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USP25 inhibits DNA damage by stabilizing BARD1 protein in a house dust mite‐induced asthmatic model in vitro and in vivo
USP25 inhibits DNA damage by stabilizing BARD1 protein in a house dust mite‐induced asthmatic model in vitro and in vivo
Abstract House dust mites (HDM) can cause DNA double-strand breaks in the lungs of asthmatic patients. However, the molecu...
Glucosamine suppresses oxidative stress and induces protective autophagy in osteoblasts by blocking the ROS/Akt/mTOR signaling pathway
Glucosamine suppresses oxidative stress and induces protective autophagy in osteoblasts by blocking the ROS/Akt/mTOR signaling pathway
AbstractOxidative stress are the crucial pathogenic factors in osteoporosis. Cell autophagy, a major form of self-digestio...
CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling
CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling
Abstract Neonatal hypoxic ischemic encephalopathy (Neonatal HIE) is a common but serious disease caused by perinatal asphy...
The effect of all‐trans retinoic acid on the mitochondrial function and survival of cardiomyoblasts exposed to local photodamage
The effect of all‐trans retinoic acid on the mitochondrial function and survival of cardiomyoblasts exposed to local photodamage
AbstractThis article is protected by copyright. All rights reserved.
Emerging role of m6A modification in cardiovascular diseases
Emerging role of m6A modification in cardiovascular diseases
Abstract Cardiovascular diseases (CVDs) contribute to the leading cause of death worldwide. Despite significant improvemen...
Melanin nanoparticles enhance the neuroprotection of mesenchymal stem cells against hypoxic‐ischemic injury by inhibiting apoptosis and upregulating antioxidant defense
Melanin nanoparticles enhance the neuroprotection of mesenchymal stem cells against hypoxic‐ischemic injury by inhibiting apoptosis and upregulating antioxidant defense
Abstract Polydopamine nanoparticles are artificial melanin nanoparticles (MNPs) that show strong antioxidant activity. The...
PDGF‐BB/PDGFRβ promotes epithelial–mesenchymal transition by affecting PI3K/AKT/mTOR‐driven aerobic glycolysis in Wilms' tumor G401 cells
PDGF‐BB/PDGFRβ promotes epithelial–mesenchymal transition by affecting PI3K/AKT/mTOR‐driven aerobic glycolysis in Wilms' tumor G401 cells
Abstract Wilms' tumor (WT) is the most common pediatric renal malignancy. PDGFRβ belongs to the type III receptor ty...
TRIM7 suppresses cell invasion and migration through inhibiting HIF‐1α accumulation in clear cell renal cell carcinoma
TRIM7 suppresses cell invasion and migration through inhibiting HIF‐1α accumulation in clear cell renal cell carcinoma
Abstract Clear cell renal cell carcinoma (ccRCC) is one frequent form of urologic malignancy characterized by deregulated ...
HPV16 E6 promotes cell proliferation, migration, and invasion of human cervical cancer cells by elevating both EMT and stemness characteristics
HPV16 E6 promotes cell proliferation, migration, and invasion of human cervical cancer cells by elevating both EMT and stemness characteristics
Abstract In most cases of cervical cancer, the high-risk of the disease is caused by the human papilloma virus (HPV). Surg...
NLRP2 inhibits cell proliferation and migration by regulating EMT in lung adenocarcinoma cells
NLRP2 inhibits cell proliferation and migration by regulating EMT in lung adenocarcinoma cells
Abstract Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are crucial types of innate immune sensors ...
Proteinase 3 associated with Wegener’s Granulomatosis
Proteinase 3 associated with Wegener’s Granulomatosis
ABSTRACT Wegener's granulomatosis (WG) is a form of systemic vasculitis characterized by granulomatous inflammation of the...
Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self‐renewal of gastric cancer cells
Zinc finger protein 852 is essential for the proliferation, drug sensitivity, and self‐renewal of gastric cancer cells
AbstractExploring cellular and molecular mechanisms responsible for gastric cancer growth, survival, self-renewal, and met...
Advances in the Research of Osteosarcoma Stem Cells and its Related Genes
Advances in the Research of Osteosarcoma Stem Cells and its Related Genes
Abstract Osteosarcoma is a malignant tumor that often occurs in adolescents. There is an urgent need of new treatment opti...
Cardiovascular‐Specific PSEN1 Deletion Leads to Abnormalities in Calcium homeostasis
Cardiovascular‐Specific PSEN1 Deletion Leads to Abnormalities in Calcium homeostasis
Abstract Mutations of PSEN1 have been reported in dilated cardiomyopathy pedigrees. Understanding the effects and mechanis...
TRIM7 suppresses cell invasion and migration through inhibiting HIF‐1 alpha accumulation in clear cell renal cell carcinoma
TRIM7 suppresses cell invasion and migration through inhibiting HIF‐1 alpha accumulation in clear cell renal cell carcinoma
AbstractClear cell renal cell carcinoma (ccRCC) is one frequent form of urologic malignancy characterized by deregulated h...
