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Monoparametric high-resolution diffusion weighted MRI as a possible first step in an MRI-directed diagnostic pathway for men with suspicion of prostate cancer
Monoparametric high-resolution diffusion weighted MRI as a possible first step in an MRI-directed diagnostic pathway for men with suspicion of prostate cancer
PurposeTo explore if a high-resolution diffusion weighted MRI sequence (DWI-only) could be used as a first step in an MRI-...
Notch signaling, hypoxia, and cancer
Notch signaling, hypoxia, and cancer
Notch signaling is involved in cell fate determination and deregulated in human solid tumors. Hypoxia is an important feat...
Preoperative prognostic prediction for stage I lung adenocarcinomas: Impact of the computed tomography features associated with the new histological grading system
Preoperative prognostic prediction for stage I lung adenocarcinomas: Impact of the computed tomography features associated with the new histological grading system
ObjectivesThis study aimed to identify the computed tomography (CT) features associated with the new International Associa...
Nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma
Nomogram incorporating preoperative clinical and ultrasound indicators to predict aggressiveness of solitary papillary thyroid carcinoma
ObjectiveTo construct a nomogram based on preoperative clinical and ultrasound indicators to predict aggressiveness of sol...
A CT-based radiomics approach to predict immediate response of radiofrequency ablation in colorectal cancer lung metastases
A CT-based radiomics approach to predict immediate response of radiofrequency ablation in colorectal cancer lung metastases
ObjectivesTo objectively and accurately assess the immediate efficacy of radiofrequency ablation (RFA) on colorectal cance...
Lipid profile as a novel prognostic predictor for patients with acute myeloid leukemia
Lipid profile as a novel prognostic predictor for patients with acute myeloid leukemia
PurposeThis study investigated the relationship between serum lipid levels and clinical outcomes in acute myeloid leukemia...
Survival effect of pre-RT PET-CT on cervical cancer: Image-guided intensity-modulated radiation therapy era
Survival effect of pre-RT PET-CT on cervical cancer: Image-guided intensity-modulated radiation therapy era
Condensed abstractNo large-scale, well-designed randomized study with a long-term follow-up has evaluated the survival eff...
The emerging role of MCPH1/BRIT1 in carcinogenesis
The emerging role of MCPH1/BRIT1 in carcinogenesis
The MCPH1 gene, also known as BRCT-repeat inhibitor of hTERT expression (BRIT1), has three BRCA1 carboxyl-terminal domains...
A multicenter randomized trial for quality of life evaluation by non-invasive intelligent tools during post-curative treatment follow-up for head and neck cancer: Clinical study protocol
A multicenter randomized trial for quality of life evaluation by non-invasive intelligent tools during post-curative treatment follow-up for head and neck cancer: Clinical study protocol
Patients surviving head and neck cancer (HNC) suffer from high physical, psychological, and socioeconomic burdens. Achievi...
Cancer mortality in 2020 and its trend analysis in Inner Mongolia during four time periods from 1973 to 2020
Cancer mortality in 2020 and its trend analysis in Inner Mongolia during four time periods from 1973 to 2020
Cancer is one of the leading causes of mortality in China and is responsible for placing a major burden on its economic sy...
The optimal regional irradiation volume for breast cancer patients: A comprehensive systematic review and network meta-analysis of published studies
The optimal regional irradiation volume for breast cancer patients: A comprehensive systematic review and network meta-analysis of published studies
BackgroundCurrently, the optimal adjuvant regional nodal irradiation (RNI) volume for breast cancer (BC) remained controve...
Interleukin-34 and immune checkpoint inhibitors: Unified weapons against cancer
Interleukin-34 and immune checkpoint inhibitors: Unified weapons against cancer
Interleukin-34 (IL-34) is a cytokine that is involved in the regulation of immune cells, including macrophages, in the tum...
Emerging landscape of circFNDC3B and its role in human malignancies
Emerging landscape of circFNDC3B and its role in human malignancies
In recent years, more attention has been paid to expanding the abundance of Circular RNAs (circRNAs), while the circRNAs t...
A novel prognostic model related to oxidative stress for treatment prediction in lung adenocarcinoma
A novel prognostic model related to oxidative stress for treatment prediction in lung adenocarcinoma
BackgroundThe prognostic model based on oxidative stress for lung adenocarcinoma (LUAD) remains unclear.MethodsThe informa...
Single-cell transcriptome analysis reveals the metabolic changes and the prognostic value of malignant hepatocyte subpopulations and predict new therapeutic agents for hepatocellular carcinoma
Single-cell transcriptome analysis reveals the metabolic changes and the prognostic value of malignant hepatocyte subpopulations and predict new therapeutic agents for hepatocellular carcinoma
BackgroundThe development of HCC is often associated with extensive metabolic disturbances. Single cell RNA sequencing (sc...
