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circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p
circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p
Extensive inflammation of endothelial cells (ECs) facilitates atherosclerotic lesion formation. Circular RNA (circRNA) par...
Correction: Laboratory methods to decipher epigenetic signatures: a comparative review
Correction: Laboratory methods to decipher epigenetic signatures: a comparative review
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Pou3f1 mediates the effect of Nfatc3 on ulcerative colitis-associated colorectal cancer by regulating inflammation
Pou3f1 mediates the effect of Nfatc3 on ulcerative colitis-associated colorectal cancer by regulating inflammation
Ulcerative colitis-associated colorectal cancer (UC-CRC) is an important complication of ulcerative colitis. Pou3f1 (POU c...
Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid
Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid
Exosomes, known as a type of extracellular vesicles (EVs), are lipid particles comprising heterogeneous contents such as n...
Melatonin and cancer suppression: insights into its effects on DNA methylation
Melatonin and cancer suppression: insights into its effects on DNA methylation
Melatonin is an important naturally occurring hormone in mammals. Melatonin-mediated biological effects include the regula...
Diversification of PAR signaling through receptor crosstalk
Diversification of PAR signaling through receptor crosstalk
Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, thes...
Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC
Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC
Current evidence suggests that the hypoxic tumor microenvironment further aggravates tumor progression, leading to poor th...
Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting
Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting
Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of differentiating into osteocytes, chondrocytes...
SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway
SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway
Sestrin2 (SESN2), a stress-inducible protein, has been reported to protect against denervated muscle atrophy through unfol...
Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions
Comprehensive overview of COVID-19-related respiratory failure: focus on cellular interactions
The pandemic outbreak of coronavirus disease 2019 (COVID-19) has created health challenges in all parts of the world. Unde...
Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment
Recent insights into the microRNA-dependent modulation of gliomas from pathogenesis to diagnosis and treatment
Gliomas are the most lethal primary brain tumors in adults. These highly invasive tumors have poor 5-year survival for pat...
Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
The Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is involved in many immun...
DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis
DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis
Previously, we reported the expression of DLX4 isoforms (BP1 and DLX7) in myeloid leukemia, but the functional role of DLX...
The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors
The promising therapeutic effects of metformin on metabolic reprogramming of cancer-associated fibroblasts in solid tumors
Tumor-infiltrated lymphocytes are exposed to many toxic metabolites and molecules in the tumor microenvironment (TME) that...
Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury
Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury
Coenzyme Q10 (CoQ10), an endogenous antioxidant, has been reported frequently to exert an outstanding protective effect on...
Raman microspectroscopy fingerprinting of organoid differentiation state
Raman microspectroscopy fingerprinting of organoid differentiation state
Organoids, which are organs grown in a dish from stem or progenitor cells, model the structure and function of organs and ...
The role of epigenetic modifications in drug resistance and treatment of breast cancer
The role of epigenetic modifications in drug resistance and treatment of breast cancer
Breast cancer is defined as a biological and molecular heterogeneous disorder that originates from breast cells. Genetic p...
WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy
WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy
Diabetic nephropathy (DN) is prevalent in patients with diabetes. N6-methyladenosine (m6A) methylation has been found to c...
Metformin inhibits melanoma cell metastasis by suppressing the miR-5100/SPINK5/STAT3 axis
Metformin inhibits melanoma cell metastasis by suppressing the miR-5100/SPINK5/STAT3 axis
Melanoma is the most lethal skin cancer characterized by its high metastatic potential. It is urgent to find novel therapy...
Integrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells
Integrated analysis of tRNA-derived small RNAs in proliferative human aortic smooth muscle cells
Abnormal proliferation of vascular smooth muscle cells (VSMCs) contributes to vascular remodeling diseases. Recently, it h...
SARS-CoV-2: phenotype, genotype, and characterization of different variants
SARS-CoV-2: phenotype, genotype, and characterization of different variants
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), a major ...