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Renoprotective effect of a novel combination of 6-gingerol and metformin in high-fat diet/streptozotocin-induced diabetic nephropathy in rats via targeting miRNA-146a, miRNA-223, TLR4/TRAF6/NLRP3 inflammasome pathway and HIF-1α
Renoprotective effect of a novel combination of 6-gingerol and metformin in high-fat diet/streptozotocin-induced diabetic nephropathy in rats via targeting miRNA-146a, miRNA-223, TLR4/TRAF6/NLRP3 inflammasome pathway and HIF-1α
MiRNA-146a and miRNA-223 are key epigenetic regulators of toll-like receptor 4 (TLR4)/tumor necrosis factor-receptor-assoc...
Chrysin-loaded PEGylated liposomes protect against alloxan-induced diabetic neuropathy in rats: the interplay between endoplasmic reticulum stress and autophagy
Chrysin-loaded PEGylated liposomes protect against alloxan-induced diabetic neuropathy in rats: the interplay between endoplasmic reticulum stress and autophagy
Diabetic neuropathy (DN) is recognized as a significant complication arising from diabetes mellitus (DM). Pathogenesis of ...
Lead and calcium crosstalk tempted acrosome damage and hyperpolarization of spermatozoa: signaling and ultra-structural evidences
Lead and calcium crosstalk tempted acrosome damage and hyperpolarization of spermatozoa: signaling and ultra-structural evidences
Exposure of humans and animals to heavy metals is increasing day-by-day; thus, lead even today remains of significant publ...
Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology
Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology
The nucleus incertus (NI) was originally described by Streeter in 1903, as a midline region in the floor of the fourth ven...
Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice
Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice
Retinopathy of Prematurity (ROP) is a proliferative retinal vascular disease occurring in the retina of premature infants ...
Exercise reduces physical alterations in a rat model of fetal alcohol spectrum disorders
Exercise reduces physical alterations in a rat model of fetal alcohol spectrum disorders
Prenatal alcohol exposure (PAE) has serious physical consequences for children such as behavioral disabilities, growth dis...
Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice
Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice
The brain cortex is responsible for many higher-level cognitive functions. Disruptions during cortical development have lo...
Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression
Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression
Spreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neur...
Distinct properties of putative trophoblast stem cells established from somatic cell nuclear-transferred pig blastocysts
Distinct properties of putative trophoblast stem cells established from somatic cell nuclear-transferred pig blastocysts
Genetically modified pigs are considered ideal models for studying human diseases and potential sources for xenotransplant...
The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice
The crucial role of HFM1 in regulating FUS ubiquitination and localization for oocyte meiosis prophase I progression in mice
Helicase for meiosis 1 (HFM1), a putative DNA helicase expressed in germ-line cells, has been reported to be closely assoc...
The current insights of mitochondrial hormesis in the occurrence and treatment of bone and cartilage degeneration
The current insights of mitochondrial hormesis in the occurrence and treatment of bone and cartilage degeneration
It is widely acknowledged that aging, mitochondrial dysfunction, and cellular phenotypic abnormalities are intricately ass...
Electroacupuncture attenuates neuropathic pain via suppressing BIP-IRE-1α-mediated endoplasmic reticulum stress in the anterior cingulate cortex
Electroacupuncture attenuates neuropathic pain via suppressing BIP-IRE-1α-mediated endoplasmic reticulum stress in the anterior cingulate cortex
Studies have suggested that endoplasmic reticulum stress (ERS) is involved in neurological dysfunction and that electroacu...
Effect of Cannabis sativa L. extracts, phytocannabinoids and their acetylated derivates on the SHSY-5Y neuroblastoma cells’ viability and caspases 3/7 activation
Effect of Cannabis sativa L. extracts, phytocannabinoids and their acetylated derivates on the SHSY-5Y neuroblastoma cells’ viability and caspases 3/7 activation
There is a need for novel treatments for neuroblastoma, despite the emergence of new biological and immune treatments, sin...
