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Co-inhibition of TIGIT and PD-1/PD-L1 in Cancer Immunotherapy: Mechanisms and Clinical Trials
Co-inhibition of TIGIT and PD-1/PD-L1 in Cancer Immunotherapy: Mechanisms and Clinical Trials
Over the past decade, immune checkpoint inhibitors (ICIs) have emerged as a revolutionary cancer treatment modality, offer...
CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth
CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth
Though the CXCR2 chemokine receptor is known to play a key role in cancer growth and response to therapy, a direct link be...
The role of m6A methylation in therapy resistance in cancer
The role of m6A methylation in therapy resistance in cancer
Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topi...
A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer
A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer
Chemoresistance is a major cause of treatment failure in colorectal cancer (CRC) therapy. In this study, the impact of the...
EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?
EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?
Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are genetic determinants of cellular p...
IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression
IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression
Neuroblastoma is the most common solid tumor in infants accounting for approximately 15% of all cancer-related deaths. Ove...
New opportunities for RGD-engineered metal nanoparticles in cancer
New opportunities for RGD-engineered metal nanoparticles in cancer
The advent of nanotechnology has opened new possibilities for bioimaging. Metal nanoparticles (such as gold, silver, iron,...
The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer
The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer
The discovery of functionally relevant KRAS effectors in lung and pancreatic ductal adenocarcinoma (LUAD and PDAC) may yie...
EZH2 mediated metabolic rewiring promotes tumor growth independently of histone methyltransferase activity in ovarian cancer
EZH2 mediated metabolic rewiring promotes tumor growth independently of histone methyltransferase activity in ovarian cancer
Enhancer of zeste homolog 2 (EZH2), the key catalytic subunit of polycomb repressive complex 2 (PRC2), is overexpressed an...
Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy
Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy
Checkpoint blockade immunotherapy, represented by PD-1 or PD-L1 antibody treatment, has been of tremendous success in clin...
Deciphering and advancing CAR T-cell therapy with single-cell sequencing technologies
Deciphering and advancing CAR T-cell therapy with single-cell sequencing technologies
Chimeric antigen receptor (CAR) T-cell therapy has made remarkable progress in cancer immunotherapy, but several challenge...
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that ...
CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks
CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks
CAR T cell-based therapies have revolutionized the treatment of hematological malignancies such as leukemia and lymphoma w...
Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer
Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer
RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function ...
Retraction Note: Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer
Retraction Note: Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0844-7.
Circulating biosignatures in multiple myeloma and their role in multidrug resistance
Circulating biosignatures in multiple myeloma and their role in multidrug resistance
A major obstacle to chemotherapeutic success in cancer treatment is the development of drug resistance. This occurs when a...
Correction: minimally invasive approaches for the early detection of endometrial cancer
Correction: minimally invasive approaches for the early detection of endometrial cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Molecular mimicry and cancer vaccine development
Molecular mimicry and cancer vaccine development
The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor...
CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure
CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure
CircZBTB44 (hsa_circ_0002484) has been identified to be upregulated in renal cell carcinoma (RCC) tissues, while its role ...
Correction to: The function and mechanisms of action of circular RNAs in Urologic Cancer
Correction to: The function and mechanisms of action of circular RNAs in Urologic Cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Editorial Expression of Concern: Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7
Editorial Expression of Concern: Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer
A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer
Hypoxia is a hallmark of solid tumors and leads to the metabolic reprogramming of cancer cells. The role of epigenetic reg...
Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers
Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers
Mesenchymal gastrointestinal cancers are represented by the gastrointestinal stromal tumors (GISTs) which occur throughout...
Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma
Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma
Extranodal natural killer/T-cell lymphoma (NKTL) is an aggressive type of non-Hodgkin lymphoma with dismal outcome. A bett...
Immunotherapy of thymic epithelial tumors: molecular understandings and clinical perspectives
Immunotherapy of thymic epithelial tumors: molecular understandings and clinical perspectives
Immunotherapy has emerged to play a rapidly expanding role in the treatment of cancers. Currently, many clinical trials of...
The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy
The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy
The development of head and neck squamous cell carcinoma (HNSCC) is a multi-step process, and its survival depends on a co...
HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose expression is strongly correlated wi...
CDK9 inhibition induces epigenetic reprogramming revealing strategies to circumvent resistance in lymphoma
CDK9 inhibition induces epigenetic reprogramming revealing strategies to circumvent resistance in lymphoma
Diffuse large B-cell lymphoma (DLBCL) exhibits significant genetic heterogeneity which contributes to drug resistance, nec...
Reprogramming anchorage dependency by adherent-to-suspension transition promotes metastatic dissemination
Reprogramming anchorage dependency by adherent-to-suspension transition promotes metastatic dissemination
Although metastasis is the foremost cause of cancer-related death, a specialized mechanism that reprograms anchorage depen...
CAR T-Cell therapy for the management of mantle cell lymphoma
CAR T-Cell therapy for the management of mantle cell lymphoma
Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma (NHL) of mature B-cells characterized by translocation, wh...
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