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Bakuchicin alleviates ovalbumin-induced allergic asthma by regulating M2 macrophage polarization
Bakuchicin alleviates ovalbumin-induced allergic asthma by regulating M2 macrophage polarization
Asthma is an airway inflammatory disease caused by activation of numerous immune cells including macrophages. Bakuchicin (...
Causal role of myeloid cells in Parkinson’s disease: Mendelian randomization study
Causal role of myeloid cells in Parkinson’s disease: Mendelian randomization study
Previous studies have observed elevated myeloid cells in the peripheral blood of patients with Parkinson's disease (PD...
Inflammation in heart failure: pathophysiology and therapeutic strategies
Inflammation in heart failure: pathophysiology and therapeutic strategies
A role for inflammation in the development and progression of heart failure (HF) has been proposed for decades. Multiple s...
Identification of a novel ADCC-related gene signature for predicting the prognosis and therapy response in lung adenocarcinoma
Identification of a novel ADCC-related gene signature for predicting the prognosis and therapy response in lung adenocarcinoma
Previous studies have largely neglected the role of ADCC in LUAD, and no study has systematically compiled ADCC-associated...
Tricarboxylic acid cycle metabolites: new players in macrophage
Tricarboxylic acid cycle metabolites: new players in macrophage
Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role...
The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target
The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target
Cellular NAD+ declines in inflammatory states associated with increased activity of the leukocyte-expressed NADase CD38. I...
Bridging the divide: unveiling mutual immunological pathways of cancer and pregnancy
Bridging the divide: unveiling mutual immunological pathways of cancer and pregnancy
The juxtaposition of two seemingly disparate physiological phenomena within the human body—namely, cancer and pregna...
Imbalance of T follicular helper cell subsets trigger the differentiation of pathogenic B cells in idiopathic membranous nephropathy
Imbalance of T follicular helper cell subsets trigger the differentiation of pathogenic B cells in idiopathic membranous nephropathy
This study aims to elucidate the role of T follicular helper (Tfh) cells and their subsets in idiopathic membranous nephro...
Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation
Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation
This study aims to investigate the role of Acyl-CoA synthetase 4 (ACSL4) in mediating mitochondrial fatty acid metabolism ...
SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice
SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice
Neuroinflammation is crucial in the development of postoperative cognitive dysfunction (POCD), and microglial activation i...
Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps
Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps
The treatment of eosinophilic chronic rhinosinusitis with nasal polyps (E-CRSwNP) remains a challenge due to its complex p...
Inflammatory cell death PANoptosis is induced by the anti-cancer curaxin CBL0137 via eliciting the assembly of ZBP1-associated PANoptosome
Inflammatory cell death PANoptosis is induced by the anti-cancer curaxin CBL0137 via eliciting the assembly of ZBP1-associated PANoptosome
PANoptosis, a new form of regulated cell death, concomitantly manifests hallmarks for pyroptosis, apoptosis, and necroptos...
Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models
Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models
Inflammatory bowel disease (IBD) is an increasingly prevalent global health concern that has garnered substantial attentio...
Anti-CD20 treatment attenuates Th2 cell responses: implications for the role of lung follicular mature B cells in the asthmatic mice
Anti-CD20 treatment attenuates Th2 cell responses: implications for the role of lung follicular mature B cells in the asthmatic mice
B cells were believed to act as antigen-presenting cells (APCs) to promote T helper type 2 (Th2) cell responses. However, ...
Genetically proxied PCSK9 inhibition is associated with reduced psoriatic arthritis risk
Genetically proxied PCSK9 inhibition is associated with reduced psoriatic arthritis risk
Lipid pathways play a crucial role in psoriatic arthritis development, and some lipid-lowering drugs are believed to have ...
CCL18, CHI3L1, ANG2, IL-6 systemic levels are associated with the extent of lung damage and radiomic features in SARS-CoV-2 infection
CCL18, CHI3L1, ANG2, IL-6 systemic levels are associated with the extent of lung damage and radiomic features in SARS-CoV-2 infection
We aimed to identify cytokines whose concentrations are related to lung damage, radiomic features, and clinical outcomes i...
Identification of inflammatory biomarkers in IgA nephropathy using the NanoString technology: a validation study in Caucasians
Identification of inflammatory biomarkers in IgA nephropathy using the NanoString technology: a validation study in Caucasians
Immunoglobulin A nephropathy (IgAN) is a kidney disease characterized by the accumulation of IgA deposits in the glomeruli...
Identification of RRM2 as a key ferroptosis-related gene in sepsis
Identification of RRM2 as a key ferroptosis-related gene in sepsis
Sepsis and sepsis-associated organ failure are devastating conditions for which there are no effective therapeutic agent. ...
Endoplasmic reticulum stress interferes with the development of type 1 regulating T cells
Endoplasmic reticulum stress interferes with the development of type 1 regulating T cells
A variety of stimuli can cause endoplasmic reticulum (ER) stress, which is a common cellular reaction. It is not yet clear...
Advances in lung ischemia/reperfusion injury: unraveling the role of innate immunity
Advances in lung ischemia/reperfusion injury: unraveling the role of innate immunity
Lung ischemia/reperfusion injury (LIRI) is a common occurrence in clinical practice and represents a significant complicat...
A systematic review and meta-analysis of circulating adhesion molecules in rheumatoid arthritis
A systematic review and meta-analysis of circulating adhesion molecules in rheumatoid arthritis
The availability of robust biomarkers of endothelial activation might enhance the identification of subclinical atheroscle...
CD8 + T cell-based molecular subtypes with heterogeneous immune landscapes and clinical significance in acute myeloid leukemia
CD8 + T cell-based molecular subtypes with heterogeneous immune landscapes and clinical significance in acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy. Although high-dose chemotherapy is the primary t...