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The crosstalk between alternative splicing and circular RNA in cancer: pathogenic insights and therapeutic implications
The crosstalk between alternative splicing and circular RNA in cancer: pathogenic insights and therapeutic implications
RNA splicing is a fundamental step of gene expression. While constitutive splicing removes introns and joins exons unbiase...
Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions
Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions
HBO1, also known as KAT7 or MYST2, is a crucial histone acetyltransferase with diverse cellular functions. It typically fo...
Early and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation
Early and late phases of liver sinusoidal endothelial cell (LSEC) defenestration in mouse model of systemic inflammation
Liver sinusoidal endothelial cells (LSECs) have transcellular pores, called fenestrations, participating in the bidirectio...
m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus
m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus
Circular RNAs (circRNAs) are differentially expressed in various cardiovascular diseases, including myocardial infarction ...
The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death
The role of reactive oxygen species in severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection-induced cell death
Coronavirus disease 2019 (COVID-19) represents the novel respiratory infectious disorder caused by severe acute respirator...
Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research
Human Gb3/CD77 synthase: a glycosyltransferase at the crossroads of immunohematology, toxicology, and cancer research
Human Gb3/CD77 synthase (α1,4-galactosyltransferase, P1/Pk synthase, UDP-galactose: β-d-galactosyl-β1-R 4-&...
Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis
Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis
Oral cancer accounts for 2% of cancer-related deaths globally, with over 90% of cases being oral cavity squamous cell carc...
Research progress of MUC1 in genitourinary cancers
Research progress of MUC1 in genitourinary cancers
MUC1 is a highly glycosylated transmembrane protein with a high molecular weight. It plays a role in lubricating and prote...
Chemokine CXCL13–CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases
Chemokine CXCL13–CXCR5 signaling in neuroinflammation and pathogenesis of chronic pain and neurological diseases
Chronic pain dramatically affects life qualities of the sufferers. It has posed a heavy burden to both patients and the he...
Correction: Extracellular vesicles derived from CD4 + T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation
Correction: Extracellular vesicles derived from CD4 + T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors
Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors
Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular p...
Research progress of ankyrin repeat domain 1 protein: an updated review
Research progress of ankyrin repeat domain 1 protein: an updated review
Ankyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the muscle ankyrin repeat protein (MARP) fam...
Caspase-8 in inflammatory diseases: a potential therapeutic target
Caspase-8 in inflammatory diseases: a potential therapeutic target
Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for its regulatory...
The role and therapeutic potential of itaconate in lung disease
The role and therapeutic potential of itaconate in lung disease
Lung diseases triggered by endogenous or exogenous factors have become a major concern, with high morbidity and mortality ...
Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification
Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification
Acute transplant rejection is a major component of poor prognoses for organ transplantation. Owing to the multiple complex...
A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ
A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ
Circular RNAs (circRNAs) can influence a variety of biological functions and act as a significant role in the progression ...
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis
mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis
Patients with tuberous sclerosis complex (TSC) develop renal cysts and/or angiomyolipomas (AMLs) due to inactive mutations...
The oncogenic ADAMTS1–VCAN–EGFR cyclic axis drives anoikis resistance and invasion in renal cell carcinoma
The oncogenic ADAMTS1–VCAN–EGFR cyclic axis drives anoikis resistance and invasion in renal cell carcinoma
Metastasis, the leading cause of renal cell carcinoma (RCC) mortality, involves cancer cells resisting anoikis and invadin...
Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling
Tetraspanin 3 promotes NSCLC cell proliferation via regulation of β1 integrin intracellular recycling
The involvement of tetraspanins in cancer development has been widely implicated. In this study, the function and molecula...
Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer
Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer
Zinc finger MIZ-type containing 2 (ZMIZ2) can function as a coactivator and participate in the progression of certain mali...
The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis
The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis
Loss-of-function mutations of ZBTB24 cause immunodeficiency, centromeric instability, and facial anomalies syndrome 2 (ICF...
Glucokinase (GCK) in diabetes: from molecular mechanisms to disease pathogenesis
Glucokinase (GCK) in diabetes: from molecular mechanisms to disease pathogenesis
Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose sensing and insulin secretion in pa...
MicroRNAs in metabolism for precision treatment of lung cancer
MicroRNAs in metabolism for precision treatment of lung cancer
The dysregulation of miRNAs in lung cancer has been extensively documented, with specific miRNAs acting as both tumor supp...
Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK/mTOR signaling pathway
Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK/mTOR signaling pathway
Drug-induced liver injury (DILI) is gradually becoming a common global problem that causes acute liver failure, especially...
Hsa_circ_0000520 suppresses vasculogenic mimicry formation and metastasis in bladder cancer through Lin28a/PTEN/PI3K signaling
Hsa_circ_0000520 suppresses vasculogenic mimicry formation and metastasis in bladder cancer through Lin28a/PTEN/PI3K signaling
Vasculogenic mimicry (VM) is a potential cause of resistance to antiangiogenic therapy and is closely related to the malig...
Lysosome quality control in health and neurodegenerative diseases
Lysosome quality control in health and neurodegenerative diseases
Lysosomes are acidic organelles involved in crucial intracellular functions, including the degradation of organelles and p...
Inverse correlation between TP53 gene status and PD-L1 protein levels in a melanoma cell model depends on an IRF1/SOX10 regulatory axis
Inverse correlation between TP53 gene status and PD-L1 protein levels in a melanoma cell model depends on an IRF1/SOX10 regulatory axis
PD-L1 expression on cancer cells is an important mechanism of tumor immune escape, and immunotherapy targeting the PD-L1/P...
Single-cell RNA sequencing identifies inherent abnormalities of adipose-derived stem cells from nonlesional sites of patients with localized scleroderma
Single-cell RNA sequencing identifies inherent abnormalities of adipose-derived stem cells from nonlesional sites of patients with localized scleroderma
Localized scleroderma (LoS) is an autoimmune disorder that primarily affects the skin, and is often treated with autologou...
Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation
Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation
Stroke is a type of acute brain damage that can lead to a series of serious public health challenges. Demonstrating the mo...
Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer
Triptolide-induced cuproptosis is a novel antitumor strategy for the treatment of cervical cancer
Cuproptosis is a unique copper-dependent form of cell death that is highly correlated with the metabolic state of cells. T...
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