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IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis
Allergic rhinitis (AR) represents a persistent inflammatory condition affecting the upper respiratory tract, characterized...
IL-8 promotes pyroptosis through ERK pathway and mediates glucocorticoid resistance in chronic rhinosinusitis with nasal polyps
IL-8 promotes pyroptosis through ERK pathway and mediates glucocorticoid resistance in chronic rhinosinusitis with nasal polyps
This study seeks to elucidate the role and molecular mechanisms of IL-8 in nasal epithelial cell pyroptosis and its impact...
The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies
The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies
Particulate matter (PM) exposure has been proposed as one of the causes of steroid resistance. However, studies investigat...
Mechanisms of mitochondrial damage-associated molecular patterns associated with inflammatory response in cardiovascular diseases
Mechanisms of mitochondrial damage-associated molecular patterns associated with inflammatory response in cardiovascular diseases
Cardiovascular diseases (CVDs) continue to be a substantial global healthcare burden despite considerable progress in ther...
Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses
Mitochondrial dysfunction is a major cause of thromboinflammation and inflammatory cell death in critical illnesses
Mitochondria generate the adenosine triphosphate (ATP) necessary for eukaryotic cells, serving as their primary energy sup...
IL-17 as a putative hallmark of intense arthralgia and age-related serum immune mediator networks during acute chikungunya fever
IL-17 as a putative hallmark of intense arthralgia and age-related serum immune mediator networks during acute chikungunya fever
The present study aimed at evaluating the systemic profile and network connectivity of immune mediators during acute chiku...
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease
Chronic inflammation is well recognized as a key factor related to renal function deterioration in patients with diabetic ...
Rare constituents of the nasal microbiome contribute to the acute exacerbation of chronic rhinosinusitis
Rare constituents of the nasal microbiome contribute to the acute exacerbation of chronic rhinosinusitis
Dysbiosis of the nasal microbiome is considered to be related to the acute exacerbation of chronic rhinosinusitis (AECRS)....
Silencing aquaporin 1 inhibits autophagy to exert anti-rheumatoid arthritis effects in TNF-α-induced fibroblast-like synoviocytes and adjuvant-induced arthritis rats
Silencing aquaporin 1 inhibits autophagy to exert anti-rheumatoid arthritis effects in TNF-α-induced fibroblast-like synoviocytes and adjuvant-induced arthritis rats
Fibroblast-like synoviocytes (FLS) are key players in rheumatoid arthritis (RA) by resisting apoptosis via increased autop...
Lysine acetylation and its role in the pathophysiology of acute pancreatitis
Lysine acetylation and its role in the pathophysiology of acute pancreatitis
Acute pancreatitis (AP) represents a severe inflammatory condition of the exocrine pancreas, precipitating systemic organ ...
Comparative analysis of adenosine 1 receptor expression and function in hippocampal and hypothalamic neurons
Comparative analysis of adenosine 1 receptor expression and function in hippocampal and hypothalamic neurons
Adenosine, an ATP degradation product, is a sleep pressure factor. The adenosine 1 receptor (A1R) reports sleep need. Hist...
TAX1BP1 regulates the apoptosis of renal tubular epithelial cells in ischemia/reperfusion injury via the NF-kB/PMAIP1 signaling pathway
TAX1BP1 regulates the apoptosis of renal tubular epithelial cells in ischemia/reperfusion injury via the NF-kB/PMAIP1 signaling pathway
The pathogenesis of acute kidney injury (AKI) is not fully understood. Tax1-binding protein 1 (TAX1BP1) modulates inflamma...
Mediating role of blood metabolites in the relationship between immune cell traits and sepsis: a Mendelian randomization and mediation analysis
Mediating role of blood metabolites in the relationship between immune cell traits and sepsis: a Mendelian randomization and mediation analysis
A significant association between immune cells and sepsis has been suggested by observational studies. However, the precis...
MAIT cells modulating the oral lichen planus immune microenvironment: a cellular crosstalk perspective
MAIT cells modulating the oral lichen planus immune microenvironment: a cellular crosstalk perspective
Mucosal-associated invariant T (MAIT) cells, a type of T lymphocytes with innate-like characteristics, are crucial in brid...
