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Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage
Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, wit...
Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis
Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis
Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulat...
Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function
Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function
Endometrial fibrosis, a significant characteristic of intrauterine adhesion (IUA), is caused by the excessive differentiat...
The long-chain flavodoxin FldX1 improves the biodegradation of 4-hydroxyphenylacetate and 3-hydroxyphenylacetate and counteracts the oxidative stress associated to aromatic catabolism in Paraburkholderia xenovorans
The long-chain flavodoxin FldX1 improves the biodegradation of 4-hydroxyphenylacetate and 3-hydroxyphenylacetate and counteracts the oxidative stress associated to aromatic catabolism in Paraburkholderia xenovorans
Bacterial aromatic degradation may cause oxidative stress. The long-chain flavodoxin FldX1 of Paraburkholderia xenovorans ...
MicroRNA-148b secreted by bovine oviductal extracellular vesicles enhance embryo quality through BPM/TGF-beta pathway
MicroRNA-148b secreted by bovine oviductal extracellular vesicles enhance embryo quality through BPM/TGF-beta pathway
Extracellular vesicles (EVs) and their cargoes, including MicroRNAs (miRNAs) play a crucial role in cell-to-cell communica...
YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions
YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions
The senescence of renal tubular epithelial cells (RTECs) is crucial in the progression of diabetic kidney disease (DKD). A...
Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson’s disease
Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson’s disease
Parkinson’s disease (PD) is characterized by death of dopaminergic neurons leading to dopamine deficiency, excessive...
Glial-restricted progenitor cells: a cure for diseased brain?
Glial-restricted progenitor cells: a cure for diseased brain?
The central nervous system (CNS) is home to neuronal and glial cells. Traditionally, glia was disregarded as just the stru...
Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile
Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile
The convergence of hypervirulence and carbapenem resistance in the bacterial pathogen Klebsiella pneumoniae represents a c...
Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice
Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice
The monthly regeneration of human endometrial tissue is maintained by the presence of human endometrial mesenchymal stroma...
Embryo development is impaired by sperm mitochondrial-derived ROS
Embryo development is impaired by sperm mitochondrial-derived ROS
Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte f...
Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1
Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1
Fibrous scars frequently form at the sites of bone nonunion when attempts to repair bone fractures have failed. However, t...
MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack ...
Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cells
Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cells
Increasing evidence suggests a double-faceted role of alpha-synuclein (α-syn) following infection by a variety of vir...
Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities
Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities
Tumor-derived small extracellular vesicles (sEVs) can promote tumorigenic and metastatic capacities in less aggressive rec...
Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome ...
The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial s...
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
Impaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG...
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo ...
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to med...
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression
Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the ...
Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure (PEE) (mainly through maternal alcohol consumption) has become widespread. However, studies sugg...
Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue
Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue
The decline in the quantity and quality of mitochondria are closely associated with infertility, particularly in advanced ...
Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia
Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of chronic intermittent hypoxia (CIH), which has been...
Heat-responsive microRNAs participate in regulating the pollen fertility stability of CMS-D2 restorer line under high-temperature stress
Heat-responsive microRNAs participate in regulating the pollen fertility stability of CMS-D2 restorer line under high-temperature stress
Anther development and pollen fertility of cytoplasmic male sterility (CMS) conditioned by Gossypium harknessii cytoplasm ...
Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells
Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells
Neural progenitor cells (NPCs) are essential for in vitro drug screening and cell-based therapies for brain-related disord...
Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia
Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia
Endotoxic shock (ExSh) and cecal ligature and puncture (CLP) are models that induce sepsis. In this work, we investigated ...
An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm
An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm
In vitro incubation of epididymal and vas deferens sperm with Mn2+ induces Sperm Chromatin Fragmentation (SCF), a mechanis...
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An as...
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760
Angiotensin converting enzyme 2 (ACE2) plays a crucial role in the infection cycle of SARS-CoV-2 responsible for formation...
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