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Oxygen-sensing pathways below autoregulatory threshold act to sustain myocardial oxygen delivery during reductions in perfusion pressure
Oxygen-sensing pathways below autoregulatory threshold act to sustain myocardial oxygen delivery during reductions in perfusion pressure
The coronary circulation has an innate ability to maintain constant blood flow over a wide range of perfusion pressures. H...
Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice
Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice
Coronary microvascular dysfunction (CMD) is associated with cardiac dysfunction and predictive of cardiac mortality in obe...
Membrane remodelling triggers maturation of excitation–contraction coupling in 3D-shaped human-induced pluripotent stem cell-derived cardiomyocytes
Membrane remodelling triggers maturation of excitation–contraction coupling in 3D-shaped human-induced pluripotent stem cell-derived cardiomyocytes
The prospective use of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) for cardiac regenerative medi...
A cardiologist’s guide to machine learning in cardiovascular disease prognosis prediction
A cardiologist’s guide to machine learning in cardiovascular disease prognosis prediction
A modern-day physician is faced with a vast abundance of clinical and scientific data, by far surpassing the capabilities ...
Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure
Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure
Precision-based molecular phenotyping of heart failure must overcome limited access to cardiac tissue. Although epigenetic...
Ploidy-stratified single cardiomyocyte transcriptomics map Zinc Finger E-Box Binding Homeobox 1 to underly cardiomyocyte proliferation before birth
Ploidy-stratified single cardiomyocyte transcriptomics map Zinc Finger E-Box Binding Homeobox 1 to underly cardiomyocyte proliferation before birth
Whereas cardiomyocytes (CMs) in the fetal heart divide, postnatal CMs fail to undergo karyokinesis and/or cytokinesis and ...
Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside
Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside
The mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-cell RNA sequencing (scRNA-seq) ha...
Toll-like receptor-3 contributes to the development of aortic valve stenosis
Toll-like receptor-3 contributes to the development of aortic valve stenosis
Aortic valve stenosis (AS) development is driven by distinct molecular and cellular mechanisms which include inflammatory ...
The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
Long non-coding RNAs (lncRNAs) can act as regulatory RNAs which, by altering the expression of target genes, impact on the...
Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation
Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation
During embryonic development, cardiomyocytes undergo differentiation and maturation, processes that are tightly regulated ...
Anti-angiogenic effect of exo-LncRNA TUG1 in myocardial infarction and modulation by remote ischemic conditioning
Anti-angiogenic effect of exo-LncRNA TUG1 in myocardial infarction and modulation by remote ischemic conditioning
The successful use of exosomes in therapy after myocardial infarction depends on an improved understanding of their role i...
Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction
Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction
Following an acute myocardial infarction, reperfusion of an occluded coronary artery is often accompanied by microvascular...
Reduction in mitochondrial ROS improves oxidative phosphorylation and provides resilience to coronary endothelium in non-reperfused myocardial infarction
Reduction in mitochondrial ROS improves oxidative phosphorylation and provides resilience to coronary endothelium in non-reperfused myocardial infarction
Recent studies demonstrated that mitochondrial antioxidant MnSOD that reduces mitochondrial (mito) reactive oxygen species...
Beta-3 adrenergic receptor overexpression reverses aortic stenosis–induced heart failure and restores balanced mitochondrial dynamics
Beta-3 adrenergic receptor overexpression reverses aortic stenosis–induced heart failure and restores balanced mitochondrial dynamics
Aortic stenosis (AS) is associated with left ventricular (LV) hypertrophy and heart failure (HF). There is a lack of thera...
Chemical and mechanical activation of resident cardiac macrophages in the living myocardial slice ex vivo model
Chemical and mechanical activation of resident cardiac macrophages in the living myocardial slice ex vivo model
Resident cardiac macrophages (rcMACs) are among the most abundant immune cells in the heart. Plasticity and activation are...
Retraction Note to: Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: role of autophagy
Retraction Note to: Cardiomyocyte-specific deletion of endothelin receptor A rescues aging-associated cardiac hypertrophy and contractile dysfunction: role of autophagy
The Chief Editor has retracted this article following an institutional investigation by the University of Wyoming due to c...
