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Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation
Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation
Protein translation regulation is a crucial and tightly controlled regulatory process that contribute...
Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2
Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2
Human coronaviruses are pathogens capable of causing respiratory illnesses in humans, with seven iden...
System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning
System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning
The suprachiasmatic nucleus (SCN) is the mammalian central circadian pacemaker with heterogeneous neurons acting in concer...
Peripheral cancer remodeling of central neural system
Peripheral cancer remodeling of central neural system
Recent work in the field of cancer neuroscience has demonstrated bidirectional interactions between n...
APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer’s disease
APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer’s disease
This work was supported by the National Key R&D Program of China (2017YFE0126500), the National Natural Science Founda...
Structural basis for human Cav3.2 inhibition by selective antagonists
Structural basis for human Cav3.2 inhibition by selective antagonists
The Cav3.2 subtype of T-type calcium channels has been targeted for developing analgesics and anti-epileptics for...
Author Correction: Substrate and drug recognition mechanisms of SLC19A3
These authors contributed equally: Yu Dang, Tianyi Zhang, Shabareesh Pidathala, Guopeng Wang, Yijie Wang, Nanhao Chen.Stat...
Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs
Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs
CRISPR-Cas systems and IS200/IS605 transposon-associated TnpBs have been utilized for the development of genome editing te...
Immunotherapy for atherosclerosis by targeting pro-inflammatory T cells
Recent advancements in atherosclerosis management have shifted focus beyond lipid-lowering strategies...
Persistent in vivo epigenetic silencing of Pcsk9
Persistent in vivo epigenetic silencing of Pcsk9
The quest for safer therapeutic alternatives to genome editing heralds epigenome editing as a promisi...
Substrate and drug recognition mechanisms of SLC19A3
Substrate and drug recognition mechanisms of SLC19A3
Cryo-EM density maps of thiamine-, pyridoxamine-, and fedratinib-bound SLC19A3 have been deposit...
Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans
Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans
Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation of lipid ...
Metabolic engineering of the paclitaxel anticancer drug
Metabolic engineering of the paclitaxel anticancer drug
In a recently published Science article, Jiang et al. unraveled a couple of missing enzymes achieving...
Multiple cancer cell types release LIF and Gal3 to hijack neural signals
Multiple cancer cell types release LIF and Gal3 to hijack neural signals
Neural signals can significantly influence cancer prognosis. However, how cancer cells may proactively modulate the nervou...
Treating insomnia with 40 Hz light flicker
A new study published in Cell Research reports that 40 Hz light flicker induces a somnogenic effect m...
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1)...
MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis
MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis
Recent data from Cho et al. demonstrate that the DNA repair protein MRE11 liberates CGAS from nucleos...
T follicular regulatory cells keep B cell-directed autoreactivity in check
T follicular regulatory cells keep B cell-directed autoreactivity in check
The immune system well illustrates the need for balance between aggression and tolerance: mechanisms ...
Complement(ing) the microbiome in infants through breastmilk
Complement(ing) the microbiome in infants through breastmilk
Breastfeeding has a major impact on the health of infants. In a recent study published in Cell, Xu et...
Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels
Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Cav2.1 channels
We thank Xiaomin Li and Jianlin Lei for technical support during EM image acquisition. We thank the Tsinghua University Br...
Enabling whole pathway reconstruction using artificial chromosomes
In synthetic biology it is desirable to transfer megabase-scale DNA as this enables introduction of c...
An all-in-one targeted protein degradation platform guided by degradation condensates-bridging bi-specific nanobodies
An all-in-one targeted protein degradation platform guided by degradation condensates-bridging bi-specific nanobodies
This work was supported by grants from the National Natural Science Foundation of China (32150023 to P.L.), the National K...
Cytolytic too: Granzyme B-expressing human ILC2s mediate tumor rejection
Cytolytic too: Granzyme B-expressing human ILC2s mediate tumor rejection
Group 2 innate lymphoid cells (ILC2s), known for their role in defending against parasites and regula...
CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization
CAR-Toner: an AI-driven approach for CAR tonic signaling prediction and optimization
Tonic signaling of chimeric antigen receptors (CARs) plays a pivotal role in governing CAR-T cell fit...
Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice
Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice
Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder featured by left ventricular (LV) ...
Sensing the toxic aluminum cations in acidic soils
Sensing the toxic aluminum cations in acidic soils
Plant cells are regularly challenged by harmful pathogens and toxins in the environment, and they mus...
Convenient synthesis and delivery of a megabase-scale designer accessory chromosome empower biosynthetic capacity
Convenient synthesis and delivery of a megabase-scale designer accessory chromosome empower biosynthetic capacity
Synthetic biology confers new functions to hosts by introducing exogenous genetic elements, yet rebuilding complex traits ...
B cell-reactive triad of B cells, follicular helper and regulatory T cells at homeostasis
B cell-reactive triad of B cells, follicular helper and regulatory T cells at homeostasis
Autoreactive B cells are silenced through receptor editing, clonal deletion and anergy induction. Additional autoreactive ...
Identification of oleic acid as an endogenous ligand of GPR3
Identification of oleic acid as an endogenous ligand of GPR3
Although GPR3 plays pivotal roles in both the nervous system and metabolic processes, such as cold-induced thermogenesis, ...