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How inhaled corticosteroids target inflammation in COPD
How inhaled corticosteroids target inflammation in COPD
AbstractInhaled corticosteroids (ICS) are the most commonly used anti-inflammatory drugs for the treatment of COPD. COPD h...
Systematic review of ceftaroline fosamil in the management of patients with methicillin-resistant Staphylococcus aureus pneumonia
Systematic review of ceftaroline fosamil in the management of patients with methicillin-resistant Staphylococcus aureus pneumonia
AbstractMethicillin-resistant Staphylococcus aureus (MRSA) is responsible for an array of problematic community- and healt...
Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis
Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis
IntroductionAsthma and allergic rhinitis affect >300 million people globally [1, 2], comprising 10–30% of all adults an...
Ergonomics of bronchoscopy: good advice or a pain in the neck?
Ergonomics of bronchoscopy: good advice or a pain in the neck?
AbstractInterventional pulmonologists require a unique set of skills including precise motor abilities and physical endura...
The re-emerging role of linoleic acid in paediatric asthma
The re-emerging role of linoleic acid in paediatric asthma
AbstractAsthma is the most common chronic disease within the paediatric population. Although it is multifactorial, its ons...
Self-management interventions for people with pulmonary fibrosis: a scoping review
Self-management interventions for people with pulmonary fibrosis: a scoping review
BackgroundPulmonary fibrosis (PF) significantly impacts the physical and psychosocial wellbeing of people living with the ...
Association of preserved ratio impaired spirometry with mortality: a systematic review and meta-analysis
Association of preserved ratio impaired spirometry with mortality: a systematic review and meta-analysis
AbstractBackground: Preserved ratio impaired spirometry (PRISm) is prevalent within the general population. Increased mort...
Nebulised granulocyte-macrophage colony-stimulating factor (GM-CSF) in autoimmune pulmonary alveolar proteinosis: a systematic review and meta-analysis
Nebulised granulocyte-macrophage colony-stimulating factor (GM-CSF) in autoimmune pulmonary alveolar proteinosis: a systematic review and meta-analysis
AbstractBackground: Autoimmune pulmonary alveolar proteinosis (aPAP) results from impaired macrophage-mediated clearance o...
Molecular monitoring of lung allograft health: is it ready for routine clinical use?
Molecular monitoring of lung allograft health: is it ready for routine clinical use?
IntroductionLong-term care of lung transplant recipients (LTRs) is sometimes akin to tightrope walking, requiring the care...
Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis
Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis
AbstractBackground: Reduced mobility is a central feature of COPD. Assessment of mobility outcomes that can be measured di...
Respiratory viruses: their importance and lessons learned from COVID-19
Respiratory viruses: their importance and lessons learned from COVID-19
AbstractRespiratory virus infection can cause severe illnesses capable of inducing acute respiratory failure that can prog...
The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic
The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic
AbstractAntibiotic resistance is recognised as a global threat to human health by national healthcare agencies, government...
Non-Aspergillus mould lung infections
Non-Aspergillus mould lung infections
AbstractNon-Aspergillus filamentous fungi causing invasive mould infections have increased over the last years due to the ...
How and when to manage respiratory infections out of hospital
How and when to manage respiratory infections out of hospital
Acute bronchitisDefinitionAcute bronchitis is defined as an acute illness causing cough and other symptoms and signs sugge...
Respiratory infections
Respiratory infections
Respiratory infections, whether acute or chronic, are extremely frequent in both adults and children, representing an incr...
Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis
Diagnostic yield and safety of transbronchial lung cryobiopsy and surgical lung biopsy in interstitial lung diseases: a systematic review and meta-analysis
BackgroundInterstitial lung diseases (ILDs) are a group of diseases characterised by inflammation and scarring of the lung...
Riociguat and the right ventricle in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
Riociguat and the right ventricle in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
AbstractPulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are progressive di...
The effects of COVID-19 on respiratory muscle performance: making the case for respiratory muscle testing and training
The effects of COVID-19 on respiratory muscle performance: making the case for respiratory muscle testing and training
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in multiorgan damage primarily medi...
Prognostic value of echocardiography-derived right ventricular dysfunction in haemodynamically stable pulmonary embolism: a systematic review and meta-analysis
Prognostic value of echocardiography-derived right ventricular dysfunction in haemodynamically stable pulmonary embolism: a systematic review and meta-analysis
AbstractBackground We sought to determine the prognostic value of transthoracic echocardiography (TTE)-derived right ventr...
Phage therapy for pulmonary infections: lessons from clinical experiences and key considerations
Phage therapy for pulmonary infections: lessons from clinical experiences and key considerations
AbstractLower respiratory tract infections lead to significant morbidity and mortality. They are increasingly caused by mu...
Biochemical shunt: where and how?
Biochemical shunt: where and how?
Reply to G. Harutyunyan and co-workers:G. Harutyunyan and co-workers, in their reply to our correspondence, introduce the ...
Non-typeable Haemophilus influenzae airways infection: the next treatable trait in asthma?
Non-typeable Haemophilus influenzae airways infection: the next treatable trait in asthma?
AbstractAsthma is a complex, heterogeneous condition that affects over 350 million people globally. It is characterised by...
Performance of saline and water gargling for SARS-CoV-2 reverse transcriptase PCR testing: a systematic review and meta-analysis
Performance of saline and water gargling for SARS-CoV-2 reverse transcriptase PCR testing: a systematic review and meta-analysis
AbstractThe performance of gargling for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcriptase...
Hypoxaemia in the early stage of COVID-19: prevalence of physical or biochemical factors?
Hypoxaemia in the early stage of COVID-19: prevalence of physical or biochemical factors?
AbstractThe ventilation–perfusion mismatch can't explain the high PaCO2–PETCO2 gap in the setting of COVID-19 induced hypo...
Ventilatory neural drive in chronically hypercapnic patients with COPD: effects of sleep and nocturnal noninvasive ventilation
Ventilatory neural drive in chronically hypercapnic patients with COPD: effects of sleep and nocturnal noninvasive ventilation
Ventilatory neural drive in awake hypercapnic patients with COPDThe pathophysiological hallmark of COPD is expiratory flow...
Effectiveness of home-based pulmonary rehabilitation: systematic review and meta-analysis
Effectiveness of home-based pulmonary rehabilitation: systematic review and meta-analysis
Study selectionWe identified a total of 6185 records from six databases (figure 1) and found 1133 records from forward cit...
Multidisciplinary teams in the clinical care of fibrotic interstitial lung disease: current perspectives
Multidisciplinary teams in the clinical care of fibrotic interstitial lung disease: current perspectives
AbstractMultidisciplinary team (MDT) meetings, involving the integrated collaboration of healthcare professionals, are inc...
Physical activity and its correlates in people with cystic fibrosis: a systematic review
Physical activity and its correlates in people with cystic fibrosis: a systematic review
IntroductionCystic fibrosis (CF) is a life-shortening hereditary multisystem disease affecting approximately one in 2000 t...
The relationship of early-life household air pollution with childhood asthma and lung function
The relationship of early-life household air pollution with childhood asthma and lung function
IntroductionAsthma is responsible for a significant health burden in children. Asthma symptoms are experienced by 14% of c...
Obesity, leptin and host defence of Streptococcus pneumoniae: the case for more human research
Obesity, leptin and host defence of Streptococcus pneumoniae: the case for more human research
AbstractPneumococcal pneumonia is the leading cause of community-acquired pneumonia. Obesity is a risk factor for pneumoni...
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