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Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis
Bile acids can regulate liver disease progression by affecting the functions of gut microbiota and immune cells. As the mo...
A novel mechanism for inhibiting proliferation of rheumatoid arthritis fibroblast-like synoviocytes: geniposide suppresses HIF-1α accumulation in the hypoxic microenvironment of synovium
The excessive proliferation of fibroblast-like synoviocytes (FLSs) is a key inducement for the occurrence and development ...
IL10/AMPK pathway was associated with the hippocampal anti-inflammatory response to high-sugar and high-fat diet withdrawal
The present experimental study aimed to evaluate the effect of consuming an obesogenic diet (OD) on serum and hippocampal ...
The role of adenosine A1 receptor on immune cells
Adenosine, acting as a regulator by mediating the activation of G protein-coupled adenosine receptor families (A1, A2A, A2...
Novel insight into ferroptosis-related genes, molecular subtypes, and immune characteristics in intracranial aneurysms
This study aimed to identify the role of ferroptosis in intracranial aneurysm (IA). GSE122897, GSE75436, GSE15629, and GSE...
Retraction Note: Knockdown of long non‑coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA‑15a and repressing ROCK1 expression
The Editor-in-Chief has retracted this article. After publication, concerns were raised regarding potential repetitive gra...
Retraction Note: Tripterine ameliorates monosodium urate crystal‑induced gouty arthritis by altering macrophage polarization via the miR‑449a/NLRP3 axis
The Editor-in-Chief has retracted this article. After publication, concerns were raised regarding data similarity in the f...
Type 2 alveolar epithelial cell-derived circulating extracellular vesicle-encapsulated surfactant protein C as a mediator of cardiac inflammation in COVID-19
Among the countless endeavours made at elucidating the pathogenesis of COVID-19, those aimed at the histopathological alte...
Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia
In this study, we describe the kinetics of a new potential inflammatory biomarker, presepsin, together with a panel of wel...
Long-term implications of COVID-19 on bone health: pathophysiology and therapeutics
SARS-CoV-2 is a highly infectious respiratory virus associated with coronavirus disease (COVID-19). Discoveries in the fie...
Knockdown of lncRNA H19 alleviates ox-LDL-induced HCAECs inflammation and injury by mediating miR-20a-5p/HDAC4 axis
Coronary artery disease (CAD) seriously disturbs the life of people. LncRNA H19 is reported to promote the progression of ...
Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-κB signaling pathway
Acute pancreatitis (AP) is an inflammatory process of the pancreas resulting from biliary obstruction or alcohol consumpti...
Review: the role of GSDMD in sepsis
Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the gasdermin family GSDMD gene and is the ultimate execut...
Comprehensive comparison of the prognostic value of systemic inflammation biomarkers for cancer cachexia: a multicenter prospective study
Systemic inflammation plays an important role in cancer cachexia. However, among the systemic inflammatory biomarkers, it ...
Knockdown of TRIM27 alleviated sepsis-induced inflammation, apoptosis, and oxidative stress via suppressing ubiquitination of PPARγ and reducing NOX4 expression
Sepsis is a global fatal disease and leads to severe lung injury due to dysfunction of inflammation response. TRIM27 is cl...
Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in mice
Acute lung injury (ALI)/ acute respiratory distress syndrome (ARDS) was increasingly recognized as one of the most severe ...
CD20+ T cells: an emerging T cell subset in human pathology
Although CD20 is classically a B cell marker, in the last three decades, dim expression has been noted on a subset of T ce...
Lipoxin alleviates oxidative stress: a state-of-the-art review
This review aims to summarize the capability of lipoxin in regulating oxidative stress. Oxidative stress is defined as an ...
Fenofibrate for COVID-19 and related complications as an approach to improve treatment outcomes: the missed key for Holy Grail
Fenofibrate is an agonist of peroxisome proliferator activated receptor alpha (PPAR-α), that possesses anti-inflammat...
RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway
Pulmonary fibrosis (PF) is a chronic, progressive interstitial lung disease with unknown etiology, associated with increas...
Increased miR-124-3p alleviates type 2 inflammatory response in allergic rhinitis via IL-4Rα
miRNAs play a crucial role in regulating immune responses. However, the effect of miR-124-3p on type 2 inflammation in all...
Extracellular histones induce inflammation and senescence of vascular smooth muscle cells by activating the AMPK/FOXO4 signaling pathway
Sepsis is an abnormal immune-inflammatory response that is mainly caused by infection. It can lead to life-threatening org...
STAT1-mediated induction of Ly6c-expressing macrophages are involved in the pathogenesis of an acute colitis model
The development of inflammatory bowel diseases is thought to be multifactorial, but the exact steps in pathogenesis are po...
Human mast cells induce osteoclastogenesis through cell surface RANKL
We employed the co-culture of CD34+ stem cell-derived human mast cells (HMC) and human monocyte-derived osteoclast precurs...
IL-25 directly modulates adipocyte function and inflammation through the regulation of adiponectin
This study aimed to investigate the direct role of IL-25 in modulating adipocyte function during homeostasis and low-grade...
Heme oxygenase-1 protects against endotoxin-induced acute lung injury depends on NAD+-mediated mitonuclear communication through PGC1α/PPARγ signaling pathway
Endotoxin-induced acute lung injury (ALI) is a challenging life-threatening disease for which no specific therapy exists. ...
The effect of immunomodulatory properties of naringenin on the inhibition of inflammation and oxidative stress in autoimmune disease models: a systematic review and meta-analysis of preclinical evidence
Naringenin is a member of the flavonoid family that can perform many biological processes to treat a wide range of inflamm...
Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination
Acute liver injury is liver cell injury that occurs rapidly in a short period of time. Caffeine has been shown to maintain...
The role of Th17 cells: explanation of relationship between periodontitis and COPD?
Periodontitis and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases with common risk factors,...
MAIT cells and their implication in human oral diseases
Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that are abundant in humans, accounting for 1-1...
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