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Cathelicidins Induce Toll-Interacting Protein Synthesis to Prevent Apoptosis in Colonic Epithelium
Cathelicidins Induce Toll-Interacting Protein Synthesis to Prevent Apoptosis in Colonic Epithelium
Cathelicidin peptides secreted by leukocytes and epithelial cells are microbicidal but also regulate pathogen sensing via ...
Ex vivo and in vitro Monocyte Responses Do Not Reflect in vivo Immune Responses and Tolerance
Ex vivo and in vitro Monocyte Responses Do Not Reflect in vivo Immune Responses and Tolerance
Cytokine production by ex vivo (EV)-stimulated leukocytes is commonly used to gauge immune function and frequently propose...
Procoagulant Activity of Blood and Microvesicles Is Disturbed by Pneumococcal Pneumolysin, Which Interacts with Coagulation Factors
Procoagulant Activity of Blood and Microvesicles Is Disturbed by Pneumococcal Pneumolysin, Which Interacts with Coagulation Factors
The coagulation and contact systems are parts of the innate immune system as they prevent bleeding and dissemination of pa...
Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19
Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19
Mannose-binding lectin-associated serine protease 2 (MASP-2) is the main activator of the lectin complement pathway and ha...
Slc6a13 Deficiency Attenuates Pasteurella multocida Infection-Induced Inflammation via Glycine-Inflammasome Signaling
Slc6a13 Deficiency Attenuates Pasteurella multocida Infection-Induced Inflammation via Glycine-Inflammasome Signaling
We have previously demonstrated that Slc6a13-deficient (Slc6a13−/−; KO) mice are resistant to <i>P</i>. <i&...
Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA
Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA
Macrophages promote an early host response to infection by releasing pro-inflammatory cytokines such as interleukin (IL) 1...
Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways
Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways
Respiratory influenza A virus (IAV) infection continues to pose significant challenges in healthcare of human diseases inc...
Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections
Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections
Virus infections of the central nervous system (CNS) cause important diseases of humans and animals. As in other tissues, ...
Regulation of TLR10 Expression and Its Role in Chemotaxis of Human Neutrophils
Regulation of TLR10 Expression and Its Role in Chemotaxis of Human Neutrophils
Toll-like receptors are innate immune receptors that play a critical role in pathogen-associated molecular pattern recogni...
Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex
Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex
Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of t...
IL-1 Mediates Tissue-Specific Inflammation and Severe Respiratory Failure in COVID-19
IL-1 Mediates Tissue-Specific Inflammation and Severe Respiratory Failure in COVID-19
Acute respiratory distress syndrome (ARDS) in COVID-19 has been associated with catastrophic inflammation. We present meas...
Bruton’s Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae
Bruton’s Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae
Humans with dysfunctional Bruton’s tyrosine kinase (Btk) are highly susceptible to bacterial infections. Compelling eviden...
HMGB1-Like Dorsal Switch Protein 1 Triggers a Damage Signal in Mosquito Gut to Activate Dual Oxidase via Eicosanoids
HMGB1-Like Dorsal Switch Protein 1 Triggers a Damage Signal in Mosquito Gut to Activate Dual Oxidase via Eicosanoids
Several mosquitoes transmit human pathogens by blood feeding, with the gut being the main entrance for the pathogens. Thus...
Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions
Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions
The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate...
Staphylococcus aureus Activates the Aryl Hydrocarbon Receptor in Human Keratinocytes
Staphylococcus aureus Activates the Aryl Hydrocarbon Receptor in Human Keratinocytes
<i>Staphylococcus aureus</i> is an important pathogen causing various infections, including – as most frequent...
GDF15 Suppresses Lymphoproliferation and Humoral Autoimmunity in a Murine Model of Systemic Lupus Erythematosus
GDF15 Suppresses Lymphoproliferation and Humoral Autoimmunity in a Murine Model of Systemic Lupus Erythematosus
Growth and differentiation factor 15 (GDF15), a divergent member of the transforming growth factor-β superfamily, has been...
The Capsule of Acinetobacter baumannii Protects against the Innate Immune Response
The Capsule of Acinetobacter baumannii Protects against the Innate Immune Response
<i>Acinetobacter baumannii</i> is an opportunistic pathogen that has recently emerged as a global threat assoc...
The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases
The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases
Citrullination of proteins is crucial for the formation of neutrophil extracellular traps (NETs) – strands of nuclear DNA ...
Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production
Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production
Stimulator of interferon genes (STING) plays a pivotal role in type I interferon-mediated innate immune response to the cy...
Impaired Degradation of Neutrophil Extracellular Traps: A Possible Severity Factor of Elderly Male COVID-19 Patients
Impaired Degradation of Neutrophil Extracellular Traps: A Possible Severity Factor of Elderly Male COVID-19 Patients
Neutrophil extracellular traps (NETs) have been described as a potential trigger of severe COVID-19. NETs are known as ext...