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Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
Synthetic CRISPR/dCas9-KRAB system driven by specific PSA promoter suppresses malignant biological behavior of prostate cancer cells through negative feedback inhibition of PSA expression
PSA is a type of proto-oncogene that is specifically and highly expressed in embryonic and prostate cancer cells, but not ...
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system
Arachidonic acid 15-lipoxygenases (ALOX15) play a role in mammalian erythropoiesis but they have also been&nb...
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
Periostin is an extracellular matrix protein that plays a critical role in cell fate determination and tissue remodeling, ...
Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis
Long-term exposure of humans to air pollution is associated with an increasing risk of cardiovascular diseases (CVDs). Ast...
N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2′-O methylation
N6-methyladenosine-modified oncofetal lncRNA MIR4435-2HG contributed to stemness features of hepatocellular carcinoma cells by regulating rRNA 2′-O methylation
The unique expression pattern endows oncofetal genes with great value in cancer diagnosis and treatment. However, only a f...
Cellular senescence in skeletal disease: mechanisms and treatment
Cellular senescence in skeletal disease: mechanisms and treatment
The musculoskeletal system supports the movement of the entire body and provides blood production while acting as an endoc...
GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells
GCN5L1 regulates pulmonary surfactant production by modulating lamellar body biogenesis and trafficking in mouse alveolar epithelial cells
The pulmonary surfactant that lines the air–liquid surface within alveoli is a protein–lipid mixture essential...
Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury
Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury
To investigate the mechanism of action of Srg3 in acute lung injury caused by sepsis. First, a sepsis-induced acute lung i...
Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis
Exosomal miR-155-5p drives widespread macrophage M1 polarization in hypervirulent Klebsiella pneumoniae-induced acute lung injury via the MSK1/p38-MAPK axis
Hypervirulent Klebsiella pneumoniae (hvKp) infection-induced sepsis-associated acute lung injury (ALI) has emerged as a si...
Retraction Note: MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virusrelated hepatocellular carcinoma by downregulation of aquaporin 5
Retraction Note: MicroRNA-325-3p inhibits cell proliferation and induces apoptosis in hepatitis B virusrelated hepatocellular carcinoma by downregulation of aquaporin 5
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction
Inhibition of SQSTM1 S403 phosphorylation facilitates the aggresome formation of ubiquitinated proteins during proteasome dysfunction
Ubiquitin–proteasome-system-mediated clearance of misfolded proteins is essential for cells to maintain proteostasis...
Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer
Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer
Mitochondrial transfer regulates intercellular communication, and mitochondria regulate cell metabolism and cell survival....
A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
Zinc finger protein X-linked (ZFX) has been shown to promote the growth of tumor cells, including leukemic cells. However,...
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
The mitochondrial gene MCCC2, a subunit of the heterodimer of 3-methylcrotonyl-CoA carboxylase, plays a pivotal role in ca...
N6-methyladenosine modification—a key player in viral infection
N6-methyladenosine modification—a key player in viral infection
N6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of ...
Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice
Lupus nephritis (LN) is associated with significant mortality and morbidity, while effective therapeutics and biomarkers a...
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
Hepatic fibrosis is a common consequence of chronic liver diseases without approved antifibrotic therapies. Long noncoding...
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
During aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, inc...
Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main pathological change, is the ...
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β1-adrenoceptor autoantibodies
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β1-adrenoceptor autoantibodies
Cardiomyocyte death induced by autophagy inhibition is an important cause of cardiac dysfunction. In-depth exploration of ...
N6-methyladenosine modification of PLOD2 causes spermatocyte damage in rats with varicocele
N6-methyladenosine modification of PLOD2 causes spermatocyte damage in rats with varicocele
In recent years, N6-methyladenosine (m6A) methylation modification of mRNA has been studied extensively. It has been repor...
CRISPR applications in cancer diagnosis and treatment
CRISPR applications in cancer diagnosis and treatment
Cancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic ...
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
Mechanical pressure overload and other stimuli often contribute to heart hypertrophy, a significant factor in the inductio...
CRISPR/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis
CRISPR/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis
Chronic apical periodontitis is a prevalent oral disease characterized by bone loss, and its underlying mechanisms remain ...
Correction: Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62–Keap1–NRF2 pathway
Correction: Inhibition of CISD2 promotes ferroptosis through ferritinophagy-mediated ferritin turnover and regulation of p62–Keap1–NRF2 pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide
Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide
Desmocollin-1 (DSC1) is a desmosomal transmembrane glycoprotein that maintains cell-to-cell adhesion. DSC1 was previously ...
Prenatal lipopolysaccharide exposure induces anxiety-like behaviour in male mouse offspring and aberrant glial differentiation of embryonic neural stem cells
Prenatal lipopolysaccharide exposure induces anxiety-like behaviour in male mouse offspring and aberrant glial differentiation of embryonic neural stem cells
Prenatal infection has been implicated in the development of neuropsychiatric disorders in children. We hypothesised that ...
MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4
MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4
Endothelial dysfunction and deregulated microRNAs (miRNAs) participate in the development of sepsis and are associated wit...
Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain
Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain
Peripheral nerve damage causes neuroinflammation, which plays a critical role in establishing and maintaining neuropathic ...
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