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Towards understanding cancer dormancy over strategic hitching up mechanisms to technologies
Towards understanding cancer dormancy over strategic hitching up mechanisms to technologies
Delving into cancer dormancy has been an inherent task that may drive the lethal recurrence of cancer after primary tumor ...
Correction: CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502–5p/KRAS and IGF2BP2/Myc axes
Correction: CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502–5p/KRAS and IGF2BP2/Myc axes
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
Extracellular vesicles in tumor immunity: mechanisms and novel insights
Extracellular vesicles in tumor immunity: mechanisms and novel insights
Extracellular vesicles (EVs), nanoscale vesicles secreted by cells, have attracted considerable attention in recent years ...
Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer
Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6is) in combination with endocrine therapy are the standard treatment for pat...
Multimodal lung cancer theranostics via manganese phosphate/quercetin particle
Multimodal lung cancer theranostics via manganese phosphate/quercetin particle
The diagnosis and treatment of non-small cell lung cancer in clinical settings face serious challenges, particularly due t...
Hijacking of the nervous system in cancer: mechanism and therapeutic targets
Hijacking of the nervous system in cancer: mechanism and therapeutic targets
The activity of neurons in the vicinity of tumors is linked to a spectrum of cellular mechanisms, including the facilitati...
Correction: The landscape of BRAF transcript and protein variants in human cancer
Correction: The landscape of BRAF transcript and protein variants in human cancer
Oncogenomics Unit, Core Research Laboratory, Istituto Toscano Tumori (ITT), AOUP, CNR-IFC, Via Moruzzi 1, 56124, Pisa, Ita...
Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins
Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins
Cancer creates an immunosuppressive environment that hampers immune responses, allowing tumors to grow and resist therapy....
SELP+ TEC:CD8+ T cell crosstalk associates with improved radiotherapy efficacy in cervical cancer
SELP+ TEC:CD8+ T cell crosstalk associates with improved radiotherapy efficacy in cervical cancer
P-selectin (SELP) expression in tumor cells has been implicated in promoting tumor progression and treatment resistance ac...
Radioresistance in rectal cancer: can nanoparticles turn the tide?
Radioresistance in rectal cancer: can nanoparticles turn the tide?
Rectal cancer accounts for over 35% of the worldwide colorectal cancer burden representing a distinctive subset of cancers...
Correction: miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer
Correction: miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
lncRNAs: the unexpected link between protein synthesis and cancer adaptation
lncRNAs: the unexpected link between protein synthesis and cancer adaptation
Cancer progression relies on the ability of cells to adapt to challenging environments overcoming stresses and growth cons...
CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance
CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance
Oral cancer ranks among the most common malignancies within the head and neck region; however, its etiology remains inadeq...
Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation
Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation
Sorafenib, an FDA-approved drug for advanced hepatocellular carcinoma (HCC), faces resistance issues, partly due to myeloi...
Correction: LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer
Correction: LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis
CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis
The high mortality rate from hepatocellular carcinoma (HCC) is due primarily to challenges in early diagnosis and the deve...
The micro(nano)plastics perspective: exploring cancer development and therapy
The micro(nano)plastics perspective: exploring cancer development and therapy
Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ec...
Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer
Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer
Metastasis is a leading cause of cancer-related death in castration-resistant prostate cancer (CRPC) patients. Circular RN...
Comprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenvironment heterogeneity between primary lesions and metastases
Comprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenvironment heterogeneity between primary lesions and metastases
Colorectal neuroendocrine tumors with liver metastases (CRNELM) are associated with a poorer prognosis compared to their n...
Tailoring traditional Chinese medicine in cancer therapy
Tailoring traditional Chinese medicine in cancer therapy
Cancer remains a formidable global health challenge, necessitating innovative therapeutic approaches to enhance treatment ...
Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells
Intercellular TIMP-1-CD63 signaling directs the evolution of immune escape and metastasis in KRAS-mutated pancreatic cancer cells
Oncogenic KRAS mutations are present in approximately 90% of pancreatic ductal adenocarcinoma (PDAC). However, Kras mutati...
Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges
Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges
Clinically, multimodal therapies are adopted worldwide for the management of cancer, which continues to be a leading cause...
Bidirectional role of neutrophils in tumor development
Bidirectional role of neutrophils in tumor development
Neutrophils, traditionally considered as non-specific components of the innate immune system, have garnered considerable r...
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment
Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment
The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implicati...
Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance
Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance
Drug resistance is a common challenge in clinical tumor treatment. A reduction in drug sensitivity of tumor cells is often...
Resistance mechanisms to immune checkpoint inhibitors: updated insights
Resistance mechanisms to immune checkpoint inhibitors: updated insights
The last decade has witnessed unprecedented succusses with the use of immune checkpoint inhibitors in treating cancer. Nev...
The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications
The mycobiome in human cancer: analytical challenges, molecular mechanisms, and therapeutic implications
The polymorphic microbiome is considered a new hallmark of cancer. Advances in High-Throughput Sequencing have fostered ra...
ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner
ALKBH5 suppresses gastric cancer tumorigenesis and metastasis by inhibiting the translation of uncapped WRAP53 RNA isoforms in an m6A-dependent manner
The N6-methyladenosine (m6A) modification serves as an essential epigenetic regulator in eukaryotic cells, playing a signi...
Biometallic ions and derivatives: a new direction for cancer immunotherapy
Biometallic ions and derivatives: a new direction for cancer immunotherapy
Biometallic ions play a crucial role in regulating the immune system. In recent years, cancer immunotherapy has become a b...
The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy
The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy
KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking,...
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