End-of-neoadjuvant treatment circulating microRNAs and HER2-positive breast cancer patient prognosis: An exploratory analysis from NeoALTTO
End-of-neoadjuvant treatment circulating microRNAs and HER2-positive breast cancer patient prognosis: An exploratory analysis from NeoALTTO
BackgroundThe absence of breast cancer cells in surgical specimens, i.e., pathological complete response (pCR), is widely ...
Prognostic and predictive factors of secondary gliosarcoma: A single-institution series of 18 cases combined with 89 cases from literature
Prognostic and predictive factors of secondary gliosarcoma: A single-institution series of 18 cases combined with 89 cases from literature
IntroductionSecondary gliosarcomas (SGS) are rare malignancies that are diagnosed subsequent to pre-existing glioma. Clini...
Guidance for clinicians and patients with non-small cell lung cancer in the time of precision medicine
Guidance for clinicians and patients with non-small cell lung cancer in the time of precision medicine
Major advances in the diagnosis and treatment of non-small cell lung cancer (NSCLC) have resulted in a sharp decline in as...
Combining prognostic nutritional index (PNI) and controlling nutritional status (CONUT) score as a valuable prognostic factor for overall survival in patients with stage I–III colorectal cancer
Combining prognostic nutritional index (PNI) and controlling nutritional status (CONUT) score as a valuable prognostic factor for overall survival in patients with stage I–III colorectal cancer
Background and aimsThis study compared the prognostic significance of various nutritional and inflammatory indicators such...
Outcomes and prognostic factors in initially unresectable hepatocellular carcinoma treated using conversion therapy with lenvatinib and TACE plus PD-1 inhibitors
Outcomes and prognostic factors in initially unresectable hepatocellular carcinoma treated using conversion therapy with lenvatinib and TACE plus PD-1 inhibitors
PurposeTo evaluate the outcomes and prognostic factors for patients using conversion therapy with lenvatinib combined with...
Prioritization of patients for germline testing based on tumor profiling of hematopoietic malignancies
Prioritization of patients for germline testing based on tumor profiling of hematopoietic malignancies
Germline predisposition to hematopoietic malignancies is more common than previously appreciated, with several clinical gu...
Review of the status of neoadjuvant therapy in HER2-positive breast cancer
Review of the status of neoadjuvant therapy in HER2-positive breast cancer
PurposeThe development of human epidermal growth factor receptor 2 (HER2)-directed therapies has revolutionized the treatm...
Relapsed/refractory diffuse large B cell lymphoma with cardiac involvement: A case report and literature review
Relapsed/refractory diffuse large B cell lymphoma with cardiac involvement: A case report and literature review
BackgroundHematological malignancies of the heart (CHMs) are extremely rare, and include leukemia, lymphoma infiltration, ...
Pathologic and molecular insights in nodal T-follicular helper cell lymphomas
Pathologic and molecular insights in nodal T-follicular helper cell lymphomas
T-follicular helper (TFH) cells are one of the T-cell subsets with a critical role in the regulation of germinal center (G...
DNA repair deficiency as circulating biomarker in prostate cancer
DNA repair deficiency as circulating biomarker in prostate cancer
Deleterious aberrations in DNA repair genes are actionable in approximately 25% of metastatic castration-resistant prostat...
Discordance between germline genetic findings and abnormal tumor immunohistochemistry staining of mismatch repair proteins in individuals with suspected Lynch syndrome
Discordance between germline genetic findings and abnormal tumor immunohistochemistry staining of mismatch repair proteins in individuals with suspected Lynch syndrome
Background and AimsTumor immunohistochemical staining (IHC) of DNA mismatch repair (MMR) proteins is often used to guide g...
Expression and significance of m6A-RNA-methylation in oral cancer and precancerous lesion
Expression and significance of m6A-RNA-methylation in oral cancer and precancerous lesion
BackgroundOral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) are a series of related pat...
Locoregional treatment of de novo stage IV breast cancer in the era of modern oncology
Locoregional treatment of de novo stage IV breast cancer in the era of modern oncology
Approximately 6% of metastatic breast cancers arise de novo. While systemic therapy (ST) remains the treatment backbone as...
Circulating tumour DNA as biomarker for rectal cancer: A systematic review and meta-analyses
Circulating tumour DNA as biomarker for rectal cancer: A systematic review and meta-analyses
BackgroundCirculating tumour DNA (ctDNA) has been established as a promising (prognostic) biomarker with the potential to ...
Is percutaneous drainage better than endoscopic drainage in the management of patients with malignant obstructive jaundice? A meta-analysis of RCTs
Is percutaneous drainage better than endoscopic drainage in the management of patients with malignant obstructive jaundice? A meta-analysis of RCTs
To compare the safety and efficacy of endoscopic retrograde cholangiopancreatography (ERCP) and percutaneous transhepatic ...
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