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Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies
Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to ...
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Commercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgk...
Effects of RNA methylation on Tumor angiogenesis and cancer progression
Effects of RNA methylation on Tumor angiogenesis and cancer progression
Tumor angiogenesis plays vital roles in the growth and metastasis of cancer. RNA methylation is one of the most common mod...
A liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer
A liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer
Colorectal cancer (CRC) is one of the most threatening tumors in the world, and chemotherapy remains dominant in the treat...
Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provid...
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT...
hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma
hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma
Circular RNAs (circRNAs) play important roles in the occurrence and development of cancer and chemoresistance. DNA damage ...
Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?
Hepatocellular carcinoma (HCC), one of the most prevalent forms of cancer worldwide, presents a significant global healthc...
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
Current research has demonstrated that extracellular vesicles (EVs) and circulating tumor cells (CTCs) are very closely re...
Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients
Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients
Immune checkpoint inhibitors (ICIs) are a therapeutic strategy for various cancers although only a subset of patients resp...
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
Despite major improvements in immunotherapeutic strategies, the immunosuppressive tumor microenvironment remains a major o...
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lac...
The University of Kansas Cancer Center (KUCC), an NCI designated comprehensive cancer center
The University of Kansas Cancer Center (KUCC), an NCI designated comprehensive cancer center
With world-class, transdisciplinary, expertise and technical capabilities in drug discovery and cellular immunotherapeutic...
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for...
CDK5: an oncogene or an anti-oncogene: location location location
CDK5: an oncogene or an anti-oncogene: location location location
Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 an...
Exploiting innate immunity for cancer immunotherapy
Exploiting innate immunity for cancer immunotherapy
Immunotherapies have revolutionized the treatment paradigms of various types of cancers. However, most of these immunomodu...
The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer
The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer
Currently, only limited knowledge is available regarding the phenotypic association between fibroblast growth factor recep...
ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma
ELF5 drives angiogenesis suppression though stabilizing WDTC1 in renal cell carcinoma
Renal cell carcinoma (RCC) is a common malignant tumor of the urinary system. Angiogenesis is a main contributing factor f...
Outsmarting trogocytosis to boost CAR NK/T cell therapy
Outsmarting trogocytosis to boost CAR NK/T cell therapy
Chimeric antigen receptor (CAR) NK and T cell therapy are promising immunotherapeutic approaches for the treatment of canc...
CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Noncoding RNAs such as circular RNAs (circRNAs) are abundant in the human body and influence the occurrence and developmen...
Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid
Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid
Knowing the homologous recombination deficiency (HRD) status in advanced epithelial ovarian cancer (EOC) is vital for pati...
Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: immune escape mechanisms and current implications for therapy
Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: immune escape mechanisms and current implications for therapy
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by the expansion of immature myeloid cells in the bo...
Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis
Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis
The limited sensitivity of circulating tumor cell (CTC) detection in pancreatic adenocarcinoma (PDAC) stems from their ext...
A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better
A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better
Stimulating inflammatory tumor associated macrophages can overcome resistance to PD-(L)1 blockade. We previously conducted...
circPSD3 is a promising inhibitor of uPA system to inhibit vascular invasion and metastasis in hepatocellular carcinoma
circPSD3 is a promising inhibitor of uPA system to inhibit vascular invasion and metastasis in hepatocellular carcinoma
Vascular invasion is a major route for intrahepatic and distant metastasis in hepatocellular carcinoma (HCC) and is a stro...
Correction: CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling
Correction: CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset of tumor cells characteri...
The strategies to cure cancer patients by eradicating cancer stem-like cells
The strategies to cure cancer patients by eradicating cancer stem-like cells
Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable capability in proliferation, self-renew...
Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment
Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population that plays a crucial role in remodeling the tumor...
Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation
Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation
Pancreatic cancer (PC) is one of the most common malignancies. Surgical resection is a potential curative approach for PC,...
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