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Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
Over the past decades, various forms of regulated cell death (RCD) have been explored to develop anticancer drugs [1,2]. A...
Dopamine D1 receptor agonist alleviates acute lung injury via modulating inflammatory responses in macrophages and barrier function in airway epithelial cells
Acute lung injury (ALI) or its severe form, acute respiratory distress syndrome (ARDS) is a life-threatening illness witho...
Salivary lipid mediators: Key indexes of inflammation regulation in heart failure disease
Cardiovascular diseases (CVDs) represent a global burden whose incidence continues to increase [1]. CVDs refer to all the ...
STAT3 signaling promotes cardiac injury by upregulating NCOA4-mediated ferritinophagy and ferroptosis in high-fat-diet fed mice
KeywordsFerroptosisFerritinophagyReactive oxygen species (ROS)HFD-Induced cardiac injuryObesitySTAT3AbbreviationsPTGS2pros...
Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling
Sepsis is a fatal infection mainly attributed to bacterial infections and causes substantial morbidity and mortality world...
WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism
β-propeller protein-associated neurodegeneration (BPAN), also known as static encephalopathy of childhood with neurodegene...
Mitochondrial H2O2 metabolism as central event of heart complex I syndrome in early diabetes
Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients [[1], [2], [3]]. Several ...
Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway
Cigarette smoking, a major risk factor for cardiovascular diseases (CVD), has been shown to aggravate the progression of a...
JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy
KeywordsChondrocyteFerritinophagyFerroptosisJUNNCOA4Osteoarthritis (OA)Chemical compounds studied in this article3-methyla...
TLR2-hif1α-mediated glycolysis contributes to pyroptosis and oxidative stress in allergic airway inflammation
Asthma, which characterized by chronic airway inflammation and bronchial hyperresponsiveness, is identified as a major glo...
Endogenous production of ω-3 polyunsaturated fatty acids mitigates cisplatin-induced myelosuppression by regulating NRF2-MDM2-p53 signaling pathway
Cisplatin (cis-diamminedichloroplatinum, CDDP) has been widely used in cancer chemotherapy since its initial discovery [1,...
SLC27A4-mediated selective uptake of mono-unsaturated fatty acids promotes ferroptosis defense in hepatocellular carcinoma
Hepatocellular carcinoma (HCC), which accounts for 90% of all primary liver cancers, is the fourth most common cause of ca...
Argon gas plasma-treated physiological solutions stimulate immunogenic cell death and eradicates immunosuppressive CD47 protein in lung carcinoma
Cancer remains one of the most severe and rapidly spreading health problems worldwide. GLOBOCAN2020 revealed 10.0 million ...
Double C-2 like domain beta (DOC2B) induces calcium dependent oxidative stress to promote lipotoxicity and mitochondrial dysfunction for its tumor suppressive function
With an estimated 604,000 new cases and 342,000 deaths in 2020, cervical cancer (CC) is the fourth most prevalent gynecolo...
Knockdown of SIRT3 perturbs protective effects of irisin against bone loss in diabetes and periodontitis
A well-recognized risk factor for periodontitis, diabetes mellitus (DM) aggravates periodontal disease with increasing alv...
Celastrol confers ferroptosis resistance via AKT/GSK3β signaling in high-fat diet-induced cardiac injury
In recent years, obesity has become a serious health problem worldwide globally [1]. Obesity can mediate a variety of chro...
The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity
Numerous studies have confirmed that nicotine decreased sperm quality through unbalancing the spermatogenesis and damaged ...
Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis
Ferroptosis is a newly discovered type of iron-dependent programmed cell death, which is different from apoptosis, necrosi...
Ultrasound sensitive O2 microbubbles radiosensitize murine breast cancer but lead to higher metastatic spread
Volume 199, April 2023, Pages 166-176Author links open overlay panel, , , , , Highlights•Tumor tissue responds heterogeneo...
Plasmonic optical fiber biosensor development for point-of-care detection of malondialdehyde as a biomarker of oxidative stress
In living organisms under physiological conditions, there is a preservation of the sub-cellular redox balance, also called...
Iron chelation alleviates multiple pathophysiological pathways in a rat model of cardiac pressure overload
Tremendous strides have been taken during the last 50 years in the understanding and treatment of cardiovascular pathologi...
Mutation of Arabidopsis SME1 and Sm core assembly improves oxidative stress resilience
Alternative splicing (AS) increases gene expression complexity by producing diverse protein coding transcripts from a sing...
Activation of neuronal NADPH oxidase NOX2 promotes inflammatory neurodegeneration
Chronic neuroinflammation especially over-activation of microglia is a common feature shared by all neurodegenerative dise...
Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-κB pathway
Hypertension is one of the most important risk factors for coronary heart disease, heart failure, stroke, and other cardio...
ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance
Insulin resistance (IR) refers to the reduced biological efficacy of insulin and the consequent decrease in glucose uptake...
Integrative approach to uncover antioxidant properties of Bupleuri Radix and its active compounds: Multiscale interactome-level analysis with experimental validation
Volume 199, April 2023, Pages 141-153Author links open overlay panel, , , , Highlights•Bupleuri Radix (BR) is a representa...
ChREBP-β/TXNIP aggravates frucose-induced renal injury through triggering ferroptosis of renal tubular epithelial cells
Volume 199, April 2023, Pages 154-165Author links open overlay panel, , , , , , , , Highlights•High fructose consumption c...
New insights in the molecular regulation of the NADPH oxidase 2 activity: Negative modulation by Poldip2
Poldip2 (polymerase delta-interacting protein 2) is also known as PDIP38 [[1], [2], [3], [4]] or mitogenin I [5]. Poldip2 ...
Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury
Traumatic brain injury (TBI) is responsible for significant morbidity and mortality worldwide, with considerable socioecon...
Nox4-and Tf/TfR-mediated peroxidation and iron overload exacerbate neuronal ferroptosis after intracerebral hemorrhage: Involvement of EAAT3 dysfunction
Available online 18 February 2023Author links open overlay panel, , , , , , , , Highlights•The abnormal up-regulation of N...
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