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Macrophages enhance sodium channel expression in cardiomyocytes
Macrophages enhance sodium channel expression in cardiomyocytes
Cardiac macrophages facilitate electrical conduction through the atrioventricular-node (AV) in mice. A possible role for c...
Cardio-oncology: chances and challenges
Cardio-oncology: chances and challenges
Cardio-oncology is an emerging field that aims to ensure optimal cancer treatment while minimising cardiovascular toxicity...
Deep learning segmentation model for quantification of infarct size in pigs with myocardial ischemia/reperfusion
Deep learning segmentation model for quantification of infarct size in pigs with myocardial ischemia/reperfusion
Infarct size (IS) is the most robust end point for evaluating the success of preclinical studies on cardioprotection. The ...
Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction
Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure with preserved ejection fraction
Inflammation, fibrosis and metabolic stress critically promote heart failure with preserved ejection fraction (HFpEF). Exp...
Cardiac wasting in patients with cancer
Cardiac wasting in patients with cancer
Patients with cancer face a significant risk of cardiovascular death, regardless of time since cancer diagnosis. Elderly p...
Cardioprotection strategies for anthracycline cardiotoxicity
Cardioprotection strategies for anthracycline cardiotoxicity
Thanks to the fantastic progress in cancer therapy options, there is a growing population of cancer survivors. This succes...
Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients
Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: an under-estimated threat for cancer patients
Immunotherapy represents an emergent and heterogeneous group of anticancer treatments harnessing the human immune-surveill...
Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3
Cardioprotection of voluntary exercise against breast cancer-induced cardiac injury via STAT3
Exercise is an effective way to alleviate breast cancer-induced cardiac injury to a certain extent. However, whether volun...
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury
β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia–reperfusion injury
β3-Adrenergic receptor (β3AR) agonists have been shown to protect against ischemia–reperfusion injury (IRI...
Proprioceptors of the human pericardium
Proprioceptors of the human pericardium
In the human organism, all functions are regulated and, therefore, require a feedback mechanism. This control involves a p...
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
Deficiency of the sphingosine-1-phosphate (S1P) transporter Mfsd2b protects the heart against hypertension-induced cardiac remodeling by suppressing the L-type-Ca2+ channel
The erythrocyte S1P transporter Mfsd2b is also expressed in the heart. We hypothesized that S1P transport by Mfsd2b is inv...
Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study
Recombinant human placental growth factor-2 in post-infarction left ventricular dysfunction: a randomized, placebo-controlled, preclinical study
Placental growth factor (PlGF)-2 induces angio- and arteriogenesis in rodents but its therapeutic potential in a clinicall...
SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart
SGLT1 contributes to glucose-mediated exacerbation of ischemia–reperfusion injury in ex vivo rat heart
Hyperglycaemia is common during acute coronary syndromes (ACS) irrespective of diabetic status and portends excess infarct...
Preclinical models of cardiotoxicity from immune checkpoint inhibitor therapy
Preclinical models of cardiotoxicity from immune checkpoint inhibitor therapy
Immune checkpoint inhibitor (ICI) therapy represents a ground-breaking paradigm in cancer treatment, harnessing the immune...
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2
Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute the only medication class that consistently prevents or atte...
Bone marrow cells contribute to seven different endothelial cell populations in the heart
Bone marrow cells contribute to seven different endothelial cell populations in the heart
Understanding the mechanisms underlying vascular regeneration in the heart is crucial for developing novel therapeutic str...
Molecular fingerprints of cardiovascular toxicities of immune checkpoint inhibitors
Molecular fingerprints of cardiovascular toxicities of immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by unleashing the power of the immune system agains...
The attenuated hepatic clearance of propionate increases cardiac oxidative stress in propionic acidemia
The attenuated hepatic clearance of propionate increases cardiac oxidative stress in propionic acidemia
Propionic acidemia (PA), arising from PCCA or PCCB variants, manifests as life-threatening cardiomyopathy and arrhythmias,...
Increased [18F]FDG uptake in the infarcted myocardial area displayed by combined PET/CMR correlates with snRNA-seq-detected inflammatory cell invasion
Increased [18F]FDG uptake in the infarcted myocardial area displayed by combined PET/CMR correlates with snRNA-seq-detected inflammatory cell invasion
Combined [18F]FDG PET-cardiac MRI imaging (PET/CMR) is a useful tool to assess myocardial viability and cardiac function i...
Sodium–glucose cotransporter 2 inhibitors and the cancer patient: from diabetes to cardioprotection and beyond
Sodium–glucose cotransporter 2 inhibitors and the cancer patient: from diabetes to cardioprotection and beyond
Sodium–glucose cotransporter 2 inhibitors (SGLT2i), a new drug class initially designed and approved for treatment o...
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium in cardiac ischemia/reperfusion injury and cardioprotection
Mitochondrial calcium (Ca2+) signals play a central role in cardiac homeostasis and disease. In the healthy heart, mitocho...
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies
Despite recent progress, ischemic heart disease poses a persistent global challenge, driving significant morbidity and mor...
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
The mitochondrial metabolite succinate is a key driver of ischemia/reperfusion injury (IRI). Targeting succinate metabolis...
Cardioprotection in cardiovascular surgery
Cardioprotection in cardiovascular surgery
Since the invention of cardiopulmonary bypass, cardioprotective strategies have been investigated to mitigate ischemic inj...
Heart-specific NFAT5 knockout suppresses type I interferon signaling and aggravates coxsackievirus-induced myocarditis
Heart-specific NFAT5 knockout suppresses type I interferon signaling and aggravates coxsackievirus-induced myocarditis
Nuclear factor of activated T cells 5 (NFAT5) is an osmosensitive transcription factor that is well-studied in renal but r...
Targeting Gαi2 in neutrophils protects from myocardial ischemia reperfusion injury
Targeting Gαi2 in neutrophils protects from myocardial ischemia reperfusion injury
Neutrophils are not only involved in immune defense against infection but also contribute to the exacerbation of tissue da...
Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities
Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities
Multiple common cardiovascular comorbidities produce coronary microvascular dysfunction. We previously observed in swine t...
Chronic kidney disease activates the HDAC6-inflammatory axis in the heart and contributes to myocardial remodeling in mice: inhibition of HDAC6 alleviates chronic kidney disease-induced myocardial remodeling
Chronic kidney disease activates the HDAC6-inflammatory axis in the heart and contributes to myocardial remodeling in mice: inhibition of HDAC6 alleviates chronic kidney disease-induced myocardial remodeling
Chronic kidney disease (CKD) adversely affects the heart. The underlying mechanism and the interplay between the kidney an...
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat
Comparison of the stage-dependent mitochondrial changes in response to pressure overload between the diseased right and left ventricle in the rat
The right ventricle (RV) differs developmentally, anatomically and functionally from the left ventricle (LV). Therefore, c...
Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections
Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections
Ascending thoracic aortic aneurysm (ATAA) remains a significant medical concern, with its asymptomatic nature posing diagn...
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