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Single-cell transcriptome unveils unique transcriptomic signatures of human organ-specific endothelial cells
Single-cell transcriptome unveils unique transcriptomic signatures of human organ-specific endothelial cells
The heterogeneity of endothelial cells (ECs) across human tissues remains incompletely inventoried. We constructe...
Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice
Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice
Despite accumulating data on underlying mechanisms, the influence of sex and prevalent cardio-metabolic co-morbidities on ...
4E-BP3 deficiency impairs dendritic cell activation and CD4+ T cell differentiation and attenuates α-myosin-specific T cell-mediated myocarditis in mice
4E-BP3 deficiency impairs dendritic cell activation and CD4+ T cell differentiation and attenuates α-myosin-specific T cell-mediated myocarditis in mice
Immune checkpoint inhibitor (ICI)-associated myocarditis is a rare but potentially fatal immune-related adverse event. Pre...
Investigating the cause of cardiovascular dysfunction in chronic kidney disease: capillary rarefaction and inflammation may contribute to detrimental cardiovascular outcomes
Investigating the cause of cardiovascular dysfunction in chronic kidney disease: capillary rarefaction and inflammation may contribute to detrimental cardiovascular outcomes
Myocardial ischemia–reperfusion (IR) injury is a major cause of morbidity and mortality in patients with chronic kid...
The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
The IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): multicenter pig study on the effect of ischemic preconditioning
Numerous cardioprotective interventions have been reported to reduce myocardial infarct size (IS) in pre-clinical studies....
Oxidative stress initiates hemodynamic change in CKD-induced heart disease
Oxidative stress initiates hemodynamic change in CKD-induced heart disease
Chronic kidney disease (CKD) predisposes to cardiac remodeling and coronary microvascular dysfunction. Studies in swine id...
Macrophages enhance sodium channel expression in cardiomyocytes
Macrophages enhance sodium channel expression in cardiomyocytes
Cardiac macrophages facilitate electrical conduction through the atrioventricular-node (AV) in mice. A possible role for c...
Cardio-oncology: chances and challenges
Cardio-oncology: chances and challenges
Cardio-oncology is an emerging field that aims to ensure optimal cancer treatment while minimising cardiovascular toxicity...
Deep learning segmentation model for quantification of infarct size in pigs with myocardial ischemia/reperfusion
Deep learning segmentation model for quantification of infarct size in pigs with myocardial ischemia/reperfusion
Infarct size (IS) is the most robust end point for evaluating the success of preclinical studies on cardioprotection. The ...
Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction
Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction
Inflammation, fibrosis and metabolic stress critically promote heart failure with preserved ejection fraction (HFpEF). Exp...
Cardiac wasting in patients with cancer
Cardiac wasting in patients with cancer
Patients with cancer face a significant risk of cardiovascular death, regardless of time since cancer diagnosis. Elderly p...
Cardioprotection strategies for anthracycline cardiotoxicity
Cardioprotection strategies for anthracycline cardiotoxicity
Thanks to the fantastic progress in cancer therapy options, there is a growing population of cancer survivors. This succes...
Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients
Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients
Immunotherapy represents an emergent and heterogeneous group of anticancer treatments harnessing the human immune-surveill...
Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3
Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3
Exercise is an effective way to alleviate breast cancer-induced cardiac injury to a certain extent. However, whether volun...
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury
β3-Adrenergic receptor (β3AR) agonists have been shown to protect against ischemia–reperfusion injury (IRI...
Proprioceptors of the human pericardium
Proprioceptors of the human pericardium
In the human organism, all functions are regulated and, therefore, require a feedback mechanism. This control involves a p...
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
The erythrocyte S1P transporter Mfsd2b is also expressed in the heart. We hypothesized that S1P transport by Mfsd2b is inv...
Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study
Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study
Placental growth factor (PlGF)-2 induces angio- and arteriogenesis in rodents but its therapeutic potential in a clinicall...
SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart
SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart
Hyperglycaemia is common during acute coronary syndromes (ACS) irrespective of diabetic status and portends excess infarct...
Preclinical models of cardiotoxicity from immune checkpoint inhibitor therapy
Preclinical models of cardiotoxicity from immune checkpoint inhibitor therapy
Immune checkpoint inhibitor (ICI) therapy represents a ground-breaking paradigm in cancer treatment, harnessing the immune...
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2
Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute the only medication class that consistently prevents or atte...
Bone marrow cells contribute to seven different endothelial cell populations in the heart
Bone marrow cells contribute to seven different endothelial cell populations in the heart
Understanding the mechanisms underlying vascular regeneration in the heart is crucial for developing novel therapeutic str...
Molecular fingerprints of cardiovascular toxicities of immune checkpoint inhibitors
Molecular fingerprints of cardiovascular toxicities of immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by unleashing the power of the immune system agains...
The attenuated hepatic clearance of propionate increases cardiac oxidative stress in propionic acidemia
The attenuated hepatic clearance of propionate increases cardiac oxidative stress in propionic acidemia
Propionic acidemia (PA), arising from PCCA or PCCB variants, manifests as life-threatening cardiomyopathy and arrhythmias,...
Increased [18F]FDG uptake in the infarcted myocardial area displayed by combined PET/CMR correlates with snRNA-seq-detected inflammatory cell invasion
Increased [18F]FDG uptake in the infarcted myocardial area displayed by combined PET/CMR correlates with snRNA-seq-detected inflammatory cell invasion
Combined [18F]FDG PET-cardiac MRI imaging (PET/CMR) is a useful tool to assess myocardial viability and cardiac function i...
Sodium–glucose cotransporter 2 inhibitors and the cancer patient: from diabetes to cardioprotection and beyond
Sodium–glucose cotransporter 2 inhibitors and the cancer patient: from diabetes to cardioprotection and beyond
Sodium–glucose cotransporter 2 inhibitors (SGLT2i), a new drug class initially designed and approved for treatment o...
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium (Ca2+) signals play a central role in cardiac homeostasis and disease. In the healthy heart, mitocho...
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Despite recent progress, ischemic heart disease poses a persistent global challenge, driving significant morbidity and mor...
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
The mitochondrial metabolite succinate is a key driver of ischemia/reperfusion injury (IRI). Targeting succinate metabolis...
Cardioprotection in cardiovascular surgery
Cardioprotection in cardiovascular surgery
Since the invention of cardiopulmonary bypass, cardioprotective strategies have been investigated to mitigate ischemic inj...
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