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Reciprocal negative feedback between Prrx1 and miR-140-3p regulates rapid chondrogenesis in the regenerating antler
Reciprocal negative feedback between Prrx1 and miR-140-3p regulates rapid chondrogenesis in the regenerating antler
During growth phase, antlers exhibit a very rapid rate of chondrogenesis. The antler is formed from its growth center rese...
miR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A
miR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A
Viral myocarditis (VMC) is a disease resulting from viral infection, which manifests as inflammation of myocardial cells. ...
Role of reactive oxygen species in myelodysplastic syndromes
Role of reactive oxygen species in myelodysplastic syndromes
Reactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox react...
Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b
Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b
The trafficking of cargoes from endosomes to the trans-Golgi network requires numerous sequential and coordinated steps. C...
CRISPR–Cas9 applications in T cells and adoptive T cell therapies
CRISPR–Cas9 applications in T cells and adoptive T cell therapies
T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing immune checkpoint blockade and ad...
Combined therapy of dabrafenib and an anti-HER2 antibody–drug conjugate for advanced BRAF-mutant melanoma
Combined therapy of dabrafenib and an anti-HER2 antibody–drug conjugate for advanced BRAF-mutant melanoma
Melanoma is the most lethal skin cancer characterized by its high metastatic potential. In the past decade, targeted and i...
Methylated lncRNAs suppress apoptosis of gastric cancer stem cells via the lncRNA–miRNA/protein axis
Methylated lncRNAs suppress apoptosis of gastric cancer stem cells via the lncRNA–miRNA/protein axis
Long noncoding RNAs (lncRNAs) play essential roles in the tumorigenesis of gastric cancer. However, the influence of lncRN...
Escaping from CRISPR–Cas-mediated knockout: the facts, mechanisms, and applications
Escaping from CRISPR–Cas-mediated knockout: the facts, mechanisms, and applications
Clustered regularly interspaced short palindromic repeats and associated Cas protein (CRISPR–Cas), a powerful genome...
G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1–Bax-mediated mitochondrial apoptosis pathway
G6PD maintains the VSMC synthetic phenotype and accelerates vascular neointimal hyperplasia by inhibiting the VDAC1–Bax-mediated mitochondrial apoptosis pathway
Glucose-6-phosphate dehydrogenase (G6PD) plays an important role in vascular smooth muscle cell (VSMC) phenotypic switchin...
Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells
Sialylation on vesicular integrin β1 determined endocytic entry of small extracellular vesicles into recipient cells
Small extracellular vesicles (sEV) are closely associated with the development and metastasis of many types of mammalian c...
Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells
Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells
Both glucocorticoid receptor and peroxisome proliferator-activated receptor-γ (PPARγ) play a critical role in ad...
Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)
Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)
Aspartate–glutamate carrier isoform 1 (AGC1) is a carrier responsible for the export of mitochondrial aspartate in e...
Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease
Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease
Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively associated with highly curved and prominent ...
Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer
Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer
Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of ...
Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis
Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis
Circular RNAs (circRNAs) are single-stranded RNAs with covalently closed structures that have been implicated in cancer pr...
Decoding epitranscriptomic regulation of viral infection: mapping of RNA N6-methyladenosine by advanced sequencing technologies
Decoding epitranscriptomic regulation of viral infection: mapping of RNA N6-methyladenosine by advanced sequencing technologies
Elucidating the intricate interactions between viral pathogens and host cellular machinery during infection is paramount f...
IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
IGF2BP3 functions as an RNA-binding protein (RBP) and plays a role in the posttranscriptional control of mRNA localization...
MRE11A: a novel negative regulator of human DNA mismatch repair
MRE11A: a novel negative regulator of human DNA mismatch repair
DNA mismatch repair (MMR) is a highly conserved pathway that corrects DNA replication errors, the loss of which is attribu...
Obesity-induced downregulation of miR-192 exacerbates lipopolysaccharide-induced acute lung injury by promoting macrophage activation
Obesity-induced downregulation of miR-192 exacerbates lipopolysaccharide-induced acute lung injury by promoting macrophage activation
Macrophage activation may play a crucial role in the increased susceptibility of obese individuals to acute lung injury (A...
Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor
Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor
Aryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subseque...
The micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice
The micro-743a-3p–GSTM1 pathway is an endogenous protective mechanism against alcohol-related liver disease in mice
Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed p...
A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
A multiplex RPA-CRISPR/Cas12a-based POCT technique and its application in human papillomavirus (HPV) typing assay
Persistent infection with high-risk human papillomavirus (HR-HPV) is the primary and initiating factor for cervical cancer...
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
Gut microbiota regulates various aspects of human physiology by producing metabolites, metabolizing enzymes, and toxins. M...
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
Inhibition of Drp1- Fis1 interaction alleviates aberrant mitochondrial fragmentation and acute kidney injury
Acute kidney injury (AKI) is a common clinical disorder with complex etiology and poor prognosis, and currently lacks spec...
Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review
Curriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review
RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they ca...
Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies
Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies
Exosomes are nano-sized membrane extracellular vesicles which can be released from var...
Loss of miR-101-3p in melanoma stabilizes genomic integrity, leading to cell death prevention
Loss of miR-101-3p in melanoma stabilizes genomic integrity, leading to cell death prevention
Malignant melanoma remains the most lethal form of skin cancer, exhibiting poor prognosis after forming distant metastasis...
N6-methyladenosine-modified circ_104797 sustains cisplatin resistance in bladder cancer through acting as RNA sponges
N6-methyladenosine-modified circ_104797 sustains cisplatin resistance in bladder cancer through acting as RNA sponges
Bladder cancer (BCa) ranks among the predominant malignancies affecting the urinary system. Cisplatin (CDDP) remains a cor...
The ancestral type of the R-RAS protein has oncogenic potential
The ancestral type of the R-RAS protein has oncogenic potential
The R-RAS2 is a small GTPase highly similar to classical RAS proteins at the regulatory and signaling levels. The high evo...
High-content image screening to identify chemical modulators for peroxisome and ferroptosis
High-content image screening to identify chemical modulators for peroxisome and ferroptosis
The peroxisome is a dynamic organelle with variety in number, size, shape, and activity in different cell types and physio...
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