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Immune checkpoint inhibitors targeting PD-1/PD-L1 in the treatment of human lymphomas
Immune checkpoint inhibitors targeting PD-1/PD-L1 in the treatment of human lymphomas
Non-Hodgkin lymphomas (NHLs) encompass a diverse group of malignancies arising from B cells, T cells, and natural killer (...
Editorial: Prospective utilization and clinical applications of artificial intelligence and data-driven automation for radiotherapy
The development of automation and artificial intelligence (AI) software has been progressing rapidly for many years in rad...
Case report: Sequential treatment strategy for advanced basal cell carcinoma in Gorlin-Goltz syndrome: integration of vismodegib, radiotherapy, surgery, and high-intensity focused ultrasound
Case report: Sequential treatment strategy for advanced basal cell carcinoma in Gorlin-Goltz syndrome: integration of vismodegib, radiotherapy, surgery, and high-intensity focused ultrasound
Managing advanced basal cell carcinoma (BCC) in patients with Gorlin-Goltz syndrome presents unique clinical challenges du...
A fine-tuned vision transformer based enhanced multi-class brain tumor classification using MRI scan imagery
A fine-tuned vision transformer based enhanced multi-class brain tumor classification using MRI scan imagery
Brain tumors occur due to the expansion of abnormal cell tissues and can be malignant (cancerous) or benign (not cancerous...
Preclinical models for the study of pediatric solid tumors: focus on bone sarcomas
Preclinical models for the study of pediatric solid tumors: focus on bone sarcomas
Sarcomas comprise between 10–15% of all pediatric malignancies. Osteosarcoma and Ewing sarcoma are the two most common ped...
Effect of resistance exercise on physical fitness, quality of life, and fatigue in patients with cancer: a systematic review
Effect of resistance exercise on physical fitness, quality of life, and fatigue in patients with cancer: a systematic review
ObjectiveThe purpose of this study is to conduct a systematic review to assess the effects of different forms of resistanc...
Advancing early onset colorectal cancer research: research advocacy, health disparities, and scientific imperatives
Advancing early onset colorectal cancer research: research advocacy, health disparities, and scientific imperatives
Early onset colorectal cancer (EOCRC) emerged as the fourth foremost contributor to cancer-related mortality among both ge...
High charge of cerebroid nests in nodular melanomas predicts tumor aggressiveness and high mutational tumoral burden: a pilot study
High charge of cerebroid nests in nodular melanomas predicts tumor aggressiveness and high mutational tumoral burden: a pilot study
PurposeEven today, melanoma is a highly aggressive neoplasm with a high mortality rate. The nodular type is very aggressiv...
The application of mixed reality technique in oromaxillo-facial reconstruction with the perforator flap for malignant tumor patients
The application of mixed reality technique in oromaxillo-facial reconstruction with the perforator flap for malignant tumor patients
ObjectivesThe integration of quantitative imaging techniques such as computed tomography (CT) and magnetic resonance imagi...
Impact of osteopenia and osteosarcopenia on the outcomes after surgery of hepatobiliary-pancreatic cancers
Impact of osteopenia and osteosarcopenia on the outcomes after surgery of hepatobiliary-pancreatic cancers
ObjectiveThe purpose of this study is to investigate potential associations between osteopenia, osteosarcopenia, and posto...
Prediction of lateral lymph node metastasis in rectal cancer patients based on MRI using clinical, deep transfer learning, radiomic, and fusion models
Prediction of lateral lymph node metastasis in rectal cancer patients based on MRI using clinical, deep transfer learning, radiomic, and fusion models
IntroductionLateral lymph node (LLN) metastasis in rectal cancer significantly affects patient treatment and prognosis. Th...
Impact of treatment delays on future survival outcomes in non-surgical patients with esophageal cancer in Shandong Province, China
Impact of treatment delays on future survival outcomes in non-surgical patients with esophageal cancer in Shandong Province, China
The treatment process of tumors in surgical patients is typically prompt and efficient, whereas non-surgical patients are ...
Obstacles to global implementation of CAR T cell therapy in myeloma and lymphoma
Obstacles to global implementation of CAR T cell therapy in myeloma and lymphoma
Chimeric Antigen Receptor T-cell (CAR-T) therapies are transforming the treatment of B-cell lymphoproliferative disorders ...
Hypoxanthine in the microenvironment can enable thiopurine resistance in acute lymphoblastic leukemia
Hypoxanthine in the microenvironment can enable thiopurine resistance in acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, with relapse being a major obstacle to success...
Comprehensive dosimetric commissioning of proton minibeam radiotherapy on a single gantry proton system
Comprehensive dosimetric commissioning of proton minibeam radiotherapy on a single gantry proton system
BackgroundProton minibeam radiation therapy (pMBRT) can deliver spatially fractionated dose distributions with submillimet...
