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Objection non-responsive! How maternal immune activation in pregnancy weakens subsequent microglial immune response
Objection non-responsive! How maternal immune activation in pregnancy weakens subsequent microglial immune response
Virus-like immunological stress during pregnancy diminishes subsequent microglia reactivity, elevating as...
Sanofi-Cell Research outstanding paper award of 2021
Sanofi-Cell Research outstanding paper award of 2021
We are pleased to announce the winners of the 2021 Sanofi-Cell Research Outstanding Research Article Awar...
A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein
A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein
The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the effica...
AI-empowered integrative structural characterization of m6A methyltransferase complex
AI-empowered integrative structural characterization of m6A methyltransferase complex
N6-methyladenosine (m6A) is the most abundant and prevalent internal modification in mRNA.1 In mammals, m...
Off-the-shelf CAR T cells to treat cancer
Off-the-shelf CAR T cells to treat cancer
Chimeric antigen receptor (CAR) T cell therapies approved for cancer treatment are manufactured from a pa...
Molecular recognition of itch-associated neuropeptides by bombesin receptors
Molecular recognition of itch-associated neuropeptides by bombesin receptors
Itch, especially persistent itch (or chronic pruritus) in patients with allergic skin diseases and/or neu...
Author Correction: Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons
Author Correction: Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons
These authors contributed equally: Pingping Zhu, Tiankun Lu, Jiayi Wu, Dongdong Fan.CAS Key Laboratory of Infection and Im...
A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers
A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers
Mutations of the RAS oncogene are found in around 30% of all human cancers yet direct targeting of RAS is still considered...
A type III-E CRISPR Craspase exhibiting RNase and protease activities
A type III-E CRISPR Craspase exhibiting RNase and protease activities
Type III-E CRISPR-Cas effector gRAMP/Cas7-11 is a RNA-guided RNA endonuclease associated with a putative ...
Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT
Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT
We thank Anqi Zhang and Changyou Guo of the EM platform at the School of Life Science and Technology of Harbin Institute o...
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity
STING, an endoplasmic reticulum (ER) transmembrane protein, mediates innate immune activation upon cGAMP stimulation and i...
mTOR gets greasy: lysosomal sensing of cholesterol
mTOR gets greasy: lysosomal sensing of cholesterol
The mechanistic Target of Rapamycin Complex 1 (mTORC1) regulates diverse metabolic processes in response ...
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia
Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report ...
Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors
Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors
Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive tumor heteroge...
Putting memories in their place
Spatial learning and the rodent hippocampus have served as a powerful model system to study memory, spann...
Producing hybrid seeds like conventional rice
Producing hybrid seeds like conventional rice
Production of hybrid rice seed is laborious and costly, because the restorer lines providing pollen need ...
Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain
Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain
Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-associated decline in organ functions i...
Illuminating brain development
Illuminating brain development
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are light-sensing neurons in the retina that...
Deep learning-based rapid generation of broadly reactive antibodies against SARS-CoV-2 and its Omicron variant
Deep learning-based rapid generation of broadly reactive antibodies against SARS-CoV-2 and its Omicron variant
The COVID-19 pandemic has been ongoing for nearly two and half years, and new variants of concern (VOCs) ...
Cryo-EM structures of human m6A writer complexes
Cryo-EM structures of human m6A writer complexes
N6-methyladenosine (m6A) is the most abundant ribonucleotide modification among eukaryotic messenger RNAs. The m6A “...
Adaptation to MOMP drives cancer persistence
Adaptation to MOMP drives cancer persistence
While widespread mitochondrial outer membrane permeabilization (MOMP) generally seals the fate of stresse...
mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2
mRNA vaccines expressing homo-prototype/Omicron and hetero-chimeric RBD-dimers against SARS-CoV-2
Since emerging in 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an on...
CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification
CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification
The dynamic three-dimensional structures of chromatin and extrachromosomal DNA molecules regulate fundamental cellular pro...
Creation of artificial karyotypes in mice reveals robustness of genome organization
Creation of artificial karyotypes in mice reveals robustness of genome organization
We thank N. Li and D. Li for critical discussions. We thank L. Hui for providing the immortalized plasmid. We thank Genome...
Proviral role of caspase-6 in coronavirus infections
Proviral role of caspase-6 in coronavirus infections
Pathogenic human coronaviruses induce apoptosis in infected cells. Caspase-6 activated under apoptotic co...
A structural platform for B cell receptor signaling
A structural platform for B cell receptor signaling
Three groups recently determined the cryo-EM structures of full-length transmembrane B cell receptor (BCR...
Author Correction: Cryo-EM structure of the AVP–vasopressin receptor 2–Gs signaling complex
Author notesThese authors contributed equally: Lei Wang, Jun Xu.Authors and AffiliationsKobilka Institute of Innovative Dr...