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Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities
Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by hyperplastic synovium, pannus formation, immun...
O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
O-GlcNAc modification of GSDMD attenuates LPS-induced endothelial cells pyroptosis
Increased O-linked β-N-acetylglucosamine (O-GlcNAc) stimulation has been reported to protect against sepsis associate...
Lidocaine pretreatment attenuates inflammatory response and protects against sepsis-induced acute lung injury via inhibiting potassium efflux-dependent NLRP3 activation
Lidocaine pretreatment attenuates inflammatory response and protects against sepsis-induced acute lung injury via inhibiting potassium efflux-dependent NLRP3 activation
Sepsis may often result in acute lung injury (ALI), with a high mortality and morbidity. Available evidence indicates that...
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice
Postoperative cognitive dysfunction (POCD) is a neurological complication occurring after anesthesia and surgery. Neuroinf...
Effects of neutrophil fate on inflammation
Effects of neutrophil fate on inflammation
Neutrophils are important participants in the innate immune response. They rapidly and efficiently identify and clear infe...
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation
Kidney stones commonly occur with a 50% recurrence rate within 5 years, and can elevate the risk of chronic kidne...
Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration
Mitochondrial dysfunction: a new molecular mechanism of intervertebral disc degeneration
Intervertebral disc degeneration (IVDD) is a chronic degenerative orthopedic illness that causes lower back pain as a typi...
Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response
Mutant p53R211* ameliorates inflammatory arthritis in AIA rats via inhibition of TBK1-IRF3 innate immune response
Rheumatoid arthritis (RA) is an autoimmune inflammation disease characterized by imbalance of immune homeostasis. p53 muta...
Application of omics in Sjögren’s syndrome
Application of omics in Sjögren’s syndrome
The pathogenesis, diagnosis, and treatment of Sjögren’s syndrome (SS) face many challenges, and there is an urg...
Treg plasticity and human diseases
Treg plasticity and human diseases
As a subset of CD4+ T cells, regulatory T cells (Tregs) with the characteristic expression of transcription factor FOXP3 p...
Identification of novel N7-methylguanine-related gene signatures associated with ulcerative colitis and the association with biological therapy
Identification of novel N7-methylguanine-related gene signatures associated with ulcerative colitis and the association with biological therapy
Ulcerative colitis (UC) is an inflammatory disease characterized by recurrent episodes of chronic intestinal inflammation....
Epigenetic regulation of 15-lipoxygenase-1 expression in human chondrocytes by promoter methylation
Epigenetic regulation of 15-lipoxygenase-1 expression in human chondrocytes by promoter methylation
15-Lipoxygenase-1 (15-LOX-1) catalyzes the biosynthesis of many anti-inflammatory and immunomodulatory lipid mediators and...
A suitable model to investigate acute neurological consequences of coronavirus infection
A suitable model to investigate acute neurological consequences of coronavirus infection
The present study aimed to investigate the neurochemical and behavioral effects of the acute consequences after coronaviru...
Targeting MyD88: Therapeutic mechanisms and potential applications of the specific inhibitor ST2825
Targeting MyD88: Therapeutic mechanisms and potential applications of the specific inhibitor ST2825
Myeloid differentiation factor-88 (MyD88) is a crucial adapter protein that coordinates the innate immune response and est...
Ångstrom-scale silver particles ameliorate collagen-induced and K/BxN-transfer arthritis in mice via the suppression of inflammation and osteoclastogenesis
Ångstrom-scale silver particles ameliorate collagen-induced and K/BxN-transfer arthritis in mice via the suppression of inflammation and osteoclastogenesis
Nanoparticles (NPs) hold a great promise in combating rheumatoid arthritis, but are often compromised by their toxicities ...
Role of histamine H4 receptor in the anti-inflammatory pathway of glucocorticoid-induced leucin zipper (GILZ) in a model of lung fibrosis
Role of histamine H4 receptor in the anti-inflammatory pathway of glucocorticoid-induced leucin zipper (GILZ) in a model of lung fibrosis
This study investigates the interactions between histaminergic system and glucocorticoid-induced leucin zipper (GILZ) in t...
