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Oscillatory shear stress modulates Notch-mediated endothelial mesenchymal plasticity in cerebral arteriovenous malformations
Oscillatory shear stress modulates Notch-mediated endothelial mesenchymal plasticity in cerebral arteriovenous malformations
Cerebral arteriovenous malformations (cAVM) are a significant cause of intracranial hemorrhagic stroke and brain damage. T...
Extracellular vesicles derived from CD4+ T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation
Extracellular vesicles derived from CD4+ T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation
Sepsis is an abnormal immune response after infection, wherein the lung is the most susceptible organ to fail, leading to ...
TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea
TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea
Phosphatidylserine is translocated to the inner leaflet of the phospholipid bilayer membrane by the flippase function of t...
Overexpression of miR-92a attenuates kidney ischemia–reperfusion injury and improves kidney preservation by inhibiting MEK4/JNK1-related autophagy
Overexpression of miR-92a attenuates kidney ischemia–reperfusion injury and improves kidney preservation by inhibiting MEK4/JNK1-related autophagy
Kidney ischemia–reperfusion injury is inevitable in kidney transplantation, and is essential for primary graft dysfu...
Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties...
3D genomics and its applications in precision medicine
3D genomics and its applications in precision medicine
Three-dimensional (3D) genomics is an emerging discipline that studies the three-dimensional structure of chromatin and th...
Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs)
Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs)
Esophageal squamous carcinoma (ESCC) is a common malignancy that originates in the digestive tract. Lymph node metastasis ...
Human umbilical cord mesenchymal stem cell exosome-derived miR-874-3p targeting RIPK1/PGAM5 attenuates kidney tubular epithelial cell damage
Human umbilical cord mesenchymal stem cell exosome-derived miR-874-3p targeting RIPK1/PGAM5 attenuates kidney tubular epithelial cell damage
Kidney insults due to various pathogenic factors, such as trauma, infection, and inflammation, can cause tubular epithelia...
Single-cell transcriptome analysis reveals liver injury induced by glyphosate in mice
Single-cell transcriptome analysis reveals liver injury induced by glyphosate in mice
Glyphosate (GLY), as the active ingredient of the most widely used herbicide worldwide, is commonly detected in the enviro...
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling
TGFβ1 is a major profibrotic mediator in chronic kidney disease (CKD). Its direct inhibition, however, is limited by ...
Low-intensity pulsed ultrasound (LIPUS) enhances the anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles
Low-intensity pulsed ultrasound (LIPUS) enhances the anti-inflammatory effects of bone marrow mesenchymal stem cells (BMSCs)-derived extracellular vesicles
Bone marrow-derived mesenchymal stem cells (BMSCs)-derived extracellular vesicles (EVs) have shown potent anti-inflammator...
Outside the limit: questioning the distance restrictions for cooperative miRNA binding sites
Outside the limit: questioning the distance restrictions for cooperative miRNA binding sites
Among the concepts in biology that are widely taken granted is a potentiated cooperative effect of multiple miRNAs on the ...
LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells
LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells
Mechanotransduction mechanisms whereby periodontal ligament stem cells (PDLSCs) translate mechanical stress into biochemic...
TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt
TRIM8: a double-edged sword in glioblastoma with the power to heal or hurt
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor and one of the most lethal central nervous system tumor...
Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis
Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis
Secondary spinal cord injury (SCI) often causes the aggravation of inflammatory reaction and nerve injury, which affects t...
Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemia–reperfusion injury
Formyl peptide receptor 2 activation by mitochondrial formyl peptides stimulates the neutrophil proinflammatory response via the ERK pathway and exacerbates ischemia–reperfusion injury
Ischemia–reperfusion injury (IRI) is an inevitable process in renal transplantation that significantly increases the...
Correction: TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis
Correction: TMEM43 promotes pancreatic cancer progression by stabilizing PRPF3 and regulating RAP2B/ERK axis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions
Robo4 inhibits gamma radiation-induced permeability of a murine microvascular endothelial cell by regulating the junctions
Hematopoietic stem cell transplantation involves irradiation preconditioning which causes bone marrow endothelial cell dys...
Three-dimensional genome landscape comprehensively reveals patterns of spatial gene regulation in papillary and anaplastic thyroid cancers: a study using representative cell lines for each cancer type
Three-dimensional genome landscape comprehensively reveals patterns of spatial gene regulation in papillary and anaplastic thyroid cancers: a study using representative cell lines for each cancer type
Spatial chromatin structure is intricately linked with somatic aberrations, and somatic mutations of various cancer-relate...
Retraction Note to: MicroRNA-488 inhibits tongue squamous carcinoma cell invasion and EMT by directly targeting ATF3
Retraction Note to: MicroRNA-488 inhibits tongue squamous carcinoma cell invasion and EMT by directly targeting ATF3
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
PSMC3 promotes RNAi by maintaining AGO2 stability through USP14
Argonaute 2 (AGO2), the only protein with catalytic activity in the human Argonaute family, is considered as a key compone...
Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress
Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress
Metabolic disorder is considered a well-established risk factor for endometrial carcinoma (EC). However, the mechanism rem...
The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive hypoxic response when oxygen leve...
MF-094 nanodelivery inhibits oral squamous cell carcinoma by targeting USP30
MF-094 nanodelivery inhibits oral squamous cell carcinoma by targeting USP30
Oral squamous cell carcinoma (OSCC) is a common head and neck cancer, and the incidence of OSCC is increasing. As the mort...
Exosomal miR-628-5p from M1 polarized macrophages hinders m6A modification of circFUT8 to suppress hepatocellular carcinoma progression
Exosomal miR-628-5p from M1 polarized macrophages hinders m6A modification of circFUT8 to suppress hepatocellular carcinoma progression
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. CircFUT8 has been shown to be upregulated in cance...
Absent in melanoma 2 (AIM2) in rheumatoid arthritis: novel molecular insights and implications
Absent in melanoma 2 (AIM2) in rheumatoid arthritis: novel molecular insights and implications
Absent in melanoma 2 (AIM2), a member of the Pyrin and HIN domain protein family, is a cytoplasmic receptor that recognize...
Targeting uridine–cytidine kinase 2 induced cell cycle arrest through dual mechanism and could improve the immune response of hepatocellular carcinoma
Targeting uridine–cytidine kinase 2 induced cell cycle arrest through dual mechanism and could improve the immune response of hepatocellular carcinoma
Pyrimidine metabolism is critical for tumour progression. Uridine–cytidine kinase 2 (UCK2), a key regulator of pyrim...
A rare mutation (p.F149del) of the NT5C3A gene is associated with pyrimidine 5′-nucleotidase deficiency
A rare mutation (p.F149del) of the NT5C3A gene is associated with pyrimidine 5′-nucleotidase deficiency
Pyrimidine 5′-nucleotidase deficiency is a rare erythrocyte enzymopathy. Here we report two cases of hemolytic anemi...
Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development
Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates the toxicities of several e...
ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity
ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood–testis barrier integrity
RNA N6-methyladenosine (m6A) is involved in mammalian spermatogenesis. In both germ cells and Leydig cells, ALKBH5 regulat...
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