Causal genes identification of giant cell arteritis in CD4+ Memory t cells: an integration of multi-omics and expression quantitative trait locus analysis
Causal genes identification of giant cell arteritis in CD4+ Memory t cells: an integration of multi-omics and expression quantitative trait locus analysis
Giant cell arteritis (GCA) is a prevalent artery and is strongly correlated with age. The role of CD4+ Memory T cell...
A universal gene expression signature-based strategy for the high-throughput discovery of anti-inflammatory drugs
A universal gene expression signature-based strategy for the high-throughput discovery of anti-inflammatory drugs
Traditional Chinese medicine (TCM) is a valuable resource for drug discovery and has demonstrated excellent efficacy in tr...
Targeting mitochondrial function as a potential therapeutic approach for allergic asthma
Targeting mitochondrial function as a potential therapeutic approach for allergic asthma
Allergic asthma is a chronic complex airway disease characterized by airway hyperresponsiveness, eosinophilic inflammation...
Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis
Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis
Mitochondrial dysfunction and damage can result in the release of mitochondrial DNA (mtDNA) into the cytoplasm, which subs...
The combination of hyaluronic acids and collagen boosts human Achilles tendon-derived cell escape from inflammation and matrix remodeling in vitro
The combination of hyaluronic acids and collagen boosts human Achilles tendon-derived cell escape from inflammation and matrix remodeling in vitro
This study explores whether hyaluronic acid (HA) of different molecular weights and collagen, given their role in tendon e...
Mechanistic and therapeutic insights into the function of N6-methyladenosine in arthritic diseases
Mechanistic and therapeutic insights into the function of N6-methyladenosine in arthritic diseases
Arthritis is a class of diseases, characterized by joint and surrounding inflammation, accompanied by joint swelling, pain...
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury
Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury
Cynarin decreases neuroinflammation levels and attenuates microglial pyroptosis. Cynarin hinders the formation of NLRP3 in...
The role of Gαq in regulating NLRP3 inflammasome activation
The role of Gαq in regulating NLRP3 inflammasome activation
G proteins are a class of important signal transducers in mammalians. G proteins can corpoarated with G proteincoupled rec...
Environmental and inflammatory factors influencing concurrent gut and lung inflammation
Environmental and inflammatory factors influencing concurrent gut and lung inflammation
Crohn’s disease and chronic obstructive pulmonary disease (COPD) are chronic inflammatory diseases that affect the g...
Pentoxifylline in COVID-19 and considerations for its research in long COVID
Pentoxifylline in COVID-19 and considerations for its research in long COVID
Pentoxifylline (PTX) affects most blood components and the blood vessels, potentially modulating various conditions. Due t...
CD90’s role in vascularization and healing of rib fractures: insights from Dll4/notch regulation
CD90’s role in vascularization and healing of rib fractures: insights from Dll4/notch regulation
Vascularization after rib fracture is a crucial physiological process that is essential for the repair and healing of the ...
Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis
Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis
Studies have reported an association among systemic immune inflammation index (SII), all-cause and cause-specific mortalit...
Macrophage activation syndrome in Sepsis: from pathogenesis to clinical management
Macrophage activation syndrome in Sepsis: from pathogenesis to clinical management
Sepsis represents a significant global health and hygiene challenge. Excessive activation of macrophages in sepsis can res...
Modulation of Plet1 expression by N-Acetylglucosamine through the IL-17 A-MAPK pathway in an imiquimod-induced psoriasis mouse model
Modulation of Plet1 expression by N-Acetylglucosamine through the IL-17 A-MAPK pathway in an imiquimod-induced psoriasis mouse model
Psoriasis (Ps) is a chronic inflammatory disorder marked by skin plaque formation, driven by immune dysregulation and gene...
Molecular mechanism of mechanical pressure induced changes in the microenvironment of intervertebral disc degeneration
Molecular mechanism of mechanical pressure induced changes in the microenvironment of intervertebral disc degeneration
Lower back pain, as a typical clinical symptom of spinal degenerative diseases, is emerging as a major social problem. Acc...
Single-cell transcriptome analysis of the mouse lungs during the injury and recovery periods after lipopolysaccharide administration
Single-cell transcriptome analysis of the mouse lungs during the injury and recovery periods after lipopolysaccharide administration
This study sought to investigate the cellular and molecular alterations during the injury and recovery periods of ALI and ...
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