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Rocaglamide regulates iron homeostasis by suppressing hepcidin expression
Rocaglamide regulates iron homeostasis by suppressing hepcidin expression
Iron is one of the most abundant trace elements in the human body, and it is an essential trace element in many physiologi...
The NEDD8 activating enzyme inhibitor MLN4924 mitigates doxorubicin-induced cardiotoxicity in mice
The NEDD8 activating enzyme inhibitor MLN4924 mitigates doxorubicin-induced cardiotoxicity in mice
Doxorubicin (DOX), an anthracycline antitumor agent, exhibits profound efficacy across diverse tumor types. Nonetheless, t...
Bridging clinical radiotherapy and space radiation therapeutics through reactive oxygen species (ROS)-triggered delivery
Bridging clinical radiotherapy and space radiation therapeutics through reactive oxygen species (ROS)-triggered delivery
Ionizing radiation (IR), characterized by high-energy particles capable of displacing electrons from their atomic orbits, ...
MSC-derived small extracellular vesicles mitigate diabetic retinopathy by stabilizing Nrf2 through miR-143-3p-mediated inhibition of neddylation
MSC-derived small extracellular vesicles mitigate diabetic retinopathy by stabilizing Nrf2 through miR-143-3p-mediated inhibition of neddylation
Diabetic retinopathy (DR) is a highly hazardous and widespread complication associated with diabetes mellitus (DM). It aff...
iNOS regulates hematopoietic stem and progenitor cells via mitochondrial signaling and is critical for bone marrow regeneration
iNOS regulates hematopoietic stem and progenitor cells via mitochondrial signaling and is critical for bone marrow regeneration
Available online 16 April 2024Author links open overlay panel, , , , , , , , , Highlights•Under steady-state conditions, H...
Selenium maintains intestinal epithelial cells to activate M2 macrophages against deoxynivalenol injury
Selenium maintains intestinal epithelial cells to activate M2 macrophages against deoxynivalenol injury
In today’s world, food safety is a critical concern that poses a significant risk to the health of individuals worldwide. ...
TRPC4 Aggravates Hypoxic Pulmonary Hypertension by Promoting Pulmonary Endothelial Cell Apoptosis
TRPC4 Aggravates Hypoxic Pulmonary Hypertension by Promoting Pulmonary Endothelial Cell Apoptosis
Pulmonary hypertension (PH) is a chronic life-threatening disorder, characterized by excessive pulmonary arterial remodeli...
TRIM47-CDO1 axis dictates hepatocellular carcinoma progression by modulating ferroptotic cell death through the ubiquitin‒proteasome system
TRIM47-CDO1 axis dictates hepatocellular carcinoma progression by modulating ferroptotic cell death through the ubiquitin‒proteasome system
Hepatocellular carcinoma (HCC) ranks sixth in cancer prevalence globally and has the third highest fatality rate [1]. The ...
SP2509 functions as a novel ferroptosis inhibitor by reducing intracellular iron level in vascular smooth muscle cells
SP2509 functions as a novel ferroptosis inhibitor by reducing intracellular iron level in vascular smooth muscle cells
Previous studies have shown that ferroptosis of vascular smooth muscle cells (VSMCs) is involved in the development of aor...
Itaconate as a key player in cardiovascular immunometabolism
Itaconate as a key player in cardiovascular immunometabolism
Cardiovascular diseases (CVDs), including ischemic heart disease, stroke, hypertensive heart disease, and peripheral arter...
The therapeutic potential of thiocyanate and hypothiocyanous acid against pulmonary infections
The therapeutic potential of thiocyanate and hypothiocyanous acid against pulmonary infections
Acute respiratory infections (ARIs) are a major global health concern, leading to significant hospitalizations and mortali...
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes
Non-alcoholic fatty liver disease (NAFLD) is well recognized as the primary etiology of chronic hepatic disorders, with a ...
TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis
TXNIP knockdown protects rats against bupivacaine-induced spinal neurotoxicity via the inhibition of oxidative stress and apoptosis
Bupivacaine (BUP) is an anesthetic commonly used in clinical practice that when used for spinal anesthesia, might exert ne...
TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation
TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation
Nonalcoholic fatty liver disease (NAFLD) encompasses various conditions such as simple fatty liver disease (SFL), nonalcoh...
