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Biofilm-forming strains of P. aeruginosa and S. aureus isolated from cystic fibrosis patients differently affect inflammatory phenotype of macrophages
Biofilm-forming strains of P. aeruginosa and S. aureus isolated from cystic fibrosis patients differently affect inflammatory phenotype of macrophages
Lung cystic fibrosis (CF) is characterized by chronic infections and hyperinflammatory response of neutrophils and macroph...
New small molecules in dermatology: for the autoimmunity, inflammation and beyond
New small molecules in dermatology: for the autoimmunity, inflammation and beyond
The discovery of new inflammatory pathways and the mechanism of action of inflammatory, autoimmune, genetic, and neoplasti...
Rhein-attenuates LPS-induced acute lung injury via targeting NFATc1/Trem2 axis
Rhein-attenuates LPS-induced acute lung injury via targeting NFATc1/Trem2 axis
Evidence indicated that the early stage transition of macrophages’ polarization stages yielded a superior prognosis ...
Neutrophil sub-types in maintaining immune homeostasis during steady state, infections and sterile inflammation
Neutrophil sub-types in maintaining immune homeostasis during steady state, infections and sterile inflammation
Neutrophils are component of innate immune system and a) eliminate pathogens b) maintain immune homeostasis by regulating ...
Correction to: Fructose malabsorption in ChREBP-deficient mice disrupts the small intestine immune microenvironment and leads to diarrhea-dominant bowel habit changes
Correction to: Fructose malabsorption in ChREBP-deficient mice disrupts the small intestine immune microenvironment and leads to diarrhea-dominant bowel habit changes
Department of Health Science and Technology, Gachon Advanced Institute for Health Science and Technology, Gachon Universit...
Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation
Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation
Observational studies have shown that Helicobacter pylori (H. pylori) infection and H. pylori antibodies are associated wi...
Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-κB signaling pathway activation in aged mice
Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-κB signaling pathway activation in aged mice
Postoperative cognitive dysfunction (POCD) is a common complication following surgery among elderly patients. Emerging evi...
4-OI ameliorates bleomycin-induced pulmonary fibrosis by activating Nrf2 and suppressing macrophage-mediated epithelial-mesenchymal transition
4-OI ameliorates bleomycin-induced pulmonary fibrosis by activating Nrf2 and suppressing macrophage-mediated epithelial-mesenchymal transition
Pulmonary fibrosis (PF) is a chronic and refractory interstitial lung disease with limited therapeutic options. 4-octyl it...
Cuproptosis-related gene CDKN2A as a molecular target for IPF diagnosis and therapeutics
Cuproptosis-related gene CDKN2A as a molecular target for IPF diagnosis and therapeutics
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic interstitial lung disease with limited therapeutic options. C...
Efficacy of Janus kinase inhibitors in rheumatoid arthritis
Efficacy of Janus kinase inhibitors in rheumatoid arthritis
Janus kinase inhibitors (JAKis) is a new therapeutic class in autoimmune and inflammatory diseases. Four molecules are app...
The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma
The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma
Lipids, significant signaling molecules, regulate a multitude of cellular responses and biological pathways in asthma whic...
CX3CR1 modulates SLE-associated glomerulonephritis and cardiovascular disease in MRL/lpr mice
CX3CR1 modulates SLE-associated glomerulonephritis and cardiovascular disease in MRL/lpr mice
Patients with systemic lupus erythematosus (SLE) often develop multi-organ damages including heart and kidney complication...
Quercetin alleviates tubulointerstitial inflammation by inhibiting exosomes-mediated crosstalk between tubular epithelial cells and macrophages
Quercetin alleviates tubulointerstitial inflammation by inhibiting exosomes-mediated crosstalk between tubular epithelial cells and macrophages
Tubulointerstitial inflammation (TII) is a critical pathological feature of kidney disease leading to renal fibrosis, and ...
Inactivation of the gene encoding procalcitonin prevents antibody-mediated arthritis
Inactivation of the gene encoding procalcitonin prevents antibody-mediated arthritis
Procalcitonin (PCT) is applied as a sensitive biomarker to exclude bacterial infections in patients with rheumatoid arthri...
Artesunate targets cellular metabolism to regulate the Th17/Treg cell balance
Artesunate targets cellular metabolism to regulate the Th17/Treg cell balance
Metabolic reprogramming is one of the important mechanisms of cell differentiation, and different cells have different pre...
