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CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway
Bladder cancer (BC) is a prevalent malignant tumor that accounts for nearly 170,000 deaths worldwide [1]. Over the past de...
Exhaustive exercise alters native and site-specific H2O2 emission in red and white skeletal muscle mitochondria
Exhaustive exercise alters native and site-specific H2O2 emission in red and white skeletal muscle mitochondria
The metabolic rate of skeletal muscle increases by more than an order of magnitude during contraction [1,2] and therefore ...
NECAB2 is an endosomal protein important for striatal function
NECAB2 is an endosomal protein important for striatal function
The striatum is an important brain structure involved in motor and action planning, decision-making, motivation and reward...
Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
Aging is a complex and inevitable process that affects all multicellular organisms. It is characterized by the progressive...
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is a common type of stroke, and the ruptured cerebral aneurysm is the most common cause of s...
Canagliflozin reduces chemoresistance in hepatocellular carcinoma through PKM2-c-Myc complex-mediated glutamine starvation
Canagliflozin reduces chemoresistance in hepatocellular carcinoma through PKM2-c-Myc complex-mediated glutamine starvation
Hepatocellular carcinoma (HCC) remains a global health challenge with a high incidence and poor prognosis [1,2]. The 5-yea...
Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation
Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation
Volume 208, 1 November 2023, Pages 478-493Author links open overlay panel, , , , , , , , Highlights•Nrf2 deficiency in A54...
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis
Chronic kidney disease (CKD), as a global public health problem, has caused a heavy burden on economic and social developm...
Asiatic acid protects against pressure overload-induced heart failure in mice by inhibiting mitochondria-dependent apoptosis
Asiatic acid protects against pressure overload-induced heart failure in mice by inhibiting mitochondria-dependent apoptosis
Aortic stenosis (AS) is one of the most commonly seen and severe valvular heart diseases, characterized by restriction of ...
Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs
Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs
Volume 208, 1 November 2023, Pages 458-467Author links open overlay panel, , , , , , , , , , Highlights•Association with m...
TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner
TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner
Parkinson's disease (PD) is a common and progressive neurodegenerative disorder affecting more than 1% of the population a...
Mitochondrial vulnerability to oxidation in human brain organoids modelling Alzheimer's disease
Mitochondrial vulnerability to oxidation in human brain organoids modelling Alzheimer's disease
Alzheimer's disease (AD) is characterized by the presence of amyloid beta (Aβ) deposits and tau-derived neurofibrillary ta...
Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway
Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway
Apical periodontitis (AP) is an infectious disease that causes periapical tissue inflammation and bone destruction. Ferrop...
STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury
STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury
Volume 208, 1 November 2023, Pages 348-360Author links open overlay panel, , , , , , , , , , , , Highlights•STING regulate...
Melatonin ameliorates histone modification disorders in mammalian aged oocytes by neutralizing the alkylation of HDAC1
Melatonin ameliorates histone modification disorders in mammalian aged oocytes by neutralizing the alkylation of HDAC1
Volume 208, 1 November 2023, Pages 361-370Author links open overlay panel, , , , , Highlights•markedly alter the status of...
Azoramide prevents MPP+-induced dopaminergic neuronal death via upregulating ER chaperone BiP expression
Azoramide prevents MPP+-induced dopaminergic neuronal death via upregulating ER chaperone BiP expression
Parkinson's disease (PD), the second most common neurodegenerative disease, results from the progressive death or function...