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Phytochemistry and Biological Properties of Sanguisorba spp.: an Updated Review
Plants from the genus Sanguisorba have been the center of attention for many years in different societies due to their med...
Quercetin Attenuates Depressive- Like Behavior in a Rat Model of Alzheimer’s Disease: Involvement of Galectin-3 Signaling Pathway
Background and objectives: Clinical studies have consistently identified depression-related disorders as the most prevalen...
Mitigation of Ochratoxin A-Induced Renal Toxicity by Kaempferol in Albino Mice
Background and objective: This study investigated the protective effects of kaempferol, a natural flavonoid known for its ...
In-Vitro Evaluation of the Anti-Angiogenic Effects of Three Evergreen Plants
Background and objectives: Inhibition of tumor angiogenesis is a promising strategy employed in the treatment of various c...
Introducing Coffee as a Complementary Agent Beside Metformin Against Type 2 Diabetes
Background and objectives: Positive role of coffee consumption on regulation of human blood sugar has been highlighted by ...
Antiepileptic Activity of Zingerone on Maximal Electroshock and Pentylenetetrazole-Induced Seizure in Mice
Background and objectives: Epilepsy is a chronic disorder affecting a broad spectrum of individuals. Recently, there has b...
Antimycobacterial Activity and Brine Shrimp Toxicity of Wild Mushrooms Used by Communities in Southern Tanzania
Background and objectives: Several wild mushroom species occur in southern Tanzania and are used as food by the local trib...
Assessing the Anti-Colitis Properties of Aqueous and Hydroalcoholic Extracts of Pinus eldarica in Rats with Acetic Acid-Induced Colitis
Background and objectives: Ulcerative colitis is a challenging inflammatory bowel disease that requires new treatments. Pi...
Wound Healing Effect of a Topical Product from Ajuga chamaecistus ssp. tomentella in Pressure Ulcer: a Randomized Double-Blind Placebo-Controlled Clinical Trial
Background and objectives: Ajuga genus is used as wound healing in traditional Persian medicine. This study aimed to evalu...
The Effects of Moringa oleifera Leaves Extract and Physical Activity on the Levels of Transforming Growth Factor-β, Caspase 3, and Cognitive Function in Geriatric Mice Model
Background and objectives: As the global geriatric population continues to grow, degenerative-related disorders such as im...
Quercetin Mitigates Acetamiprid-Induced Memory Impairment and Neuronal Damage in Rats
Background and objectives: Acetamiprid, a widely used neonicotinoid pesticide in agriculture, acts as a stimulant on nicot...
Evaluation of Wound Healing and Cytotoxic Activities of Anacardic Acid (13:0) Isolated from Pistacia vera Hull Extract
Background and objectives: Pistacia vera fruit is a popular nut belonging to Anacardiaceae family. Traditionally, the hull...
Hydroalcoholic Extract of Avena sativa Exerts Antidepressant-like Effects Through the Monoaminergic System
Background and objectives: Previous research has demonstrated the antidepressant potential of Avena sativa; however; its m...
Effect of Umbelliprenin on HIF-1α- Driven Angiogenesis Induced by EGF and CoCl2 in T47D Cell Line
Background and objectives: Breast cancer is a highly common cancer that affects women worldwide. Different forms of breast...
The Efficacy of Evening Primrose in Rheumatoid Arthritis: a Systematic Review
Considering the different side effects of the long-time conventional anti-rheumatic drugs prescribed for the treatment of ...
Holothuria scabra Extract Improves Histopathological Features and Inhibits Cancer Growth Through IL-6 and NF-κB Signaling Pathways in Breast Cancer Mice Model
Background and objectives: The high incidence and mortality rate of breast cancer indicates that managing this disease is ...
Potassium Alum Vaginal Suppository: Irritation Assessment in Rabbit
Background and objective: Potassium alum, called “Zaj-e-abyaz” in Iranian traditional medicine, is used vaginally in tradi...
Evaluating the Role of Biochanin A in Acetic acid-Induced Colitis in Rats: Involvement of Nitric Oxide Pathway
Background and objectives: Inflammatory bowel disease (IBD) refers to idiopathic chronic and inflammatory bowel disorders ...
The Effect of Melissa officinalis L. Extract on Ovalbumin- Induced Lung Inflammation in Rats
Background and objectives: Asthma is an inflammatory chronic disease that has become prevalent internationally. Melissa of...
Matricaria chamomilla: an Updated Review on Biological Activities of the Plant and Constituents
Chamomile or camomile (Matricaria chamomilla L. syn. Matricaria recutita L.) belongs to the family Asteraceae. It is nativ...
Hesperidin Plays Neuroprotective Effects Against Quinolinic Acid in Human SH-SY5Y Cells: Focusing on ROS Levels and Cell Cycle Arrest
Background and objectives: In some neurodegenerative diseases, an aberrant accumulation of quinolinic acid is frequently a...
Exploration of Endophytic Fungi and Their Bioactive Potential Isolated from the Medicinal Plant Adhatoda vasica
Background and objective: The plants with pharmacological potential host potential endophytic fungi having metabolic inter...
Inhibition of EGF and CoCl2-Induced HIF-1α and VEGF Production in Triple Negative MDA-MB-468 Cells by Umbelliprenin: Unveiling the Role of PI3K/AKT/mTOR and MAPK Pathways
Background and objectives: Triple-negative breast cancer is a significant global health challenge, and there's growin...
X-ray Diffraction, Electronic Circular Dichroism, and Quantum Mechanics (TD-DFT) Investigations on 4 Dehydroxyaltersolanol A, a Secondary Metabolite from Endophytic Fungus Nigrospora oryzae
Background and objectives: A tetrahydro anthraquinone derivative, 4-dehydroxyaltersolanol A, has been obtained from Nigros...
An Insight into the Traditional Uses, Phytoconstituents and Pharmacological Activities of the Genus Tylophora
Traditional plants have huge demand as medicines to treat a wide range of illnesses. Tylophora is an important genus of me...
Antinociceptive Effect of Artemisia dracunculus Essential Oil in Formalin Test and Possible Involvement of Serotoninergic Receptors and Nitric Oxide Pathway
Background and objectives: Artemisia dracunculus (tarragon) essential oil has shown antinociceptive effect in some animal ...
The Possible Applications of Endophytic Fungi
Endophytic fungi are microorganisms that colonize plants during their entire, or a significant part of their life cycle wi...
Himalayan Blackberry (Rubus discolor) Leaves and Stems: Phytochemical Analysis, Antioxidant, Antimicrobial and Cytotoxic Activities
Background and objectives: The fruits and leaves of Rubus discolor Weihe & Nees (Rosaceae) have been used for treatmen...
Considerable Effects of Caffeinated Coffee on Mouse Liver Function
Background and objectives: Coffee is a favorable drink in the world with advantages that are documented during different i...
Evaluation of Acute and Subacute Toxicity of Coriander Triphala Tablet in Wistar Rats
Background and objectives:  This study evaluated the acute and subacute toxicity of the Coriander Triphala tablet (CTT) in...
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