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Unveiling the PDK4-centered rituximab-resistant mechanism in DLBCL: the potential of the “Smart” exosome nanoparticle therapy
Unveiling the PDK4-centered rituximab-resistant mechanism in DLBCL: the potential of the “Smart” exosome nanoparticle therapy
Diffuse large B-cell lymphoma (DLBCL) represents a prevalent malignant tumor, with approximately 40% of patients encounter...
Unmutated RRAS2 emerges as a key oncogene in post-partum-associated triple negative breast cancer
Unmutated RRAS2 emerges as a key oncogene in post-partum-associated triple negative breast cancer
Breast cancer (BC) is the most common cancer in women, with triple negative BC (TNBC) accounting for 20% of cases. While e...
ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-κB pathway
ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-κB pathway
Emerging evidence indicates the pivotal involvement of circular RNAs (circRNAs) in cancer initiation and progression. Unde...
Clinical application of liquid biopsy in colorectal cancer: detection, prediction, and treatment monitoring
Clinical application of liquid biopsy in colorectal cancer: detection, prediction, and treatment monitoring
Colorectal cancer (CRC) is one of the most prevalent malignancies affecting the gastrointestinal tract and is ranked third...
PD1/PD-L1 blockade in clear cell renal cell carcinoma: mechanistic insights, clinical efficacy, and future perspectives
PD1/PD-L1 blockade in clear cell renal cell carcinoma: mechanistic insights, clinical efficacy, and future perspectives
The advent of PD1/PD-L1 inhibitors has significantly transformed the therapeutic landscape for clear cell renal cell carci...
Patients with ASPSCR1-TFE3 fusion achieve better response to ICI based combination therapy among TFE3-rearranged renal cell carcinoma
Patients with ASPSCR1-TFE3 fusion achieve better response to ICI based combination therapy among TFE3-rearranged renal cell carcinoma
TFE3-rearranged renal cell carcinoma (TFE3-rRCC) is a rare but highly heterogeneous renal cell carcinoma (RCC) entity, of ...
Deciphering the tumor immune microenvironment from a multidimensional omics perspective: insight into next-generation CAR-T cell immunotherapy and beyond
Deciphering the tumor immune microenvironment from a multidimensional omics perspective: insight into next-generation CAR-T cell immunotherapy and beyond
Tumor immune microenvironment (TIME) consists of intra-tumor immunological components and plays a significant role in tumo...
Serum small RNAs in metastatic colorectal cancer predict response to chemotherapy and characterize high-risk patients
Serum small RNAs in metastatic colorectal cancer predict response to chemotherapy and characterize high-risk patients
Metastatic colorectal cancer (mCRC) presents significant challenges in clinical management due to its heterogeneity and va...
Circ6834 suppresses non-small cell lung cancer progression by destabilizing ANHAK and regulating miR-873-5p/TXNIP axis
Circ6834 suppresses non-small cell lung cancer progression by destabilizing ANHAK and regulating miR-873-5p/TXNIP axis
Circular RNAs (circRNAs) play important roles in cancer progression and metastasis. However, the expression profiles and b...
The role of RNA methylation in tumor immunity and its potential in immunotherapy
The role of RNA methylation in tumor immunity and its potential in immunotherapy
RNA methylation, a prevalent post-transcriptional modification, has garnered considerable attention in research circles. I...
Advances in spatial transcriptomics and its applications in cancer research
Advances in spatial transcriptomics and its applications in cancer research
Malignant tumors have increasing morbidity and high mortality, and their occurrence and development is a complicate proces...
Multi-omics profiling reveal cells with novel oncogenic cluster, TRAP1low/CAMSAP3low, emerge more aggressive behavior and poor-prognosis in early-stage endometrial cancer
Multi-omics profiling reveal cells with novel oncogenic cluster, TRAP1low/CAMSAP3low, emerge more aggressive behavior and poor-prognosis in early-stage endometrial cancer
The clinical heterogeneity of early-stage endometrial cancer (EC) is worthy of further study to identify high-quality prog...
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer
Cell surface CD55 traffics to the nucleus leading to cisplatin resistance and stemness by inducing PRC2 and H3K27 trimethylation on chromatin in ovarian cancer
Platinum resistance is the primary cause of poor survival in ovarian cancer (OC) patients. Targeted therapies and biomarke...
Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
Mechanism of ERBB2 gene overexpression by the formation of super-enhancer with genomic structural abnormalities in lung adenocarcinoma without clinically actionable genetic alterations
In an extensive genomic analysis of lung adenocarcinomas (LUADs), driver mutations have been recognized as potential targe...
Exosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancer
Exosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancer
Breast cancer is the most common malignant tumor, and metastasis remains the major cause of poor prognosis. Glucose metabo...
OLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9/GSK3β/β-catenin pathway
OLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9/GSK3β/β-catenin pathway
Intestinal metaplasia (IM) is classified into complete intestinal metaplasia (CIM) and incomplete intestinal metaplasia (I...
Effects of super-enhancers in cancer metastasis: mechanisms and therapeutic targets
Effects of super-enhancers in cancer metastasis: mechanisms and therapeutic targets
Metastasis remains the principal cause of cancer-related lethality despite advancements in cancer treatment. Dysfunctional...
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy
Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclass...
Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients
Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients
The efficacy of anthracycline-based chemotherapeutics, which include doxorubicin and its structural relatives daunorubicin...
Correction: Circ-ZEB1 promotes PIK3CA expression by silencing miR-199a-3p and affects the proliferation and apoptosis of hepatocellular carcinoma
Correction: Circ-ZEB1 promotes PIK3CA expression by silencing miR-199a-3p and affects the proliferation and apoptosis of hepatocellular carcinoma
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer
Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer
Triple negative breast cancer (TNBC) remains exceptionally challenging to treat. While CDK4/6 inhibitors have revolutioniz...
N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2
N6-methyladenosine-modified SENP1, identified by IGF2BP3, is a novel molecular marker in acute myeloid leukemia and aggravates progression by activating AKT signal via de-SUMOylating HDAC2
Elevated evidence suggests that the SENPs family plays an important role in tumor progression. However, the role of SENPs ...
A new era of cancer immunotherapy: combining revolutionary technologies for enhanced CAR-M therapy
A new era of cancer immunotherapy: combining revolutionary technologies for enhanced CAR-M therapy
Significant advancements have been made in the application of chimeric antigen receptor (CAR)-T treatment for blood cancer...
Molecular classification and biomarkers of outcome with immunotherapy in extensive-stage small-cell lung cancer: analyses of the CASPIAN phase 3 study
Molecular classification and biomarkers of outcome with immunotherapy in extensive-stage small-cell lung cancer: analyses of the CASPIAN phase 3 study
We explored potential predictive biomarkers of immunotherapy response in patients with extensive-stage small-cell lung can...
CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis
CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis
The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_00070...
JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression
JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression
Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven proces...
Correction: Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2
Correction: Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
New-generation advanced PROTACs as potential therapeutic agents in cancer therapy
New-generation advanced PROTACs as potential therapeutic agents in cancer therapy
Proteolysis-targeting chimeras (PROTACs) technology has garnered significant attention over the last 10 years, re...
PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer
PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer
Poly (ADP-ribose) polymerase inhibitor (PARPi) resistance poses a significant challenge in ovarian carcinoma (OC). While t...
KDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges
KDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges
Breast cancer (BC) is the most frequent malignant cancer diagnosis and is a primary factor for cancer deaths in women. The...
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