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Dynamic regulation of proximal tubular autophagy from injury to repair after ischemic kidney damage
Dynamic regulation of proximal tubular autophagy from injury to repair after ischemic kidney damage
The role of proximal tubular autophagy in repairing kidney injury following ischemia remains unclear. In this study, we ut...
The miR-6240 target gene Igf2bp3 promotes myoblast fusion by enhancing myomaker mRNA stability
The miR-6240 target gene Igf2bp3 promotes myoblast fusion by enhancing myomaker mRNA stability
Myoblast fusion plays a crucial role in myogenesis. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) function...
Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2
Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2
Traumatic injuries to spinal cord lead to severe motor, sensory, and autonomic dysfunction. The accumulation of inhibitory...
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM
Vasculopathy underlies diabetic complications, with perivascular adipose tissue (PVAT) playing crucial roles in its develo...
Exercise promotes skeletal muscle growth in adolescents via modulating Mettl3-mediated m6A methylation of MyoD in muscle satellite cells
Exercise promotes skeletal muscle growth in adolescents via modulating Mettl3-mediated m6A methylation of MyoD in muscle satellite cells
Exercise exerts positive impacts on skeletal muscle health and homeostasis. Emerging evidence suggests that m6A methylatio...
Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha
Salivary gland protective and antiinflammatory effects of genistein in Sjögren’s syndrome by inhibiting Xist/ACSL4-mediated ferroptosis following binding to estrogen receptor-alpha
Sjögren’s syndrome (SS) is an autoimmune disease with limited effective treatment options. This study aimed to ...
SENP3 mediates deSUMOylation of SIX1 to promote prostate cancer proliferation and migration
SENP3 mediates deSUMOylation of SIX1 to promote prostate cancer proliferation and migration
Sentrin/SUMO-specific protease 3 (SENP3) is essential to regulate protein stability and function in normal and cancer cell...
The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis
The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis
Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. Th...
KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells
KPNB1-ATF4 induces BNIP3-dependent mitophagy to drive odontoblastic differentiation in dental pulp stem cells
Differentiating dental pulp stem cells (DPSCs) into odontoblasts is a critical process for tooth self-repair and dentine&#...
Different amyloid β42 preparations induce different cell death pathways in the model of SH-SY5Y neuroblastoma cells
Different amyloid β42 preparations induce different cell death pathways in the model of SH-SY5Y neuroblastoma cells
Amyloid β42 (Aβ42) plays a decisive role in the pathology of Alzheimer’s disease. The Aβ42 peptide ca...
The crosstalk between alternative splicing and circular RNA in cancer: pathogenic insights and therapeutic implications
The crosstalk between alternative splicing and circular RNA in cancer: pathogenic insights and therapeutic implications
RNA splicing is a fundamental step of gene expression. While constitutive splicing removes introns and joins exons unbiase...
Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions
Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions
HBO1, also known as KAT7 or MYST2, is a crucial histone acetyltransferase with diverse cellular functions. It typically fo...
Early and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation
Early and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation
Liver sinusoidal endothelial cells (LSECs) have transcellular pores, called fenestrations, participating in the bidirectio...
m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus
m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus
Circular RNAs (circRNAs) are differentially expressed in various cardiovascular diseases, including myocardial infarction ...
The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death
The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death
Coronavirus disease 2019 (COVID-19) represents the novel respiratory infectious disorder caused by severe acute respirator...
Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research
Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research
Human Gb3/CD77 synthase (α1,4-galactosyltransferase, P1/Pk synthase, UDP-galactose: β-d-galactosyl-β1-R 4-&...
Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis
Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis
Oral cancer accounts for 2% of cancer-related deaths globally, with over 90% of cases being oral cavity squamous cell carc...
Research progress of MUC1 in genitourinary cancers
Research progress of MUC1 in genitourinary cancers
MUC1 is a highly glycosylated transmembrane protein with a high molecular weight. It plays a role in lubricating and prote...
Chemokine CXCL13–CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases
Chemokine CXCL13–CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases
Chronic pain dramatically affects life qualities of the sufferers. It has posed a heavy burden to both patients and the he...
Correction: Extracellular vesicles derived from CD4 + T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation
Correction: Extracellular vesicles derived from CD4 + T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors
Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors
Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular p...
Research progress of ankyrin repeat domain 1 protein: an updated review
Research progress of ankyrin repeat domain 1 protein: an updated review
Ankyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the muscle ankyrin repeat protein (MARP) fam...
Caspase-8 in inflammatory diseases: a potential therapeutic target
Caspase-8 in inflammatory diseases: a potential therapeutic target
Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for its regulatory...
The role and therapeutic potential of itaconate in lung disease
The role and therapeutic potential of itaconate in lung disease
Lung diseases triggered by endogenous or exogenous factors have become a major concern, with high morbidity and mortality ...
Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification
Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification
Acute transplant rejection is a major component of poor prognoses for organ transplantation. Owing to the multiple complex...
A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ
A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ
Circular RNAs (circRNAs) can influence a variety of biological functions and act as a significant role in the progression ...
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis
Patients with tuberous sclerosis complex (TSC) develop renal cysts and/or angiomyolipomas (AMLs) due to inactive mutations...
The oncogenic ADAMTS1–VCAN–EGFR cyclic axis drives anoikis resistance and invasion in renal cell carcinoma
The oncogenic ADAMTS1–VCAN–EGFR cyclic axis drives anoikis resistance and invasion in renal cell carcinoma
Metastasis, the leading cause of renal cell carcinoma (RCC) mortality, involves cancer cells resisting anoikis and invadin...
Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling
Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling
The involvement of tetraspanins in cancer development has been widely implicated. In this study, the function and molecula...
Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer
Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer
Zinc finger MIZ-type containing 2 (ZMIZ2) can function as a coactivator and participate in the progression of certain mali...
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