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Respiratory viruses: their importance and lessons learned from COVID-19
Respiratory viruses: their importance and lessons learned from COVID-19
AbstractRespiratory virus infection can cause severe illnesses capable of inducing acute respiratory failure that can prog...
The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic
The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic
AbstractAntibiotic resistance is recognised as a global threat to human health by national healthcare agencies, government...
Non-Aspergillus mould lung infections
Non-Aspergillus mould lung infections
AbstractNon-Aspergillus filamentous fungi causing invasive mould infections have increased over the last years due to the ...
How and when to manage respiratory infections out of hospital
How and when to manage respiratory infections out of hospital
Acute bronchitisDefinitionAcute bronchitis is defined as an acute illness causing cough and other symptoms and signs sugge...
Respiratory infections
Respiratory infections
Respiratory infections, whether acute or chronic, are extremely frequent in both adults and children, representing an incr...
Riociguat and the right ventricle in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
Riociguat and the right ventricle in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension
AbstractPulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are progressive di...
The effects of COVID-19 on respiratory muscle performance: making the case for respiratory muscle testing and training
The effects of COVID-19 on respiratory muscle performance: making the case for respiratory muscle testing and training
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in multiorgan damage primarily medi...
Phage therapy for pulmonary infections: lessons from clinical experiences and key considerations
Phage therapy for pulmonary infections: lessons from clinical experiences and key considerations
AbstractLower respiratory tract infections lead to significant morbidity and mortality. They are increasingly caused by mu...
Biochemical shunt: where and how?
Biochemical shunt: where and how?
Reply to G. Harutyunyan and co-workers:G. Harutyunyan and co-workers, in their reply to our correspondence, introduce the ...
Non-typeable Haemophilus influenzae airways infection: the next treatable trait in asthma?
Non-typeable Haemophilus influenzae airways infection: the next treatable trait in asthma?
AbstractAsthma is a complex, heterogeneous condition that affects over 350 million people globally. It is characterised by...
Performance of saline and water gargling for SARS-CoV-2 reverse transcriptase PCR testing: a systematic review and meta-analysis
Performance of saline and water gargling for SARS-CoV-2 reverse transcriptase PCR testing: a systematic review and meta-analysis
AbstractThe performance of gargling for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcriptase...
Hypoxaemia in the early stage of COVID-19: prevalence of physical or biochemical factors?
Hypoxaemia in the early stage of COVID-19: prevalence of physical or biochemical factors?
AbstractThe ventilation–perfusion mismatch can't explain the high PaCO2–PETCO2 gap in the setting of COVID-19 induced hypo...
Ventilatory neural drive in chronically hypercapnic patients with COPD: effects of sleep and nocturnal noninvasive ventilation
Ventilatory neural drive in chronically hypercapnic patients with COPD: effects of sleep and nocturnal noninvasive ventilation
Ventilatory neural drive in awake hypercapnic patients with COPDThe pathophysiological hallmark of COPD is expiratory flow...
Effectiveness of home-based pulmonary rehabilitation: systematic review and meta-analysis
Effectiveness of home-based pulmonary rehabilitation: systematic review and meta-analysis
Study selectionWe identified a total of 6185 records from six databases (figure 1) and found 1133 records from forward cit...
Multidisciplinary teams in the clinical care of fibrotic interstitial lung disease: current perspectives
Multidisciplinary teams in the clinical care of fibrotic interstitial lung disease: current perspectives
AbstractMultidisciplinary team (MDT) meetings, involving the integrated collaboration of healthcare professionals, are inc...
Physical activity and its correlates in people with cystic fibrosis: a systematic review
Physical activity and its correlates in people with cystic fibrosis: a systematic review
IntroductionCystic fibrosis (CF) is a life-shortening hereditary multisystem disease affecting approximately one in 2000 t...
The relationship of early-life household air pollution with childhood asthma and lung function
The relationship of early-life household air pollution with childhood asthma and lung function
IntroductionAsthma is responsible for a significant health burden in children. Asthma symptoms are experienced by 14% of c...
Obesity, leptin and host defence of Streptococcus pneumoniae: the case for more human research
Obesity, leptin and host defence of Streptococcus pneumoniae: the case for more human research
AbstractPneumococcal pneumonia is the leading cause of community-acquired pneumonia. Obesity is a risk factor for pneumoni...
Does pulmonary rehabilitation address treatable traits? A systematic review
Does pulmonary rehabilitation address treatable traits? A systematic review
AbstractBackground There is growing interest in a “treatable traits” approach to pulmonary rehabilitation in chronic airwa...
The 6-min walk test as a primary end-point in interstitial lung disease
The 6-min walk test as a primary end-point in interstitial lung disease
AbstractThere is a need for clinical trial end-points to better assess how patients feel and function, so that interventio...
Intensive versus short face-to-face smoking cessation interventions: a meta-analysis
Intensive versus short face-to-face smoking cessation interventions: a meta-analysis
IntroductionTobacco smoking is the deadliest preventable behavioural lifestyle factor worldwide, with over 1 billion curre...
Medications for the treatment of pulmonary arterial hypertension: a systematic review and network meta-analysis
Medications for the treatment of pulmonary arterial hypertension: a systematic review and network meta-analysis
AbstractBackground: There is no consensus on the most effective treatments of pulmonary arterial hypertension (PAH). Our o...
Air pollution, metabolites and respiratory health across the life-course
Air pollution, metabolites and respiratory health across the life-course
AbstractPrevious studies have explored the relationships of air pollution and metabolic profiles with lung function. Howev...
Air pollution as an early determinant of COPD
Air pollution as an early determinant of COPD
AbstractCOPD is a progressive and debilitating disease often diagnosed after 50 years of age, but more recent evidence sug...
Biologic drugs in treating allergic bronchopulmonary aspergillosis in patients with cystic fibrosis: a systematic review
Biologic drugs in treating allergic bronchopulmonary aspergillosis in patients with cystic fibrosis: a systematic review
IntroductionCystic fibrosis (CF) is an autosomal recessive genetic disease due to mutations in the cystic fibrosis transme...
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics
AbstractSingle-cell ribonucleic acid sequencing is becoming widely employed to study biological processes at a novel resol...
Lung cancer occurrence after an episode of tuberculosis: a systematic review and meta-analysis
Lung cancer occurrence after an episode of tuberculosis: a systematic review and meta-analysis
AbstractIntroduction: People with tuberculosis experience long-term health effects beyond cure, including chronic respirat...
Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
Immune processes in the pathogenesis of chronic lung allograft dysfunction: identifying the missing pieces of the puzzle
Immune processes in CLADT-cell-mediated immunityCell-mediated immunity is perhaps the best understood alloimmune pathway. ...