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RHIMoving fibrils of death
Necroptosis relies on interactions between RIP Homotypic Interaction Motif (RHIM)-containing proteins to ...
scNanoCOOL-seq: a long-read single-cell sequencing method for multi-omics profiling within individual cells
scNanoCOOL-seq: a long-read single-cell sequencing method for multi-omics profiling within individual cells
Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, Chin...
Cryo-EM structures of human organic anion transporting polypeptide OATP1B1
Cryo-EM structures of human organic anion transporting polypeptide OATP1B1
Members of the solute carrier organic anion transporting polypeptide (OATPs) family function as transporters for a large v...
Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells
Platelet and myeloid lineage biases of transplanted single perinatal mouse hematopoietic stem cells
Hematopoietic stem cells (HSCs) residing in adult mouse bone marrow (BM) are highly heterogenous,1 rangin...
Swiss army knife T cell: one T cell many tumor targets
Swiss army knife T cell: one T cell many tumor targets
T cell immunotherapies have revolutionized the treatment of many types of cancer; however, the exact mech...
Development of a highly-efficient erythrocyte-drug covalent conjugation platform and its use in treating thrombotic disorders
Development of a highly-efficient erythrocyte-drug covalent conjugation platform and its use in treating thrombotic disorders
We appreciate the technical support from the Biomedical Research Core Facilities and Laboratory Animal Resources Center of...
Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex
Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex
In Saccharomyces cerevisiae, cryptic transcription at the coding region is prevented by the activity of Sin3 histone deace...
Heartbreakers: innate sensors ZBP1 and cGAS linked to cardiotoxicity
Heartbreakers: innate sensors ZBP1 and cGAS linked to cardiotoxicity
As an innate immune sensor, ZBP1 senses infections and cellular damage, triggering the formation of a PAN...
HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation
HSPA8 acts as an amyloidase to suppress necroptosis by inhibiting and reversing functional amyloid formation
Ultra-stable fibrous structure is a hallmark of amyloids. In contrast to canonical disease-related amyloids, emerging rese...
Studying human embryo development with E-assembloids
Stem cell-based models of early human embryo development can provide important insights into key stages o...
Uridine: as sweet as sugar for some cells?
Uridine: as sweet as sugar for some cells?
Nucleosides fuel mammalian cell energy needs and biosynthetic pathways such as ribosylation, glycosylatio...
Atypical bacterial Argonautes regulate antiphage defense
Atypical bacterial Argonautes regulate antiphage defense
Unusual Argonaute (Ago) proteins have been recently identified in prokaryotic immune systems, which upon ...
Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria
Maternal aging increases offspring adult body size via transmission of donut-shaped mitochondria
Maternal age at childbearing has continued to increase in recent decades. However, whether and how it influences offspring...
Cleaving an epithelial path to food tolerance
Cleaving an epithelial path to food tolerance
The intestine is in constant contact with antigenically foreign dietary and microbial products, but must ...
Cryo-EM structure of the ssDNA-activated SPARTA complex
Cryo-EM structure of the ssDNA-activated SPARTA complex
We thank the EM and NMR platform at School of Life Science and Technology of Harbin Institute of Technology and the cryo-E...
Structural insights into plant phytochrome A as a highly sensitized photoreceptor
Structural insights into plant phytochrome A as a highly sensitized photoreceptor
Phytochromes (phys), first discovered in plants, are red and far-red photoreceptors that are also widely ...
Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles
Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles
Eukaryotic ribosome assembly is a highly orchestrated process that involves over two hundred protein factors. After early ...
Lactylation regulates cardiac function
Lactylation regulates cardiac function
A new study connects the metabolism of the heart with its underlying function. This connecti...
Unveiling the hidden battlefield: dissecting the invasive zone in liver cancer
Unveiling the hidden battlefield: dissecting the invasive zone in liver cancer
Understanding the tumor ecosystem, particularly the tumor invasive margins, is crucial for studying tumor...
Towards the understanding of “Herbal RNA Code” for traditional medicine
Towards the understanding of “Herbal RNA Code” for traditional medicine
Recent emerging studies have unveiled the presence of millions of herbal small RNAs (sRNAs) ...
Treating lung cancer: defining surgical curative time window
Lung cancer remains the leading cause of cancer-related deaths worldwide. Despite the great strides made ...
A digital bridge to reverse paralysis
A digital bridge to reverse paralysis
Injury to the spinal cord can disrupt the neural circuits necessary for locomotion. In a recent paper pub...
Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids
Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids
Studies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge o...
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P
Pyroptosis is a type of regulated cell death executed by gasdermin family members. However, how gasdermin-mediated pyropto...
The complete and fully-phased diploid genome of a male Han Chinese
The complete and fully-phased diploid genome of a male Han Chinese
Since the release of the complete human genome, the priority of human genomic study has now been shifting towards closing ...
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac structure and contrac...
Senolysis through thrombomodulation
Senolysis through thrombomodulation
In a recent study published in Cell Research, Pan et al. show that thrombomodulin (THBD), a cell surface ...
Steering G protein activation by mGlu heterodimer
Steering G protein activation by mGlu heterodimer
Heterodimerization of metabotropic glutamate receptors (mGlus) generates functional units that modulate t...
Plant phytochrome A in the Pr state assembles as an asymmetric dimer
Plant phytochrome A in the Pr state assembles as an asymmetric dimer
We thank the Cryo-EM Center of School of Advanced Agricultural Sciences of Peking University and the Center for Protein Re...
Lysine metabolism at the nexus of crotonylation and tumor immunity
Lysine metabolism at the nexus of crotonylation and tumor immunity
A recent study by Yuan et al. in Nature explores the biological mechanisms underlying lysine catabolism a...
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