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Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1G93A ALS mouse model
Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1G93A ALS mouse model
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal paralytic disorder associated with motor neuron death. Mut...
Enrichment of trimethyl histone 3 lysine 4 in the Dlk1 and Grb10 genes affects pregnancy outcomes due to dietary manipulation of excess folic acid and low vitamin B12
Enrichment of trimethyl histone 3 lysine 4 in the Dlk1 and Grb10 genes affects pregnancy outcomes due to dietary manipulation of excess folic acid and low vitamin B12
The aberrant expression of placental imprinted genes due to epigenetic alterations during pregnancy can impact fetal devel...
EZH1/2 plays critical roles in oocyte meiosis prophase I in mice
EZH1/2 plays critical roles in oocyte meiosis prophase I in mice
abnormalities or defects in oocyte meiosis can result in decreased oocyte quality, reduced ovarian reserve, and female dis...
Impact of salmon farming in the antibiotic resistance and structure of marine bacterial communities from surface seawater of a northern Patagonian area of Chile
Impact of salmon farming in the antibiotic resistance and structure of marine bacterial communities from surface seawater of a northern Patagonian area of Chile
Aquaculture and salmon farming can cause environmental problems due to the pollution of the surrounding waters with nutrie...
Phenotyping of a new yeast mapping population reveals differences in the activation of the TORC1 signalling pathway between wild and domesticated yeast strains
Phenotyping of a new yeast mapping population reveals differences in the activation of the TORC1 signalling pathway between wild and domesticated yeast strains
Domestication can be understood as a symbiotic relationship that benefits both domesticator and domesticated species, invo...
The sodium/ascorbic acid co-transporter SVCT2 distributes in a striated membrane-enriched domain at the M-band level in slow-twitch skeletal muscle fibers
The sodium/ascorbic acid co-transporter SVCT2 distributes in a striated membrane-enriched domain at the M-band level in slow-twitch skeletal muscle fibers
Vitamin C plays key roles in cellular homeostasis, functioning as a potent antioxidant and a positive regulator of cell di...
GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions
GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions
During diabetes, prorenin is highly produced by the renal collecting ducts. The binding of prorenin to (pro)renin receptor...
Advances in genomic tools for plant breeding: harnessing DNA molecular markers, genomic selection, and genome editing
Advances in genomic tools for plant breeding: harnessing DNA molecular markers, genomic selection, and genome editing
Conventional pre-genomics breeding methodologies have significantly improved crop yields since the mid-twentieth century. ...
Increasing carotenoid production in Xanthophyllomyces dendrorhous/Phaffia rhodozyma: SREBP pathway activation and promoter engineering
Increasing carotenoid production in Xanthophyllomyces dendrorhous/Phaffia rhodozyma: SREBP pathway activation and promoter engineering
The yeast Xanthophyllomyces dendrorhous synthesizes astaxanthin, a high-value carotenoid with biotechnological relevance i...
DLK1 and DLK2, two non-canonical ligands of NOTCH receptors, differentially modulate the osteogenic differentiation of mesenchymal C3H10T1/2 cells
DLK1 and DLK2, two non-canonical ligands of NOTCH receptors, differentially modulate the osteogenic differentiation of mesenchymal C3H10T1/2 cells
C3H10T1/2 is a mesenchymal cell line capable of differentiating into osteoblasts, adipocytes and chondrocytes. The differe...
Enhancing late postmortem interval prediction: a pilot study integrating proteomics and machine learning to distinguish human bone remains over 15 years
Enhancing late postmortem interval prediction: a pilot study integrating proteomics and machine learning to distinguish human bone remains over 15 years
Determining the postmortem interval (PMI) accurately remains a significant challenge in forensic sciences, especially for ...
Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells
Cisplatin-resistance and aggressiveness are enhanced by a highly stable endothelin-converting enzyme-1c in lung cancer cells
Lung cancer constitutes the leading cause of cancer mortality. High levels of endothelin-1 (ET-1), its cognate receptor ET...
Landscape transcriptomic analysis of bovine follicular cells during key phases of ovarian follicular development
Landscape transcriptomic analysis of bovine follicular cells during key phases of ovarian follicular development
There are many gaps in our understanding of the mechanisms involved in ovarian follicular development in cattle, particula...
