SCI时时刷

search
Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential
Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential
Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from various human tissues and organs. Th...
Ligands stimulating antitumour immunity as the next G-quadruplex challenge
Ligands stimulating antitumour immunity as the next G-quadruplex challenge
G-quadruplex (G4) binders have been investigated to discover new anticancer drugs worldwide in past decades. As these liga...
Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma
Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma
Although, micropeptides encoded by non-coding RNA have been shown to have an important role in a variety of tumors process...
The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates
The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates
Up to 80% of cases of prostate cancer present with multifocal independent tumour lesions leading to the concept of a field...
Malignant clonal evolution drives multiple myeloma cellular ecological diversity and microenvironment reprogramming
Malignant clonal evolution drives multiple myeloma cellular ecological diversity and microenvironment reprogramming
Multiple myeloma (MM) is a heterogeneous disease with different patterns of clonal evolution and a complex tumor microenvi...
A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer
A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer
Epidermal growth factor receptor (EGFR) is both a driver oncogene and a therapeutic target in advanced head and neck squam...
PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma
PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma
Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin T cell lymphoma commonly driven by NPM-ALK. AP-1 transc...
Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous and aggressive blood cancer that results from diverse genetic aberrations ...
A two-stage genome-wide association study to identify novel genetic loci associated with acute radiotherapy toxicity in nasopharyngeal carcinoma
A two-stage genome-wide association study to identify novel genetic loci associated with acute radiotherapy toxicity in nasopharyngeal carcinoma
Genetic variants associated with acute side effects of radiotherapy in nasopharyngeal carcinoma (NPC) remain largely unkno...
TIPE3 is a candidate prognostic biomarker promoting tumor progression via elevating RAC1 in pancreatic cancer
TIPE3 is a candidate prognostic biomarker promoting tumor progression via elevating RAC1 in pancreatic cancer
TIPE3 expression is up-regulated in PC specimensTIPE3 mRNA expression were analyzed including 171 normal individuals and 1...
Retraction Note to: Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner
Retraction Note to: Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0783-3.
Targeting KRAS mutant cancers: from druggable therapy to drug resistance
Targeting KRAS mutant cancers: from druggable therapy to drug resistance
Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently mutated oncogene, occurring in a variety of tumor...
Retraction Note: Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer
Retraction Note: Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-019-0981-7.
BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer
Brother of regulator of imprinted sites (BORIS) is expressed in most cancers and often associated with short survival and ...
Correction: Cisplatin-induced epigenetic activation of miR-34a sensitizes bladder cancer cells to chemotherapy
Correction: Cisplatin-induced epigenetic activation of miR-34a sensitizes bladder cancer cells to chemotherapy
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Multiplex Epstein-Barr virus BALF2 genotyping detects high-risk variants in plasma for population screening of nasopharyngeal carcinoma
Multiplex Epstein-Barr virus BALF2 genotyping detects high-risk variants in plasma for population screening of nasopharyngeal carcinoma
Epstein-Barr Virus (EBV)-associated nasopharyngeal carcinoma (NPC) exhibits unusual geographic restriction despite ubiquit...
A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML
A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AML
Myeloid and lymphoid malignancies associated with chimeric FGFR1 kinases are the hallmark of stem cell leukemia and lympho...
CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma
CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma
Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumors...
A PIK3CA-mutant breast cancer metastatic patient-derived organoid approach to evaluate alpelisib treatment for multiple secondary lesions
A PIK3CA-mutant breast cancer metastatic patient-derived organoid approach to evaluate alpelisib treatment for multiple secondary lesions
An 82-year-old woman was diagnosed in 2018 with invasive ductal carcinoma (IDC) of the right breast, grade 3, ER-/PR-/HER2...
E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer
E3 ubiquitin ligase MAGI3 degrades c-Myc and acts as a predictor for chemotherapy response in colorectal cancer
Recurrence and chemoresistance constitute the leading cause of death in colorectal cancer (CRC). Thus, it is of great sign...
CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma
CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma
Emerging evidence indicates that circular RNAs (circRNAs) and m6A RNA methylation participate in the pathogenesis and meta...
MARCKSL1–2 reverses docetaxel-resistance of lung adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b
MARCKSL1–2 reverses docetaxel-resistance of lung adenocarcinoma cells by recruiting SUZ12 to suppress HDAC1 and elevate miR-200b
Long non-coding RNAs (lncRNAs) are implicated in the development of multiple cancers. In our previous study, we demonstrat...
CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p
CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p
Circular RNAs (circRNAs) have been demonstrated to contribute to esophageal cancer progression. CircBCAR3 (hsa_circ_000762...
Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance
Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance
The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to recurrence and metastasis ...
Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic developme...