibitors
Design, synthesis and anticancer activity studies of novel indole derivatives as Bcl-2/Mcl-1 dual inhibitors
A series of novel indole derivatives were designed, synthesized and evaluated for the binding affinity of Bcl-2 family pro...
Synthesis of myricetin derivatives and evaluation of their hypoglycemic activities
Synthesis of myricetin derivatives and evaluation of their hypoglycemic activities
Myricetin is a common plant-derived flavonoid and exhibits a wide range of activities. However, myricetin also exhibits su...
Synthesis and in vitro antimicrobial evaluation of benzothiazolylindenopyrazoles
Synthesis and in vitro antimicrobial evaluation of benzothiazolylindenopyrazoles
In the present study, a series of benzothiazolylindenopyrazoles 5a‒o has been efficiently synthesized by refluxing a...
Clotrimazole-based hybrid structures of pyrazole and benzimidazole: synthesis, antifungal evaluation and computational studies
Clotrimazole-based hybrid structures of pyrazole and benzimidazole: synthesis, antifungal evaluation and computational studies
Some new N-substituted hetero aromatic compounds, derived from clotrimazole, were synthesized. In this regard, imidazole r...
RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review
RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review
Viral diseases are the cause of many global epidemics, leading to deaths, affecting the quality of life of populations, an...
Sphingosine 1-phosphate receptor modulators for the treatment of inflammatory bowel disease and other immune-mediated diseases
Sphingosine 1-phosphate receptor modulators for the treatment of inflammatory bowel disease and other immune-mediated diseases
Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease involving the ileum, rectum, and colon. ...
Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells
Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells
Imidazo[1,2-a]pyridine cores have increasing importance in the pharmaceutical industry with their wide range pharmacologic...
In vitro antiproliferative activity of Parrotia persica exclusive gallotannin
In vitro antiproliferative activity of Parrotia persica exclusive gallotannin
The aim of this study was to identify the cytotoxic compounds of Parrotia persica plant leaf extracts. Based on the antipr...
The potential of chalcone derivatives as human carbonic anhydrase inhibitors in the therapy of glaucoma
The potential of chalcone derivatives as human carbonic anhydrase inhibitors in the therapy of glaucoma
Despite the significant development of diagnostic procedures and therapeutic options in past few decades, glaucoma is stil...
Synthesis and in vitro SAR evaluation of natural vanillin-based chalcones tethered quinolines as antiplasmodial agents
Synthesis and in vitro SAR evaluation of natural vanillin-based chalcones tethered quinolines as antiplasmodial agents
A series of novel chalcone derivatives were synthesized and investigated against the chloroquine-sensitive P. falciparum 3...
Enhanced biological activity of Curcumin Cinnamates: an experimental and computational analysis
Enhanced biological activity of Curcumin Cinnamates: an experimental and computational analysis
The binding of bioactive component in a drug molecule with proteins is important for their delivery at the target site in ...
4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity
4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity
Three new 4-phenylcoumarins, mesuaferlinns A–C (1–3), together with ten other known 4-phenylcoumarins, 4–...
Synthesis,characterization and biological activities of nitrogen-containing Combretastatin A-4 derivatives
Synthesis,characterization and biological activities of nitrogen-containing Combretastatin A-4 derivatives
A series of new combretastatin A4 derivatives (6a-6c, 9a-12c) containing nitrogen atoms and nitrogen heterocycles were syn...
Synthesis, trypanocidal and cytotoxic activities of α,β-unsaturated ketones derived from eugenol and analogues
Synthesis, trypanocidal and cytotoxic activities of α,β-unsaturated ketones derived from eugenol and analogues
This work describes the synthesis, structural characterization, trypanocide and cytotoxic evaluation of α,β-unsa...
Synthesis, theoretical investigations and biological evaluation of ibuprofen drug hybrids
Synthesis, theoretical investigations and biological evaluation of ibuprofen drug hybrids
In the present work, four Ibuprofen drug hybrids (1–4) were designed by modifying free amino groups of 4-aminoantipy...
Research progress on antidiabetic activity of apigenin derivatives
Research progress on antidiabetic activity of apigenin derivatives
Diabetes has always been a global health issue of great concern. The current treatment methods include oral and injection ...
Synthesis and biological evaluation of (+)-paeoveitol derivatives as novel antidepressants
Synthesis and biological evaluation of (+)-paeoveitol derivatives as novel antidepressants
The antidepressant activity of (+) and (−)-paeoveitol was first evaluated using the forced swimming test (FST), and ...
Synthesis and biological evaluation of new thiazolyl-urea derivatives as potential dual C-RAF/FLT3 inhibitors
Synthesis and biological evaluation of new thiazolyl-urea derivatives as potential dual C-RAF/FLT3 inhibitors
Based on a structure-activity relationship of compounds such as Sorafenib and Quizartinib, a series of thiazol-urea deriva...
Synthesis, biological evaluation, and bioinformatics analysis of indole analogs on AChE and GST activities
Synthesis, biological evaluation, and bioinformatics analysis of indole analogs on AChE and GST activities
In this article, we aimed to (1) synthesize novel 3-substitue 2-methyl indole analogs, and (2) evaluate their biological a...
Cyclohepta[b]pyran: an important scaffold in biologically active natural products
Cyclohepta[b]pyran: an important scaffold in biologically active natural products
Heterocycle-fused cycloheptanoid derivatives are one of the specific natural product scaffolds with a broad range of biolo...
Discovery of novel neuroprotective cinnamoyl-M30D hybrids targeting Alzheimer’s disease
Discovery of novel neuroprotective cinnamoyl-M30D hybrids targeting Alzheimer’s disease
M30D is a new multifunctional compound against AD and joined to FDA-approved drugs exhibits neuroprotective properties; an...