H Antigen expression modulates epidermal Keratinocyte Integrity and differentiation
H Antigen expression modulates epidermal Keratinocyte Integrity and differentiation
ABO blood group antigens (ABH antigens) are carbohydrate chains glycosylated on epithelial and red blood cells. Recent fin...
Oviduct epithelial spheroids during in vitro culture of bovine embryos mitigate oxidative stress, improve blastocyst quality and change the embryonic transcriptome
Oviduct epithelial spheroids during in vitro culture of bovine embryos mitigate oxidative stress, improve blastocyst quality and change the embryonic transcriptome
In vitro embryo production is increasingly used for genetic improvement in cattle but bypasses the oviduct environment and...
Ozone therapy mitigates parthanatos after ischemic stroke
Ozone therapy mitigates parthanatos after ischemic stroke
Stroke is a leading cause of death worldwide, with oxidative stress and calcium overload playing significant roles in the ...
Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting conseq...
Identification and functional characteristics of CHD1L gene variants implicated in human Müllerian duct anomalies
Identification and functional characteristics of CHD1L gene variants implicated in human Müllerian duct anomalies
Müllerian duct anomalies (MDAs) are congenital developmental disorders that present as a series of abnormalities with...
LYP regulates SLP76 and other adaptor proteins in T cells
LYP regulates SLP76 and other adaptor proteins in T cells
The LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmun...
Comparative study of the growth, stress status and reproductive capabilities of four wild-type zebrafish (Danio rerio) lines
Comparative study of the growth, stress status and reproductive capabilities of four wild-type zebrafish (Danio rerio) lines
Zebrafish are widely used in various research fields and to fulfil the diverse research needs, numerous zebrafish lines ar...
PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1
PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1
Spermatogonial stem cells (SSCs) are essential for the maintenance and initiation of male spermatogenesis. Despite the adv...
The effect of CGRP and SP and the cell signaling dialogue between sensory neurons and endothelial cells
The effect of CGRP and SP and the cell signaling dialogue between sensory neurons and endothelial cells
Increasing evidences demonstrate the role of sensory innervation in bone metabolism, remodeling and repair, however neurov...
Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb
Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb
Testicular macrophages (TM) have long been recognized for their role in immune response within the testicular environment....
Fruit sugar hub: gene regulatory network associated with soluble solids content (SSC) in Prunus persica
Fruit sugar hub: gene regulatory network associated with soluble solids content (SSC) in Prunus persica
Chilean peach growers have achieved worldwide recognition for their high-quality fruit products. Among the main factors in...
Hormonal influence: unraveling the impact of sex hormones on vascular smooth muscle cells
Hormonal influence: unraveling the impact of sex hormones on vascular smooth muscle cells
Sex hormones play a pivotal role as endocrine hormones that exert profound effects on the biological characteristics and v...
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model
Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model
Infertility is a growing global health concern affecting millions of couples worldwide. Among several factors, an extreme ...
Antimicrobial activity of compounds identified by artificial intelligence discovery engine targeting enzymes involved in Neisseria gonorrhoeae peptidoglycan metabolism
Antimicrobial activity of compounds identified by artificial intelligence discovery engine targeting enzymes involved in Neisseria gonorrhoeae peptidoglycan metabolism
Neisseria gonorrhoeae (Ng) causes the sexually transmitted disease gonorrhoea. There are no vaccines and infections are tr...
Deciphering genetic and nongenetic factors underlying tumour dormancy: insights from multiomics analysis of two syngeneic MRD models of melanoma and leukemia
Deciphering genetic and nongenetic factors underlying tumour dormancy: insights from multiomics analysis of two syngeneic MRD models of melanoma and leukemia
Tumour dormancy, a resistance mechanism employed by cancer cells, is a significant challenge in cancer treatment, contribu...
Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice
Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice
Adipocytokines play a pivotal role in maintaining adipose tissue homeostasis by regulating cellular metabolism, proliferat...
Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology
Selective disruption of synaptic NMDA receptors of the hippocampal trisynaptic circuit in Aβ pathology
Synaptic dysfunction is an early feature in Alzheimer’s disease (AD) pathogenesis and a major morphological correlat...
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