Molecular mechanisms of N‐acyl homoserine lactone signals perception by plants
Molecular mechanisms of N‐acyl homoserine lactone signals perception by plants
AbstractN-acyl homoserine lactones (AHLs) belong to the class of bacterial quorum sensing signal molecules involved in dis...
Overexpression of NDUFV1 alleviates renal damage by improving mitochondrial function in unilateral ureteral obstruction model mice
Overexpression of NDUFV1 alleviates renal damage by improving mitochondrial function in unilateral ureteral obstruction model mice
Abstract Mitochondrial homeostasis plays essential roles for the proper functioning of the kidney. NADH-Ubiquinone Oxidore...
Nuclear variations and tapetum polyploidy related to pollen grain development in Passiflora L. (Passifloraceae)
Nuclear variations and tapetum polyploidy related to pollen grain development in Passiflora L. (Passifloraceae)
AbstractTapetal cells comprise an anther tissue fundamental to pollen grain development. They are associated with endoredu...
Why do cells need oxygen? Insights from mitochondrial composition and function
Why do cells need oxygen? Insights from mitochondrial composition and function
Abstract Mitochondrial membrane-embedded redox proteins are classically perceived as deterministic ‘electron transp...
Stem cells technology as a platform for generating reproductive system organoids and treatment of infertility‐related diseases
Stem cells technology as a platform for generating reproductive system organoids and treatment of infertility‐related diseases
AbstractIn recent years, stem cells have known as a helpful biological tool for the accurate diagnosis, treatment and reco...
Ribosome ADP‐ribosylation: a mechanism for maintaining protein homeostasis in cancers
Ribosome ADP‐ribosylation: a mechanism for maintaining protein homeostasis in cancers
Abstract A recent study suggests that ribosome MARylation in cancers maintains proteostasis by reducing protein synthesis ...
Adhesion and proliferation properties of type I collagen‐derived peptide for possible use in skin tissue engineering application
Adhesion and proliferation properties of type I collagen‐derived peptide for possible use in skin tissue engineering application
Abstract Surface properties of 3D scaffolds are improved by coating or covalently linking certain adhesion promoting prote...
P2X7 receptor inhibition attenuates podocyte injury by oxLDL through deregulating CXCL16
P2X7 receptor inhibition attenuates podocyte injury by oxLDL through deregulating CXCL16
Abstract This study aims to evaluate the effect of P2X7R antagonist A438079 in kidney of children with primary nephrotic s...
HPV16 E6/E7 stabilize PGK1 protein by reducing its poly‐ubiquitination in cervical cancer
HPV16 E6/E7 stabilize PGK1 protein by reducing its poly‐ubiquitination in cervical cancer
Abstract This study aimed to explore the expression profile, prognostic value, regulatory effect, and the underlying mecha...
Research progress of Bub3 gene in malignant tumors
Research progress of Bub3 gene in malignant tumors
Abstract The spindle assembly checkpoint (SAC) is a highly conserved monitoring system that ensures a fidelity of chromoso...
Tbx18 promoted the conversion of human‐induced pluripotent stem cell‐derived cardiomyocytes into sinoatrial node‐like pacemaker cells
Tbx18 promoted the conversion of human‐induced pluripotent stem cell‐derived cardiomyocytes into sinoatrial node‐like pacemaker cells
Abstract Sinoatrial node (SAN) pacemaker cells originate from Tbx18 (T-box transcription factor 18)-expressing progenitor ...
Melatonin protects H9c2 cardiomyoblasts from oxygen glucose deprivation and reperfusion‐induced injury by inhibiting Rac1/JNK/Foxo3a/Bim signaling pathway
Melatonin protects H9c2 cardiomyoblasts from oxygen glucose deprivation and reperfusion‐induced injury by inhibiting Rac1/JNK/Foxo3a/Bim signaling pathway
Abstract Melatonin has been shown to protect against ischemia/reperfusion (I/R)-induced myocardial injury, however, the pr...
Low frequency oscillations of murine skin microcirculations and periodic changes of [Ca2+]i and [NO]i levels in murine endotheliocytes: an effect of provocative tests
Low frequency oscillations of murine skin microcirculations and periodic changes of [Ca2+]i and [NO]i levels in murine endotheliocytes: an effect of provocative tests
Abstract The five frequency intervals of skin blood oscillation were described: cardiac, respiratory, myogenic, neurogenic...
FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC.
FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC.
Abstract Head and neck squamous cell carcinoma (HNSCC) is the 6th most common malignancy globally. The etiology of HNSCC i...
The role of mesenchymal stem cells in liver injury
The role of mesenchymal stem cells in liver injury
Abstract Recently, mesenchymal stem cell (MSC) therapy has been suggested as an effective alternate approach for the treat...
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