Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ

Agasing AM, Wu Q, Khatri B, Borisow N, Ruprecht K, Brandt AU et al (2020) Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica. Nat Commun 11:2856. https://doi.org/10.1038/s41467-020-16625-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Behnen M, Leschczyk C, Möller S, Batel T, Klinger M, Solbach W et al (2014) Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcγRIIIB and Mac-1. J Immunol 193:1954–1965. https://doi.org/10.4049/jimmunol.1400478

Article  CAS  PubMed  Google Scholar 

Beltran E, Gerdes LA, Hansen J, Flierl-Hecht A, Krebs S, Blum H et al (2019) Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis. J Clin Investig 129:4758–4768. https://doi.org/10.1172/JCI128475

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S et al (2019) To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death Differ 26:395–408. https://doi.org/10.1038/s41418-018-0261-x

Article  PubMed  PubMed Central  Google Scholar 

Brinkmann V, Zychlinsky A (2012) Neutrophil extracellular traps: is immunity the second function of chromatin? J Cell Biol 198:773–783. https://doi.org/10.1083/jcb.201203170

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brucklacher-Waldert V, Stuerner K, Kolster M, Wolthausen J, Tolosa E (2009) Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 132:3329–3341. https://doi.org/10.1093/brain/awp289

Article  PubMed  Google Scholar 

Buggert M, Price DA, Mackay LK, Betts MR (2023) Human circulating and tissue-resident memory CD8(+) T cells. Nat Immunol 24:1076–1086. https://doi.org/10.1038/s41590-023-01538-6

Article  CAS  PubMed  Google Scholar 

Carnero Contentti E, Correale J (2023) Association between infections, the microbiome, vaccination, and neuromyelitis optica spectrum disorder. Mult Scler 29:492–501. https://doi.org/10.1177/13524585221113272

Article  CAS  PubMed  Google Scholar 

Cassinotto C, Deramond H, Olindo S, Aveillan M, Smadja D, Cabre P (2009) MRI of the spinal cord in neuromyelitis optica and recurrent longitudinal extensive myelitis. J Neuroradiol 36:199–205. https://doi.org/10.1016/j.neurad.2008.12.008

Article  CAS  PubMed  Google Scholar 

Charabati M, Zandee S, Fournier AP, Tastet O, Thai K, Zaminpeyma R et al (2023) MCAM+ brain endothelial cells contribute to neuroinflammation by recruiting pathogenic CD4+ T lymphocytes. Brain 146:1483–1495. https://doi.org/10.1093/brain/awac389

Article  PubMed  Google Scholar 

Cheuk S, Schlums H, Gallais Serezal I, Martini E, Chiang SC, Marquardt N et al (2017) CD49a Expression Defines Tissue-Resident CD8(+) T Cells Poised for Cytotoxic Function in Human Skin. Immunity 46:287–300. https://doi.org/10.1016/j.immuni.2017.01.009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cree BAC, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM et al (2019) Inebilizumab for the treatment of neuromyelitis optica spectrum disorder (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial. Lancet 394:1352–1363. https://doi.org/10.1016/S0140-6736(19)31817-3

Article  CAS  PubMed  Google Scholar 

Daniel C, Leppkes M, Munoz LE, Schley G, Schett G, Herrmann M (2019) Extracellular DNA traps in inflammation, injury and healing. Nat Rev Nephrol 15:559–575. https://doi.org/10.1038/s41581-019-0163-2

Article  CAS  PubMed  Google Scholar 

Dean JW, Helm EY, Fu Z, Xiong L, Sun N, Oliff KN et al (2023) The aryl hydrocarbon receptor cell intrinsically promotes resident memory CD8(+) T cell differentiation and function. Cell Rep 42:111963. https://doi.org/10.1016/j.celrep.2022.111963

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan T, Verkman AS (2020) Experimental animal models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders: progress and shortcomings. Brain Pathol 30:13–25. https://doi.org/10.1111/bpa.12793

Article  PubMed  Google Scholar 

Felix CM, Levin MH, Verkman AS (2016) Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G. J Neuroinflammation 13:275. https://doi.org/10.1186/s12974-016-0746-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flanagan K, Fitzgerald K, Baker J, Regnstrom K, Gardai S, Bard F et al (2012) Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS. PLoS ONE 7:e40443. https://doi.org/10.1371/journal.pone.0040443

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fousert E, Toes R, Desai J (2020) Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses. Cells. https://doi.org/10.3390/cells9040915

