SCI时时刷

search
+
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway
Bladder cancer (BC) is a prevalent malignant tumor that accounts for nearly 170,000 deaths worldwide [1]. Over the past de...
Exhaustive exercise alters native and site-specific H2O2 emission in red and white skeletal muscle mitochondria
Exhaustive exercise alters native and site-specific H2O2 emission in red and white skeletal muscle mitochondria
The metabolic rate of skeletal muscle increases by more than an order of magnitude during contraction [1,2] and therefore ...
Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition
Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition
Cancer is the leading cause of mortality worldwide [1], and its metastasis is a more critical factor for mortality than th...
Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase
Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase
The liver is an indispensable organ in the human body that helps with metabolism, nutrient storage, and detoxification in ...
NECAB2 is an endosomal protein important for striatal function
NECAB2 is an endosomal protein important for striatal function
The striatum is an important brain structure involved in motor and action planning, decision-making, motivation and reward...
Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
Mitochondria pleiotropism in stem cell senescence: Mechanisms and therapeutic approaches
Aging is a complex and inevitable process that affects all multicellular organisms. It is characterized by the progressive...
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) is a common type of stroke, and the ruptured cerebral aneurysm is the most common cause of s...
Canagliflozin reduces chemoresistance in hepatocellular carcinoma through PKM2-c-Myc complex-mediated glutamine starvation
Canagliflozin reduces chemoresistance in hepatocellular carcinoma through PKM2-c-Myc complex-mediated glutamine starvation
Hepatocellular carcinoma (HCC) remains a global health challenge with a high incidence and poor prognosis [1,2]. The 5-yea...
Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation
Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation
Volume 208, 1 November 2023, Pages 478-493Author links open overlay panel, , , , , , , , Highlights•Nrf2 deficiency in A54...
The mechanism and targeted intervention of the HIF-1 pathway in improving atherosclerotic heart's sensitivity to ischemic postconditioning
The mechanism and targeted intervention of the HIF-1 pathway in improving atherosclerotic heart's sensitivity to ischemic postconditioning
Primary mitral regurgitation (PMR) is associated with oxidative and inflammatory myocardial damage. We reported greater ex...
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis
Chronic kidney disease (CKD), as a global public health problem, has caused a heavy burden on economic and social developm...
Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression
Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression
Colon cancer is the third most common cancer worldwide, which results in large social and economic burdens [1,2]. Currentl...
Asiatic acid protects against pressure overload-induced heart failure in mice by inhibiting mitochondria-dependent apoptosis
Asiatic acid protects against pressure overload-induced heart failure in mice by inhibiting mitochondria-dependent apoptosis
Aortic stenosis (AS) is one of the most commonly seen and severe valvular heart diseases, characterized by restriction of ...
Exploring the relationship between urinary phthalate metabolites and Crohn's disease via oxidative stress, and the potential moderating role of gut microbiota: A conditional mediation model
Exploring the relationship between urinary phthalate metabolites and Crohn's disease via oxidative stress, and the potential moderating role of gut microbiota: A conditional mediation model
Crohn's disease (CD) is an autoinflammatory and immune-mediated disorder characterized by chronic gastrointestinal inflamm...
Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs
Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs
Volume 208, 1 November 2023, Pages 458-467Author links open overlay panel, , , , , , , , , , Highlights•Association with m...
TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner
TFEB regulates cellular labile iron and prevents ferroptosis in a TfR1-dependent manner
Parkinson's disease (PD) is a common and progressive neurodegenerative disorder affecting more than 1% of the population a...
Macrophage CAPN4 regulates CVB3-induced cardiac inflammation and injury by promoting NLRP3 inflammasome activation and phenotypic transformation to the inflammatory subtype
Macrophage CAPN4 regulates CVB3-induced cardiac inflammation and injury by promoting NLRP3 inflammasome activation and phenotypic transformation to the inflammatory subtype
Myocarditis is an inflammatory heart disease characterized by diffuse lesions in the myocardium [1]. Next to hypertrophic ...
2-Deoxy-d-ribose induces ferroptosis in renal tubular epithelial cells via ubiquitin-proteasome system-mediated xCT protein degradation
2-Deoxy-d-ribose induces ferroptosis in renal tubular epithelial cells via ubiquitin-proteasome system-mediated xCT protein degradation
Ferroptosis is a novel form of cell death triggered by iron-dependent lipid peroxidation. Recent findings suggest that inh...
