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Maraviroc/cisplatin combination inhibits gastric cancer tumoroid growth and improves mice survival
Maraviroc/cisplatin combination inhibits gastric cancer tumoroid growth and improves mice survival
Gastric cancer (GC) is a significant cancer-related cause of death worldwide. GC’s most used chemotherapeutic regime...
Protein palmitoylation is involved in regulating mouse sperm motility via the signals of calcium, protein tyrosine phosphorylation and reactive oxygen species
Protein palmitoylation is involved in regulating mouse sperm motility via the signals of calcium, protein tyrosine phosphorylation and reactive oxygen species
Protein palmitoylation, a critical posttranslational modification, plays an indispensable role in various cellular process...
The periplasmic protein HslJ is the first-line of defense against oxidative stress in Acinetobacter baumannii
The periplasmic protein HslJ is the first-line of defense against oxidative stress in Acinetobacter baumannii
Acinetobacter baumannii poses a significant threat globally, causing infections primarily in healthcare settings, with hig...
A novel CUL4B gene variant activating Wnt4/β-catenin signal pathway to karyotype 46, XY female with disorders of sex development
A novel CUL4B gene variant activating Wnt4/β-catenin signal pathway to karyotype 46, XY female with disorders of sex development
Karyotype 46, XY female disorders of sex development (46, XY female DSD) are congenital conditions due to irregular gonada...
Regional Hereditary Cancer Program in Chile: A scalable model of genetic counseling and molecular diagnosis to improve clinical outcomes for patients with hereditary cancer across Latin America
Regional Hereditary Cancer Program in Chile: A scalable model of genetic counseling and molecular diagnosis to improve clinical outcomes for patients with hereditary cancer across Latin America
Breast cancer is a leading cause of cancer-related mortality worldwide, with hereditary forms accounting for approximately...
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development
A snapshot of cancer in Chile II: an update on research, strategies and analytical frameworks for equity, innovation and national development
Chile has achieved developed nation status and boasts a life expectancy of 81 + years; however, the healthcare...
NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion
NOX proteins and ROS generation: role in invadopodia formation and cancer cell invasion
NADPH oxidases (NOX) are membrane-bound proteins involved in the localized generation of reactive oxygen species (ROS) at ...
Are we cultivating the perfect storm for a human avian influenza pandemic?
Are we cultivating the perfect storm for a human avian influenza pandemic?
The emergence of highly pathogenic avian influenza (HPAI) A H5N1 virus in dairy cattle marks a troubling new chapter in th...
Lack of canonical activities of connexins in highly aggressive human prostate cancer cells
Lack of canonical activities of connexins in highly aggressive human prostate cancer cells
Connexins (Cxs) have the ability to form channels that allow the exchange of ions/metabolites between adjacent cells (gap ...
A single-base deletion in exon 2 of Hd1 delineates monogenic recessive photoperiod insensitivity in aromatic Joha rice: a novel allele for seasonal adaptability
A single-base deletion in exon 2 of Hd1 delineates monogenic recessive photoperiod insensitivity in aromatic Joha rice: a novel allele for seasonal adaptability
Assam's aromatic Joha rice is a unique rice class famous for its aroma, taste, and nutritional benef...
Heterogeneity in the formation of primary and secondary visual fields during human prenatal development
Heterogeneity in the formation of primary and secondary visual fields during human prenatal development
The human neocortex has a huge surface area with unique cytoarchitectonics, most of which is concealed in sulci. Some cyto...
Stress drives premature hive exiting behavior that leads to death in young honey bee (Apis mellifera) workers
Stress drives premature hive exiting behavior that leads to death in young honey bee (Apis mellifera) workers
The Western honey bee, Apis mellifera, is an economically important pollinator, as well as a tractable species for studyin...
Perturbation of mammary epithelial cell apicobasal polarity by RHBDF1-facilitated nuclear translocation of PKCζ
Perturbation of mammary epithelial cell apicobasal polarity by RHBDF1-facilitated nuclear translocation of PKCζ
The establishment of apicobasal polarity in epithelial cells is of critical importance in morphogenesis of mammary gland a...
Study on the therapeutic potential of induced neural stem cells for Alzheimer's disease in mice
Study on the therapeutic potential of induced neural stem cells for Alzheimer's disease in mice
Induced neural stem cells (iNSCs), which have similar properties to neural stem cells and are able to self-proliferate and...
Female prediabetic rats are protected from vascular dysfunction: the role of nitroso and sulfide signaling
Female prediabetic rats are protected from vascular dysfunction: the role of nitroso and sulfide signaling
The activity of perivascular adipose tissue (PVAT), a specific deposit of adipose tissue surrounding blood vessels, could ...