The hepatoprotective effect of 4-phenyltetrahydroquinolines on carbon tetrachloride induced hepatotoxicity in rats through autophagy inhibition
The hepatoprotective effect of 4-phenyltetrahydroquinolines on carbon tetrachloride induced hepatotoxicity in rats through autophagy inhibition
The liver serves as a metabolic hub within the human body, playing a crucial role in various essential functions, such as ...
Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket
Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket
Members of the β-subfamily of connexins contain an intracellular pocket surrounded by amino acid residues from the fo...
IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma
IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), are present in most gliomas. IDH1 mutation is an important ...
Therapeutic potential of oleic acid supplementation in myotonic dystrophy muscle cell models
Therapeutic potential of oleic acid supplementation in myotonic dystrophy muscle cell models
We recently reported that upregulation of Musashi 2 (MSI2) protein in the rare neuromuscular disease myotonic dystrophy ty...
Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis
Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis
The activated microglia have been reported as pillar factors in neuropathic pain (NP) pathology, but the molecules driving...
Combined transcriptomics and proteomics unveil the impact of vitamin C in modulating specific protein abundance in the mouse liver
Combined transcriptomics and proteomics unveil the impact of vitamin C in modulating specific protein abundance in the mouse liver
Vitamin C (ascorbate) is a water-soluble antioxidant and an important cofactor for various biosynthetic and regulatory enz...
MicroRNA-721 regulates gluconeogenesis via KDM2A-mediated epigenetic modulation in diet-induced insulin resistance in C57BL/6J mice
MicroRNA-721 regulates gluconeogenesis via KDM2A-mediated epigenetic modulation in diet-induced insulin resistance in C57BL/6J mice
Aberrant gluconeogenesis is considered among primary drivers of hyperglycemia under insulin resistant conditions, with mul...
Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer
Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer
Prostate cancer (PCa) is a major urological disease that is associated with significant morbidity and mortality in men. LL...
Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters
Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters
Despite the record speed of developing vaccines and therapeutics against the SARS-CoV-2 virus, it is not a given that such...
High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats
High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats
Obesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban so...
The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells
The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells
Diabetes mellitus (DM) is a global epidemic with increasing incidences. DM is a metabolic disease associated with chronic ...
General regulatory factors exert differential effects on nucleosome sliding activity of the ISW1a complex
General regulatory factors exert differential effects on nucleosome sliding activity of the ISW1a complex
Chromatin dynamics is deeply involved in processes that require access to DNA, such as transcriptional regulation. Among t...
Establishment of primary prostate epithelial and tumorigenic cell lines using a non-viral immortalization approach
Establishment of primary prostate epithelial and tumorigenic cell lines using a non-viral immortalization approach
Research on prostate cancer is mostly performed using cell lines derived from metastatic disease, not reflecting stages of...
Control of astrocytic Ca2+ signaling by nitric oxide-dependent S-nitrosylation of Ca2+ homeostasis modulator 1 channels
Control of astrocytic Ca2+ signaling by nitric oxide-dependent S-nitrosylation of Ca2+ homeostasis modulator 1 channels
Astrocytes Ca2+ signaling play a central role in the modulation of neuronal function. Activation of metabotropic glutamate...
Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats
Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats
Patients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoo...
Noncoding RNAs in skeletal development and disorders
Noncoding RNAs in skeletal development and disorders
Protein-encoding genes only constitute less than 2% of total human genomic sequences, and 98% of genetic information was p...
Identification and expression analysis of two steamer-like retrotransposons in the Chilean blue mussel (Mytilus chilensis)
Identification and expression analysis of two steamer-like retrotransposons in the Chilean blue mussel (Mytilus chilensis)
Disseminated neoplasia (DN) is a proliferative cell disorder of the circulatory system of bivalve mollusks. The disease is...
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