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Should all patients with polymyalgia rheumatica have a vascular ultrasound assessment?
Should all patients with polymyalgia rheumatica have a vascular ultrasound assessment?
There is a growing appreciation that both giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely interrel...
Kauko Vainio (1913-1989): pioneer of rheumaorthopaedic surgery
Kauko Vainio (1913-1989): pioneer of rheumaorthopaedic surgery
We now live in a time of numerous pharmacological treatment possibilities for the most common rheumatic disorders. Already...
Altered serum metabolome as an indicator of paraneoplasia or concomitant cancer in patients with rheumatic disease
Altered serum metabolome as an indicator of paraneoplasia or concomitant cancer in patients with rheumatic disease
IntroductionBoth rheumatic musculoskeletal diseases (RMDs) and cancer occur frequently in the general population and these...
Expression of HIF1{alpha} in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery
Expression of HIF1{alpha} in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery
WHAT IS KNOWN ON THIS TOPICWHAT THIS STUDY ADDSThis study shows that the death of intestinal epithelial cells via necropto...
Characterisation of choroid plexus-infiltrating T cells reveals novel therapeutic targets in murine neuropsychiatric lupus
Characterisation of choroid plexus-infiltrating T cells reveals novel therapeutic targets in murine neuropsychiatric lupus
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Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort study
Risk of flare and damage accrual after tapering glucocorticoids in modified serologically active clinically quiescent patients with systemic lupus erythematosus: a multinational observational cohort study
IntroductionSerological activity in systemic lupus erythematosus (SLE) generally refers to the presence of anti-dsDNA anti...
Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis
Risk of cardiovascular disease with high-dose versus low-dose use of non-steroidal anti-inflammatory drugs in ankylosing spondylitis
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Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials
Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials
IntroductionSystemic lupus erythematosus (SLE) is a complex autoimmune disease in which patients experience diverse organ ...
Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes
Primary osteoarthritis chondrocyte map of chromatin conformation reveals novel candidate effector genes
IntroductionOsteoarthritis is a highly complex disease that poses a significant burden on both individuals and society due...
Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögrens disease
Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sjögrens disease
AbstractObjectives Inflammatory cytokines that signal through the Janus kinases–signal transducer and activator of transcr...
Changes in alcohol intake and serum urate changes: longitudinal analyses of annual medical examination database
Changes in alcohol intake and serum urate changes: longitudinal analyses of annual medical examination database
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Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis
Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis
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An ulcerating skin tumour in a patient with rheumatoid arthritis
An ulcerating skin tumour in a patient with rheumatoid arthritis
A 78-year-old white woman was diagnosed in 2010 with IgM-rheumatoid factor negative, anticyclic citrullinated peptide-posi...
Development and evaluation of a text analytics algorithm for automated application of national COVID-19 shielding criteria in rheumatology patients
Development and evaluation of a text analytics algorithm for automated application of national COVID-19 shielding criteria in rheumatology patients
WHAT IS ALREADY KNOWN ON THIS TOPICIn April 2020, several Western countries used varying population-level strategies to id...
Annals of the Rheumatic Diseases collection on pregnancy 2018-2023: observational data-driven knowledge
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Shift in perspective: autoimmunity protecting against rheumatoid arthritis
Shift in perspective: autoimmunity protecting against rheumatoid arthritis
A hallmark of rheumatoid arthritis (RA) is the increased levels of autoantibodies preceding the onset and contributing to ...
Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis
Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis
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EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3
EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3
WHAT IS ALREADY KNOWN ON THIS TOPICAnaemia occurs in 30%–70% of patients with rheumatoid arthritis (RA), which leads to th...
Goodbye to the term 'ankylosing spondylitis, hello 'axial spondyloarthritis: time to embrace the ASAS-defined nomenclature
Goodbye to the term 'ankylosing spondylitis, hello 'axial spondyloarthritis: time to embrace the ASAS-defined nomenclature
Ankylosing spondylitis (AS) is the historic term used for decades for the HLA-B27-associated inflammatory disease affectin...
Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-{alpha} in rheumatoid arthritis
Proinflammatory phenotype of B10 and B10pro cells elicited by TNF-{alpha} in rheumatoid arthritis
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Can rheumatologists unequivocally diagnose axial spondyloarthritis in patients with chronic back pain of less than 2 years duration? Primary outcome of the 2-year SPondyloArthritis Caught Early (SPACE) cohort
Can rheumatologists unequivocally diagnose axial spondyloarthritis in patients with chronic back pain of less than 2 years duration? Primary outcome of the 2-year SPondyloArthritis Caught Early (SPACE) cohort
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Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis
Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis
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Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types
Deep immunophenotyping reveals that autoimmune and autoinflammatory disorders are spread along two immunological axes capturing disease inflammation levels and types
IntroductionAutoimmune diseases (AD) and autoinflammatory diseases (AIF) are pathological conditions arising from the imba...
Comparison of the effect of treatment with NSAIDs added to anti-TNF therapy versus anti-TNF therapy alone on the progression of structural damage in the spine over 2 years in patients with radiographic axial spondyloarthritis from the randomised-controlled CONSUL trial
Comparison of the effect of treatment with NSAIDs added to anti-TNF therapy versus anti-TNF therapy alone on the progression of structural damage in the spine over 2 years in patients with radiographic axial spondyloarthritis from the randomised-controlled CONSUL trial
WHAT IS ALREADY KNOWN ON THIS TOPICContinuous intake of celecoxib over 2 years was associated with retardation of radiogra...
Prognostic model to predict the incidence of radiographic knee osteoarthritis
Prognostic model to predict the incidence of radiographic knee osteoarthritis
IntroductionOsteoarthritis (OA) is one of the most prevalent and disabling rheumatic diseases, and therefore, causes a sig...
Withdrawal of immunosuppressants and low-dose steroids in patients with stable IgG4-RD (WInS IgG4-RD): an investigator-initiated, multicentre, open-label, randomised controlled trial
Withdrawal of immunosuppressants and low-dose steroids in patients with stable IgG4-RD (WInS IgG4-RD): an investigator-initiated, multicentre, open-label, randomised controlled trial
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Vasculitis that did not read the books
Vasculitis that did not read the books
A 29-year-old woman presented to our rheumatology clinic with a 6-month history of cough, dysphonia, dyspnoea and weight l...
Associations of residential greenness with bone mineral density and osteoporosis: the modifying effect of genetic susceptibility
Associations of residential greenness with bone mineral density and osteoporosis: the modifying effect of genetic susceptibility
WHAT IS ALREADY KNOWN ON THIS TOPICOsteoporosis is a complex disease caused by both genetic and environmental factors.The ...
Immunomodulators and risk for breakthrough COVID-19 after third SARS-CoV-2 mRNA vaccine among patients with rheumatoid arthritis: a cohort study
Immunomodulators and risk for breakthrough COVID-19 after third SARS-CoV-2 mRNA vaccine among patients with rheumatoid arthritis: a cohort study
The US Centers for Disease Control and Prevention (CDC) recommends three SARS-CoV-2 messenger ribonucleic acid (mRNA) vacc...
Validation of the definition of rheumatoid arthritis flare based on SDAI and CDAI in clinical practice in two French independent cohorts
Validation of the definition of rheumatoid arthritis flare based on SDAI and CDAI in clinical practice in two French independent cohorts
New definitions for flares in rheumatoid arthritis (RA) based on the Simplified and Clinical Disease Activity Indices (SDA...
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