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Unravelling the USP6 gene: an update
Unravelling the USP6 gene: an update
Ubiquitin-specific protease 6 (USP6) rearrangements have been identified in aneurysmal bone cyst, nodular fasciitis, myos...
Failure to thrive in a man in his late forties
Failure to thrive in a man in his late forties
Clinical presentationA man in his late 40s with a 30 pack-year cigarette smoking history and no other comorbidities presen...
Ketamine: friend or foe?
Ketamine: friend or foe?
Ketamine, a dissociative anaesthetic drug, acts on the central nervous system (CNS) primarily through antagonism of the n-...
Quantitative p53 immunostaining aids in the detection of prevalent dysplasia
Quantitative p53 immunostaining aids in the detection of prevalent dysplasia
IntroductionOesophageal adenocarcinoma (EAC) is an aggressive disease with a mean 5-year survival rate of only 15%.1 Most ...
Development of a LAG-3 immunohistochemistry assay for melanoma
Development of a LAG-3 immunohistochemistry assay for melanoma
IntroductionImmune checkpoint inhibitor–based therapies have greatly improved clinical outcomes across multiple disease se...
Postmortem survey of haemoglobin A1c, non-alcoholic steatohepatitis and liver fibrosis within a general population
Postmortem survey of haemoglobin A1c, non-alcoholic steatohepatitis and liver fibrosis within a general population
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MYCN amplification and International Neuroblastoma Risk Group stratification on fine-needle aspiration biopsy and their correlation to survival in neuroblastoma
MYCN amplification and International Neuroblastoma Risk Group stratification on fine-needle aspiration biopsy and their correlation to survival in neuroblastoma
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Implementation of the updated NICE haematological cancers (NG47) improving outcomes guidelines across Specialist Integrated Haematological Malignancy Diagnostic Services (SIHMDS) in England: a UK NEQAS LI survey
Implementation of the updated NICE haematological cancers (NG47) improving outcomes guidelines across Specialist Integrated Haematological Malignancy Diagnostic Services (SIHMDS) in England: a UK NEQAS LI survey
IntroductionThe National Institute for Health and Care Excellence (NICE) produces evidence-based guidance, based on clinic...
Improving care of melanoma patients through efficient, integrated cellular-molecular pathology workflows using tissue samples with low tumour nuclear content
Improving care of melanoma patients through efficient, integrated cellular-molecular pathology workflows using tissue samples with low tumour nuclear content
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One-step genotyping of {alpha}-thalassaemia by multiplex symmetric PCR melting curve
One-step genotyping of {alpha}-thalassaemia by multiplex symmetric PCR melting curve
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Beyond the routine CBC: machine learning and statistical analyses identify research CBC parameter associations with myelodysplastic syndromes and specific underlying pathogenic variants
Beyond the routine CBC: machine learning and statistical analyses identify research CBC parameter associations with myelodysplastic syndromes and specific underlying pathogenic variants
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Preparing for the next pandemic: lessons learnt from the implementation of point-of-care SARS-CoV-2 testing in an emergency department
Preparing for the next pandemic: lessons learnt from the implementation of point-of-care SARS-CoV-2 testing in an emergency department
IntroductionRapid laboratory diagnosis of SARS-CoV-2 is essential for hospital management of COVID-19. In addition to aidi...
Prevalence of elevated serum concentrations of biotin in patients from South East England, Korea, Singapore and Thailand and risk of immunoassay interference
Prevalence of elevated serum concentrations of biotin in patients from South East England, Korea, Singapore and Thailand and risk of immunoassay interference
Biotin interference in immunoassays using biotin-streptavidin binding technology is well recognised by clinical laboratori...
Assessing transfer of value from industry to physicians: the importance of studying and reporting the appropriate population
Assessing transfer of value from industry to physicians: the importance of studying and reporting the appropriate population
We read with interest a recent study analysing industry payments to pathologists in the USA.1 In this study, Murayama and ...
