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New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities
New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities
Two new cerebrosides, raphimanosides A (1) and B (2), and a new ceramide, raphimanide (3), were isolated from the aerial p...
Resveratrol as a BCL6 natural inhibitor suppresses germinal center derived Non-Hodgkin lymphoma cells growth
Resveratrol as a BCL6 natural inhibitor suppresses germinal center derived Non-Hodgkin lymphoma cells growth
Non-Hodgkin lymphomas (NHL), including diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), and follicular lympho...
Ergostane-type steroids from mushrooms of Pleurotus genus
Ergostane-type steroids from mushrooms of Pleurotus genus
Steroids are physiologically important compounds for animals, plants, and fungi, and they have significantly contributed t...
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis
Macrocyclization of peptides reduces conformational flexibilities, potentially leading to improved drug-like properties. H...
Cytotoxic activity of C17 polyacetylenes from the roots of Glehnia littoralis against drug-resistant colorectal and lung cancer cells
Cytotoxic activity of C17 polyacetylenes from the roots of Glehnia littoralis against drug-resistant colorectal and lung cancer cells
In the preliminary screening, falcarinol and falcarindiol, C17 polyacetylenes from the roots of Glehnia littoralis F. Schm...
Xanthohumol attenuates TXNIP-mediated renal tubular injury in vitro and in vivo diabetic models
Xanthohumol attenuates TXNIP-mediated renal tubular injury in vitro and in vivo diabetic models
Thioredoxin-interacting protein (TXNIP), as a pivotal protein in the cellular stress response, plays a significant role in...
Red ginseng prevents niraparib-induced myelosuppression in C57BL/6 mice via inhibiting p53-mediated upregulation of p21 and p27
Red ginseng prevents niraparib-induced myelosuppression in C57BL/6 mice via inhibiting p53-mediated upregulation of p21 and p27
Myelosuppression is a serious and common complication of targeted therapy for cancer patients, and there are few studies e...
Ten new resin glycosides, ipoalbins I–X, from Ipomoea alba seeds
Ten new resin glycosides, ipoalbins I–X, from Ipomoea alba seeds
Ipomoea alba L. (Convolvulaceae) is an annual vine native to tropical America that is cultivated primarily for ornamental ...
Ellagic acid prevents ovariectomy-induced bone loss and attenuates oxidative damage of osteoblasts by activating SIRT1
Ellagic acid prevents ovariectomy-induced bone loss and attenuates oxidative damage of osteoblasts by activating SIRT1
Oxidative stress has been implicated as a causative factor for the development and progression of osteoporosis(OP). Ellagi...
Optimizing post-harvest processing conditions for Angelica acutiloba roots in Hokkaido: storage temperature and duration
Optimizing post-harvest processing conditions for Angelica acutiloba roots in Hokkaido: storage temperature and duration
The traditional post-harvest processing method of Angelica acutiloba roots, which involves hanging the roots outdoors afte...
Huanglian decoction prevents and treats radiation-induced intestinal injury in lung cancer by regulating endoplasmic reticulum stress
Huanglian decoction prevents and treats radiation-induced intestinal injury in lung cancer by regulating endoplasmic reticulum stress
Radiotherapy is a primary treatment method for lung cancer, and radiation-induced lung injury has been widely studied. How...
Two novel butyrolactone lignan dimers from leaves of Castanopsis chinensis and their anti-inflammatory activities
Two novel butyrolactone lignan dimers from leaves of Castanopsis chinensis and their anti-inflammatory activities
Castanopsis genus (Fagaceae) were rich in plant polyphenols and often used as medicinal plants. In this study, two new lig...
Meroterpenoids with BACE1-inhibitory activity from the fruiting bodies of Suillus bovinus and Boletinus cavipes
Meroterpenoids with BACE1-inhibitory activity from the fruiting bodies of Suillus bovinus and Boletinus cavipes
Alzheimer disease (AD) is the most common type of dementia and accounts for the largest proportion of dementia cases. The ...
