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A GSDMD agonist boosts specific antitumor immunity
The beneficial role of gasdermin activation and pyroptosis induction in antitumor immunity has been i...
Structure and genome editing activity of the novel CRISPR-Cas12o1 effector
Structure and genome editing activity of the novel CRISPR-Cas12o1 effector
This work was supported by Shandong BellaGen Biotechnology Co., Ltd., and by grants from the National Natural Science Foun...
A cross-species foundation model for single cells
A cross-species foundation model for single cells
Foundation models in transcriptomics have gained attention due to their ability to generalize across ...
Structural insight into GPR55 ligand recognition and G-protein coupling
Structural insight into GPR55 ligand recognition and G-protein coupling
GPR55 was originally considered the third cannabinoid receptor (CB3) due to its high expression in th...
Structure basis of ligand recognition and activation of GPR55
Structure basis of ligand recognition and activation of GPR55
This work was supported by the National Key R&D Program of China (2022YFA1302902, 2023YFC2509100 to T.H.), the Nationa...
The mechanism of bacterial defense system DdmDE from Lactobacillus casei
The mechanism of bacterial defense system DdmDE from Lactobacillus casei
The atomic coordinates of LcDdmD-fork DNA, LcDdmE-gDNA-bubbleDNA, and LcDdmDE-guide-bubbleDNA ha...
Nucleophagy repairs toxic DNA lesions
Nucleophagy repairs toxic DNA lesions
In a recent study in Cell, Lascaux et al. revealed a novel pathway to repair toxic DNA lesions, provi...
Fine-tuning protein hunger: sex- and mating-dependent setpoint control
Fine-tuning protein hunger: sex- and mating-dependent setpoint control
While a balanced intake of macronutrients — carbohydrates, fats, and proteins — is essential for meta...
Knowing when to stop: MICL self-regulates neutrophil NETosis
In a recent study published in Nature, Malamud et al. identified how neutrophil MICL recognizes neutr...
Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis
Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis
The capacity to effectively adapt metabolism to environmental demands is crucial for cell viability, ...
Immunity hubs orchestrating antiviral defense
Immunity hubs orchestrating antiviral defense
Understanding the intricate dynamics of the immune response to SARS-CoV-2 is crucial for developing e...
Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits
Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits
DNA methylation plays multiple regulatory roles in crop development. However, the relationships of methylation polymorphis...
GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model
GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model
Deciphering universal gene regulatory mechanisms in diverse organisms holds great potential for advancing our knowledge of...
Feeling the danger: local wound signaling in plants
Feeling the danger: local wound signaling in plants
Local wound signaling in plants informs the surrounding tissues about an injury and initiates the reg...
PCDH10 is a neuronal receptor for western equine encephalitis virus
PCDH10 is a neuronal receptor for western equine encephalitis virus
Western equine encephalitis virus (WEEV) is a mosquito-borne alphavirus that uses birds as reservoirs...
Author Correction: Targeting pro-inflammatory T cells as a novel therapeutic approach to potentially resolve atherosclerosis in humans
Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, Chin...
α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy
α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy
This work was supported by the National Natural Science Foundation (NSF) of China (82188101 and 32171236 to C.L.; 92353302...
AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension
AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension
Calorie restriction (CR) that chronically reduces average daily caloric intake without causing malnut...
Lysine methylation steps into another step of the central dogma
Lysine methylation steps into another step of the central dogma
Lysine methylation is an important protein modification that regulates replication and transcription,...
tRNA repair: the key to thermo-sensitive male sterility in rice
tRNA repair: the key to thermo-sensitive male sterility in rice
The tms5 mutation exists in most current thermo-sensitive genic male sterility lines, which are essen...
Impaired 2′,3′-cyclic phosphate tRNA repair causes thermo-sensitive genic male sterility in rice
Impaired 2′,3′-cyclic phosphate tRNA repair causes thermo-sensitive genic male sterility in rice
Hybrid rice, widely planted in Asia, is pathogen resistant and has superior yields, making it a major contributor to globa...
Transport mechanism and structural pharmacology of human urate transporter URAT1
Transport mechanism and structural pharmacology of human urate transporter URAT1
Urate is an endogenous product of purine metabolism in the liver. High urate levels in the blood lead to gout, a very comm...
Reducing off-target effects of DdCBEs by reversing amino acid charge near DNA interaction sites
Reducing off-target effects of DdCBEs by reversing amino acid charge near DNA interaction sites
DddAtox-derived cytosine base editors (DdCBEs) can mediate precise, CRISPR-independent editing of mit...
Designing de novo D-protein binders
Designing de novo D-protein binders
D-proteins hold considerable potential in biotechnological applications because of their generally an...
The 1% gift to humanity: The Human Genome Project II
The mission of HGP2 will be to empower all of humanity to read and use the knowledge of their genomes to lead healthier an...
Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter
Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter
Norepinephrine (NE), also known as noradrenaline, is an important neurotransmitter that plays crucial...
PDK1 neddylation by Smurf1 drives Akt activation
PDK1 neddylation by Smurf1 drives Akt activation
The PI3K/Akt pathway, one of the most frequently dysregulated signaling pathways in various cancers, ...
Preservation of a youthful path to evergreen platelets?
The enhanced myeloid lineage bias of old hematopoietic stem cells (HSCs) has been implicated to under...
Structural basis of the bacterial flagellar motor rotational switching
Structural basis of the bacterial flagellar motor rotational switching
The bacterial flagellar motor is a huge bidirectional rotary nanomachine that drives rotation of the flagellum for bacteri...
Illuminating nucleosome interactions
Illuminating nucleosome interactions
In a recent article published in Cell Research, the structure of an array of 12 nucleosomes compacted...
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