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Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis
Periostin is an extracellular matrix protein that plays a critical role in cell fate determination and tissue remodeling, ...
Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Correction: Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis
Long-term exposure of humans to air pollution is associated with an increasing risk of cardiovascular diseases (CVDs). Ast...
Cellular senescence in skeletal disease: mechanisms and treatment
Cellular senescence in skeletal disease: mechanisms and treatment
The musculoskeletal system supports the movement of the entire body and provides blood production while acting as an endoc...
Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury
Irf7 regulates the expression of Srg3 and ferroptosis axis aggravated sepsis-induced acute lung injury
To investigate the mechanism of action of Srg3 in acute lung injury caused by sepsis. First, a sepsis-induced acute lung i...
Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer
Cadmium promotes nonalcoholic fatty liver disease by inhibiting intercellular mitochondrial transfer
Mitochondrial transfer regulates intercellular communication, and mitochondria regulate cell metabolism and cell survival....
A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells
Zinc finger protein X-linked (ZFX) has been shown to promote the growth of tumor cells, including leukemic cells. However,...
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer
The mitochondrial gene MCCC2, a subunit of the heterodimer of 3-methylcrotonyl-CoA carboxylase, plays a pivotal role in ca...
N6-methyladenosine modification—a key player in viral infection
N6-methyladenosine modification—a key player in viral infection
N6-methyladenosine (m6A) modification is a dynamic, reversible process and is the most prevalent internal modification of ...
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
Hepatic fibrosis is a common consequence of chronic liver diseases without approved antifibrotic therapies. Long noncoding...
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
During aging and after traumatic injuries, cartilage and bone cells are exposed to various pathophysiologic mediators, inc...
Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main pathological change, is the ...
N6-methyladenosine modification of PLOD2 causes spermatocyte damage in rats with varicocele
N6-methyladenosine modification of PLOD2 causes spermatocyte damage in rats with varicocele
In recent years, N6-methyladenosine (m6A) methylation modification of mRNA has been studied extensively. It has been repor...
CRISPR applications in cancer diagnosis and treatment
CRISPR applications in cancer diagnosis and treatment
Cancer remains a significant global health challenge, necessitating the exploration of novel and more precise therapeutic ...
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
Mechanical pressure overload and other stimuli often contribute to heart hypertrophy, a significant factor in the inductio...
CRISPR/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis
CRISPR/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis
Chronic apical periodontitis is a prevalent oral disease characterized by bone loss, and its underlying mechanisms remain ...
Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide
Desmocollin-1 is associated with pro-metastatic phenotype of luminal A breast cancer cells and is modulated by parthenolide
Desmocollin-1 (DSC1) is a desmosomal transmembrane glycoprotein that maintains cell-to-cell adhesion. DSC1 was previously ...
MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4
MiR-15b-5p and PCSK9 inhibition reduces lipopolysaccharide-induced endothelial dysfunction by targeting SIRT4
Endothelial dysfunction and deregulated microRNAs (miRNAs) participate in the development of sepsis and are associated wit...
Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain
Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain
Peripheral nerve damage causes neuroinflammation, which plays a critical role in establishing and maintaining neuropathic ...