Integrative analysis of multi-omics data to identify three immune-related genes in the formation and progression of intracranial aneurysms
Integrative analysis of multi-omics data to identify three immune-related genes in the formation and progression of intracranial aneurysms
The prevalence of intracranial aneurysms (IAs) has increased globally. We performed bioinformatics analysis to identify ke...
Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1α
Resveratrol-induced SIRT1 activation inhibits glycolysis-fueled angiogenesis under rheumatoid arthritis conditions independent of HIF-1α
This study investigated the impacts of SIRT1 activation on rheumatoid arthritis (RA)-related angiogenesis. HUVECs were cul...
Curcumin inhibits the pruritus in mice through mast cell MrgprB2 receptor
Curcumin inhibits the pruritus in mice through mast cell MrgprB2 receptor
Curcumin is a diketone compound extracted from the rhizomes of some plants in the Zingiberaceae and Araceae family. It pos...
Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19
Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19
Fatigue is a prominent symptom in the general population and may follow viral infection, including SARS-CoV2 infection whi...
Comprehensive analysis of arachidonic acid metabolism-related genes in diagnosis and synovial immune in osteoarthritis: based on bulk and single-cell RNA sequencing data
Comprehensive analysis of arachidonic acid metabolism-related genes in diagnosis and synovial immune in osteoarthritis: based on bulk and single-cell RNA sequencing data
Osteoarthritis (OA) is one of degenerative-related arthritis, which can be aggravated by low-grade synovitis. It is known ...
Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38
Inhibition of importin-7 attenuates ventilator-induced lung injury by targeting nuclear translocation of p38
The ability of p38 to phosphorylate substrates in the nucleus and the role of nuclear p38 in the regulation of inflammatio...
Clinical manifestations of COVID-19 infection in dialysis patients and protective effect of COVID-19 vaccine
Clinical manifestations of COVID-19 infection in dialysis patients and protective effect of COVID-19 vaccine
COVID-19 infection poses a special challenge to patients with dialysis patients. The purpose of this study was to evaluate...
Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19
Reduction in the number of neutrophils in the broncho-alveolar aspirate is associated with worse prognosis in elderly patients with severe COVID-19
The blood levels of neutrophils are associated with the severity of COVID -19. However, their role in the pulmonary enviro...
BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer
BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer
BacSp222 bacteriocin is a bactericidal and proinflammatory peptide stimulating immune cells to produce selected cytokines ...
Increased sympathetic outflow induced by emotional stress aggravates myocardial ischemia–reperfusion injury via activation of TLR7/MyD88/IRF5 signaling pathway
Increased sympathetic outflow induced by emotional stress aggravates myocardial ischemia–reperfusion injury via activation of TLR7/MyD88/IRF5 signaling pathway
Emotional stress substantially increases the risk of ischemic cardiovascular diseases. Previous study indicates that sympa...
Distinct cytokine profiles in patients with preeclampsia
Distinct cytokine profiles in patients with preeclampsia
Preeclampsia (PE) is a common but serious pregnancy complication that adversely affects both maternal and fetal health. Ho...
A case of complete recovery in a hypereosinophilic dermatitis patient with dupilumab
A case of complete recovery in a hypereosinophilic dermatitis patient with dupilumab
Hypereosinophilic dermatitis (HED) is a subtype of hypereosinophilic syndrome (HES). Glucocorticoids are preferred for tre...
Activating α7nAChR helps post-myocardial infarction healing by regulating macrophage polarization via the STAT3 signaling pathway
Activating α7nAChR helps post-myocardial infarction healing by regulating macrophage polarization via the STAT3 signaling pathway
Monocytes/macrophages play critical roles in inflammation and cardiac remodeling following myocardial infarction (MI). The...
SOCS2 regulates alveolar bone loss in Aggregatibacter actinomycetemcomitans-induced periodontal disease
SOCS2 regulates alveolar bone loss in Aggregatibacter actinomycetemcomitans-induced periodontal disease
The role of suppressor of cytokine signaling 2 (SOCS2) in Aggregatibacter actinomycetemcomitans (Aa)-induced alveolar bone...
Colchicine reduces the activation of NLRP3 inflammasome in COVID-19 patients
Colchicine reduces the activation of NLRP3 inflammasome in COVID-19 patients
To evaluate whether colchicine treatment was associated with the inhibition of NLRP3 inflammasome activation in patients w...
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