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Real-world patient characteristics, treatment patterns, and clinical outcomes associated with tucatinib therapy in HER2-positive metastatic breast cancer
Real-world patient characteristics, treatment patterns, and clinical outcomes associated with tucatinib therapy in HER2-positive metastatic breast cancer
BackgroundTucatinib is an oral human epidermal growth factor receptor 2 (HER2)-directed therapy approved in combination wi...
Lobectomy versus segmentectomy for stage IA3 (T1cN0M0) non-small cell lung cancer: a meta-analysis and systematic review
Lobectomy versus segmentectomy for stage IA3 (T1cN0M0) non-small cell lung cancer: a meta-analysis and systematic review
BackgroundSegmentectomy has been proven to have better survival and perioperative efficacy than lobectomy for non-small ce...
Predicting head and neck cancer treatment outcomes with pre-treatment quantitative ultrasound texture features and optimising machine learning classifiers with texture-of-texture features
Predicting head and neck cancer treatment outcomes with pre-treatment quantitative ultrasound texture features and optimising machine learning classifiers with texture-of-texture features
AimCancer treatments with radiation present a challenging physical toll for patients, which can be justified by the potent...
Prognostic role of preoperative lymphocyte/C-reactive protein associated with upper gastrointestinal cancer: a meta-analysis
Prognostic role of preoperative lymphocyte/C-reactive protein associated with upper gastrointestinal cancer: a meta-analysis
PurposeThe lymphocyte/C-reactive protein (LCR) is a novel immunoinflammatory score and prognostic marker, but the relation...
The novel high-affinity humanized antibody IMM40H targets CD70, eliminates tumors via Fc-mediated effector functions, and interrupts CD70/CD27 signaling
The novel high-affinity humanized antibody IMM40H targets CD70, eliminates tumors via Fc-mediated effector functions, and interrupts CD70/CD27 signaling
BackgroundA significant level of CD70 can be detected in various types of tumor tissues and CD27 is expressed on Treg cell...
Severe thyrotoxicosis induced by tislelizumab: a case report and literature review
Severe thyrotoxicosis induced by tislelizumab: a case report and literature review
Immune checkpoint inhibitors (ICIs) have made significant breakthroughs in the treatment of a variety of malignancies. As ...
Development and clinical validation of a microfluidic-based platform for CTC enrichment and downstream molecular analysis
Development and clinical validation of a microfluidic-based platform for CTC enrichment and downstream molecular analysis
BackgroundAlthough many CTC isolation and detection methods can provide information on cancer cell counts, downstream gene...
The value of ultrasound combined with CT in identifying early low-grade appendiceal mucinous neoplasm and appendicitis
The value of ultrasound combined with CT in identifying early low-grade appendiceal mucinous neoplasm and appendicitis
ObjectiveThe aim of this study is to investigate the value of ultrasound combined with computed tomography (CT) in identif...
An image-based modeling framework for predicting spatiotemporal brain cancer biology within individual patients
An image-based modeling framework for predicting spatiotemporal brain cancer biology within individual patients
Imaging is central to the clinical surveillance of brain tumors yet it provides limited insight into a tumor’s underlying ...
Pancreatic cancer challenge in 52 Asian countries: age-centric insights and the role of modifiable risk factors (1990-2019)
Pancreatic cancer challenge in 52 Asian countries: age-centric insights and the role of modifiable risk factors (1990-2019)
BackgroundPancreatic cancer is renowned for its elevated incidence and mortality rates on a global scale. The disease burd...
Definers and drivers of functional high-risk multiple myeloma: insights from genomic, transcriptomic, and immune profiling
Definers and drivers of functional high-risk multiple myeloma: insights from genomic, transcriptomic, and immune profiling
Traditional prognostic models for newly diagnosed patients with multiple myeloma (MM), including International Staging Sys...
Case Report: Stroke-like migraine attacks after radiation therapy syndrome: a rare complication 26 years after cranial radiotherapy
Case Report: Stroke-like migraine attacks after radiation therapy syndrome: a rare complication 26 years after cranial radiotherapy
Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare delayed complication of cranial radiothera...
Comparative analysis of dose calculation algorithms for CyberKnife-based stereotactic radiotherapy in lung cancer
Comparative analysis of dose calculation algorithms for CyberKnife-based stereotactic radiotherapy in lung cancer
PurposeThe accuracy of dose calculation is the prerequisite for CyberKnife (CK) to implement precise stereotactic body rad...
Targeting M-MDSCs enhances the therapeutic effect of BNCT in the 4-NQO-induced murine head and neck squamous cell carcinoma model
Targeting M-MDSCs enhances the therapeutic effect of BNCT in the 4-NQO-induced murine head and neck squamous cell carcinoma model
PurposeMalignant head and neck squamous cell carcinoma (HNSCC) is characterized by a poor prognosis and resistance to conv...
Risk factors of breast cancer recurrence in pathologic complete response achieved by patients following neoadjuvant chemotherapy: a single-center retrospective study
Risk factors of breast cancer recurrence in pathologic complete response achieved by patients following neoadjuvant chemotherapy: a single-center retrospective study
ObjectivePathologic complete response (pCR) of breast cancer after neoadjuvant chemotherapy (NAC) is highly related to mol...