Phosphatidylethanolamine alleviates OX-LDL-induced macrophage inflammation by upregulating autophagy and inhibiting NLRP1 inflammasome activation
Phosphatidylethanolamine alleviates OX-LDL-induced macrophage inflammation by upregulating autophagy and inhibiting NLRP1 inflammasome activation
Enhanced oxidation of low-density lipoprotein (LDL) in plasma is a critical factor in the initiation and development of at...
A Drosophila model of gestational antimony exposure uncovers growth and developmental disorders caused by disrupting oxidative stress homeostasis
A Drosophila model of gestational antimony exposure uncovers growth and developmental disorders caused by disrupting oxidative stress homeostasis
One of the heavier pnictogens, antimony (Sb) is a metalloid belonging to Group 15 of the Periodic Table. Since ancient tim...
Mitochondrial vulnerability to oxidation in human brain organoids modelling Alzheimer's disease
Mitochondrial vulnerability to oxidation in human brain organoids modelling Alzheimer's disease
Alzheimer's disease (AD) is characterized by the presence of amyloid beta (Aβ) deposits and tau-derived neurofibrillary ta...
Molecular dynamics simulation of the transmembrane transport process of reactive species under the synergistic effect of plasma oxidation and an electric field
Molecular dynamics simulation of the transmembrane transport process of reactive species under the synergistic effect of plasma oxidation and an electric field
Cold atmospheric pressure plasma (CAP) possesses rich physical and chemical factors, including ultraviolet light, heat and...
Corrigendum to “Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a]pyrene-induced apoptosis” [Free Radic Biol Med. 112 (2017) 452–463]
Corrigendum to “Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a]pyrene-induced apoptosis” [Free Radic Biol Med. 112 (2017) 452–463]
Volume 208, 1 November 2023, Page 371Author links open overlay panelDurgesh Nandini Das a, Prajna Paramita Naik a, Subhadi...
Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway
Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway
Apical periodontitis (AP) is an infectious disease that causes periapical tissue inflammation and bone destruction. Ferrop...
STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury
STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury
Volume 208, 1 November 2023, Pages 348-360Author links open overlay panel, , , , , , , , , , , , Highlights•STING regulate...
Melatonin ameliorates histone modification disorders in mammalian aged oocytes by neutralizing the alkylation of HDAC1
Melatonin ameliorates histone modification disorders in mammalian aged oocytes by neutralizing the alkylation of HDAC1
Volume 208, 1 November 2023, Pages 361-370Author links open overlay panel, , , , , Highlights•markedly alter the status of...
5-(3′,4′-dihydroxyphenyl)-γ-valerolactone, a microbiota metabolite of flavan-3-ols, activates SIRT1-mediated autophagy to attenuate H₂O₂-induced inhibition of osteoblast differentiation in MC3T3-E1 cells
5-(3′,4′-dihydroxyphenyl)-γ-valerolactone, a microbiota metabolite of flavan-3-ols, activates SIRT1-mediated autophagy to attenuate H₂O₂-induced inhibition of osteoblast differentiation in MC3T3-E1 cells
Osteoporosis (OP), a gradual decline in mass and degradation of bone, is a systemic disease predisposing to bone fracture ...
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy
A multitude of motor, sensory, and autonomic disorders arise as a consequence of spinal cord (SC) impairment [1]. SCI path...
Plasma oxylipin profiling by high resolution mass spectrometry reveal signatures of inflammation and hypermetabolism in amyotrophic lateral sclerosis
Plasma oxylipin profiling by high resolution mass spectrometry reveal signatures of inflammation and hypermetabolism in amyotrophic lateral sclerosis
Lipids are emerging as key regulators of fundamental cellular processes including cell survival, division, and death [1]. ...
Azoramide prevents MPP+-induced dopaminergic neuronal death via upregulating ER chaperone BiP expression
Azoramide prevents MPP+-induced dopaminergic neuronal death via upregulating ER chaperone BiP expression
Parkinson's disease (PD), the second most common neurodegenerative disease, results from the progressive death or function...
阅读更多
format_indent_increase