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Single-cell and spatial transcriptomics identify COL6A3 as a prognostic biomarker in undifferentiated pleomorphic sarcoma
Single-cell and spatial transcriptomics identify COL6A3 as a prognostic biomarker in undifferentiated pleomorphic sarcoma
Undifferentiated pleomorphic sarcoma (UPS) and related tumors are the most common type of soft tissue sarcoma. However, th...
Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: culprits or new hope
Cuproptosis, ferroptosis and PANoptosis in tumor immune microenvironment remodeling and immunotherapy: culprits or new hope
Normal life requires cell division to produce new cells, but cell death is necessary to maintain balance. Dysregulation of...
Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer
Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer
Fibroblast growth factors (FGFs) and their receptors regulate numerous cellular processes, such as metabolism and signal t...
Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies
Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies
Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clin...
The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer
The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer
KRASG12C and KRASG12D inhibitors represent a major translational breakthrough for non-small cell lung cancer (NSCLC) and c...
Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer
Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer
PD-1/PD-L1 blockade therapies have displayed extraordinary clinical efficacy for melanoma, renal, bladder and lung cancer;...
SARS-CoV-2 nucleocapsid protein interaction with YBX1 displays oncolytic properties through PKM mRNA destabilization
SARS-CoV-2 nucleocapsid protein interaction with YBX1 displays oncolytic properties through PKM mRNA destabilization
SARS-CoV-2, a highly contagious coronavirus, is responsible for the global pandemic of COVID-19 in 2019. Currently, it rem...
A prospective multi-cohort study identifies and validates a 5-gene peripheral blood signature predictive of immunotherapy response in non-small cell lung cancer
A prospective multi-cohort study identifies and validates a 5-gene peripheral blood signature predictive of immunotherapy response in non-small cell lung cancer
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape for non-small cell lung cancer (NSCLC). Th...
Variability in non-tumor areas of colorectal cancer patients as revealed by endoscopic intestinal step biopsies
Variability in non-tumor areas of colorectal cancer patients as revealed by endoscopic intestinal step biopsies
A comprehensive endoscopic small and large intestinal untargeted step biopsy procedure was conducted to compare gene expre...
Regulatory T cells in immune checkpoint blockade antitumor therapy
Regulatory T cells in immune checkpoint blockade antitumor therapy
Regulatory T cells (Tregs), an essential component of the human immune system, are a heterogeneous group of T lymphocytes ...
Traditional Chinese medicine in treating upper digestive tract cancers
Traditional Chinese medicine in treating upper digestive tract cancers
Upper digestive tract cancers, such as oral cavity, laryngeal, esophageal, and gastric cancers, account for 10% of cancer ...
Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers
Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers
Chitosan nanoparticles (NPs) are well-recognized as promising vehicles for delivering anticancer drugs due to their distin...
Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment
Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment
Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from bone tissues and can ...
Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors
Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors
Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 sign...
Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer
Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer
Tryptophan (Trp) metabolism involves three primary pathways: the kynurenine (Kyn) pathway (KP), the 5-hydroxytryptamine (s...
Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment
Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment
Prostate cancer ranks as the second most frequently diagnosed cancer in men worldwide. Recent research highlights the cruc...
Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway
Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway
Small cell lung cancer (SCLC) stands as one of the most lethal malignancies, characterized by a grim diagnosis and prognos...
Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells
Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells
In the ongoing battle against BCR-ABL+ leukemia, despite significant advances with tyrosine kinase inhibitors (TKIs)...
Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth
Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth
Cancer is the leading cause of disease-related mortality in children. Causes of leukemia, the most common form, are largel...
CAR-NK cells for gastrointestinal cancer immunotherapy: from bench to bedside
CAR-NK cells for gastrointestinal cancer immunotherapy: from bench to bedside
Gastrointestinal (GI) cancers represent a significant health burden worldwide. Their incidence continues to increase, and ...
Membrane-bound IL-7 immobilized by the CD8 transmembrane region improves efficacy of CD19 CAR-T cell therapy
Membrane-bound IL-7 immobilized by the CD8 transmembrane region improves efficacy of CD19 CAR-T cell therapy
Enhancing the efficacy of CD19 CAR-T cell therapy can significantly improve patient outcomes by reducing relapse rates in ...
A multidimensional recommendation framework for identifying biological targets to aid the diagnosis and treatment of liver metastasis in patients with colorectal cancer
A multidimensional recommendation framework for identifying biological targets to aid the diagnosis and treatment of liver metastasis in patients with colorectal cancer
The quest to understand the molecular mechanisms of tumour metastasis and identify pivotal biomarkers for cancer therapy i...
MicroRNAs are enriched at COVID-19 genomic risk regions, and their blood levels correlate with the COVID-19 prognosis of cancer patients infected by SARS-CoV-2
MicroRNAs are enriched at COVID-19 genomic risk regions, and their blood levels correlate with the COVID-19 prognosis of cancer patients infected by SARS-CoV-2
Cancer patients are more susceptible to an aggressive course of COVID-19. Developing biomarkers identifying cancer patient...
Anti irradiation nanoparticles shelter immune organ from radio-damage via preventing the IKK/IκB/NF-κB activation
Anti irradiation nanoparticles shelter immune organ from radio-damage via preventing the IKK/IκB/NF-κB activation
Normal tissue and immune organ protection are critical parts of the tumor radiation therapy process. Radiation-induced imm...
Correction: Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway
Correction: Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
R-loops’ m6A modification and its roles in cancers
R-loops’ m6A modification and its roles in cancers
R-loops are three-stranded nucleic acid structures composed of an RNA–DNA hybrid and a displaced DNA strand. They ar...
Tumor-intrinsic role of ICAM-1 in driving metastatic progression of triple-negative breast cancer through direct interaction with EGFR
Tumor-intrinsic role of ICAM-1 in driving metastatic progression of triple-negative breast cancer through direct interaction with EGFR
Triple-negative breast cancer (TNBC), the most aggressive subtype, presents a critical challenge due to the absence of app...
Prostate cancer microenvironment: multidimensional regulation of immune cells, vascular system, stromal cells, and microbiota
Prostate cancer microenvironment: multidimensional regulation of immune cells, vascular system, stromal cells, and microbiota
Prostate cancer (PCa) is one of the most prevalent malignancies in males worldwide. Increasing research attention has focu...
Size matters: integrating tumour volume and immune activation signatures predicts immunotherapy response
Size matters: integrating tumour volume and immune activation signatures predicts immunotherapy response
Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, providing significant benefit to patients across va...
Chaperone-mediated autophagy modulates Snail protein stability: implications for breast cancer metastasis
Chaperone-mediated autophagy modulates Snail protein stability: implications for breast cancer metastasis
Breast cancer remains a significant health concern, with triple-negative breast cancer (TNBC) being an aggressive subtype ...
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