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Metabolite is a part of immune-regulating circuit
Metabolite is a part of immune-regulating circuit
Metabolites play a critical role in regulating cell signaling by interacting...
Chemogenetics for sensing antigens
Chemogenetics for sensing antigens
Antigen-based systems offer highly specific binding and customizability, bro...
The non-canonical proteome: a novel contributor to cancer proliferation
The non-canonical proteome: a novel contributor to cancer proliferation
The non-canonical proteome, comprising hundreds of unannotated peptides enco...
Rice transcription factor bHLH25 confers resistance to multiple diseases by sensing H2O2
Rice transcription factor bHLH25 confers resistance to multiple diseases by sensing H2O2
Hydrogen peroxide (H2O2) is a ubiquitous signal regulating many biological processes, including innate immunity, in all eu...
Comprehensive discovery and functional characterization of the noncanonical proteome
Comprehensive discovery and functional characterization of the noncanonical proteome
The systematic identification and functional characterization of noncanonical translation products, such as novel peptides...
Fourth-generation chimeric antigen receptor T-cell therapy is tolerable and efficacious in treatment-resistant rheumatoid arthritis
Fourth-generation chimeric antigen receptor T-cell therapy is tolerable and efficacious in treatment-resistant rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterize...
Intrathymic alloantigen expression—the Holy Grail or reinventing the wheel?
In clinical solid organ transplantation, strategies that achieve long-term i...
Neoself-antigen presentation in SLE: Mordred’s coronation in Arthur’s absence
Neoself-antigen presentation in SLE: Mordred’s coronation in Arthur’s absence
In a recent study led by Dr. Hisashi Arase published in Cell, a new mechanis...
The conjugation-associated linear-BAC iterative assembling (CALBIA) method for cloning 2.1-Mb human chromosomal DNAs in bacteria
The conjugation-associated linear-BAC iterative assembling (CALBIA) method for cloning 2.1-Mb human chromosomal DNAs in bacteria
Despite the advancements in the human genome project,1 comprehending and man...
Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
Immunometabolism is critical in the regulation of immunity and inflammation; however, the mechanism of preventing aberrant...
Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism
Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism
Neurotensin (NTS) is a secretory peptide produced by lymphatic endothelial cells. Our previous study revealed that NTS sup...
Neurotensin signaling in fat modulates food intake
Neurotensin signaling in fat modulates food intake
White adipose tissue is a highly specialized organ that not only stores exce...
Donor MHC-specific thymus vaccination allows for immunocompatible allotransplantation
Donor MHC-specific thymus vaccination allows for immunocompatible allotransplantation
Organ transplantation is the last-resort option to treat organ failure. However, less than 10% of patients benefit from th...
Modern biology of extrachromosomal DNA: A decade-long voyage of discovery
Modern biology of extrachromosomal DNA: A decade-long voyage of discovery
Genomic instability is a hallmark of cancer and is a major driving force of tumorigenesis. A key manifestation of genomic ...
Tau(t)ing glucocorticoid binding
Tau(t)ing glucocorticoid binding
Glucocorticoids are two-faced drugs: they have beneficial anti-inflammatory ...
LKB1 inactivation unleashes prostate cancer lineage plasticity
LKB1 inactivation unleashes prostate cancer lineage plasticity
While it is well established that androgen receptor pathway inhibition leads...
LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer
LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer
Epigenetic regulation profoundly influences the fate of cancer cells and their capacity to switch between lineages by modu...
Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
Glucocorticoids (GCs) are the most prescribed anti-inflammatory and immunosuppressive drugs. However, their use is often l...
Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice
Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice
Aging is a process accompanied by functional decline in tissues and organs with great social and medical consequences. Dev...
Heat acclimation in mice requires preoptic BDNF neurons and postsynaptic potentiation
Heat acclimation in mice requires preoptic BDNF neurons and postsynaptic potentiation
Heat acclimation (HA) is a key adaptive response in mammals to repeated heat...
Astrocytes: emerging stars of engrams
Astrocytes: emerging stars of engrams
During learning experience, a subset of astrocytes in the hippocampus is act...
Tug of war between phosphatase and kinase during sleep
Tug of war between phosphatase and kinase during sleep
In a recent work published in Nature, Wang et al. reveal how protein kinase ...
Correction: Sanofi-Cell Research outstanding paper award of 2023
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Photoactivated SOPP3 enables APEX2-mediated proximity labeling with high spatio-temporal resolution in live cells
Photoactivated SOPP3 enables APEX2-mediated proximity labeling with high spatio-temporal resolution in live cells
Proximity labeling (PL) is an emerging technology for probing protein intera...
Triaptosis: an endosome-dependent cell death modality
Triaptosis: an endosome-dependent cell death modality
Recent research published in Science reveals that menadione, a precursor to ...
Encoding immune responses: the moonlighting function of alanyl-tRNA synthetase
Encoding immune responses: the moonlighting function of alanyl-tRNA synthetase
The emerging role of L-lactate and L-lactylation has been functionally reported in various biological...
Stressing out the intestinal microbiota via a brain-neuroglandular circuit
Stressing out the intestinal microbiota via a brain-neuroglandular circuit
A new study published in Cell identifies a stress-sensitive brain-neuroglandular circuit that regulat...
Sanofi-Cell Research outstanding paper award of 2023
Sanofi-Cell Research outstanding paper award of 2023
We are pleased to announce the recipients of the 2023 Sanofi-Cell Research Outstanding Research Artic...
A GSDMD agonist boosts specific antitumor immunity
The beneficial role of gasdermin activation and pyroptosis induction in antitumor immunity has been i...
Structure and genome editing activity of the novel CRISPR-Cas12o1 effector
Structure and genome editing activity of the novel CRISPR-Cas12o1 effector
This work was supported by Shandong BellaGen Biotechnology Co., Ltd., and by grants from the National Natural Science Foun...
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