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RB1: governor of the cell cycle in health and disease--a primer for the practising pathologist
RB1: governor of the cell cycle in health and disease--a primer for the practising pathologist
RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer...
Emerging and under-recognised patterns of colorectal carcinoma morphologies: a comprehensive review
Emerging and under-recognised patterns of colorectal carcinoma morphologies: a comprehensive review
IntroductionAs surgical pathologists, we aspire to a ‘one size fits all’ model, yet we know that it is never so convenient...
Serrated and mucinous appendiceal lesions: a viewpoint
Serrated and mucinous appendiceal lesions: a viewpoint
Serrated lesions in the gastrointestinal tract (GIT) have attracted much attention in the last decade or so with several p...
SMARCA4 alterations in non-small cell lung cancer: a systematic review and meta-analysis
SMARCA4 alterations in non-small cell lung cancer: a systematic review and meta-analysis
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Histopathology reporting of temporal artery biopsy specimens for giant cell arteritis: results of a modified Delphi study
Histopathology reporting of temporal artery biopsy specimens for giant cell arteritis: results of a modified Delphi study
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionReportedly first de...
In-house homologous recombination deficiency testing in ovarian cancer: a multi-institutional Italian pilot study
In-house homologous recombination deficiency testing in ovarian cancer: a multi-institutional Italian pilot study
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionEpithelial ovarian ...
Clinicopathological features of kidney injury in patients receiving immune checkpoint inhibitors (ICPi) combined with anti-vascular endothelial growth factor (anti-VEGF) therapy
Clinicopathological features of kidney injury in patients receiving immune checkpoint inhibitors (ICPi) combined with anti-vascular endothelial growth factor (anti-VEGF) therapy
IntroductionNovel anti-cancer therapy, including anti-vascular endothelial growth factor (VEGF) and immune checkpoint inhi...
Faecal immunochemical testing (FIT) in primary care: a follow-up service evaluation
Faecal immunochemical testing (FIT) in primary care: a follow-up service evaluation
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Landscape of cancer biomarker testing in England following genomic services reconfiguration: insights from a nationwide pathologist survey
Landscape of cancer biomarker testing in England following genomic services reconfiguration: insights from a nationwide pathologist survey
IntroductionOver the past decade, transformative advances in genomic sequencing technologies and the corresponding increas...
International Delphi consensus on the histopathological diagnosis of adenomyosis
International Delphi consensus on the histopathological diagnosis of adenomyosis
Adenomyosis has long been referred to as the ‘elusive’ condition in gynaecology.1 Clinical diagnosis is complicated by sym...
Use of CD32, CD44 and CD71 to differentiate follicular lymphoma and diffuse large B-cell lymphoma subtypes by flow cytometry
Use of CD32, CD44 and CD71 to differentiate follicular lymphoma and diffuse large B-cell lymphoma subtypes by flow cytometry
Many lymphomas can be immunophenotyped by flow cytometry (FCM), providing valuable diagnostic information.1 However, FCM c...
C3 concentrations can be normal in patients with C3 glomerulopathy secondary to C3 nephritic factor
C3 concentrations can be normal in patients with C3 glomerulopathy secondary to C3 nephritic factor
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Diagnosis and clinical relevance of uncommon subtypes of colorectal carcinoma
Diagnosis and clinical relevance of uncommon subtypes of colorectal carcinoma
I read with interest the article by Deshpande et al 1 regarding the immune milieu and the prognosis of micropapillary colo...
Practical guide to the use of digital slides in histopathology education
Practical guide to the use of digital slides in histopathology education
BackgroundTraditionally, histopathology education has been delivered using glass slides, conventional light microscopy and...
The difficulty with measuring the largest melanoma tumour diameter in sentinel lymph nodes
The difficulty with measuring the largest melanoma tumour diameter in sentinel lymph nodes
Identification of sentinel node (SN) metastases can set the adjuvant systemic therapy indication for stage III melanoma pa...
PHOX2B: a diagnostic cornerstone in neurocristopathies and neuroblastomas
PHOX2B: a diagnostic cornerstone in neurocristopathies and neuroblastomas
Paired-like homeobox 2B (PHOX2B) is a gene essential in the development of the autonomic nervous system. PHOX2B mutations ...
GPT-4 and histopathological image detection and classification of colorectal adenomas
GPT-4 and histopathological image detection and classification of colorectal adenomas
We would like to respond to a comment on the published article entitled ‘Accuracy of GPT-4 in histopathological image dete...
Clinical, pathological, genetics and intratumoural immune milieu of micropapillary carcinoma of the colon
Clinical, pathological, genetics and intratumoural immune milieu of micropapillary carcinoma of the colon
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Russell body typhilitis: An unusual mimicker of malignancy!
Russell body typhilitis: An unusual mimicker of malignancy!
Colorectal Russell body lesions are exceedingly rare with only four cases described in literature to date.1 We report here...
Spatial resolution of renal amyloid deposits through MALDI-MSI: a combined digital and molecular approach to monoclonal gammopathies
Spatial resolution of renal amyloid deposits through MALDI-MSI: a combined digital and molecular approach to monoclonal gammopathies
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Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality: new data and meta-analyses
Plasma viscosity, immunoglobulins and risk of cardiovascular disease and mortality: new data and meta-analyses
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Analysis of PRAME immunocytochemistry in 109 acral malignant melanoma in situ
Analysis of PRAME immunocytochemistry in 109 acral malignant melanoma in situ
WHAT IS ALREADY KNOWN ON THIS TOPICHOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICYIntroductionDespite advances in...
Unusual fusion gene rearrangements in patients with nodular fasciitis: a study of rare and novel USP6 fusion partners with a review of the literature
Unusual fusion gene rearrangements in patients with nodular fasciitis: a study of rare and novel USP6 fusion partners with a review of the literature
WHAT IS ALREADY KNOWN ON THIS TOPICIn recent years, the detection of various fusion partners with USP6 has been very popul...
Digital odyssey: lessons learnt from a reverse transition from a digital to a manual pathology workflow
Digital odyssey: lessons learnt from a reverse transition from a digital to a manual pathology workflow
In the fully digital Caltagirone pathology laboratory, a reverse shift from a digital to a manual workflow occurred due to...
Clinicopathological features of CD5-positive splenic marginal zone lymphoma
Clinicopathological features of CD5-positive splenic marginal zone lymphoma
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Rapid microdissection of tissue sections via laser ablation
Rapid microdissection of tissue sections via laser ablation
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Endometriosis with colonic mucosal colonisation: a diagnostic confounder
Endometriosis with colonic mucosal colonisation: a diagnostic confounder
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Assessment of large droplet fat in frozen sections of donor liver biopsies: utility and interobserver variability of the newly described Banff method compared to a simplified Average of Fields method
Assessment of large droplet fat in frozen sections of donor liver biopsies: utility and interobserver variability of the newly described Banff method compared to a simplified Average of Fields method
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Macroscopic pathology and all that: a personal view
Macroscopic pathology and all that: a personal view
I hope that this treatise adds to the excellent reviews by Varma and colleagues, emphasising the importance of accurate ma...
Macroscopic examination of pathology specimens: a critical reappraisal
Macroscopic examination of pathology specimens: a critical reappraisal
IntroductionMacroscopic examination of specimens and tissue sampling are critical steps on the road to an accurate histopa...
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