Effect of chronic exogenous oxytocin administration on exercise performance and cardiovagal control in hypobaric hypoxia in rats
Effect of chronic exogenous oxytocin administration on exercise performance and cardiovagal control in hypobaric hypoxia in rats
Outstanding exercise performance has been associated with an exacerbated vagal outflow. Nevertheless, during high-altitude...
Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration
Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration
Depression and memory loss are prevalent neurodegenerative disorders, with diabetic patients facing an elevated risk of br...
Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1G93A ALS mouse model
Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1G93A ALS mouse model
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal paralytic disorder associated with motor neuron death. Mut...
Enrichment of trimethyl histone 3 lysine 4 in the Dlk1 and Grb10 genes affects pregnancy outcomes due to dietary manipulation of excess folic acid and low vitamin B12
Enrichment of trimethyl histone 3 lysine 4 in the Dlk1 and Grb10 genes affects pregnancy outcomes due to dietary manipulation of excess folic acid and low vitamin B12
The aberrant expression of placental imprinted genes due to epigenetic alterations during pregnancy can impact fetal devel...
EZH1/2 plays critical roles in oocyte meiosis prophase I in mice
EZH1/2 plays critical roles in oocyte meiosis prophase I in mice
abnormalities or defects in oocyte meiosis can result in decreased oocyte quality, reduced ovarian reserve, and female dis...
Impact of salmon farming in the antibiotic resistance and structure of marine bacterial communities from surface seawater of a northern Patagonian area of Chile
Impact of salmon farming in the antibiotic resistance and structure of marine bacterial communities from surface seawater of a northern Patagonian area of Chile
Aquaculture and salmon farming can cause environmental problems due to the pollution of the surrounding waters with nutrie...
Phenotyping of a new yeast mapping population reveals differences in the activation of the TORC1 signalling pathway between wild and domesticated yeast strains
Phenotyping of a new yeast mapping population reveals differences in the activation of the TORC1 signalling pathway between wild and domesticated yeast strains
Domestication can be understood as a symbiotic relationship that benefits both domesticator and domesticated species, invo...
The sodium/ascorbic acid co-transporter SVCT2 distributes in a striated membrane-enriched domain at the M-band level in slow-twitch skeletal muscle fibers
The sodium/ascorbic acid co-transporter SVCT2 distributes in a striated membrane-enriched domain at the M-band level in slow-twitch skeletal muscle fibers
Vitamin C plays key roles in cellular homeostasis, functioning as a potent antioxidant and a positive regulator of cell di...
GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions
GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions
During diabetes, prorenin is highly produced by the renal collecting ducts. The binding of prorenin to (pro)renin receptor...
Advances in genomic tools for plant breeding: harnessing DNA molecular markers, genomic selection, and genome editing
Advances in genomic tools for plant breeding: harnessing DNA molecular markers, genomic selection, and genome editing
Conventional pre-genomics breeding methodologies have significantly improved crop yields since the mid-twentieth century. ...
Increasing carotenoid production in Xanthophyllomyces dendrorhous/Phaffia rhodozyma: SREBP pathway activation and promoter engineering
Increasing carotenoid production in Xanthophyllomyces dendrorhous/Phaffia rhodozyma: SREBP pathway activation and promoter engineering
The yeast Xanthophyllomyces dendrorhous synthesizes astaxanthin, a high-value carotenoid with biotechnological relevance i...
DLK1 and DLK2, two non-canonical ligands of NOTCH receptors, differentially modulate the osteogenic differentiation of mesenchymal C3H10T1/2 cells
DLK1 and DLK2, two non-canonical ligands of NOTCH receptors, differentially modulate the osteogenic differentiation of mesenchymal C3H10T1/2 cells
C3H10T1/2 is a mesenchymal cell line capable of differentiating into osteoblasts, adipocytes and chondrocytes. The differe...
Enhancing late postmortem interval prediction: a pilot study integrating proteomics and machine learning to distinguish human bone remains over 15 years
Enhancing late postmortem interval prediction: a pilot study integrating proteomics and machine learning to distinguish human bone remains over 15 years
Determining the postmortem interval (PMI) accurately remains a significant challenge in forensic sciences, especially for ...
Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells
Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells
Lung cancer constitutes the leading cause of cancer mortality. High levels of endothelin-1 (ET-1), its cognate receptor ET...
Landscape transcriptomic analysis of bovine follicular cells during key phases of ovarian follicular development
Landscape transcriptomic analysis of bovine follicular cells during key phases of ovarian follicular development
There are many gaps in our understanding of the mechanisms involved in ovarian follicular development in cattle, particula...
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