Inhibition of amyloid β aggregation and BACE1, and protective effect on SH-SY5Y cells, by p-terphenyl compounds from mushroom Thelephora aurantiotincta
Inhibition of amyloid β aggregation and BACE1, and protective effect on SH-SY5Y cells, by p-terphenyl compounds from mushroom Thelephora aurantiotincta
The number of patients with Alzheimer’s disease (AD) is expected to increase as the population ages. The amyloid cas...
Pharmacokinetics of seven major components in Aβ1-42-treated rats after oral administration of an aqueous extract of Curculiginis Rhizoma and Epimedii Folium
Pharmacokinetics of seven major components in Aβ1-42-treated rats after oral administration of an aqueous extract of Curculiginis Rhizoma and Epimedii Folium
Alzheimer’s disease (AD) is the main cause of dementia. Aβ-mediated neuroinflammation plays a crucial role in t...
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro
The persistence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of new mutant ...
Dendrobium nobile Lindl. alkaloids protect CCl4-induced acute liver injury via upregulating LAMP1 expression and activating autophagy flux
Dendrobium nobile Lindl. alkaloids protect CCl4-induced acute liver injury via upregulating LAMP1 expression and activating autophagy flux
Dendrobium nobile Lindl. alkaloids (DNLA) are considered important active ingredients of Dendrobium, which have a variety ...
Cathagines A–D, new bisindole alkaloids from Catharanthus roseus
Cathagines A–D, new bisindole alkaloids from Catharanthus roseus
Four new bisindole alkaloids, cathagines A (1)–D (4) consisting of an aspidosperma and the fused tetracyclic 3-spiro...
Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity
Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity
Two novel aromatic polyketides, penicanesins J and K (1, 2), were isolated from the marine-derived fungus Didymella aeria,...
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells
3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells
Inflammation is a vital and normal physiological response; however, excessive inflammation can contribute to the ...
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Cardiotoxicity is one of the major obstacles to anthracycline chemotherapy. Anthracycline cardiotoxicity is closely associ...
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity
Methoxyflavone glucosides and caffeoyl phenylethanoid glycoside from Lysionotus pauciflorus: their structures and anti-ferroptosis activity
Phytochemical investigation on the aerial parts of Lysionotus pauciflorus Maxim. (Gesneriaceae), a medicinal plant used in...
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Currently, there are no effective prophylactic or therapeutic drugs for the treatment of paclitaxel (PTX)-induced peripher...
Exploring the inhibitory activity and mechanism on lipid production in 3T3-L1 cells by hot water extract derived from Acacia confusa flowers
Exploring the inhibitory activity and mechanism on lipid production in 3T3-L1 cells by hot water extract derived from Acacia confusa flowers
Acacia confusa Merr. (Fabaceae) (A. confusa) is a native tree species of Taiwan, commonly found in the low-altitude mounta...
New sesquiterpenes from the soft coral Litophyton arboreum
New sesquiterpenes from the soft coral Litophyton arboreum
Two new sesquiterpenes; 8α,11-dihydroxy-β-cyperon (2), and 5-epi-7α-hydroxy-( +)-oplopanone (3), were...
Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway
Eucommiae cortex extract alleviates renal fibrosis in CKD mice induced by adenine through the TGF-β1/Smad signaling pathway
Research into the potential therapeutic benefits of herbal remedies for treating chronic kidney disease (CKD), a condition...
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
Angelic acid triggers ferroptosis in colorectal cancer cells via targeting and impairing NRF2 protein stability
Ferroptosis is a unique programmed cell death driven by iron-dependent phospholipid peroxidation. Tumor cells that escape ...
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation
The inhibition of amyloid β (Aβ) aggregation and degradation of Aβ aggregates are promising approaches for ...
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Epilepsy, characterized by recurrent seizures, often accompanies neurocognitive impairments and is associated with increas...
Research on the quality evaluation of crude drugs
Research on the quality evaluation of crude drugs
As crude drugs are natural products, their quality may vary. However, the degradation of the active ingredients in the com...
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