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EWSR1: the promiscuous king of mesenchymal neoplasia
EWSR1: the promiscuous king of mesenchymal neoplasia
Ewing Sarcoma breakpoint region 1 (EWSR1) encodes EWSR1, a multifunctional RNA-binding protein that regulates the express...
Should a borderline negative HER2 result in a core biopsy of invasive carcinoma of the breast have HER2 assessment repeated in the excision specimen?
Should a borderline negative HER2 result in a core biopsy of invasive carcinoma of the breast have HER2 assessment repeated in the excision specimen?
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PD-L1 protein expression in breast cancer
PD-L1 protein expression in breast cancer
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Cross-sectional study to evaluate the utility of elastic tissue staining in primary cicatricial alopecia
Cross-sectional study to evaluate the utility of elastic tissue staining in primary cicatricial alopecia
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Correlation of low numbers of intratumoral FOXP3+ cells with worse progression-free survival in angioimmunoblastic T cell lymphoma
Correlation of low numbers of intratumoral FOXP3+ cells with worse progression-free survival in angioimmunoblastic T cell lymphoma
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Molecular diagnosis of tuberous sclerosis complex in fetuses and infants: an institutional case series
Molecular diagnosis of tuberous sclerosis complex in fetuses and infants: an institutional case series
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Nuclear staining for pan-Trk by immunohistochemistry is highly specific for secretory carcinoma of breast: pan-Trk in various subtypes of breast carcinoma
Nuclear staining for pan-Trk by immunohistochemistry is highly specific for secretory carcinoma of breast: pan-Trk in various subtypes of breast carcinoma
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Application of algorithmic cytomorphological assessment and immunocytochemistry with the international system for reporting serous fluid cytopathology on pericardial fluid cytology
Application of algorithmic cytomorphological assessment and immunocytochemistry with the international system for reporting serous fluid cytopathology on pericardial fluid cytology
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PAX5 and CD70 are expressed in thymic carcinoma but not in atypical thymoma (WHO type B3 thymoma): an immunohistochemical analysis of 60 cases
PAX5 and CD70 are expressed in thymic carcinoma but not in atypical thymoma (WHO type B3 thymoma): an immunohistochemical analysis of 60 cases
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Medium-term storage of frozen residual antenatal sera in gel separator tube is suitable for subsequent serological investigation of intrauterine infection
Medium-term storage of frozen residual antenatal sera in gel separator tube is suitable for subsequent serological investigation of intrauterine infection
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Pitfalls in the diagnosis and management of acid-base disorders in humans: a laboratory medicine perspective
Pitfalls in the diagnosis and management of acid-base disorders in humans: a laboratory medicine perspective
Diagnostic errors affect patient management, and as blood gas analysis is mainly performed without the laboratory, users m...
How--and why--to fill up a surgical pathology requisition form
How--and why--to fill up a surgical pathology requisition form
In his excellent review on macroscopic pathology, Shepherd refers to the lack of adequate clinical information on patholog...
Some issues to consider with the use of serum indices
Some issues to consider with the use of serum indices
Haemolysis is a preanalytical interference commonly encountered in specimens drawn for laboratory testing.1 2 As haemoglob...
Haemolysis index conundrum in a COVID-19 patient
Haemolysis index conundrum in a COVID-19 patient
In this study, we report a preanalytical challenge noted in our laboratory on plasma samples from a critically ill COVID-1...
Calculated LDL-cholesterol: comparability of the extended Martin/Hopkins, Sampson/NIH, Friedewald and four other equations in South African patients
Calculated LDL-cholesterol: comparability of the extended Martin/Hopkins, Sampson/NIH, Friedewald and four other equations in South African patients
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Seasonal variation of serum potassium and related prescription pattern: an ecological time series
Seasonal variation of serum potassium and related prescription pattern: an ecological time series
WHAT IS ALREADY KNOWN ON THIS TOPICSerum potassium is a useful test for clinicians to request to investigation renal funct...
