SCI时时刷

search
+
Synthesis, in vitro activity, and molecular docking of caffeic acid and resveratrol derivatives against Alzheimer’s disease-related enzymes
Synthesis, in vitro activity, and molecular docking of caffeic acid and resveratrol derivatives against Alzheimer’s disease-related enzymes
Alzheimer’s disease (AD) is the most common form of dementia affecting about 40 million people around the world. The...
Ultrasound-assisted synthesis of 4-thiazolidinone Schiff bases and their antioxidant, α-glucosidase, α-amylase inhibition, mode of inhibition and computational studies
Ultrasound-assisted synthesis of 4-thiazolidinone Schiff bases and their antioxidant, α-glucosidase, α-amylase inhibition, mode of inhibition and computational studies
Diabetes mellitus (DM) has become a growing concern to global public health, being at the forefront of acute disorders and...
Ronald T. Borchardt: a pioneer in drug discovery and development
Ronald T. Borchardt: a pioneer in drug discovery and development
This issue of Medicinal Chemistry Research is dedicated to the occasion of the 80th b...
Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans
Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans
With the increasing of Candida albicans infections year by year, and the widespread use of azole drugs, especially flucona...
Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model
Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model
Substituted furan carboxamide and Schiff base derivatives were evaluated for their hypolipidemic activity. Fourteen deriva...
Iron porphyrin-mediated production of carbon monoxide from phenylpyruvic acid: from potential therapeutic and diagnostic use to physiological implications
Iron porphyrin-mediated production of carbon monoxide from phenylpyruvic acid: from potential therapeutic and diagnostic use to physiological implications
Because of CO’s known endogenous signaling roles and its demonstrated pharmacological activity at low and safe conce...
Synthesis and anti-leishmanial activities of uniflorol analogues
Synthesis and anti-leishmanial activities of uniflorol analogues
Chromanones are a subset of the benzopyran family, and display diverse biological activities, both as natural products and...
Identification of potential natural product derivatives as CK2 inhibitors based on GA-MLR QSAR modeling, synthesis and biological evaluation
Identification of potential natural product derivatives as CK2 inhibitors based on GA-MLR QSAR modeling, synthesis and biological evaluation
Protein kinase CK2 is a validated target for cancer therapy. Many natural products have shown inhibitory activity against ...
Bexagliflozin: a comprehensive review of a recently approved SGLT2 inhibitor for the treatment of type 2 diabetes mellitus
Bexagliflozin: a comprehensive review of a recently approved SGLT2 inhibitor for the treatment of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) remains a major global health threat, claiming millions of lives annually. Despite recent ...
ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine
ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine
Coordination complexes of cobalt represent a potential alternative to anticancer platinum-derived drugs owing to multiple ...
Potential therapeutic effects of ester derivatives of Ribavirin against SARS-CoV-2
Potential therapeutic effects of ester derivatives of Ribavirin against SARS-CoV-2
Ribavirin (1) esters 4–36 have been synthesized and tested for their anti-inflammatory and anti-viral properties aga...
A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy
A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy
Free radicals like reactive oxygen species (ROS) and reactive nitrogen species (RNS) cause cellular damage and contribute ...
Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2
Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2
The prevailing COVID-19 pandemic, triggered by the novel coronavirus SARS-CoV-2, stands as the predominant global health c...
Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment
Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment
Liver disease is a significant health burden globally and accounts for 4% of total deaths annually. Alcoholic liver diseas...
Peptide-based therapeutics: challenges and solutions
Peptide-based therapeutics: challenges and solutions
Given this special issue honors the scientific contributions of Dr. Ronald Borchardt,...
Redefining the significance of quinoline containing compounds as potent VEGFR-2 inhibitors for cancer therapy
Redefining the significance of quinoline containing compounds as potent VEGFR-2 inhibitors for cancer therapy
Vascular endothelial growth factor receptor-2 (VEGFR-2), a tyrosine kinase receptor (TKR) is frequently overexpressed in m...
Gallic acid derived diarylpropanones exhibit synergistic antibacterial activities
Gallic acid derived diarylpropanones exhibit synergistic antibacterial activities
Development of resistance against most of the clinical antibiotics is a menace to mankind for their use in future. Present...
