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Oscillatory shear stress modulates Notch-mediated endothelial mesenchymal plasticity in cerebral arteriovenous malformations
Oscillatory shear stress modulates Notch-mediated endothelial mesenchymal plasticity in cerebral arteriovenous malformations
Cerebral arteriovenous malformations (cAVM) are a significant cause of intracranial hemorrhagic stroke and brain damage. T...
TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea
TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea
Phosphatidylserine is translocated to the inner leaflet of the phospholipid bilayer membrane by the flippase function of t...
Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties...
3D genomics and its applications in precision medicine
3D genomics and its applications in precision medicine
Three-dimensional (3D) genomics is an emerging discipline that studies the three-dimensional structure of chromatin and th...
Single-cell transcriptome analysis reveals liver injury induced by glyphosate in mice
Single-cell transcriptome analysis reveals liver injury induced by glyphosate in mice
Glyphosate (GLY), as the active ingredient of the most widely used herbicide worldwide, is commonly detected in the enviro...
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling
TGFβ1 is a major profibrotic mediator in chronic kidney disease (CKD). Its direct inhibition, however, is limited by ...
Outside the limit: questioning the distance restrictions for cooperative miRNA binding sites
Outside the limit: questioning the distance restrictions for cooperative miRNA binding sites
Among the concepts in biology that are widely taken granted is a potentiated cooperative effect of multiple miRNAs on the ...
LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells
LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells
Mechanotransduction mechanisms whereby periodontal ligament stem cells (PDLSCs) translate mechanical stress into biochemic...
TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt
TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor and one of the most lethal central nervous system tumor...
Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions
Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions
Hematopoietic stem cell transplantation involves irradiation preconditioning which causes bone marrow endothelial cell dys...
PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key compone...
Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress
Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress
Metabolic disorder is considered a well-established risk factor for endometrial carcinoma (EC). However, the mechanism rem...
The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive hypoxic response when oxygen leve...
MF-094 nanodelivery inhibits oral squamous cell carcinoma by targeting USP30
MF-094 nanodelivery inhibits oral squamous cell carcinoma by targeting USP30
Oral squamous cell carcinoma (OSCC) is a common head and neck cancer, and the incidence of OSCC is increasing. As the mort...
Absent in melanoma 2 (AIM2) in rheumatoid arthritis: novel molecular insights and implications
Absent in melanoma 2 (AIM2) in rheumatoid arthritis: novel molecular insights and implications
Absent in melanoma 2 (AIM2), a member of the Pyrin and HIN domain protein family, is a cytoplasmic receptor that recognize...
A rare mutation (p.F149del) of the NT5C3A gene is associated with pyrimidine 5′-nucleotidase deficiency
A rare mutation (p.F149del) of the NT5C3A gene is associated with pyrimidine 5′-nucleotidase deficiency
Pyrimidine 5′-nucleotidase deficiency is a rare erythrocyte enzymopathy. Here we report two cases of hemolytic anemi...
ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity
ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity
RNA N6-methyladenosine (m6A) is involved in mammalian spermatogenesis. In both germ cells and Leydig cells, ALKBH5 regulat...