Mapping the interplay of immunoproteasome and autophagy in different heart failure phenotypes
Mapping the interplay of immunoproteasome and autophagy in different heart failure phenotypes
Cardiovascular diseases (CVDs), involving various disorders of blood vessels and the heart, remain the leading cause of pr...
From powerhouse to regulator: The role of mitoepigenetics in mitochondrion-related cellular functions and human diseases
From powerhouse to regulator: The role of mitoepigenetics in mitochondrion-related cellular functions and human diseases
Beyond their crucial role in energy production, mitochondria harbor a distinct genome subject to epigenetic regulation aki...
Effect of a personalized intensive dietary intervention on Base Excision Repair (BER) in colorectal cancer patients: Results from a randomized controlled trial
Effect of a personalized intensive dietary intervention on Base Excision Repair (BER) in colorectal cancer patients: Results from a randomized controlled trial
Available online 6 April 2024Author links open overlay panel, , , , , , , , , , , , Highlights•DNA repair is essential to ...
Corrigendum to “AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis” [Free Radic. Biol. Med. 129 (2018) 59–72]
Corrigendum to “AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis” [Free Radic. Biol. Med. 129 (2018) 59–72]
Available online 4 April 2024Author links open overlay panelDong Liu a 1, Zhiqiang Ma b 1, Shouyin Di b, Yang Yang c, Jing...
Doxorubicin induces phosphorylation of lamin A/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity
Doxorubicin induces phosphorylation of lamin A/C and loss of nuclear membrane integrity: A novel mechanism of cardiotoxicity
The anthracycline category Doxorubicin (Dox) is a chemotherapeutic agent useful in the treatment of various adult and paed...
Activation of lipophagy is required for RAB7 to regulate ferroptosis in sepsis-induced acute kidney injury
Activation of lipophagy is required for RAB7 to regulate ferroptosis in sepsis-induced acute kidney injury
Acute kidney injury (AKI) is a clinical syndrome characterized by a rapid decline in kidney function [1]. Research indicat...
Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor
Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor
Understanding the tumor redox status is important for efficient cancer treatment. Here, we noninvasively detected changes ...
Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells
Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells
Peroxiredoxin 6 (1-cys peroxiredoxin, Prdx6) is an atypical peroxiredoxin widely expressed throughout the body with the lu...
Mitochondrial quality control in non-exudative age-related macular degeneration: From molecular mechanisms to structural and functional recovery
Mitochondrial quality control in non-exudative age-related macular degeneration: From molecular mechanisms to structural and functional recovery
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries, with a globa...
FRBM Mini REVIEW: Chemogenetic approaches to probe redox dysregulation in heart failure
FRBM Mini REVIEW: Chemogenetic approaches to probe redox dysregulation in heart failure
Heart failure (HF) is a clinical syndrome with various etiologies and heterogeneous clinical manifestations in patients. I...
Muscle strength, quantity and quality and muscle fat quantity and their association with oxidative stress in patients with facioscapulohumeral muscular dystrophy: Effect of antioxidant supplementation
Muscle strength, quantity and quality and muscle fat quantity and their association with oxidative stress in patients with facioscapulohumeral muscular dystrophy: Effect of antioxidant supplementation
Facioscapulohumeral muscular dystrophy (FSHD), an autosomal dominant disorder, is one of the most common muscular dystroph...
Quantifying redox transcription factor dynamics as a tool to investigate redox signalling
Quantifying redox transcription factor dynamics as a tool to investigate redox signalling
Available online 2 April 2024Author links open overlay panel, , , , , Highlights•Redox transcription factors (TF) play cri...
Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system
Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system
The intracellular redox balance is crucial for maintaining normal physiological functions, while the delicate equilibrium ...
Targeting NKAα1 to treat Parkinson's disease through inhibition of mitophagy-dependent ferroptosis
Targeting NKAα1 to treat Parkinson's disease through inhibition of mitophagy-dependent ferroptosis
Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is characterized by the loss of dopaminerg...
Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis
Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis
Sjogren's syndrome (SS) is a systemic autoimmune disease that tends to occur in middle-aged and older women [1]. The main ...
Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let’s talk about sex
Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let’s talk about sex
Sarcopenia is associated with reduced quality of life and premature mortality. The sex disparities in the processes underl...
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