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Male infertility‐associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery
Male infertility‐associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery
Abstract Motile cilia on the cell surface generate movement and directional fluid flow that is crucial for various biologi...
Lamarck redux and other false arguments against SARS‐CoV‐2 vaccination
Lamarck redux and other false arguments against SARS‐CoV‐2 vaccination
The COVID-19 pandemic has triggered a new bout of anti-vaccination propaganda. These are often grounded in pseudoscience a...
Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia
Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia
Abstract Cachexia is a wasting syndrome characterized by devastating skeletal muscle atrophy that dramatically increases m...
miR‐AB, a miRNA‐based shRNA viral toolkit for multicolor‐barcoded multiplex RNAi at a single‐cell level
miR‐AB, a miRNA‐based shRNA viral toolkit for multicolor‐barcoded multiplex RNAi at a single‐cell level
Abstract Uncovering the functions of genes in a complex biological process is fundamental for systems biology. However, cu...
FACT maintains nucleosomes during transcription and stem cell viability in adult mice
FACT maintains nucleosomes during transcription and stem cell viability in adult mice
Abstract Preservation of nucleosomes during replication has been extensively studied, while the maintenance of nucleosomes...
Physiologically relevant miRNAs in mammalian oocytes are rare and highly abundant
Physiologically relevant miRNAs in mammalian oocytes are rare and highly abundant
Abstract miRNAs, ~22nt small RNAs associated with Argonaute (AGO) proteins, are important negative regulators of gene expr...
Architecture for research
Architecture for research
Buildings should serve the people who live and work there. Buildings for research should encourage and symbolize communica...
Bur1 functions with TORC1 for vacuole‐mediated cell cycle progression
Bur1 functions with TORC1 for vacuole‐mediated cell cycle progression
Abstract The vacuole/lysosome plays essential roles in the growth and proliferation of many eukaryotic cells via the activ...
HP1 maintains protein stability of H3K9 methyltransferases and demethylases
HP1 maintains protein stability of H3K9 methyltransferases and demethylases
Abstract Di- or tri-methylated H3K9 (H3K9me2/3) is an epigenetic mark of heterochromatin. Heterochromatin protein 1 (HP1) ...
Deubiquitinating enzymes UBP12 and UBP13 stabilize the brassinosteroid receptor BRI1
Deubiquitinating enzymes UBP12 and UBP13 stabilize the brassinosteroid receptor BRI1
Abstract Protein ubiquitination is a dynamic and reversible post-translational modification that controls diverse cellular...
SCAI promotes error‐free repair of DNA interstrand crosslinks via the Fanconi anemia pathway
SCAI promotes error‐free repair of DNA interstrand crosslinks via the Fanconi anemia pathway
Abstract DNA interstrand crosslinks (ICLs) are cytotoxic lesions that threaten genome integrity. The Fanconi anemia (FA) p...
Are doping tests in sports trustworthy?
Are doping tests in sports trustworthy?
The lack of clearly defined criteria for doping tests carries a great risk of punishing innocent athletes and undermines t...
Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody
Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody
Abstract Calreticulin (CALR) is recurrently mutated in myelofibrosis via a frameshift that removes an endoplasmic reticulu...
Understanding redundancy and resilience
Understanding redundancy and resilience
Understanding how evolution generates and maintains redundancy to cope with damage and loss of function in living systems ...
The mTORC1‐eIF4F axis controls paused pluripotency
The mTORC1‐eIF4F axis controls paused pluripotency
Abstract Mouse embryonic stem cells (mESCs) can self-renew indefinitely and maintain pluripotency. Inhibition of mechanist...
An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase
An RDH‐Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase
Abstract The size of lipid droplets varies greatly in vivo and is determined by both intrinsic and extrinsic factors....
How physical forces drive the process of helical membrane protein folding
How physical forces drive the process of helical membrane protein folding
Abstract Protein folding is a fundamental process of life with important implications throughout biology. Indeed, tens of ...
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation
Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation
Abstract Mammalian development begins in transcriptional silence followed by a period of widespread activation of thousand...
PI4‐kinase and PfCDPK7 signaling regulate phospholipid biosynthesis in Plasmodium falciparum
PI4‐kinase and PfCDPK7 signaling regulate phospholipid biosynthesis in Plasmodium falciparum
Abstract PfCDPK7 is an atypical member of the calcium-dependent protein kinase (CDPK) family and is crucial for the develo...
Distinct regulation of bioenergetics and translation by group I mGluR and NMDAR
Distinct regulation of bioenergetics and translation by group I mGluR and NMDAR
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment
TERT activates endogenous retroviruses to promote an immunosuppressive tumour microenvironment
Abstract Telomerase plays a pivotal role in tumorigenesis by both telomere-dependent and telomere-independent activities, ...
#IchbinHannah and the fight for permanent jobs for postdocs
#IchbinHannah and the fight for permanent jobs for postdocs
Regarding postdocs as disposable labour with limited contracts is damaging for science. Universities need to offer them be...
Cell Communication Network factor 4 promotes tumor‐induced immunosuppression in melanoma
Cell Communication Network factor 4 promotes tumor‐induced immunosuppression in melanoma
Abstract Cell Communication Network factor 4 (CCN4/WISP1) is a matricellular protein secreted by cancer cells that promote...
CACGAACTACCCTAA
CACGAACTACCCTAA
Will future archeaologists and anthropologists be able to make sense of what happened to our species in the 21st century?
A species by any other name would sound as sweet
A species by any other name would sound as sweet
David Smith argues against the prevalent practice of naming newly discovered species after human beings.
USP17 is required for peripheral trafficking of lysosomes
USP17 is required for peripheral trafficking of lysosomes
Abstract Expression of the deubiquitinase USP17 is induced by multiple stimuli, including cytokines (IL-4/6), chemokines (...
Myeloid‐derived growth factor (MYDGF) protects bone mass through inhibiting osteoclastogenesis and promoting osteoblast differentiation
Myeloid‐derived growth factor (MYDGF) protects bone mass through inhibiting osteoclastogenesis and promoting osteoblast differentiation
Abstract Whether bone marrow regulates bone metabolism through endocrine and paracrine mechanism remains largely unknown. ...
MAP kinase cascades in plant development and immune signaling
MAP kinase cascades in plant development and immune signaling
Abstract Mitogen-activated protein kinase (MAPK) cascades are important signaling modules regulating diverse biological pr...
Regulation of ER‐derived membrane dynamics by the DedA domain‐containing proteins VMP1 and TMEM41B
Regulation of ER‐derived membrane dynamics by the DedA domain‐containing proteins VMP1 and TMEM41B
Abstract The endoplasmic reticulum (ER) is a central hub for the biogenesis of various organelles and lipid-containing str...
ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export
ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export
Abstract The pluripotent state is not solely governed by the action of the core transcription factors OCT4, SOX2, and NANO...
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