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Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development
Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development
Materials and methodsPatients and normal volunteersThis study was approved by the Biomedical Ethics Committee of Anhui Med...
New WHO ACPA standard enables standardisation among anti-CCP2 assays, but not other ACPA assays using different antigens
New WHO ACPA standard enables standardisation among anti-CCP2 assays, but not other ACPA assays using different antigens
Antibodies to citrullinated protein/peptide (ACPA) are established biomarkers for diagnosis and classification of rheumato...
Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis
Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis
IntroductionRheumatoid arthritis (RA) is a chronic inflammatory joint disease that affects up to 1% of the population.1 Th...
SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase
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Rheumatoid arthritis patients harbour aberrant enteric bacteriophages with autoimmunity-provoking potential: a paired sibling study
Rheumatoid arthritis patients harbour aberrant enteric bacteriophages with autoimmunity-provoking potential: a paired sibling study
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Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease
Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease
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EULAR/PReS recommendations for the diagnosis and management of Stills disease, comprising systemic juvenile idiopathic arthritis and adult-onset Stills disease
EULAR/PReS recommendations for the diagnosis and management of Stills disease, comprising systemic juvenile idiopathic arthritis and adult-onset Stills disease
Overarching principles OP A: sJIA and AOSD are the same disease, that should be designated by the same unique name, Still...
Development of international consensus on a standardised image acquisition protocol for diagnostic evaluation of the sacroiliac joints by MRI: an ASAS-SPARTAN collaboration
Development of international consensus on a standardised image acquisition protocol for diagnostic evaluation of the sacroiliac joints by MRI: an ASAS-SPARTAN collaboration
IntroductionFor several decades, MRI has been used to investigate the early diagnosis of inflammatory sacroiliitis.1 2 How...
Clinical information on imaging referrals for suspected or known axial spondyloarthritis: recommendations from the Assessment of Spondyloarthritis International Society (ASAS)
Clinical information on imaging referrals for suspected or known axial spondyloarthritis: recommendations from the Assessment of Spondyloarthritis International Society (ASAS)
IntroductionImaging plays a pivotal role in the diagnosis and ongoing management of axial spondyloarthritis (axSpA), a con...
Early identification of rheumatoid arthritis: does it induce treatment-related cost savings?
Early identification of rheumatoid arthritis: does it induce treatment-related cost savings?
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Defects in B-lymphopoiesis and B-cell maturation underlie prolonged B-cell depletion in ANCA-associated vasculitis
Defects in B-lymphopoiesis and B-cell maturation underlie prolonged B-cell depletion in ANCA-associated vasculitis
IntroductionAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises granulomatosis with polyangii...
2023 EULAR classification criteria for hand osteoarthritis
2023 EULAR classification criteria for hand osteoarthritis
IntroductionHand osteoarthritis (OA) mainly affects the distal interphalangeal (DIP), proximal interphalangeal (PIP) and t...
Racial variability in immune responses only partially explains differential systemic sclerosis disease severity
Racial variability in immune responses only partially explains differential systemic sclerosis disease severity
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From fibrositis to fibromyalgia to nociplastic pain: how rheumatology helped get us here and where do we go from here?
From fibrositis to fibromyalgia to nociplastic pain: how rheumatology helped get us here and where do we go from here?
A historical perspective on our understanding of fibromyalgiaIn 2017, the International Association for the Study of Pain ...
Management of systemic lupus erythematosus: a systematic literature review informing the 2023 update of the EULAR recommendations
Management of systemic lupus erythematosus: a systematic literature review informing the 2023 update of the EULAR recommendations
MethodsWe followed the standardised operating procedures for the development of EULAR-endorsed recommendations and employe...
B-cell depletion in autoimmune diseases
B-cell depletion in autoimmune diseases
B cells have a pivotal function in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis, multiple scleros...
Treatment of early oligoarticular psoriatic arthritis with apremilast: primary outcomes at week 16 from the FOREMOST randomised controlled trial
Treatment of early oligoarticular psoriatic arthritis with apremilast: primary outcomes at week 16 from the FOREMOST randomised controlled trial
Video Abstract Disclaimer: this video summarises a scientific article published by BMJ Publishing Group Limited (BMJ). The...