Amyloid-independent pathogenesis for Alzheimer’s disease: implications for drug design
Amyloid-independent pathogenesis for Alzheimer’s disease: implications for drug design
Alzheimer’s disease (AD) is characterized pathologically by cerebral deposits of the amyloid β-peptide (Aβ...
Sulfur (VI) fluoride exchange (SuFEx): a versatile tool to profile protein-biomolecule interactions for therapeutic development
Sulfur (VI) fluoride exchange (SuFEx): a versatile tool to profile protein-biomolecule interactions for therapeutic development
Sulfur (VI) fluoride exchange (SuFEx), a new generation of click chemistry, enables the creation of a stable covalent link...
Docking-guided exploration of the anti-flt3 potential of isoindigo derivatives towards potential treatments of acute myeloid leukemia
Docking-guided exploration of the anti-flt3 potential of isoindigo derivatives towards potential treatments of acute myeloid leukemia
FMS-like tyrosine kinase 3 (Flt3) is an oncogenic kinase implicated in leukemia, with its primary association being acute ...
Advances in anticancer applications of platinum(II) complexes of dithiocarbamates
Advances in anticancer applications of platinum(II) complexes of dithiocarbamates
This review presents an overview of the antitumor properties of various platinum(II) complexes of dithiocarbamates. It has...
Reversible in-situ assembly of PROTACs using iminoboronate conjugation
Reversible in-situ assembly of PROTACs using iminoboronate conjugation
Proteolysis targeting chimeras (PROTACs) offer a promising degradation-based alternative to classical inhibition-based the...
N-Benzyl, N-phenethyl and N-benzyloxybenzamide derivatives inhibit amyloid-beta (Aβ42) aggregation and mitigate Aβ42-induced neurotoxicity
N-Benzyl, N-phenethyl and N-benzyloxybenzamide derivatives inhibit amyloid-beta (Aβ42) aggregation and mitigate Aβ42-induced neurotoxicity
A library of N-benzylbenzamide, N-phenethylbenzamide and N-benzyloxybenzamide derivatives were designed, synthesized and e...
In silico drug discovery: a machine learning-driven systematic review
In silico drug discovery: a machine learning-driven systematic review
This systematic review, which was carried out between 2018 and 2022 in accordance with PRISMA principles, assesses how mac...
Current trends and future directions for the synthesis and pharmacological applications of 2-(2-cyanopyrrolidin-1-yl)-N-3-hydroxyadamantan-1-yl) acetamide (Gliptins)
Current trends and future directions for the synthesis and pharmacological applications of 2-(2-cyanopyrrolidin-1-yl)-N-3-hydroxyadamantan-1-yl) acetamide (Gliptins)
Dipeptidyl peptidase 4 (DPP-4), well known as the T-cell antigen CD26 enzyme which, was discovered in the year of 1966 by ...
Unlocking therapeutic potential: exploring indole scaffolds and their structural insights as pharmacophores in designing anti-breast cancer agents
Unlocking therapeutic potential: exploring indole scaffolds and their structural insights as pharmacophores in designing anti-breast cancer agents
Indole scaffolds are well-documented for their biological accessibility and broader therapeutic applications. The cellular...
Development of novel fluoro-substituted rivastigmine derivatives as selective AChE inhibitors for the treatment of AD
Development of novel fluoro-substituted rivastigmine derivatives as selective AChE inhibitors for the treatment of AD
The classic cholinergic hypothesis was considered as the successful hypothesis due to the marketed drugs (donepezil, rivas...
Pharmacological assessment of disulfide–triazine hybrids: synthesis, enzyme inhibition, and molecular docking study
Pharmacological assessment of disulfide–triazine hybrids: synthesis, enzyme inhibition, and molecular docking study
Acetylcholinesterase (AChE) is indispensable for neurotransmission, while glutathione S-transferase (GST) plays a crucial ...
Revolutionizing drug discovery: an AI-powered transformation of molecular docking
Revolutionizing drug discovery: an AI-powered transformation of molecular docking
AI-based molecular docking, a computational technique fueled by artificial intelligence (AI) algorithms, is transforming t...
New sirtuin modulators: their uncovering, pharmacophore, and implications in drug discovery
New sirtuin modulators: their uncovering, pharmacophore, and implications in drug discovery
Sirtuins are a group of enzymes known as class III histone deacetylases that catalyze the deacetylation reaction and are p...
阅读更多
format_indent_increase