Multivariate piecewise linear regression model to predict radiosensitivity using the association with the genome-wide copy number variation
Multivariate piecewise linear regression model to predict radiosensitivity using the association with the genome-wide copy number variation
IntroductionThe search for biomarkers to predict radiosensitivity is important not only to individualize radiotherapy of c...
Questionnaire study of application about sentinel lymph node biopsy surgery in locally advanced breast cancer patients who received neoadjuvant chemotherapy
Questionnaire study of application about sentinel lymph node biopsy surgery in locally advanced breast cancer patients who received neoadjuvant chemotherapy
BackgroundNodal staging from sentinel lymph node (SLN) biopsy has become the standard procedure for early-stage breast can...
Does perioperative allogeneic blood transfusion worsen the prognosis of patients with hepatocellular carcinoma? A meta-analysis of propensity score-matched studies
Does perioperative allogeneic blood transfusion worsen the prognosis of patients with hepatocellular carcinoma? A meta-analysis of propensity score-matched studies
BackgroundAllogeneic blood transfusion is required in a part of liver resection. The effect of allogeneic blood transfusio...
Case Reports: A role of postoperative radiation therapy in completely resected early stage intrathyroid thymic carcinoma: a case report and literature review of the diagnosis and treatment
Case Reports: A role of postoperative radiation therapy in completely resected early stage intrathyroid thymic carcinoma: a case report and literature review of the diagnosis and treatment
BackgroundIntrathyroid thymic carcinoma (ITTC) is a rare malignant tumor of the thyroid, probably arising from ectopic thy...
The interplay of FLT3 and CXCR4 in acute myeloid leukemia: an ongoing debate
The interplay of FLT3 and CXCR4 in acute myeloid leukemia: an ongoing debate
FLT3 mutations are very frequent in AML and utilization of FLT3 inhibitors as approved treatment options are very common. ...
Inflammatory cell death induced by 5-aminolevulinic acid-photodynamic therapy initiates anticancer immunity
Inflammatory cell death induced by 5-aminolevulinic acid-photodynamic therapy initiates anticancer immunity
BackgroundInflammatory cell death is a form of programmed cell death (PCD) that induces inflammatory mediators during the ...
Primary presentation and clinical course of pediatric and adolescent patients with differentiated thyroid carcinoma after radioiodine therapy
Primary presentation and clinical course of pediatric and adolescent patients with differentiated thyroid carcinoma after radioiodine therapy
IntroductionDifferentiated thyroid carcinoma (DTC) in childhood and during adolescence is extremely rare. Pediatric DTC co...
The association of marital status with kidney cancer surgery morbidity - a retrospective cohort study
The association of marital status with kidney cancer surgery morbidity - a retrospective cohort study
PurposeTo better understand whether the marital status impacts 90-day postoperative outcomes following kidney cancer surge...
The stratification and prognostic importance of molecular and immune landscapes in clear cell renal cell carcinoma
The stratification and prognostic importance of molecular and immune landscapes in clear cell renal cell carcinoma
The aim of our research is to explore the various characteristics and genetic profiles of clear cell renal cell carcinoma ...
Temporal changes in treatment patterns by age group and functional status before and after PD-1/L1 inhibitor approvals in advanced urothelial carcinoma
Temporal changes in treatment patterns by age group and functional status before and after PD-1/L1 inhibitor approvals in advanced urothelial carcinoma
IntroductionMetastatic urothelial carcinoma (mUC) has poor prognosis. A high unmet need exists for novel treatment for tho...
Utilizing logistic regression to compare risk factors in disease modeling with imbalanced data: a case study in vitamin D and cancer incidence
Utilizing logistic regression to compare risk factors in disease modeling with imbalanced data: a case study in vitamin D and cancer incidence
Imbalanced data, a common challenge encountered in statistical analyses of clinical trial datasets and disease modeling, r...
Study of prevalence and risk factors of chemotherapy-induced mucositis in gastrointestinal cancer using machine learning models
Study of prevalence and risk factors of chemotherapy-induced mucositis in gastrointestinal cancer using machine learning models
ObjectiveChemotherapy-induced mucositis (CIM) significantly impacts clinical outcomes and diminishes the quality of life i...
Biological insights into the role of TET2 in T cell lymphomas
Biological insights into the role of TET2 in T cell lymphomas
Peripheral T cell lymphomas (PTCL) are a heterogenous group of mature T cell lymphomas with an overall poor prognosis. Und...
PITX1 plays essential functions in cancer
PITX1 plays essential functions in cancer
PITX1, also known as the pituitary homeobox 1 gene, has emerged as a key regulator in animal growth and development, attra...
Survival prognosis model for elderly women with epithelial ovarian cancer based on the SEER database
Survival prognosis model for elderly women with epithelial ovarian cancer based on the SEER database
ObjectivesWe aimed to analyze the risk factors of elderly women with epithelial ovarian cancer (EOC) using data on the SEE...
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