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S-Nitrosylation in endothelial cells contributes to tumor cell adhesion and extravasation during breast cancer metastasis
S-Nitrosylation in endothelial cells contributes to tumor cell adhesion and extravasation during breast cancer metastasis
Nitric oxide is produced by different nitric oxide synthases isoforms. NO activates two signaling pathways, one dependent ...
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis
Identifying pyroptosis- and inflammation-related genes in intracranial aneurysms based on bioinformatics analysis
Intracranial aneurysm (IA) is the most common cerebrovascular disease, and subarachnoid hemorrhage caused by its rupture c...
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
Drosophila Atlastin regulates synaptic vesicle mobilization independent of bone morphogenetic protein signaling
The endoplasmic reticulum (ER) contacts endosomes in all parts of a motor neuron, including the axon and presynaptic termi...
Mucin1 induced trophoblast dysfunction in gestational diabetes mellitus via Wnt/β-catenin pathway
Mucin1 induced trophoblast dysfunction in gestational diabetes mellitus via Wnt/β-catenin pathway
To elucidate the role of Mucin1 (MUC1) in the trophoblast function (glucose uptake and apoptosis) of gestational diabetes ...
Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility
Human umbilical cord mesenchymal stem cells (hUC-MSCs) alleviate paclitaxel-induced spermatogenesis defects and maintain male fertility
Chemotherapeutic drugs can cause reproductive damage by affecting sperm quality and other aspects of male fertility. Stem ...
Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians
Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians
The genomes of present-day non-Africans are composed of 1–3% of Neandertal-derived DNA as a consequence of admixture...
Identification and analysis of key hypoxia- and immune-related genes in hypertrophic cardiomyopathy
Identification and analysis of key hypoxia- and immune-related genes in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM), an autosomal dominant genetic disease, is the main cause of sudden death in adolescents...
How do prolonged anchorage-free lifetimes strengthen non-small-cell lung cancer cells to evade anoikis? – A link with altered cellular metabolomics
How do prolonged anchorage-free lifetimes strengthen non-small-cell lung cancer cells to evade anoikis? – A link with altered cellular metabolomics
Malignant cells adopt anoikis resistance to survive anchorage-free stresses and initiate cancer metastasis. It is still un...
Single nucleotide polymorphisms associated with wine fermentation and adaptation to nitrogen limitation in wild and domesticated yeast strains
Single nucleotide polymorphisms associated with wine fermentation and adaptation to nitrogen limitation in wild and domesticated yeast strains
For more than 20 years, Saccharomyces cerevisiae has served as a model organism for genetic studies and molecular biology,...
Investigating the dark-side of the genome: a barrier to human disease variant discovery?
Investigating the dark-side of the genome: a barrier to human disease variant discovery?
The human genome contains regions that cannot be adequately assembled or aligned using next generation short-read sequenci...
Polar microalgae extracts protect human HaCaT keratinocytes from damaging stimuli and ameliorate psoriatic skin inflammation in mice
Polar microalgae extracts protect human HaCaT keratinocytes from damaging stimuli and ameliorate psoriatic skin inflammation in mice
Polar microalgae contain unique compounds that enable them to adapt to extreme environments. As the skin barrier is our fi...
Correction: Utility of melatonin in mitigating ionizing radiation‑induced testis injury through synergistic interdependence of its biological properties
Correction: Utility of melatonin in mitigating ionizing radiation‑induced testis injury through synergistic interdependence of its biological properties
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Beyond energy provider: multifunction of lipid droplets in embryonic development
Beyond energy provider: multifunction of lipid droplets in embryonic development
Since the discovery, lipid droplets (LDs) have been recognized to be sites of cellular energy reserves, providing energy w...
Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus
Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus
Hyperbaric oxygen treatment (HBOT) has been reported to modulate the proliferation of neural and mesenchymal stem cell pop...
Retraction Note: Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
Retraction Note: Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Electroacupuncture protective effects after cerebral ischemia are mediated through miR-219a inhibition
Electroacupuncture protective effects after cerebral ischemia are mediated through miR-219a inhibition
Electroacupuncture (EA) is a complementary and alternative therapy which has shown protective effects on vascular cognitiv...
Topsoil and subsoil bacterial community assemblies across different drainage conditions in a mountain environment
Topsoil and subsoil bacterial community assemblies across different drainage conditions in a mountain environment
High mountainous environments are of particular interest as they play an essential role for life and human societies, whil...
Human VDAC pseudogenes: an emerging role for VDAC1P8 pseudogene in acute myeloid leukemia
Human VDAC pseudogenes: an emerging role for VDAC1P8 pseudogene in acute myeloid leukemia
Voltage-dependent anion selective channels (VDACs) are the most abundant mitochondrial outer membrane proteins, encoded in...
Functional defects in hiPSCs-derived cardiomyocytes from patients with a PLEKHM2-mutation associated with dilated cardiomyopathy and left ventricular non-compaction
Functional defects in hiPSCs-derived cardiomyocytes from patients with a PLEKHM2-mutation associated with dilated cardiomyopathy and left ventricular non-compaction
Dilated cardiomyopathy (DCM) is a primary myocardial disease, leading to heart failure and excessive risk of sudden cardia...
Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p
Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p
The main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which...
ABCA1 transporter promotes the motility of human melanoma cells by modulating their plasma membrane organization
ABCA1 transporter promotes the motility of human melanoma cells by modulating their plasma membrane organization
Melanoma is one of the most aggressive and deadliest skin tumor. Cholesterol content in melanoma cells is elevated, and a ...
Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells
Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells
Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic...
iPSCs ameliorate hypoxia-induced autophagy and atrophy in C2C12 myotubes via the AMPK/ULK1 pathway
iPSCs ameliorate hypoxia-induced autophagy and atrophy in C2C12 myotubes via the AMPK/ULK1 pathway
Duchenne muscular dystrophy (DMD) is an X-linked lethal genetic disorder for which there is no effective treatment. Previo...
Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux
Ursodeoxycholic acid induces sarcopenia associated with decreased protein synthesis and autophagic flux
Skeletal muscle generates force and movements and maintains posture. Under pathological conditions, muscle fibers suffer a...
Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson’s disease models
Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson’s disease models
The underlying mechanism of Parkinson’s disease are still unidentified, but excitotoxicity, oxidative stress, and ne...
Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL
Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL
Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal ...
Activation of a hypothalamus-habenula circuit by mechanical stimulation inhibits cocaine addiction-like behaviors
Activation of a hypothalamus-habenula circuit by mechanical stimulation inhibits cocaine addiction-like behaviors
Mechanoreceptor activation modulates GABA neuron firing and dopamine (DA) release in the mesolimbic DA system, an area imp...
Maintenance of chronicity signatures in fibroblasts isolated from recessive dystrophic epidermolysis bullosa chronic wound dressings under culture conditions
Maintenance of chronicity signatures in fibroblasts isolated from recessive dystrophic epidermolysis bullosa chronic wound dressings under culture conditions
Recessive Dystrophic Epidermolysis Bullosa (RDEB) is a rare inherited skin disease caused by variants in the COL7A1 gene, ...
Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis
Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Conformational characterization of the mammalian-expressed SARS-CoV-2 recombinant receptor binding domain, a COVID-19 vaccine
Conformational characterization of the mammalian-expressed SARS-CoV-2 recombinant receptor binding domain, a COVID-19 vaccine
The COVID-19 pandemic has caused a large number of diseases worldwide. There are few vaccines to constrain this disease an...
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