Correspondence on 'EULAR recommendations for the management of systemic lupus erythematosus: 2023 update by Fanouriakis et al
Correspondence on 'EULAR recommendations for the management of systemic lupus erythematosus: 2023 update by Fanouriakis et al
We read with great interest the new EULAR guidelines1 for the management of systemic lupus erythematosus (SLE), and we app...
Correspondence on 'Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis by Kim et al
Correspondence on 'Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis by Kim et al
Kim et al recently published a ‘population-based nationwide cohort study’, a currently popular study type.1 It concludes t...
Referral of patients with suspected polymyalgia rheumatica: how complete is our view of 'planet PMR?
Referral of patients with suspected polymyalgia rheumatica: how complete is our view of 'planet PMR?
Polymyalgia rheumatica (PMR) is the second most common inflammatory rheumatic disease after rheumatoid arthritis in person...
Correction: Ensuring tight control in patients with rheumatoid arthritis treated with targeted therapies during the COVID-19 pandemic using a telehealth strategy
Correction: Ensuring tight control in patients with rheumatoid arthritis treated with targeted therapies during the COVID-19 pandemic using a telehealth strategy
Ingegnoli F, Cincinelli G, Luppino AF, et al. Ensuring tight control in patients with rheumatoid arthritis treated with ta...
Efficacy and safety of sequential therapy with subcutaneous belimumab and one cycle of rituximab in patients with systemic lupus erythematosus: the phase 3, randomised, placebo-controlled BLISS-BELIEVE study
Efficacy and safety of sequential therapy with subcutaneous belimumab and one cycle of rituximab in patients with systemic lupus erythematosus: the phase 3, randomised, placebo-controlled BLISS-BELIEVE study
WHAT IS ALREADY KNOWN ON THIS TOPICAchieving low disease activity in the absence of corticosteroids remains an important t...
HLA-B27 and the role of specific T cell receptors in the pathogenesis of spondyloarthritis
HLA-B27 and the role of specific T cell receptors in the pathogenesis of spondyloarthritis
The pathogenesis of axial spondyloarthritis (axSpA), although not entirely clear yet, is largely based on genes, the stron...
Pathological autoantibody internalisation in myositis
Pathological autoantibody internalisation in myositis
WHAT IS ALREADY KNOWN ON THIS TOPICAutoantibodies targeting intracellular proteins are common in various autoimmune diseas...
Association between premature vascular smooth muscle cells senescence and vascular inflammation in Takayasus arteritis
Association between premature vascular smooth muscle cells senescence and vascular inflammation in Takayasus arteritis
IntroductionTakayasu’s arteritis (TAK) is a chronic large-vessel vasculitis (LVV) characterised by inflammation of the aor...
Paraspinal tophi
Paraspinal tophi
A young adult patient with gout was incidentally found to have a large mass on the right lumbar spine and sacrum during an...
Allogenic bone marrow-derived mesenchymal stromal cell-based therapy for patients with chronic low back pain: a prospective, multicentre, randomised placebo controlled trial (RESPINE study)
Allogenic bone marrow-derived mesenchymal stromal cell-based therapy for patients with chronic low back pain: a prospective, multicentre, randomised placebo controlled trial (RESPINE study)
WHAT IS ALREADY KNOWN ON THIS TOPICMesenchymal stromal cells have been shown to reduce disc inflammation and enhance carti...
Response to: Correspondence on 'Current myositis clinical trials and tribulations by Saygin et al
Response to: Correspondence on 'Current myositis clinical trials and tribulations by Saygin et al
We thank Azevedo et al 1 for their correspondence in response to the publication of our viewpoint entitled ‘Myositis Clini...
Dysregulation of immune checkpoint molecules as a characteristic of autoimmune congenital heart block
Dysregulation of immune checkpoint molecules as a characteristic of autoimmune congenital heart block
Autoimmune congenital heart block (CHB) represents a severe manifestation of neonatal lupus syndrome due to placental tran...
Cardiac valve immune profiling in non-radiographic axial spondyloarthritis
Cardiac valve immune profiling in non-radiographic axial spondyloarthritis
The diagnosis of ankylosing spondylitis (AS) is anchored in diagnostic changes in the sacroiliac joints as detected by pel...
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