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PDX Models in Theranostic Applications: Generation and Screening for B Cell Lymphoma of Human Origin
PDX Models in Theranostic Applications: Generation and Screening for B Cell Lymphoma of Human Origin
This MIB guide briefly summarizes the generation of patient-derived xenografts (PDXs) and highlights the importance of val...
Left Ventricular Remodelling Associated with the Transient Elevated [68Ga]Ga-Pentixafor Activity in the Remote Myocardium Following Acute Myocardial Infarction
Left Ventricular Remodelling Associated with the Transient Elevated [68Ga]Ga-Pentixafor Activity in the Remote Myocardium Following Acute Myocardial Infarction
Previous studies have initially reported accompanying elevated 2-deoxy-2[18F]fluoro-D-glucose ([18F]F-FDG) inflammatory ac...
Comparison of [18F]FDG and [68 Ga]pentixafor PET/CT in Nasopharyngeal Carcinoma
Comparison of [18F]FDG and [68 Ga]pentixafor PET/CT in Nasopharyngeal Carcinoma
This study aimed to explore the feasibility of [68 Ga]pentixafor positron emission tomography/computed tomography...
In Vivo Labeling and Detection of Circulating Tumor Cells in Mice Using OTL38
In Vivo Labeling and Detection of Circulating Tumor Cells in Mice Using OTL38
We recently developed an optical instrument to non-invasively detect fluorescently labeled circulating tumor cells (CTCs) ...
Highly Sensitive Detection of Melanin in Melanomas Using Multi-harmonic Low Frequency EPR
Highly Sensitive Detection of Melanin in Melanomas Using Multi-harmonic Low Frequency EPR
Low frequency EPR can noninvasively detect endogenous free radical melanin in melanocytic skin lesions and could potential...
Passing the Molecular Imaging and Biology Torch
Passing the Molecular Imaging and Biology Torch
I remember relaxing in a Seattle airport lounge in 2018, on my way back to Nashville ...
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
In this study, we explored the role of apoptosis as a potential biomarker for cardiac failure using functional micro-CT an...
Development of New CD38 Targeted Peptides for Cancer Imaging
Development of New CD38 Targeted Peptides for Cancer Imaging
Multiple myeloma (MM) affects over 35,000 patients each year in the US. There remains a need for versatile Positron Emissi...
Test–Retest Repeatability of Patlak Slopes versus Standardized Uptake Values for Hypermetabolic Lesions and Normal Organs in an Oncologic PET/CT Population
Test–Retest Repeatability of Patlak Slopes versus Standardized Uptake Values for Hypermetabolic Lesions and Normal Organs in an Oncologic PET/CT Population
We aimed to determine the test–retest repeatability of quantitative metrics based on the Patlak slope (PS) versus th...
MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates
MIB Guides: Measuring the Immunoreactivity of Radioimmunoconjugates
Immunoglobulins, both full-length antibodies and smaller antibody fragments, have long been regarded as effective platform...
MRI-Based Cell Tracking of OATP-Expressing Cell Transplants by Pre-Labeling with Gd-EOB-DTPA
MRI-Based Cell Tracking of OATP-Expressing Cell Transplants by Pre-Labeling with Gd-EOB-DTPA
A critical step in cell-based therapies is determining the exact position of transplanted cells immediately post-transplan...
Use of Indocyanine Green Near-Infrared Imaging for Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Pilot Study
Use of Indocyanine Green Near-Infrared Imaging for Sentinel Lymph Node Biopsy in Early Oral Squamous Cell Carcinoma: A Pilot Study
The current established technique for sentinel lymph node (SLN) biopsy is preoperative injection of 99mtechnetium-labeled ...
Pre-treatment 68 Ga-PSMA-11 PET/CT Prognostic Value in Predicting Response to 177Lu-PSMA-I&T Therapy and Patient Survival
Pre-treatment 68 Ga-PSMA-11 PET/CT Prognostic Value in Predicting Response to 177Lu-PSMA-I&T Therapy and Patient Survival
To assess the prognostic value of pre-treatment [68Ga]Ga-PSMA-11 PET/CT and other baseline clinical characteristics in pre...
Volumetric Parameters Derived from CXCR4-Directed PET/CT Predict Outcome in Patients with Gastrointestinal Neuroendocrine Carcinomas
Volumetric Parameters Derived from CXCR4-Directed PET/CT Predict Outcome in Patients with Gastrointestinal Neuroendocrine Carcinomas
Gastro-entero-pancreatic neuroendocrine carcinomas (GEP-NECs) are an aggressive subgroup of neuroendocrine neoplasms (NENs...
The Role of PET Imaging in Patients with Prion Disease: A Literature Review
The Role of PET Imaging in Patients with Prion Disease: A Literature Review
Prion diseases are rare, rapidly progressive, and fatal incurable degenerative brain disorders caused by the misfolding of...