Article  PubMed  PubMed Central  Google Scholar 

Fransen NL, Hsiao CC, van der Poel M, Engelenburg HJ, Verdaasdonk K, Vincenten MCJ et al (2020) Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions. Brain 143:1714–1730. https://doi.org/10.1093/brain/awaa117

Article  PubMed  Google Scholar 

Frieser D, Pignata A, Khajavi L, Shlesinger D, Gonzalez-Fierro C, Nguyen XH et al (2022) Tissue-resident CD8(+) T cells drive compartmentalized and chronic autoimmune damage against CNS neurons. Science translational medicine 14:6157. https://doi.org/10.1126/scitranslmed.abl6157

Article  CAS  Google Scholar 

Garcia-Romo GS, Caielli S, Vega B, Connolly J, Allantaz F, Xu Z et al (2011) Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Science translational medicine 3:7320. https://doi.org/10.1126/scitranslmed.3001201

Article  Google Scholar 

Geginat J, Vasco C, Gruarin P, Bonnal R, Rossetti G, Silvestri Y et al (2023) Eomesodermin-expressing type 1 regulatory (EOMES(+) Tr1)-like T cells: Basic biology and role in immune-mediated diseases. Eur J Immunol 53:e2149775. https://doi.org/10.1002/eji.202149775

Article  CAS  PubMed  Google Scholar 

Gredler V, Mader S, Schanda K, Hegen H, Di Pauli F, Kuenz B et al (2013) Clinical and immunological follow-up of B-cell depleting therapy in CNS demyelinating diseases. J Neurol Sci 328:77–82. https://doi.org/10.1016/j.jns.2013.02.024

Article  PubMed  Google Scholar 

Hametner S, Wimmer I, Haider L, Pfeifenbring S, Bruck W, Lassmann H (2013) Iron and neurodegeneration in the multiple sclerosis brain. Ann Neurol 74:848–861. https://doi.org/10.1002/ana.23974

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z et al (2016) In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. Ann Neurol 79:794–805. https://doi.org/10.1002/ana.24630

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hinson SR, McKeon A, Fryer JP, Apiwattanakul M, Lennon VA, Pittock SJ (2009) Prediction of neuromyelitis optica attack severity by quantitation of complement-mediated injury to aquaporin-4-expressing cells. Arch Neurol 66:1164–1167. https://doi.org/10.1001/archneurol.2009.188

Article  PubMed  Google Scholar 

Hinson SR, Romero MF, Popescu BF, Lucchinetti CF, Fryer JP, Wolburg H et al (2012) Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes. Proc Natl Acad Sci U S A 109:1245–1250. https://doi.org/10.1073/pnas.1109980108

Article  PubMed  Google Scholar 

Hokari M, Yokoseki A, Arakawa M, Saji E, Yanagawa K, Yanagimura F et al (2016) Clinicopathological features in anterior visual pathway in neuromyelitis optica. Ann Neurol 79:605–624. https://doi.org/10.1002/ana.24608

Article  CAS  PubMed  Google Scholar 

Hombrink P, Helbig C, Backer RA, Piet B, Oja AE, Stark R et al (2016) Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells. Nat Immunol 17:1467–1478. https://doi.org/10.1038/ni.3589

Article  CAS  PubMed  Google Scholar 

Horie M, Watanabe K, Bepari AK, Nashimoto J, Araki K, Sano H et al (2014) Disruption of actin-binding domain-containing Dystonin protein causes dystonia musculorum in mice. Eur J Neurosci 40:3458–3471. https://doi.org/10.1111/ejn.12711

Article  PubMed  Google Scholar 

Ikeguchi R, Shimizu Y, Kondo A, Kanda N, So H, Kojima H et al (2021) Melanoma Cell Adhesion Molecule Expressing Helper T Cells in CNS Inflammatory Demyelinating Diseases. Neurology(R) neuroimmunology & neuroinflammation 8: e1069. https://doi.org/10.1212/NXI.0000000000001069

Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi Y, Kondo T et al (2019) Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature 565:246–250. https://doi.org/10.1038/s41586-018-0824-5

Article  CAS  PubMed  Google Scholar 

Jarius S, Wildemann B (2013) Aquaporin-4 antibodies (NMO-IgG) as a serological marker of neuromyelitis optica: a critical review of the literature. Brain Pathol 23:661–683. https://doi.org/10.1111/bpa.12084

Article  CAS  PubMed  PubMed Central 

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