Fraxetin alleviates BLM-induced idiopathic pulmonary fibrosis by inhibiting NCOA4-mediated epithelial cell ferroptosis
Fraxetin alleviates BLM-induced idiopathic pulmonary fibrosis by inhibiting NCOA4-mediated epithelial cell ferroptosis
Idiopathic pulmonary fibrosis (IPF) is a debilitating lung condition with few available treatments. The early driver of wo...
Recombinant human diamine oxidase prevents hemodynamic effects of continuous histamine infusion in guinea pigs
Recombinant human diamine oxidase prevents hemodynamic effects of continuous histamine infusion in guinea pigs
To test whether recombinant human diamine oxidase (rhDAO) with a mutated heparin-binding motif (mHBM), which shows an incr...
SGLT2 inhibitors prevent LPS-induced M1 macrophage polarization and alleviate inflammatory bowel disease by downregulating NHE1 expression
SGLT2 inhibitors prevent LPS-induced M1 macrophage polarization and alleviate inflammatory bowel disease by downregulating NHE1 expression
Classically activated M1 macrophages, characterized by aberrant glycolysis and secretion of inflammatory cytokines, play p...
Advances of autoimmune rheumatic diseases related to malignant tumors
Advances of autoimmune rheumatic diseases related to malignant tumors
Malignant neoplasms are a well-recognized global public health concern, with significant impacts on human health and quali...
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis
GTP cyclohydrolase 1(GCH1) was reported to protect against ferroptosis. However, it is not clear whether GCH1 reduced lipo...
Kinins: Locally formed peptides during inflammation with potential use in tissue regeneration
Kinins: Locally formed peptides during inflammation with potential use in tissue regeneration
Kinins are a set of peptides present in tissues and involved in cardiovascular regulation, inflammation, and pain. Here, w...
Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases
Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseases
Neurodegenerative diseases are a common group of neurological disorders characterized by progressive loss of neuronal stru...
Systemic lupus erythematosus with high disease activity identification based on machine learning
Systemic lupus erythematosus with high disease activity identification based on machine learning
Clinical evaluation of systemic lupus erythematosus (SLE) disease activity is limited and inconsistent, and high disease a...
Featured immune characteristics of COVID-19 and systemic lupus erythematosus revealed by multidimensional integrated analyses
Featured immune characteristics of COVID-19 and systemic lupus erythematosus revealed by multidimensional integrated analyses
Coronavirus disease 2019 (COVID-19) shares similar immune characteristics with autoimmune diseases like systemic lupus ery...
Nafamostat mesilate prevented caerulein-induced pancreatic injury by targeting HDAC6-mediated NLRP3 inflammasome activation
Nafamostat mesilate prevented caerulein-induced pancreatic injury by targeting HDAC6-mediated NLRP3 inflammasome activation
Nafamostat mesilate (NM), a synthetic broad-spectrum serine protease inhibitor, has been commonly used for treating acute ...
Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders
Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders
Perioperative neurocognitive disorder (PND) is a common disorder following anesthesia and surgery, especially in the elder...
Association of risk of incident acne and treatment with systemic Janus kinase inhibitors in atopic dermatitis: a systematic review and meta-analysis
Association of risk of incident acne and treatment with systemic Janus kinase inhibitors in atopic dermatitis: a systematic review and meta-analysis
The therapeutic efficacy of systemic Janus kinase (JAK) inhibitors in moderate-to-severe atopic dermatitis (AD) is well es...
Endoplasmic reticulum stress: a vital process and potential therapeutic target in chronic obstructive pulmonary disease
Endoplasmic reticulum stress: a vital process and potential therapeutic target in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD), a chronic and progressive disease characterized by persistent respiratory sy...
Commentaries: Lecanemab: pioneering the way as the first approved drug for Alzheimer’s disease treatment
Commentaries: Lecanemab: pioneering the way as the first approved drug for Alzheimer’s disease treatment
Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline and neuronal abnormal...
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