Tumour stemness and poor clinical outcomes in haemochromatosis patients with hepatocellular carcinoma
Tumour stemness and poor clinical outcomes in haemochromatosis patients with hepatocellular carcinoma
WHAT IS ALREADY KNOWN ON THIS TOPICPatients with haemochromatosis (HFE) are at increased risk of developing hepatocellular...
Head-to-head comparative study: evaluating three panels for MSI-PCR testing in patients with colorectal and gastric cancer
Head-to-head comparative study: evaluating three panels for MSI-PCR testing in patients with colorectal and gastric cancer
IntroductionColorectal cancer (CRC) and gastric cancer (GC) are prevalent malignancies with diverse genetic phenotypes. De...
Prognostic implications of the immunohistochemical expression of perilipin 1 and adipophilin in high-grade liposarcoma
Prognostic implications of the immunohistochemical expression of perilipin 1 and adipophilin in high-grade liposarcoma
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Ciliated foregut cysts involving the hepatopancreaticobiliary system: a clinicopathological evaluation with focus on atypical features
Ciliated foregut cysts involving the hepatopancreaticobiliary system: a clinicopathological evaluation with focus on atypical features
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PI3K/PTEN/mTOR pathway dynamic tracking and prognostic value in HR+/HER2- BC patients with residual disease after neoadjuvant chemotherapy: a cohort study
PI3K/PTEN/mTOR pathway dynamic tracking and prognostic value in HR+/HER2- BC patients with residual disease after neoadjuvant chemotherapy: a cohort study
BackgroundHormone receptor-positive(HR+)/HER2-negative (HER2−) breast cancer (BC) encompasses almost two-thirds of all bre...
Common variable immunodeficiency disorder (CVID)-related liver disease: assessment of the main histological aspects using novel semiquantitative scoring systems, image analysis and correlation with clinical parameters of liver stiffness and portal hypertension
Common variable immunodeficiency disorder (CVID)-related liver disease: assessment of the main histological aspects using novel semiquantitative scoring systems, image analysis and correlation with clinical parameters of liver stiffness and portal hypertension
WHAT IS ALREADY KNOWN ON THIS TOPICWHAT THIS STUDY ADDSDemonstration of the coexistence of fibrosis, NRH-LC and pericellul...
Comparative analysis of antigen-presenting cells in gingival tissues in healthy and periodontitis patients
Comparative analysis of antigen-presenting cells in gingival tissues in healthy and periodontitis patients
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High-grade osteosarcoma arising from a clinically aggressive infantile fibrosarcoma
High-grade osteosarcoma arising from a clinically aggressive infantile fibrosarcoma
IntroductionInfantile fibrosarcoma (IFS) is a soft tissue tumour of intermediate malignant potential that commonly affects...
How many mislabelled samples go unidentified? Results of a pilot study to determine the occult mislabelled sample rate
How many mislabelled samples go unidentified? Results of a pilot study to determine the occult mislabelled sample rate
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Sudden cardiac death with morphologically normal heart: always do toxicology
Sudden cardiac death with morphologically normal heart: always do toxicology
BackgroundSudden cardiac death (SCD) is defined as natural unexpected death occurring within <1 hour in witnessed cases...
NTRK gene alterations were enriched in hepatoid or enteroblastic differentiation type of gastric cancer
NTRK gene alterations were enriched in hepatoid or enteroblastic differentiation type of gastric cancer
BackgroundGastric cancer (GC) ranks as the fifth most common cancer and the third-leading cause of cancer-related deaths w...
HER2/ERBB2 overexpression in advanced gallbladder carcinoma: comprehensive evaluation by immunocytochemistry and fluorescence in situ hybridisation on fine-needle aspiration cytology samples
HER2/ERBB2 overexpression in advanced gallbladder carcinoma: comprehensive evaluation by immunocytochemistry and fluorescence in situ hybridisation on fine-needle aspiration cytology samples
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Accuracy and validity of determined cause of death and manner of death following forensic autopsy prosection
Accuracy and validity of determined cause of death and manner of death following forensic autopsy prosection
WHAT IS ALREADY KNOWN ON THIS TOPICCurrently, death certificates are routinely inaccurate, often contain multiple errors a...
Laboratory investigation of peritoneal fluids: an updated practical approach based on the available evidence
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