InsP3R–RyR Ca2+ channel crosstalk facilitates arrhythmias in the failing human ventricle
InsP3R–RyR Ca2+ channel crosstalk facilitates arrhythmias in the failing human ventricle
Dysregulated intracellular Ca2+ handling involving altered Ca2+ release from intracellular stores via RyR channels underli...
Elevated platelet–leukocyte complexes are associated with, but dispensable for myocardial ischemia–reperfusion injury
Elevated platelet–leukocyte complexes are associated with, but dispensable for myocardial ischemia–reperfusion injury
P-selectin is an activatable adhesion molecule on platelets promoting platelet aggregation, and platelet–leukocyte c...
Clonal hematopoiesis and cardiovascular disease: deciphering interconnections
Clonal hematopoiesis and cardiovascular disease: deciphering interconnections
Cardiovascular and oncological diseases represent the global major causes of death. For both, a novel and far-reaching ris...
Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic syndrome
Non-responsiveness to cardioprotection by ischaemic preconditioning in Ossabaw minipigs with genetic predisposition to, but without the phenotype of the metabolic syndrome
The translation of successful preclinical and clinical proof-of-concept studies on cardioprotection to the benefit of pati...
Spinal cord astrocytes regulate myocardial ischemia–reperfusion injury
Spinal cord astrocytes regulate myocardial ischemia–reperfusion injury
Astrocytes play a key role in the response to injury and noxious stimuli, but its role in myocardial ischemia–reperf...
New insights into cardioprotection, gained by adopting the CAESAR standards of rigor
New insights into cardioprotection, gained by adopting the CAESAR standards of rigor
Over the past half century, countless therapeutic interventions have been claimed to be cardi...
Retraction Note to: Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR‑dependent pathway
Retraction Note to: Amphiregulin enhances cardiac fibrosis and aggravates cardiac dysfunction in mice with experimental myocardial infarction partly through activating EGFR‑dependent pathway
The Editor in Chief has retracted this article because of multiple concerns regarding figures presented here. Specifically...
Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte
Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte
In heart failure, an increased abundance of post-translationally detyrosinated microtubules stiffens the cardiomyocyte and...
Molecular imaging of the brain–heart axis provides insights into cardiac dysfunction after cerebral ischemia
Molecular imaging of the brain–heart axis provides insights into cardiac dysfunction after cerebral ischemia
Ischemic stroke imparts elevated risk of heart failure though the underlying mechanisms remain poorly described. We aimed ...
Remote Ischemic Conditioning: more explanations and more expectations
Remote Ischemic Conditioning: more explanations and more expectations
Audia JP, Yang X-M, Crockett ES, Housley N, UlHaq E, O’Donnell K, Cohen MV, Downey JM, Alvarez DF (2018) Caspase-1 inhibit...
Chronic high-rate pacing induces heart failure with preserved ejection fraction-like phenotype in Ossabaw swine
Chronic high-rate pacing induces heart failure with preserved ejection fraction-like phenotype in Ossabaw swine
The lack of pre-clinical large animal models of heart failure with preserved ejection fraction (HFpEF) remains a growing, ...
Osteopontin promotes infarct repair
Osteopontin promotes infarct repair
Understanding how macrophages promote myocardial repair can help create new therapies for infarct repair. We aime...
Cardiomyocyte p38 MAPKα suppresses a heart–adipose tissue–neutrophil crosstalk in heart failure development
Cardiomyocyte p38 MAPKα suppresses a heart–adipose tissue–neutrophil crosstalk in heart failure development
Although p38 MAP Kinase α (p38 MAPKα) is generally accepted to play a central role in the cardiac stress respons...
Bone marrow-derived naïve B lymphocytes improve heart function after myocardial infarction: a novel cardioprotective mechanism for empagliflozin
Bone marrow-derived naïve B lymphocytes improve heart function after myocardial infarction: a novel cardioprotective mechanism for empagliflozin
The role of adaptive immunity in myocardial recovery post myocardial infarction (MI), particularly the immune response by ...
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