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OLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9/GSK3β/β-catenin pathway
OLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9/GSK3β/β-catenin pathway
Intestinal metaplasia (IM) is classified into complete intestinal metaplasia (CIM) and incomplete intestinal metaplasia (I...
Effects of super-enhancers in cancer metastasis: mechanisms and therapeutic targets
Effects of super-enhancers in cancer metastasis: mechanisms and therapeutic targets
Metastasis remains the principal cause of cancer-related lethality despite advancements in cancer treatment. Dysfunctional...
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy
Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclass...
Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients
Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients
The efficacy of anthracycline-based chemotherapeutics, which include doxorubicin and its structural relatives daunorubicin...
Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer
Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer
Triple negative breast cancer (TNBC) remains exceptionally challenging to treat. While CDK4/6 inhibitors have revolutioniz...
A new era of cancer immunotherapy: combining revolutionary technologies for enhanced CAR-M therapy
A new era of cancer immunotherapy: combining revolutionary technologies for enhanced CAR-M therapy
Significant advancements have been made in the application of chimeric antigen receptor (CAR)-T treatment for blood cancer...
CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis
CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis
The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_00070...
JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression
JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression
Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven proces...
New-generation advanced PROTACs as potential therapeutic agents in cancer therapy
New-generation advanced PROTACs as potential therapeutic agents in cancer therapy
Proteolysis-targeting chimeras (PROTACs) technology has garnered significant attention over the last 10 years, re...
PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer
PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer
Poly (ADP-ribose) polymerase inhibitor (PARPi) resistance poses a significant challenge in ovarian carcinoma (OC). While t...
KDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges
KDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges
Breast cancer (BC) is the most frequent malignant cancer diagnosis and is a primary factor for cancer deaths in women. The...
Regulatory mechanisms of PD-1/PD-L1 in cancers
Regulatory mechanisms of PD-1/PD-L1 in cancers
Immune evasion contributes to cancer growth and progression. Cancer cells have the ability to activate different immune ch...
Aging and cancer
Aging and cancer
Aging and cancer exhibit apparent links that we will examine in this review. The null hypothesis that aging and cancer coi...
Neutrophils in Cancer immunotherapy: friends or foes?
Neutrophils in Cancer immunotherapy: friends or foes?
Neutrophils play a Janus-faced role in the complex landscape of cancer pathogenesis and immunotherapy. As immune defense c...
CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair
CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair
Long noncoding RNAs (lncRNAs) have surpassed the number of protein-coding genes, yet the majority have no known function. ...
RICTOR/mTORC2 downregulation in BRAFV600E melanoma cells promotes resistance to BRAF/MEK inhibition
RICTOR/mTORC2 downregulation in BRAFV600E melanoma cells promotes resistance to BRAF/MEK inhibition
The main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted therapy in the management of BRAF-mutated cutaneous me...
NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer
NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is marked by a dismal survival rate, lacking effective therapeutics due to its agg...
DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma
DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma
The faithful maintenance of DNA methylation homeostasis indispensably requires DNA methyltransferase 1 (DNMT1) in cancer p...
Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy
Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy
Active targeting by surface-modified nanoplatforms enables a more precise and elevated accumulation of nanoparticles withi...
Unveiling a novel fusion gene enhances CAR T cell therapy for solid tumors
Unveiling a novel fusion gene enhances CAR T cell therapy for solid tumors
The efficacy of Adoptive Cell Transfer Therapy (ACT) in combating hematological tumors has been well-documented, yet its a...