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Nuclear-Based Labeling of Cellular Immunotherapies: A Simple Protocol for Preclinical Use
Nuclear-Based Labeling of Cellular Immunotherapies: A Simple Protocol for Preclinical Use
Labeling and tracking existing and emerging cell-based immunotherapies using nuclear imaging is widely used to guide the p...
[68Ga]Ga-labeled FAPI Conjugated with Gly-Pro Sequence for PET Imaging of Malignant Tumors
[68Ga]Ga-labeled FAPI Conjugated with Gly-Pro Sequence for PET Imaging of Malignant Tumors
To improve tumor uptake and prolong tumor retention, a novel fibroblast activation protein (FAP) ligand based on a quinoli...
A Phase 2 Multicenter Clinical Trial of Intraoperative Molecular Imaging of Lung Cancer with a pH-Activatable Nanoprobe
A Phase 2 Multicenter Clinical Trial of Intraoperative Molecular Imaging of Lung Cancer with a pH-Activatable Nanoprobe
Intraoperative molecular imaging (IMI) uses tumor-targeted optical contrast agents to improve identification and clearance...
In vivo Hyperpolarized Metabolic Imaging to Monitor the Progression of Hepatitis B Virus (HBV)-Related Hepatitis to Liver Fibrosis
In vivo Hyperpolarized Metabolic Imaging to Monitor the Progression of Hepatitis B Virus (HBV)-Related Hepatitis to Liver Fibrosis
This study aimed to assess metabolic changes to monitor the progression from normal liver to hepatitis B virus (HBV)-relat...
Use of Electron Paramagnetic Resonance (EPR) to Evaluate Redox Status in a Preclinical Model of Acute Lung Injury
Use of Electron Paramagnetic Resonance (EPR) to Evaluate Redox Status in a Preclinical Model of Acute Lung Injury
Patients with hyper- vs. hypo-inflammatory subphenotypes of acute respiratory distress syndrome (ARDS) exhibit different c...
Sensing and Imaging Molecular Oxygen in Mammals with Spin Lattice Relaxation Electron Paramagnetic Resonance
Sensing and Imaging Molecular Oxygen in Mammals with Spin Lattice Relaxation Electron Paramagnetic Resonance
Molecular oxygen and its thermodynamic transformation drive nearly all life processes. Quantitative measurement and imagin...
Optimizing SUV Analysis: A Multicenter Study on Preclinical FDG-PET/CT Highlights the Impact of Standardization
Optimizing SUV Analysis: A Multicenter Study on Preclinical FDG-PET/CT Highlights the Impact of Standardization
Preclinical imaging, with translational potential, lacks a standardized method for defining volumes of interest (VOIs), im...
Rapid Assessment of Bio-distribution and Antitumor Activity of the Photosensitizer Bremachlorin in a Murine PDAC Model: Detection of PDT-induced Tumor Necrosis by IRDye® 800CW Carboxylate, Using Whole-Body Fluorescent Imaging
Rapid Assessment of Bio-distribution and Antitumor Activity of the Photosensitizer Bremachlorin in a Murine PDAC Model: Detection of PDT-induced Tumor Necrosis by IRDye® 800CW Carboxylate, Using Whole-Body Fluorescent Imaging
Photodynamic therapy (PDT) is a light-based anticancer therapy that can induce tumor necrosis and/or apoptosis. Two import...
Evaluations of an Early Change in Tumor Pathophysiology in Response to Radiotherapy with Oxygen Enhanced Electron Paramagnetic Resonance Imaging (OE EPRI)
Evaluations of an Early Change in Tumor Pathophysiology in Response to Radiotherapy with Oxygen Enhanced Electron Paramagnetic Resonance Imaging (OE EPRI)
Electron Paramagnetic Resonance Imaging (EPRI) can image the partial pressure of oxygen (pO2) within in vivo tumor models....
Partial Acquisition of Spectral Projections Accelerates Four-dimensional Spectral-spatial EPR Imaging for Mouse Tumor Models: A Feasibility Study
Partial Acquisition of Spectral Projections Accelerates Four-dimensional Spectral-spatial EPR Imaging for Mouse Tumor Models: A Feasibility Study
Our study aimed to accelerate the acquisition of four-dimensional (4D) spectral-spatial electron paramagnetic resonance (E...
Tumor Pre-Targeting System Using Streptavidin-Expressing Bacteria
Tumor Pre-Targeting System Using Streptavidin-Expressing Bacteria
A major obstacle to targeted cancer therapy is identifying suitable targets that are specifically and abundantly expressed...
Challenges in Pharmacokinetic Modelling of [18F]fluoro-PEG-folate PET/CT Imaging in Epithelial Ovarian Cancer Patients
Challenges in Pharmacokinetic Modelling of [18F]fluoro-PEG-folate PET/CT Imaging in Epithelial Ovarian Cancer Patients
To describe the pharmacokinetic properties of the [18F]fluoro-polyethylene glycol(PEG)-folate radiotracer in PET/CT imagin...
Prostate Specific Membrane Antigen Expression in a Syngeneic Breast Cancer Mouse Model
Prostate Specific Membrane Antigen Expression in a Syngeneic Breast Cancer Mouse Model
Prostate specific membrane antigen (PSMA) has been studied in human breast cancer (BCa) biopsies, however, lack of data on...
