SCI时时刷

search
+
Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin
Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin
The skin is a barrier that protects the human body against environmental factors (physical, including solar radiation, che...
Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD
Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD
Regulation of messenger RNA (mRNA) transport and translation in neurons is essential for dendritic plasticity and learning...
Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2
Effect of SNORD113-3/ADAR2 on glycolipid metabolism in glioblastoma via A-to-I editing of PHKA2
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor, characterized by its poor prognosis. Glycolipid metaboli...
The IQGAP-related RasGAP IqgC regulates cell–substratum adhesion in Dictyostelium discoideum
The IQGAP-related RasGAP IqgC regulates cell–substratum adhesion in Dictyostelium discoideum
Proper adhesion of cells to their environment is essential for the normal functioning of single cells and multicellular or...
Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells
Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells
Metabolism is error prone. For instance, the reduced forms of the central metabolic cofactors nicotinamide adenin...
Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer
Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer
Hypoxia-inducible factors (HIFs) are essential transcription factors that orchestrate cellular responses to oxygen depriva...
Epigenetic modification regulates the ligamentum flavum hypertrophy through miR-335-3p/SERPINE2/β-catenin signaling pathway
Epigenetic modification regulates the ligamentum flavum hypertrophy through miR-335-3p/SERPINE2/β-catenin signaling pathway
Epigenetic modifications have been proved to play important roles in the spinal degenerative diseases. As a type of noncod...
WNT4 promotes the symmetric fission of crypt in radiation-induced intestinal epithelial regeneration
WNT4 promotes the symmetric fission of crypt in radiation-induced intestinal epithelial regeneration
Radiotherapy for pelvic malignant tumors inevitably causes intestinal tissue damage. The regeneration of intestinal epithe...
ENPP2 promotes progression and lipid accumulation via AMPK/SREBP1/FAS pathway in chronic lymphocytic leukemia
ENPP2 promotes progression and lipid accumulation via AMPK/SREBP1/FAS pathway in chronic lymphocytic leukemia
Disorders of lipid metabolism are critical factors in the progression of chronic lymphocytic leukemia (CLL). However, the ...
Exosome-derived proteins in gastric cancer progression, drug resistance, and immune response
Exosome-derived proteins in gastric cancer progression, drug resistance, and immune response
Gastric cancer (GC) represents a prevalent malignancy globally, often diagnosed at advanced stages owing to subtle early s...
Elongation factor 2 in cancer: a promising therapeutic target in protein translation
Elongation factor 2 in cancer: a promising therapeutic target in protein translation
Aberrant elongation of proteins can lead to the activation of oncogenic signaling pathways, resulting in the dysregulation...
Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes
Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes
Pulmonary hypertension (PH) presents a puzzling sex bias, being more prevalent in women yet often less severe than in men,...
Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases
Inter- and intracellular mitochondrial communication: signaling hubs in aging and age-related diseases
Mitochondria are versatile and complex organelles that can continuously communicate and interact with the cellular milieu....
Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression
Maternal high-fat diet orchestrates offspring hepatic cholesterol metabolism via MEF2A hypermethylation-mediated CYP7A1 suppression
Maternal overnutrition, prevalent among women of childbearing age, significantly impacts offspring health throughout their...
Dynamic regulation of proximal tubular autophagy from injury to repair after ischemic kidney damage
Dynamic regulation of proximal tubular autophagy from injury to repair after ischemic kidney damage
The role of proximal tubular autophagy in repairing kidney injury following ischemia remains unclear. In this study, we ut...
The miR-6240 target gene Igf2bp3 promotes myoblast fusion by enhancing myomaker mRNA stability
The miR-6240 target gene Igf2bp3 promotes myoblast fusion by enhancing myomaker mRNA stability
Myoblast fusion plays a crucial role in myogenesis. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) function...
Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2
Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2
Traumatic injuries to spinal cord lead to severe motor, sensory, and autonomic dysfunction. The accumulation of inhibitory...
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM
Vasculopathy underlies diabetic complications, with perivascular adipose tissue (PVAT) playing crucial roles in its develo...
Exercise promotes skeletal muscle growth in adolescents via modulating Mettl3-mediated m6A methylation of MyoD in muscle satellite cells
Exercise promotes skeletal muscle growth in adolescents via modulating Mettl3-mediated m6A methylation of MyoD in muscle satellite cells
Exercise exerts positive impacts on skeletal muscle health and homeostasis. Emerging evidence suggests that m6A methylatio...
Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha
Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha
Sjögren’s syndrome (SS) is an autoimmune disease with limited effective treatment options. This study aimed to ...
SENP3 mediates deSUMOylation of SIX1 to promote prostate cancer proliferation and migration
SENP3 mediates deSUMOylation of SIX1 to promote prostate cancer proliferation and migration
Sentrin/SUMO-specific protease 3 (SENP3) is essential to regulate protein stability and function in normal and cancer cell...
The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis
The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. Th...
KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells
KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells
Differentiating dental pulp stem cells (DPSCs) into odontoblasts is a critical process for tooth self-repair and dentine&#...
Different amyloid β42 preparations induce different cell death pathways in the model of SH-SY5Y neuroblastoma cells
Different amyloid β42 preparations induce different cell death pathways in the model of SH-SY5Y neuroblastoma cells
Amyloid β42 (Aβ42) plays a decisive role in the pathology of Alzheimer’s disease. The Aβ42 peptide ca...
The crosstalk between alternative splicing and circular RNA in cancer: pathogenic insights and therapeutic implications
The crosstalk between alternative splicing and circular RNA in cancer: pathogenic insights and therapeutic implications
RNA splicing is a fundamental step of gene expression. While constitutive splicing removes introns and joins exons unbiase...
Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions
Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions
HBO1, also known as KAT7 or MYST2, is a crucial histone acetyltransferase with diverse cellular functions. It typically fo...
Early and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation
Early and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation
Liver sinusoidal endothelial cells (LSECs) have transcellular pores, called fenestrations, participating in the bidirectio...
m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus
m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus
Circular RNAs (circRNAs) are differentially expressed in various cardiovascular diseases, including myocardial infarction ...
The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death
The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death
Coronavirus disease 2019 (COVID-19) represents the novel respiratory infectious disorder caused by severe acute respirator...
Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research
Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research
Human Gb3/CD77 synthase (α1,4-galactosyltransferase, P1/Pk synthase, UDP-galactose: β-d-galactosyl-β1-R 4-&...
阅读更多
format_indent_increase