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FAM96A is essential for maintaining organismal energy balance and adipose tissue homeostasis in mice
The iron (Fe) metabolism plays important role in regulating systemic metabolism and obesity development. The Fe inside cel...
Heating of consumer cannabis oils can lead to free radical initiated degradation, causing CBD and THC depletion
Commercial cannabis oil products are widely available in Canada even though there is a significant gap in scientific infor...
Cold avoidance and heat pain hypersensitivity in neuronal nucleoredoxin knockout mice
Nucleoredoxin is a thioredoxin-like oxidoreductase that mainly acts as oxidase and thereby regulates calcium calmodulin ki...
Disruption of histamine/H1R-STAT3-SLC7A11 axis exacerbates doxorubicin-induced cardiac ferroptosis
Volume 192, 1 November 2022, Pages 98-114Highlights•Disruption of histamine/H1R signaling aggravated inflammation and Doxo...
The selenophosphate synthetase family: A review
Selenophosphate synthetases use selenium and ATP to synthesize selenophosphate. This is required for biological utilizatio...
Overlooked and valuable facts to know in the NRF2/KEAP1 field
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Silencing SIRT5 induces the senescence of UCB-MSCs exposed to TNF-α by reduction of fatty acid β-oxidation and anti-oxidation
Tumor necrosis factor-α (TNF-α) is an inflammatory cytokine involved in cell survival, apoptosis, and homeostasis. However...
Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway
BackgroundEpilepsy is one of the most common neurological disorders in childhood. However, classical antiepileptic drugs a...
TRPV1 channels in nitric oxide-mediated signalling: insight on excitatory transmission in rat CA1 pyramidal neurons
Nitric oxide (NO) is a fascinating signalling molecule implicated in a plethora of biological functions, especially at the...
Probing nitric oxide signaling using molecular MRI
Arginine (Arg)Chemical exchange saturation transfer (CEST)Caudate-putamen (CPu)Citrulline (Cit)1,4,7,10-Tetraazacyclododec...
The selenoprotein methionine sulfoxide reductase B1 (MSRB1)
Available online 7 September 2022Highlights•Met residues can be oxidized to Met sulfoxide and reduced by methionine sulfox...
Selenoprotein P – Selenium transport protein, enzyme and biomarker of selenium status
The habitual intake of selenium (Se) varies strongly around the world, and many people are at risk of inadequate supply an...
Crosstalk of nitro-oxidative stress and iron in plant immunity
Accumulation of oxygen and nitrogen radicals and their derivatives, known as reactive oxygen species (ROS) and reactive ni...
Biological Schiff bases may generate reactive triplet carbonyls and singlet oxygen: A model study
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Toxicity and virucidal activity of a neon-driven micro plasma jet on eukaryotic cells and a coronavirus
Plasma medicine is a developing field that utilizes the effects of cold physical plasma on biological substrates for thera...
LRRK2 deficiency protects the heart against myocardial infarction injury in mice via the P53/HMGB1 pathway
LRRK2 is a Ser/Thr kinase with multiple functional domains. Studies have shown that LRRK2 mutations are closely related to...
LONP1 downregulation with ageing contributes to osteoarthritis via mitochondrial dysfunction
Osteoarthritis (OA) is an age-related disorder and an important cause of disability that is characterized by a senescence-...
Propofol metabolites and derivatives inhibit the oxidant activities of neutrophils and myeloperoxidase
KeywordsPropofolPropofol-β-glucuronide2,6-Diisopropyl-1,4-p-benzoquinone3,5,3′,5′-tetraisopropyl-(4,4′)-diphenoquinoneMyel...
Pixantrone confers radiosensitization in KRAS mutated cancer cells by suppression of radiation-induced prosurvival pathways
Radioresistance towards radiation therapy has generated the need for the development of radiosensitizers as a potential dr...
Maternal hypothyroidism causes oxidative stress and endoplasmic reticulum stress in the maternal-fetal interface of rats
Maternal hypothyroidism is associated with pre-eclampsia and intrauterine growth restriction, gestational diseases involvi...