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Case report: Near-complete response to neratinib-based treatment in HR-positive HER2-amplified metastatic breast cancer refractory to trastuzumab deruxtecan
Breast cancer (BC) is the leading cause of cancer-related mortality among women. The backbone of first-line treatment in H...
Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma
1 IntroductionHepatocellular carcinoma (HCC) is one of the most common cancers in the world, accounting for about 90% of a...
A multi-centre, randomised trial for diagnostic efficacy of the automatic breast volume scanner ultrasound for breast cancer screening in China
IntroductionBreast cancer is currently the most prevalent cancer among women and a leading cause of cancer-related deaths....
Mechanistic insights into the role of traditional Chinese medicine in treating gastric cancer
1 IntroductionGastric cancer is the fifth most common malignancy globally and ranks as the third leading cause of cancer-r...
Advances in adjuvant therapy for operable N2 non-small cell lung cancer: a narrative review
1 IntroductionLung cancer ranks first among malignant tumors as the number one “killer” of human health in modern society,...
Management of CAR-T cell therapy in patients with multiple myeloma: a systematic review and expert consensus in Australia
1 IntroductionMultiple myeloma (MM) is a cancer of plasma cells and, as of 2022, was the second most common hematologic ma...
Advanced progress in the genetic modification of the oncolytic HSV-1 virus
1 IntroductionRecent advancements in cancer treatment include the utilization of replication-competent viruses for selecti...
BCL-2 inhibitors in hematological malignancies: biomarkers that predict response and management strategies
1 IntroductionHematological malignancies are characterized by aberrant and persistent cellular proliferation in the bone m...
Clinical characteristics and outcomes of surgical resection for brain metastases from lung adenocarcinoma
1 IntroductionBrain metastases (BM) are common among patients with advanced solid tumors. Estimates of the incidence of BM...
Potential biomarkers for predicting the risk of thyroid cancer in immunosenescence: a population-based and externally validated multi omics study
IntroductionThyroid cancer represents the most prevalent form of endocrine malignancy, with a global annual incidence of 1...
Development and validation of a predictive model for lymph node metastases in peripheral non-small cell lung cancer with a tumor diameter ≤ 2.0 cm and a consolidation-to-tumor ratio > 0.5
1 IntroductionLung cancer is the most common cancer worldwide and the leading cause of cancer-related death (1). Surgery i...
Apoptosis antagonizing transcription factor expression and its validation as a potential diagnostic and prognostic biomarker in oral squamous cell carcinoma
1 BackgroundOral squamous cell carcinoma (OSCC) is a highly aggressive malignancy of the head and neck, characterized by p...
Targeting the kynurenine pathway: another therapeutic opportunity in the metabolic crosstalk between cancer and immune cells
IntroductionDrug resistance in cancer remains a formidable challenge in modern oncology, severely limiting the efficacy of...
Brigatinib treatment in a patient with advanced NSCLC with XPO1-ALK fusion: a case report
1 IntroductionNSCLC, which is a malignant tumor of epithelial origin, accounts for 85%-88% of all lung cancer cases; NSCLC...
Natural killer cell engagers for cancer immunotherapy
1 IntroductionAntibody-mediated cancer immunotherapy is a type of treatment approach that harnesses the power of antibodie...
Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study
1 IntroductionGastric cancer (GC) is a global health issue, being the fifth most prevalent cancer and the third leading ca...
Trifluridine/tipiracil regimen in combination with bevacizumab for metastatic colorectal cancer in the third line: an expert opinion
1 IntroductionColorectal cancer (CRC) is recognized as the third most common solid tumor worldwide with an incidence of 1....
Correlation analysis of recurrent factors in borderline ovarian tumors undergoing fertility preservation surgery
1 IntroductionBorderline ovarian tumors (BOTs) have pathologic characteristics, biological behaviors, and prognosis betwee...
Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma
1 IntroductionLangerhans cell histiocytosis (LCH) is a myeloid neoplasm of mixed cellularity, which is characterized by ac...
Corrigendum: Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models
In the published article, authors have identified some errors that happened during the cropping and placing of the IHC ima...
Burden of esophageal cancer in global, regional and national regions from 1990 to 2021 and its projection until 2050: results from the GBD study 2021
1 IntroductionEsophageal cancer (EC) remains a significant global health challenge due to its high morbidity and mortality...
Clinical analysis of molecular typing of 146 cases of endometrial carcinoma
IntroductionEndometrial cancer (EC) is the prevailing neoplasm affecting the female reproductive system (1), with an estim...
Repeatability, reproducibility, and the effects of radiotherapy on radiomic features of lowfield MR-LINAC images of the prostate
1 IntroductionProstate cancer (PCa) is the most common malignancy among men and the second-leading cause of cancer-related...
Cyanoacrylate glue in breast surgery: the GLUBREAST Trial
IntroductionAxillary seroma is the most frequent complication following breast surgery and axillary dissection. The format...
Dual-positive gastric cancer: an extremely malignant subtype of gastric cancer with high serum alpha-fetoprotein and carcinoembryonic antigen concentrations
IntroductionSerum proteins, which holistically reflect both systemic and tumor-specific characteristics, are easy to obtai...
Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy
IntroductionBreast cancer has become the most common cancer globally, surpassing lung cancer in recent years and posing a ...
Innovative applications and future trends of multiparametric PET in the assessment of immunotherapy efficacy
1 IntroductionThe introduction of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, significantly i...
The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysis
1 IntroductionOvarian masses are occasionally found incidentally, and distinguishing between benign and malignant ovarian ...
Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia
1 IntroductionLeukemias are a group of hematological cancers characterized by the abnormal proliferation of partially-diff...
Solitary fibular metastasis from lung adenocarcinoma with gene mutation: a case report
IntroductionBased on updated estimates from the International Agency for Research on Cancer (IARC), global cancer statisti...
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