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Precision Medicine Approaches to Mental Health Care
Precision Medicine Approaches to Mental Health Care
Developing a more comprehensive understanding of the physiological underpinnings of mental illness, precision medicine has...
CATSPER Calcium Channels: twenty years on
CATSPER Calcium Channels: twenty years on
The flagellar-specific Ca2+ channel CatSper is the predominant Ca2+ entry site in mammalian sperm. CatSper-mediated Ca2+ s...
RANKL and RANK in Cancer Therapy
RANKL and RANK in Cancer Therapy
Receptor activator of nuclear factor-kB (RANK) and its ligand (RANKL) have been described as key regulators in mammalian p...
Effects of Developmental Hypoxia on the Vertebrate Cardiovascular System
Effects of Developmental Hypoxia on the Vertebrate Cardiovascular System
Developmental hypoxia has profound and persistent effects on the vertebrate cardiovascular system, but the nature, magnitu...
Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State
Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State
After years of intense research using structural, biological, and biochemical experimental procedures, it is clear that my...
Biological significance of the coupling delay in synchronized oscillations
Biological significance of the coupling delay in synchronized oscillations
The significance of the coupling delay, which is the time required for interactions between coupled oscillators, in variou...
Noncytotoxic Roles of Granzymes in Health and Disease
Noncytotoxic Roles of Granzymes in Health and Disease
Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated t...
Looking Forward to a Bright Future at APS
Looking Forward to a Bright Future at APS
Received 23 September 2022 ...
Precision Nutrition: Recent advances in obesity
Precision Nutrition: Recent advances in obesity
Precision Nutrition is an emerging area of nutrition research that focuses on understanding metabolic variability within a...
Promoting Nerve Regeneration: Electrical Stimulation, Gene Therapy, and Beyond
Promoting Nerve Regeneration: Electrical Stimulation, Gene Therapy, and Beyond
Peripheral nerve injuries often result in life-altering functional deficits even with optimal management. Unlike the centr...
Precision Medicine Approaches to Mental Healthcare
Precision Medicine Approaches to Mental Healthcare
By developing a more comprehensive understanding of the physiological underpinnings of mental illness, precision medicine ...
Myosin as a novel key modulator of striated muscle metabolism
Myosin as a novel key modulator of striated muscle metabolism
After years of intense research using structural, biological, and biochemical experimental procedures, it is clear that my...
Physiological needs: Sensations and predictions in the insular cortex
Physiological needs: Sensations and predictions in the insular cortex
Physiological needs create powerful motivations (e.g., thirst and hunger). Studies in humans and animal models have implic...
Deglutition and the regulation of the swallow motor pattern
Deglutition and the regulation of the swallow motor pattern
Despite centuries of investigation, questions and controversies remain regarding the fundamental genesis and motor pattern...
Kv1.3 K+ channel physiology assessed by genetic and pharmacological modulation
Kv1.3 K+ channel physiology assessed by genetic and pharmacological modulation
Potassium channels are widespread over all kingdoms and play an important role in the maintenance of cellular ionic homeos...
COVID-19 and Inborn Errors of Immunity
COVID-19 and Inborn Errors of Immunity
Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune host defense and immunoregulation....
Signaling through free fatty acid receptor 4 attenuates cardiometabolic disease
Signaling through free fatty acid receptor 4 attenuates cardiometabolic disease
A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlie an increase in ...
THE PHYSIOLOGY OF GLYMPHATIC SOLUTE TRANSPORT AND WASTE CLEARANCE FROM THE BRAIN
THE PHYSIOLOGY OF GLYMPHATIC SOLUTE TRANSPORT AND WASTE CLEARANCE FROM THE BRAIN
This review focuses on the physiology of glymphatic solute transport and waste clearance, using evidence from experimental...
What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?
What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?
The intertwined relationship between structure and function has been key to understanding human organ physiology and disea...
Non-Cytotoxic Roles of Granzymes in Health and Disease
Non-Cytotoxic Roles of Granzymes in Health and Disease
Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated t...
Promoting Nerve Regeneration: Electrical stimulation, stem cells and beyond
Promoting Nerve Regeneration: Electrical stimulation, stem cells and beyond
Peripheral nerve injuries often result in life-altering functional deficits even with optimal management. Unlike the centr...
Kv Channel Ancillary Subunits: Where Do We Go from Here?
Kv Channel Ancillary Subunits: Where Do We Go from Here?
Voltage-gated potassium (Kv) channels each comprise four pore-forming α-subunits that orchestrate essential duties such as...
What can an organ-on-a-chip teach us about human lung physiology?
What can an organ-on-a-chip teach us about human lung physiology?
The intertwined relationship between structure and function has been key to understanding human organ physiology and disea...
Mitochondrial metabolism in hibernation: Regulation and Implications
Mitochondrial metabolism in hibernation: Regulation and Implications
Hibernators rapidly and reversibly suppress mitochondrial respiration and whole-animal metabolism . Post-translational mod...
Logic of the temporal compartmentalization of the hepatic metabolic cycle
Logic of the temporal compartmentalization of the hepatic metabolic cycle
The mammalian liver must cope with various metabolic and physiological changes that normally recur every day and result pr...
High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses
High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses
Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that v...
Cold exposure and the metabolism of mice, men, and other wonderful creatures
Cold exposure and the metabolism of mice, men, and other wonderful creatures
Laboratory rodents and cold-adapted animals in the wild use a significant amount of the energy derived from food intake fo...
Pulsatile Basal Insulin Secretion is Driven by Glycolytic Oscillations
Pulsatile Basal Insulin Secretion is Driven by Glycolytic Oscillations
In fasted and fed states, blood insulin levels are oscillatory. While this phenomenon is well studied at high glucose leve...
Kidney development - recent insights from technological advances.
Kidney development - recent insights from technological advances.
The kidney is a complex organ, and how it forms is a fascinating process. New technologies, such as single-cell transcript...
Pathophysiology of Hemorrhage as It Relates to the Warfighter
Pathophysiology of Hemorrhage as It Relates to the Warfighter
Saving lives of wounded military Warfighters often depends on the ability to resolve or mitigate the pathophysiology of he...
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