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Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome
Barth Syndrome (BTHS) is an inherited cardiomyopathy caused by defects in the mitochondrial transacylase TAFAZZIN (Taz), r...
The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
Cardiovascular disease (CVD) is a major threat to human health, accounting for 46% of non-communicable disease deaths. Gly...
Targeting mitochondrial shape: at the heart of cardioprotection
Targeting mitochondrial shape: at the heart of cardioprotection
There remains an unmet need to identify novel therapeutic strategies capable of protecting the myocardium against the detr...
Succinate dehydrogenase is essential for epigenetic and metabolic homeostasis in hearts
Succinate dehydrogenase is essential for epigenetic and metabolic homeostasis in hearts
A hallmark of heart failure is a metabolic switch away from fatty acids β-oxidation (FAO) to glycolysis. Here, we sho...
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
Recent advances on the role of monoamine oxidases in cardiac pathophysiology
Numerous physiological and pathological roles have been attributed to the formation of mitochondrial reactive oxygen speci...
Outcomes of hypothalamic oxytocin neuron-driven cardioprotection after acute myocardial infarction
Outcomes of hypothalamic oxytocin neuron-driven cardioprotection after acute myocardial infarction
Altered autonomic balance is a hallmark of numerous cardiovascular diseases, including myocardial infarction (MI). Althoug...
Mitophagy for cardioprotection
Mitophagy for cardioprotection
Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively termed mitochondrial quality...
Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation
Novel GSDMD inhibitor GI-Y1 protects heart against pyroptosis and ischemia/reperfusion injury by blocking pyroptotic pore formation
Activation of gasdermin D (GSDMD) and its concomitant cardiomyocyte pyroptosis are critically involved in multiple cardiac...
Giant mitochondria in cardiomyocytes: cellular architecture in health and disease
Giant mitochondria in cardiomyocytes: cellular architecture in health and disease
Giant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac mus...
The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury
The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury
Ischemic heart disease remains a leading cause of human mortality worldwide. One form of ischemic heart disease is ischemi...
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressu...
Cardiac fibroblast GSK-3α aggravates ischemic cardiac injury by promoting fibrosis, inflammation, and impairing angiogenesis
Cardiac fibroblast GSK-3α aggravates ischemic cardiac injury by promoting fibrosis, inflammation, and impairing angiogenesis
Myocardial infarction (MI) is the leading cause of death worldwide. Glycogen synthase kinase-3 (GSK-3) has been considered...
Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy
Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy
Cardiotoxicity is a major complication of anthracycline therapy that negatively impacts prognosis. Effective pharmacothera...
Identification of the specific molecular and functional signatures of pre-beta-HDL: relevance to cardiovascular disease
Identification of the specific molecular and functional signatures of pre-beta-HDL: relevance to cardiovascular disease
While low concentrations of high-density lipoprotein-cholesterol (HDL-C) are widely accepted as an independent cardiovascu...
Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
Preventing mitochondrial reverse electron transport as a strategy for cardioprotection
In the context of myocardial infarction, the burst of superoxide generated by reverse electron transport (RET) at complex ...
Perspective: mitochondrial STAT3 in cardioprotection
Perspective: mitochondrial STAT3 in cardioprotection
Activation of signal transducer and activator of transcription 3 (STAT3) has been identified as a key cardioprotective sig...
Rivaroxaban attenuates neutrophil maturation in the bone marrow niche
Rivaroxaban attenuates neutrophil maturation in the bone marrow niche
Pharmacological inhibition of factor Xa by rivaroxaban has been shown to mediate cardioprotection and is frequently used i...
The heterocellular heart: identities, interactions, and implications for cardiology
The heterocellular heart: identities, interactions, and implications for cardiology
The heterocellular nature of the heart has been receiving increasing attention in recent years. In addition to cardiomyocy...
Endothelial ILK induces cardioprotection by preventing coronary microvascular dysfunction and endothelial-to-mesenchymal transition
Endothelial ILK induces cardioprotection by preventing coronary microvascular dysfunction and endothelial-to-mesenchymal transition
Endothelial dysfunction is an early event in coronary microvascular disease. Integrin-linked kinase (ILK) prevents endothe...
A tale of pigs, beta-blockers and genetic variants
A tale of pigs, beta-blockers and genetic variants
Bell RM, Basalay M, Botker HE, Beikoghli Kalkhoran S, Carr RD, Cunningham J, Davidson SM, England TJ, Giesz S, Ghosh AK, G...
Translational control of Ybx1 expression regulates cardiac function in response to pressure overload in vivo
Translational control of Ybx1 expression regulates cardiac function in response to pressure overload in vivo
RNA–protein interactions are central to cardiac function, but how activity of individual RNA-binding protein is regu...
No robust reduction of infarct size and no-reflow by metoprolol pretreatment in adult Göttingen minipigs
No robust reduction of infarct size and no-reflow by metoprolol pretreatment in adult Göttingen minipigs
Whereas prior experiments in juvenile pigs had reported infarct size reduction by intravenous metoprolol early during myoc...
Deficiency of mitochondrial calcium uniporter abrogates iron overload-induced cardiac dysfunction by reducing ferroptosis
Deficiency of mitochondrial calcium uniporter abrogates iron overload-induced cardiac dysfunction by reducing ferroptosis
Iron overload associated cardiac dysfunction remains a significant clinical challenge whose underlying mechanism(s) have y...
The RISK pathway leading to mitochondria and cardioprotection: how everything started
The RISK pathway leading to mitochondria and cardioprotection: how everything started
Ischaemic heart disease, which often manifests clinically as myocardial infarction (MI), remains a major cause of mortalit...
SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation
SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation
SMYD1, a striated muscle-specific lysine methyltransferase, was originally shown to play a key role in embryonic ...