EPR Monitoring of Oxygenation Levels in Tumors After Chlorophyllide-Based Photodynamic Therapy May Allow for Early Prediction of Treatment Outcome
EPR Monitoring of Oxygenation Levels in Tumors After Chlorophyllide-Based Photodynamic Therapy May Allow for Early Prediction of Treatment Outcome
Molecular oxygen, besides a photosensitizer and light of appropriate wavelength, is one of the three factors nece...
Pharmacokinetic Analysis of [18F]FES PET in the Human Brain and Pituitary Gland
Pharmacokinetic Analysis of [18F]FES PET in the Human Brain and Pituitary Gland
Estrogen receptors (ER) are implicated in psychiatric disorders. We assessed if ER availability in the human brain could b...
Translational Potential of a Contrast Agent for FGS Applications in pNETs
Translational Potential of a Contrast Agent for FGS Applications in pNETs
The critical need for accurate tumor detection during oncologic surgery has led to th...
EPR Imaging and Application to Biomedical Sciences: On the 80th Anniversary of the Discovery of EPR
EPR Imaging and Application to Biomedical Sciences: On the 80th Anniversary of the Discovery of EPR
It is our pleasure to present this special issue about electron paramagnetic resonanc...
Evaluating the Patterns of FAPI Uptake in the Shoulder Joint: a Preliminary Study Comparing with FDG Uptake in Oncological Studies
Evaluating the Patterns of FAPI Uptake in the Shoulder Joint: a Preliminary Study Comparing with FDG Uptake in Oncological Studies
Fibroblast activation protein inhibitor (FAPI) targeting PET has been introduced as a novel molecular imaging modality for...
Re-examining What the Results of “a Measurement of Oxygen Level in Tissues” Really Mean
Re-examining What the Results of “a Measurement of Oxygen Level in Tissues” Really Mean
Within this special issue, many eminent investigators report on measurements of oxygen (O2) levels in tissues. Given the c...
Quantification of extravasation and binding of PSMA-targeted nanobubbles by modelling the second-wave phenomenon
Quantification of extravasation and binding of PSMA-targeted nanobubbles by modelling the second-wave phenomenon
With about ten-fold smaller diameter than MBs, nanobubbles (NBs) were developed as new-generation ultrasound contrast agen...
Neoadjuvant Therapies Do Not Reduce Epidermal Growth Factor Receptor (EGFR) Expression or EGFR-Targeted Fluorescence in a Murine Model of Soft-Tissue Sarcomas
Neoadjuvant Therapies Do Not Reduce Epidermal Growth Factor Receptor (EGFR) Expression or EGFR-Targeted Fluorescence in a Murine Model of Soft-Tissue Sarcomas
ABY-029, an epidermal growth factor receptor (EGFR)-targeted, synthetic Affibody peptide labeled with a near-infrared fluo...
Spatiotemporal Dynamics of Neuroinflammation Relate to Behavioral Recovery in Rats with Spinal Cord Injury
Spatiotemporal Dynamics of Neuroinflammation Relate to Behavioral Recovery in Rats with Spinal Cord Injury
The degree and dynamic progression of neuroinflammation after traumatic spinal cord injuries (SCI) are crucial determinant...
New Horizons in Hyperpolarized 13C MRI
New Horizons in Hyperpolarized 13C MRI
Hyperpolarization techniques significantly enhance the sensitivity of magnetic resonance (MR) and thus present fascinating...
Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer
Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer
In cancer immunotherapy, the blockade of the interaction between programmed death-1 and its ligand (PD-1:PD-L1) has proven...
Correction: Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats
Correction: Multimodal Imaging Reveals that Sustained Inhibition of HIF-Prolyl Hydroxylases Induces Opposing Effects on Right and Left Ventricular Function in Healthy Rats
Translational Imaging, Merck & Co., Inc., Rahway, NJ, USAGain Robinson, Raquel Sevilla, Amy Vanko, Weisheng Zhang &...
Uterine Uptake of Estrogen and Progestogen-Based Radiotracers in Rhesus Macaques with Endometriosis
Uterine Uptake of Estrogen and Progestogen-Based Radiotracers in Rhesus Macaques with Endometriosis
Endometriosis is an estrogen-dependent disorder of menstruating primates where tissues similar to the inner lining of the ...
Multi-channel Small Animal Drug Metabolism Real-Time Monitoring Fluorescence System
Multi-channel Small Animal Drug Metabolism Real-Time Monitoring Fluorescence System
The data acquisition of drug metabolism analysis requires a lot of time and animal resources. However, there are often man...
Evaluation and Application of a PET Tracer in Preclinical and Phase 1 Studies to Determine the Brain Biodistribution of Minzasolmin (UCB0599)
Evaluation and Application of a PET Tracer in Preclinical and Phase 1 Studies to Determine the Brain Biodistribution of Minzasolmin (UCB0599)
Minzasolmin (UCB0599) is an orally administered, small molecule inhibitor of ASYN misfolding in development as a potential...
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