Comparison of the Pharmacokinetics of Gadolinium-Based and Iron Oxide-Based Contrast Agents inside the Lymphatic Structure using Magnetic Resonance Lymphangiography
Comparison of the Pharmacokinetics of Gadolinium-Based and Iron Oxide-Based Contrast Agents inside the Lymphatic Structure using Magnetic Resonance Lymphangiography
Gadolinium (Gd)-based contrast agents are primarily used for contrast-enhanced magnetic resonance lymphangiography (MRL). ...
Molecular Imaging of Fibroblast Activation in Rabbit Atherosclerotic Plaques: a Preclinical PET/CT Study
Molecular Imaging of Fibroblast Activation in Rabbit Atherosclerotic Plaques: a Preclinical PET/CT Study
Atherosclerosis remains the pathological basis of myocardial infarction and ischemic stroke. Early and accurate identifica...
PDX Models in Theranostic Applications: Generation and Screening for B Cell Lymphoma of Human Origin
PDX Models in Theranostic Applications: Generation and Screening for B Cell Lymphoma of Human Origin
This MIB guide briefly summarizes the generation of patient-derived xenografts (PDXs) and highlights the importance of val...
Left Ventricular Remodelling Associated with the Transient Elevated [68Ga]Ga-Pentixafor Activity in the Remote Myocardium Following Acute Myocardial Infarction
Left Ventricular Remodelling Associated with the Transient Elevated [68Ga]Ga-Pentixafor Activity in the Remote Myocardium Following Acute Myocardial Infarction
Previous studies have initially reported accompanying elevated 2-deoxy-2[18F]fluoro-D-glucose ([18F]F-FDG) inflammatory ac...
Comparison of [18F]FDG and [68 Ga]pentixafor PET/CT in Nasopharyngeal Carcinoma
Comparison of [18F]FDG and [68 Ga]pentixafor PET/CT in Nasopharyngeal Carcinoma
This study aimed to explore the feasibility of [68 Ga]pentixafor positron emission tomography/computed tomography...
In Vivo Labeling and Detection of Circulating Tumor Cells in Mice Using OTL38
In Vivo Labeling and Detection of Circulating Tumor Cells in Mice Using OTL38
We recently developed an optical instrument to non-invasively detect fluorescently labeled circulating tumor cells (CTCs) ...
Highly Sensitive Detection of Melanin in Melanomas Using Multi-harmonic Low Frequency EPR
Highly Sensitive Detection of Melanin in Melanomas Using Multi-harmonic Low Frequency EPR
Low frequency EPR can noninvasively detect endogenous free radical melanin in melanocytic skin lesions and could potential...
Passing the Molecular Imaging and Biology Torch
Passing the Molecular Imaging and Biology Torch
I remember relaxing in a Seattle airport lounge in 2018, on my way back to Nashville ...
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
In this study, we explored the role of apoptosis as a potential biomarker for cardiac failure using functional micro-CT an...
Development of New CD38 Targeted Peptides for Cancer Imaging
Development of New CD38 Targeted Peptides for Cancer Imaging
Multiple myeloma (MM) affects over 35,000 patients each year in the US. There remains a need for versatile Positron Emissi...
Test–Retest Repeatability of Patlak Slopes versus Standardized Uptake Values for Hypermetabolic Lesions and Normal Organs in an Oncologic PET/CT Population
Test–Retest Repeatability of Patlak Slopes versus Standardized Uptake Values for Hypermetabolic Lesions and Normal Organs in an Oncologic PET/CT Population
We aimed to determine the test–retest repeatability of quantitative metrics based on the Patlak slope (PS) versus th...
MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates
MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates
Immunoglobulins, both full-length antibodies and smaller antibody fragments, have long been regarded as effective platform...
MRI-Based Cell Tracking of OATP-Expressing Cell Transplants by Pre-Labeling with Gd-EOB-DTPA
MRI-Based Cell Tracking of OATP-Expressing Cell Transplants by Pre-Labeling with Gd-EOB-DTPA
A critical step in cell-based therapies is determining the exact position of transplanted cells immediately post-transplan...
Use of Indocyanine Green Near-Infrared Imaging for Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Pilot Study
Use of Indocyanine Green Near-Infrared Imaging for Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Pilot Study
The current established technique for sentinel lymph node (SLN) biopsy is preoperative injection of 99mtechnetium-labeled ...
Pre-treatment 68 Ga-PSMA-11 PET/CT Prognostic Value in Predicting Response to 177Lu-PSMA-I&T Therapy and Patient Survival
Pre-treatment 68 Ga-PSMA-11 PET/CT Prognostic Value in Predicting Response to 177Lu-PSMA-I&T Therapy and Patient Survival
To assess the prognostic value of pre-treatment [68Ga]Ga-PSMA-11 PET/CT and other baseline clinical characteristics in pre...
Volumetric Parameters Derived from CXCR4-Directed PET/CT Predict Outcome in Patients with Gastrointestinal Neuroendocrine Carcinomas
Volumetric Parameters Derived from CXCR4-Directed PET/CT Predict Outcome in Patients with Gastrointestinal Neuroendocrine Carcinomas
Gastro-entero-pancreatic neuroendocrine carcinomas (GEP-NECs) are an aggressive subgroup of neuroendocrine neoplasms (NENs...
The Role of PET Imaging in Patients with Prion Disease: A Literature Review
The Role of PET Imaging in Patients with Prion Disease: A Literature Review
Prion diseases are rare, rapidly progressive, and fatal incurable degenerative brain disorders caused by the misfolding of...
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