Drug-induced hyperammonaemia
Drug-induced hyperammonaemia
IntroductionHyperammonaemia (HA) (>40 µmol/L, 68 μg/L in adults, although method dependent) arises due to a number of c...
Factors predicting BRCA1/2 pathogenic variants in patients with ovarian cancer: a systematic review with meta-analysis
Factors predicting BRCA1/2 pathogenic variants in patients with ovarian cancer: a systematic review with meta-analysis
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Neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene or MYCN gene
Neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene or MYCN gene
The MYCN gene belongs to the MYC family of transcription factors. Amplification of MYCN, first discovered in neuroblastoma...
Dual resolution deep learning network with self-attention mechanism for classification and localisation of colorectal cancer in histopathological images
Dual resolution deep learning network with self-attention mechanism for classification and localisation of colorectal cancer in histopathological images
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Novel histological repertoire of crypt-associated anomalies in inflamed colon mucosa
Novel histological repertoire of crypt-associated anomalies in inflamed colon mucosa
IntroductionThe sagittal profile of the normal colon mucosa at low magnification discloses a wavy silhouette due to small ...
Overexpression of integrin alpha 2 (ITGA2) correlates with poor survival in patients with pancreatic ductal adenocarcinoma
Overexpression of integrin alpha 2 (ITGA2) correlates with poor survival in patients with pancreatic ductal adenocarcinoma
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Diagnostic utility of ERG immunostaining in dermatofibroma
Diagnostic utility of ERG immunostaining in dermatofibroma
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FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing
FOCUS4 biomarker laboratories: from the benefits to the practical and logistical issues faced during 6 years of centralised testing
IntroductionWe are seeing an increase in clinical trials, requiring biomarker assessment to randomise patients to a partic...
Underdiagnosis of iron deficiency anaemia in HIV-infected individuals: a pilot study using soluble transferrin receptors and intensive bone marrow iron stores to improve the diagnosis
Underdiagnosis of iron deficiency anaemia in HIV-infected individuals: a pilot study using soluble transferrin receptors and intensive bone marrow iron stores to improve the diagnosis
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Industry payments to pathologists in the USA between 2013 and 2021
Industry payments to pathologists in the USA between 2013 and 2021
Although proper physician-industry financial relationships are essential for improving patient care, they can also cause p...
Additions to the paper 'The Journey of Laboratory Medicine from a broader perspective
Additions to the paper 'The Journey of Laboratory Medicine from a broader perspective
With much interest, we have read the review by professor Verna on how laboratory medicine has evolved to the clinically in...
Microvesicular hyperplastic polyp and sessile serrated lesion of the large intestine: a biological continuum or separate entities?
Microvesicular hyperplastic polyp and sessile serrated lesion of the large intestine: a biological continuum or separate entities?
The clinical, morphological and molecular features of microvesicular HPs and SSLs show considerable overlap, although seve...
Wilsons disease: best practice
Wilsons disease: best practice
Wilson’s disease is an autosomal recessive disorder arising from pathogenic variants in the Atp7b gene on chromosome 13. T...
Performance and pitfalls of the tools for measuring glomerular filtration rate to guide chronic kidney disease diagnosis and assessment
Performance and pitfalls of the tools for measuring glomerular filtration rate to guide chronic kidney disease diagnosis and assessment
Accurate diagnosis, classification and risk stratification for chronic kidney disease (CKD) allow for early recognition an...
Effect of CD274 (PD-L1) overexpression on survival outcomes in 10 specific cancers: a systematic review and meta-analysis
Effect of CD274 (PD-L1) overexpression on survival outcomes in 10 specific cancers: a systematic review and meta-analysis
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Coronial postmortem reports and indirect COVID-19 pandemic-related mortality
Coronial postmortem reports and indirect COVID-19 pandemic-related mortality
AbstractAims Widespread disruption of healthcare services and excess mortality not directly attributed to COVID-19 occurre...
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