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Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells
Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells
Oncogenic KRAS mutations are present in approximately 90% of pancreatic ductal adenocarcinoma (PDAC). However, Kras mutati...
Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges
Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges
Clinically, multimodal therapies are adopted worldwide for the management of cancer, which continues to be a leading cause...
Bidirectional role of neutrophils in tumor development
Bidirectional role of neutrophils in tumor development
Neutrophils, traditionally considered as non-specific components of the innate immune system, have garnered considerable r...
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment
The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implicati...
Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance
Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance
Drug resistance is a common challenge in clinical tumor treatment. A reduction in drug sensitivity of tumor cells is often...
Resistance mechanisms to immune checkpoint inhibitors: updated insights
Resistance mechanisms to immune checkpoint inhibitors: updated insights
The last decade has witnessed unprecedented succusses with the use of immune checkpoint inhibitors in treating cancer. Nev...
The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications
The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications
The polymorphic microbiome is considered a new hallmark of cancer. Advances in High-Throughput Sequencing have fostered ra...
ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner
ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner
The N6-methyladenosine (m6A) modification serves as an essential epigenetic regulator in eukaryotic cells, playing a signi...
Biometallic ions and derivatives: a new direction for cancer immunotherapy
Biometallic ions and derivatives: a new direction for cancer immunotherapy
Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become a b...
The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy
The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy
KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking,...
Emerging role of exosomes in cancer therapy: progress and challenges
Emerging role of exosomes in cancer therapy: progress and challenges
This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, car...
Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity
Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity
Lipid nanoparticles (LNPs) for mRNA delivery have advanced significantly, but LNP-mediated DNA delivery still faces clinic...
Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC
Metabolically activated and highly polyfunctional intratumoral VISTA+ regulatory B cells are associated with tumor recurrence in early-stage NSCLC
B cells have emerged as central players in the tumor microenvironment (TME) of non-small cell lung cancer (NSCLC). However...
Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression
Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression
Hepatocellular carcinoma (HCC) genetic/transcriptomic signatures have been widely described. However, its proteomic charac...
AXL: shapers of tumor progression and immunosuppressive microenvironments
AXL: shapers of tumor progression and immunosuppressive microenvironments
As research progresses, our understanding of the tumor microenvironment (TME) has undergone profound changes. The TME evol...
Targeting KRAS: from metabolic regulation to cancer treatment
Targeting KRAS: from metabolic regulation to cancer treatment
The Kirsten rat sarcoma viral oncogene homolog (KRAS) protein plays a key pathogenic role in oncogenesis, cancer progressi...
Mir-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via chromatin loops to promote the malignant progression of hepatocellular carcinoma
Mir-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via chromatin loops to promote the malignant progression of hepatocellular carcinoma
The insulin-like growth factor 2 (IGF2) and H19 are overexpressed in hepatocellular carcinoma (HCC). IGF2-derived miR-483-...
Commentary on “Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth”
Commentary on “Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth”
VTRNA2-1 is a polymorphically imprinted locus. The proportion of individuals with a maternally imprinted VTRNA2-1 locus is...
Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance
Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance
Intratumor-resident bacteria represent an integral component of the tumor microenvironment (TME). Microbial dysbiosis, whi...
Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy
Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy
The advent of immunotherapy represents a significant breakthrough in cancer treatment, with immune checkpoint inhibitors (...
Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy
Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy
Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and a crucial determinant of tumor...
Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity
Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity
Drug resistance and immune escape continue to contribute to poor prognosis in AML. Increasing evidence suggests that exoso...
Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response
Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response
Cancer-associated Fibroblasts (CAFs) have emerged as critical regulators of anti-tumour immunity, with both beneficial and...
Pan-cancer drivers of metastasis
Pan-cancer drivers of metastasis
Metastasis remains a leading cause of cancer-related mortality, irrespective of the primary tumour origin. However, the co...
circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4
circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4
Clear cell renal cell carcinoma (ccRCC) represents the most prevalent subtype, accounting for nearly 80% of all RCC cases....
Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer
Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer
Long noncoding RNAs (lncRNAs) play a critical role in gastric cancer (GC) progression and metastasis. However, research co...
The miR-23a/27a/24 − 2 cluster drives immune evasion and resistance to PD-1/PD-L1 blockade in non-small cell lung cancer
The miR-23a/27a/24 − 2 cluster drives immune evasion and resistance to PD-1/PD-L1 blockade in non-small cell lung cancer
Programmed cell death protein ligand-1 (PD-L1) and major histocompatibility complex I (MHC-I) are key molecules related to...
Deciphering a profiling based on multiple post-translational modifications functionally associated regulatory patterns and therapeutic opportunities in human hepatocellular carcinoma
Deciphering a profiling based on multiple post-translational modifications functionally associated regulatory patterns and therapeutic opportunities in human hepatocellular carcinoma
Posttranslational modifications (PTMs) play critical roles in hepatocellular carcinoma (HCC). However, the locations of PT...
THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer
THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer
Cancer-associated fibroblasts (CAFs) exert multiple tumor-promoting functions and are key contributors to drug resistance....
Mutation of lysine-specific demethylase 5 is associated with enhanced tumor immunity and favorable outcomes in pan-cancer immune checkpoint blockade
Mutation of lysine-specific demethylase 5 is associated with enhanced tumor immunity and favorable outcomes in pan-cancer immune checkpoint blockade
The lysine-specific demethylase 5 (KDM5) family, a key post-translational modification of chromatin, can shape tumor immun...
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