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Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation
Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation
The identification of novel therapeutic strategies to overcome resistance to the MEK inhibitor trametinib in mutant KRAS l...
Efficacy and safety of bispecific antibodies vs. immune checkpoint blockade combination therapy in cancer: a real-world comparison
Efficacy and safety of bispecific antibodies vs. immune checkpoint blockade combination therapy in cancer: a real-world comparison
Emerging tumor immunotherapy methods encompass bispecific antibodies (BSABs), immune checkpoint inhibitors (ICIs), and ado...
tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application
tRNA-derived small RNAs in human cancers: roles, mechanisms, and clinical application
Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a new type of non-coding RNAs (ncRNAs) produced by the specific cleava...
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary lymphoid...
Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC
Loss of lncRNA LINC01056 leads to sorafenib resistance in HCC
Sorafenib is a major nonsurgical option for patients with advanced hepatocellular carcinoma (HCC); however, its clinical e...
Crosstalk between metabolism and cell death in tumorigenesis
Crosstalk between metabolism and cell death in tumorigenesis
It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to such an abnormally rapid pr...
Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation
Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation
Cellular senescence frequently occurs during anti-cancer treatment, and persistent senescent tumor cells (STCs) unfavorabl...
Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
T cells are fundamental components in tumour immunity and cancer immunotherapies, which have made immense strides and revo...
Cancer immunometabolism: advent, challenges, and perspective
Cancer immunometabolism: advent, challenges, and perspective
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mech...
The senescence journey in cancer immunoediting
The senescence journey in cancer immunoediting
Cancer progression is continuously controlled by the immune system which can identify and destroy nascent tumor cells or i...
Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer
Cancer-derived exosomes as novel biomarkers in metastatic gastrointestinal cancer
Gastrointestinal cancer (GIC) is the most prevalent and highly metastatic malignant tumor and has a significant impact on ...
Correction: CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer
Correction: CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway
Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway
Abnormal angiogenesis is crucial for gallbladder cancer (GBC) tumor growth and invasion, highlighting the importance of el...
Drug resistance in ovarian cancer: from mechanism to clinical trial
Drug resistance in ovarian cancer: from mechanism to clinical trial
Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance is the bottleneck in ovarian ca...
RAF inhibitor re-challenge therapy in BRAF-aberrant pan-cancers: the RE-RAFFLE study
RAF inhibitor re-challenge therapy in BRAF-aberrant pan-cancers: the RE-RAFFLE study
Previous studies have shown the clinical benefit of rechallenging the RAF pathway in melanoma patients previously treated ...
rs822336 binding to C/EBPβ and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC
rs822336 binding to C/EBPβ and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC
Efficient predictive biomarkers are needed for immune checkpoint inhibitor (ICI)-based immunotherapy in non-small cell lun...
LINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling
LINC00115 promotes chemoresistant breast cancer stem-like cell stemness and metastasis through SETDB1/PLK3/HIF1α signaling
Cancer stem-like cell is a key barrier for therapeutic resistance and metastasis in various cancers, including breast canc...
A review of the clinical efficacy of FDA-approved antibody‒drug conjugates in human cancers
A review of the clinical efficacy of FDA-approved antibody‒drug conjugates in human cancers
While strategies such as chemotherapy and immunotherapy have become the first-line standard therapies for patients with ad...
An international phase II trial and immune profiling of SBRT and atezolizumab in advanced pretreated colorectal cancer
An international phase II trial and immune profiling of SBRT and atezolizumab in advanced pretreated colorectal cancer
Immuno-radiotherapy may improve outcomes for patients with advanced solid tumors, although optimized combination modalitie...
CircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib
CircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib
Tyrosine kinase inhibitors (TKIs) are crucial in the targeted treatment of advanced colorectal cancer (CRC). Anlotinib, a ...
CTLs heterogeneity and plasticity: implications for cancer immunotherapy
CTLs heterogeneity and plasticity: implications for cancer immunotherapy
Cytotoxic T lymphocytes (CTLs) play critical antitumor roles, encompassing diverse subsets including CD4+, NK, and γ&...
Clinical effectiveness of a multitarget urine DNA test for urothelial carcinoma detection: a double-blinded, multicenter, prospective trial
Clinical effectiveness of a multitarget urine DNA test for urothelial carcinoma detection: a double-blinded, multicenter, prospective trial
Urine-based testing is promising for noninvasive diagnosis of urothelial carcinoma (UC) but has suboptimal sensitivity for...
Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects
Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects
One of the major hurdles that has hindered the success of chimeric antigen receptor (CAR) T cell therapies against solid t...
The m6A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN
The m6A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN
Long noncoding RNAs (lncRNAs) have emerged as key players in tumorigenesis and tumour progression. However, the biological...
A novel pan-PI3K inhibitor KTC1101 synergizes with anti-PD-1 therapy by targeting tumor suppression and immune activation
A novel pan-PI3K inhibitor KTC1101 synergizes with anti-PD-1 therapy by targeting tumor suppression and immune activation
Phosphoinositide 3-kinases (PI3Ks) are critical regulators of diverse cellular functions and have emerged as promising tar...
Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs
Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) is one of the causes of tumor immune tolerance and failure ...
Correction: Aurora kinase targeting in lung cancer reduces KRAS-induced transformation
Correction: Aurora kinase targeting in lung cancer reduces KRAS-induced transformation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Integration of pan-omics technologies and three-dimensional in vitro tumor models: an approach toward drug discovery and precision medicine
Integration of pan-omics technologies and three-dimensional in vitro tumor models: an approach toward drug discovery and precision medicine
Despite advancements in treatment protocols, cancer is one of the leading cause of deaths worldwide. Therefore, there is a...
The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments
The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments
Chimeric antigen receptor-T (CAR-T) cells therapy is one of the novel immunotherapeutic approaches with significant clinic...
Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression
Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression
Circular RNAs (circRNAs) play important roles in gastric cancer progression but the regulatory role of circRNAs in control...
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