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InsP3R–RyR Ca2+ channel crosstalk facilitates arrhythmias in the failing human ventricle
InsP3R–RyR Ca2+ channel crosstalk facilitates arrhythmias in the failing human ventricle
Dysregulated intracellular Ca2+ handling involving altered Ca2+ release from intracellular stores via RyR channels underli...
Elevated platelet–leukocyte complexes are associated with, but dispensable for myocardial ischemia–reperfusion injury
Elevated platelet–leukocyte complexes are associated with, but dispensable for myocardial ischemia–reperfusion injury
P-selectin is an activatable adhesion molecule on platelets promoting platelet aggregation, and platelet–leukocyte c...
Clonal hematopoiesis and cardiovascular disease: deciphering interconnections
Clonal hematopoiesis and cardiovascular disease: deciphering interconnections
Cardiovascular and oncological diseases represent the global major causes of death. For both, a novel and far-reaching ris...
Spinal cord astrocytes regulate myocardial ischemia–reperfusion injury
Spinal cord astrocytes regulate myocardial ischemia–reperfusion injury
Astrocytes play a key role in the response to injury and noxious stimuli, but its role in myocardial ischemia–reperf...
New insights into cardioprotection, gained by adopting the CAESAR standards of rigor
New insights into cardioprotection, gained by adopting the CAESAR standards of rigor
Over the past half century, countless therapeutic interventions have been claimed to be cardi...
Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte
Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte
In heart failure, an increased abundance of post-translationally detyrosinated microtubules stiffens the cardiomyocyte and...
Molecular imaging of the brain–heart axis provides insights into cardiac dysfunction after cerebral ischemia
Molecular imaging of the brain–heart axis provides insights into cardiac dysfunction after cerebral ischemia
Ischemic stroke imparts elevated risk of heart failure though the underlying mechanisms remain poorly described. We aimed ...
Remote Ischemic Conditioning: more explanations and more expectations
Remote Ischemic Conditioning: more explanations and more expectations
Audia JP, Yang X-M, Crockett ES, Housley N, UlHaq E, O’Donnell K, Cohen MV, Downey JM, Alvarez DF (2018) Caspase-1 inhibit...
Chronic high-rate pacing induces heart failure with preserved ejection fraction-like phenotype in Ossabaw swine
Chronic high-rate pacing induces heart failure with preserved ejection fraction-like phenotype in Ossabaw swine
The lack of pre-clinical large animal models of heart failure with preserved ejection fraction (HFpEF) remains a growing, ...
Osteopontin promotes infarct repair
Osteopontin promotes infarct repair
Understanding how macrophages promote myocardial repair can help create new therapies for infarct repair. We aime...
Cardiomyocyte p38 MAPKα suppresses a heart–adipose tissue–neutrophil crosstalk in heart failure development
Cardiomyocyte p38 MAPKα suppresses a heart–adipose tissue–neutrophil crosstalk in heart failure development
Although p38 MAP Kinase α (p38 MAPKα) is generally accepted to play a central role in the cardiac stress respons...
Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions
Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions
Tachycardiomyopathy is characterised by reversible left ventricular dysfunction, provoked by rapid ventricular rate. While...
Forebrain corticosteroid receptors promote post-myocardial infarction depression and mortality
Forebrain corticosteroid receptors promote post-myocardial infarction depression and mortality
Myocardial infarction (MI) with subsequent depression is associated with increased cardiac mortality. Impaired central min...
Sympathetic nerve innervation and metabolism in ischemic myocardium in response to remote ischemic perconditioning
Sympathetic nerve innervation and metabolism in ischemic myocardium in response to remote ischemic perconditioning
Sympathetic nerve denervation after myocardial infarction (MI) predicts risk of sudden cardiac death. Therefore, therapeut...
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles
Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles
Antidepressants have been reported to enhance stroke recovery independent of the presence of depressive symptoms. They hav...
Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis
Mitochondrial calpain-1 activates NLRP3 inflammasome by cleaving ATP5A1 and inducing mitochondrial ROS in CVB3-induced myocarditis
Treatment options for myocarditis are currently limited. Inhibition of calpains has been shown to prevent Coxsackievirus B...
Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop
Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop
The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 ye...
Myeloid leukocytes’ diverse effects on cardiovascular and systemic inflammation in chronic kidney disease
Myeloid leukocytes’ diverse effects on cardiovascular and systemic inflammation in chronic kidney disease
Chronic kidney disease’s prevalence rises globally. Whereas dialysis treatment replaces the kidney’s filtering...
Renal denervation reduces atrial remodeling in hypertensive rats with metabolic syndrome
Renal denervation reduces atrial remodeling in hypertensive rats with metabolic syndrome
Atrial fibrillation (AF) is highly prevalent in hypertensive patients with metabolic syndrome and is related to inflammati...
Why is endothelial resilience key to maintain cardiac health?
Why is endothelial resilience key to maintain cardiac health?
Myocardial injury as induced by myocardial infarction results in tissue ischemia, which critically incepts cardiomyocyte d...
Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice
Prolonged cardiac NR4A2 activation causes dilated cardiomyopathy in mice
Transcription factors play a fundamental role in cardiovascular adaptation to stress. Nuclear receptor subfamily 4 group A...
Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs
Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs
Alterations of RNA editing that affect the secondary structure of RNAs can cause human diseases. We therefore studied RNA ...