Swin-GA-RF: genetic algorithm-based Swin Transformer and random forest for enhancing cervical cancer classification
Swin-GA-RF: genetic algorithm-based Swin Transformer and random forest for enhancing cervical cancer classification
Cervical cancer is a prevalent and concerning disease affecting women, with increasing incidence and mortality rates. Earl...
Current chemotherapy strategies for adults with IDH-wildtype glioblastoma
Current chemotherapy strategies for adults with IDH-wildtype glioblastoma
IntroductionGlioblastoma, despite advancements in molecular evolution, remains incurable and has low survival rates. Curre...
Solid pseudopapillary neoplasm of the pancreas with hepatic metastases: problems and strategies
Solid pseudopapillary neoplasm of the pancreas with hepatic metastases: problems and strategies
BackgroundSolid pseudopapillary neoplasms of the pancreas with hepatic metastases are infrequent and difficult to diagnose...
Global trends in the application of fluorescence imaging in pancreatic diseases: a bibliometric and knowledge graph analysis
Global trends in the application of fluorescence imaging in pancreatic diseases: a bibliometric and knowledge graph analysis
BackgroundIn recent years, with the continuous development of fluorescence imaging technology, research on its application...
A bibliometric worldview of breast-conserving surgery for breast cancer from 2013 to 2023
A bibliometric worldview of breast-conserving surgery for breast cancer from 2013 to 2023
Over the last decade, significant advancements have been made in breast-conserving surgery (BCS) for breast cancer. Howeve...
Withametelin inhibits TGF-β induced Epithelial-to-Mesenchymal Transition and Programmed-Death Ligand-1 expression in vitro
Withametelin inhibits TGF-β induced Epithelial-to-Mesenchymal Transition and Programmed-Death Ligand-1 expression in vitro
Withanolides are a group of naturally occurring plant-based small molecules known for their wide range of host cellular fu...
Toxicity of immune checkpoint inhibitors and tyrosine kinase inhibitor combinations in solid tumours: a systematic review and meta-analysis
Toxicity of immune checkpoint inhibitors and tyrosine kinase inhibitor combinations in solid tumours: a systematic review and meta-analysis
The combination of immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) can be associated with signif...
Prognostic significance of histologic phenotype in periampullary adenocarcinomas
Prognostic significance of histologic phenotype in periampullary adenocarcinomas
BackgroundPeriampullary adenocarcinomas typically exhibit either intestinal or pancreatobiliary (PB) differentiation, and ...
Optimization of treatment strategies for elderly patients with advanced non-small cell lung cancer
Optimization of treatment strategies for elderly patients with advanced non-small cell lung cancer
Lung cancer stands as a malignant neoplasm bearing the highest burden of morbidity and mortality within the elderly popula...
Comprehensive strategies in breast cancer-related lymphedema prevention: insights from a multifaceted program
Comprehensive strategies in breast cancer-related lymphedema prevention: insights from a multifaceted program
BackgroundBreast cancer-related lymphedema (BCRL) profoundly impacts patients’ quality of life, causing heightened depress...
Recent advances in immunotherapy and its combination therapies for advanced melanoma: a review
Recent advances in immunotherapy and its combination therapies for advanced melanoma: a review
The incidence of melanoma is increasing year by year and is highly malignant, with a poor prognosis. Its treatment has alw...
Progress of natural sesquiterpenoids in the treatment of hepatocellular carcinoma
Progress of natural sesquiterpenoids in the treatment of hepatocellular carcinoma
Hepatocellular carcinoma is one of the common malignant tumors of digestive tract, which seriously threatens the life of p...
Neoadjuvant targeted therapy versus targeted combined with chemotherapy for resectable EGFR-mutant non–small cell lung cancer: a retrospective controlled real-world study
Neoadjuvant targeted therapy versus targeted combined with chemotherapy for resectable EGFR-mutant non–small cell lung cancer: a retrospective controlled real-world study
BackgroundThis study aimed to assess the role and effect of neoadjuvant targeted therapy (TT) versus targeted combined wit...
The landscape of cancer-associated transcript fusions in adult brain tumors: a longitudinal assessment in 140 patients with cerebral gliomas and brain metastases
The landscape of cancer-associated transcript fusions in adult brain tumors: a longitudinal assessment in 140 patients with cerebral gliomas and brain metastases
BackgroundOncogenic fusions of neurotrophic receptor tyrosine kinase NTRK1, NTRK2, or NTRK3 genes have been found in diffe...
Research progress on the correlation between intestinal flora and colorectal cancer
Research progress on the correlation between intestinal flora and colorectal cancer
Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies in the world. With the rapid pace of life ...
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