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Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers
Mitoferrin2 is a synthetic lethal target for chromosome 8p deleted cancers
Somatic copy number alterations are a hallmark of cancer that offer unique opportunities for therapeutic exploitation. Her...
CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines
CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines
Genome-wide functional screening using the CRISPR-Cas9 system is a powerful tool to uncover tumor-specific and common gene...
Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome
Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome
Chronic kidney disease (CKD) is a progressive disease for which there is no effective cure. We aimed to identify potential...
Machine learning integrative approaches to advance computational immunology
Machine learning integrative approaches to advance computational immunology
The study of immunology, traditionally reliant on proteomics to evaluate individual immune cells, has been revolutionized ...
Colorectal cancer microbiome programs DNA methylation of host cells by affecting methyl donor metabolism
Colorectal cancer microbiome programs DNA methylation of host cells by affecting methyl donor metabolism
Colorectal cancer (CRC) arises from complex interactions between host and environment, which include the gut and tissue mi...
Multi-dimensional cell-free DNA-based liquid biopsy for sensitive early detection of gastric cancer
Multi-dimensional cell-free DNA-based liquid biopsy for sensitive early detection of gastric cancer
Gastric cancer is the fifth most common cancer type. Most patients are diagnosed at advanced stages with poor prognosis. A...
Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes
Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes
Antimicrobial resistance (AMR) is an intensifying threat that requires urgent mitigation to avoid a post-antibiotic era. P...
Optimizing clinico-genomic disease prediction across ancestries: a machine learning strategy with Pareto improvement
Optimizing clinico-genomic disease prediction across ancestries: a machine learning strategy with Pareto improvement
Accurate prediction of an individual’s predisposition to diseases is vital for preventive medicine and early interve...
Knockout mice with pituitary malformations help identify human cases of hypopituitarism
Knockout mice with pituitary malformations help identify human cases of hypopituitarism
Congenital hypopituitarism (CH) and its associated syndromes, septo-optic dysplasia (SOD) and holoprosencephaly (HPE), are...
Variability of polygenic prediction for body mass index in Africa
Variability of polygenic prediction for body mass index in Africa
Polygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a...
High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology
High-throughput functional mapping of variants in an arrhythmia gene, KCNE1, reveals novel biology
KCNE1 encodes a 129-residue cardiac potassium channel (IKs) subunit. KCNE1 variants are associated with long QT syndrome a...
Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause
Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause
The role of metabolism in the variation of age at menarche (AAM) and age at natural menopause (ANM) in the female populati...
Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans
Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans
Disease prevalence and mean phenotype values differ between many populations, including Inuit and Europeans. Whether these...
Analysis of 3760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes
Analysis of 3760 hematologic malignancies reveals rare transcriptomic aberrations of driver genes
Rare oncogenic driver events, particularly affecting the expression or splicing of driver genes, are suspected to substant...
The landscape of rare genetic variation associated with inflammatory bowel disease and Parkinson’s disease comorbidity
The landscape of rare genetic variation associated with inflammatory bowel disease and Parkinson’s disease comorbidity
Inflammatory bowel disease (IBD) and Parkinson’s disease (PD) are chronic disorders that have been suggested to shar...
imply: improving cell-type deconvolution accuracy using personalized reference profiles
imply: improving cell-type deconvolution accuracy using personalized reference profiles
Using computational tools, bulk transcriptomics can be deconvoluted to estimate the abundance of constituent cell types. H...
INSaFLU-TELEVIR: an open web-based bioinformatics suite for viral metagenomic detection and routine genomic surveillance
INSaFLU-TELEVIR: an open web-based bioinformatics suite for viral metagenomic detection and routine genomic surveillance
Implementation of clinical metagenomics and pathogen genomic surveillance can be particularly challenging due to the lack ...
Identifying latent genetic interactions in genome-wide association studies using multiple traits
Identifying latent genetic interactions in genome-wide association studies using multiple traits
The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other ...
Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection
Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection
Gut dysbiosis has been linked with both HIV infection and diabetes, but its interplay with metabolic and inflammatory resp...
The emergence of highly resistant and hypervirulent Klebsiella pneumoniae CC14 clone in a tertiary hospital over 8 years
The emergence of highly resistant and hypervirulent Klebsiella pneumoniae CC14 clone in a tertiary hospital over 8 years
Klebsiella pneumoniae is a major bacterial and opportunistic human pathogen, increasingly recognized as a healthcare burde...
PheSeq, a Bayesian deep learning model to enhance and interpret the gene-disease association studies
PheSeq, a Bayesian deep learning model to enhance and interpret the gene-disease association studies
Despite the abundance of genotype-phenotype association studies, the resulting association outcomes often lack robustness ...
Single cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer
Single cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer
Most primary Triple Negative Breast Cancers (TNBCs) show amplification of the Epidermal Growth Factor Receptor (EGFR) gene...
Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer risk
Smoking-associated gene expression alterations in nasal epithelium reveal immune impairment linked to lung cancer risk
Lung cancer is the leading cause of cancer-related death in the world. In contrast to many other cancers, a direct connect...
Burden of Mendelian disorders in a large Middle Eastern biobank
Burden of Mendelian disorders in a large Middle Eastern biobank
Genome sequencing of large biobanks from under-represented ancestries provides a valuable resource for the interrogation o...
NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy
NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy
NODAL signaling plays a critical role in embryonic patterning and heart development in vertebrates. Genetic variants resul...
Race-specific coregulatory and transcriptomic profiles associated with DNA methylation and androgen receptor in prostate cancer
Race-specific coregulatory and transcriptomic profiles associated with DNA methylation and androgen receptor in prostate cancer
Prostate cancer is a significant health concern, particularly among African American (AA) men who exhibit higher incidence...