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Comparative Safety of Antipsychotic Medications and Mood Stabilizers During Pregnancy: A Systematic Review and Network Meta-analysis of Congenital Malformations and Prenatal Outcomes
Comparative Safety of Antipsychotic Medications and Mood Stabilizers During Pregnancy: A Systematic Review and Network Meta-analysis of Congenital Malformations and Prenatal Outcomes
A network meta-analysis was performed to evaluate the risk of congenital malformations and other prenatal outcomes in fetu...
TICA-CLOP STUDY: Ticagrelor Versus Clopidogrel in Acute Moderate and Moderate-to-Severe Ischemic Stroke, a Randomized Controlled Multi-Center Trial
TICA-CLOP STUDY: Ticagrelor Versus Clopidogrel in Acute Moderate and Moderate-to-Severe Ischemic Stroke, a Randomized Controlled Multi-Center Trial
Many studies evaluated the efficacy and safety of ticagrelor versus clopidogrel in patients with ischemic stroke; none of ...
The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review
The Role of GABA Receptors in Anesthesia and Sedation: An Updated Review
GABA (γ-aminobutyric acid) receptors are constituents of many inhibitory synapses within the central nervous system. ...
Recent Advances in Pharmacologic Treatments of Drug-Resistant Epilepsy: Breakthrough in Sight
Recent Advances in Pharmacologic Treatments of Drug-Resistant Epilepsy: Breakthrough in Sight
Epilepsy affects approximately 1% of the world population. Patients have recurrent seizures, increased physical and psychi...
A Multicenter, Open-Label Study to Evaluate the Long-term Safety and Efficacy of Adjunctive Brexpiprazole 2 mg Daily in Japanese Patients with Major Depressive Disorder
A Multicenter, Open-Label Study to Evaluate the Long-term Safety and Efficacy of Adjunctive Brexpiprazole 2 mg Daily in Japanese Patients with Major Depressive Disorder
Inadequate response to antidepressant monotherapy is common among patients with major depressive disorder (MDD). The effic...
Research Progress on NMDA Receptor Enhancement Drugs for the Treatment of Depressive Disorder
Research Progress on NMDA Receptor Enhancement Drugs for the Treatment of Depressive Disorder
Major depressive disorder (MDD) is a severe mental illness with a complex etiology. Currently, many medications employed i...
Efficacy of Cariprazine in the Psychosis Spectrum: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials in Schizophrenia and Bipolar Disorder
Efficacy of Cariprazine in the Psychosis Spectrum: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials in Schizophrenia and Bipolar Disorder
Psychosis represents one of the most challenging clinical presentations in psychiatry. Schizophrenia and bipolar disorder ...
The Safety of Alcohol Pharmacotherapies in Pregnancy: A Scoping Review of Human and Animal Research
The Safety of Alcohol Pharmacotherapies in Pregnancy: A Scoping Review of Human and Animal Research
Alcohol pharmacotherapies pose unknown teratogenic risks in pregnancy and are therefore recommended to be avoided. This li...
An Open-Label Extension Study Assessing the Long-Term Safety and Efficacy of Viloxazine Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder
An Open-Label Extension Study Assessing the Long-Term Safety and Efficacy of Viloxazine Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder
Viloxazine ER (extended-release capsules; Qelbree®) is a nonstimulant medication that has been approved by the United...
Long-Term (12-Month) Safety and Tolerability of STS101 (Dihydroergotamine Nasal Powder) in the Acute Treatment of Migraine: Data from the Phase 3 Open-Label ASCEND Study
Long-Term (12-Month) Safety and Tolerability of STS101 (Dihydroergotamine Nasal Powder) in the Acute Treatment of Migraine: Data from the Phase 3 Open-Label ASCEND Study
STS101 is an investigational drug–device combination comprising 5.2 mg dihydroergotamine (DHE) powder (6.0 mg DHE me...
Modafinil Versus Amphetamine-Dextroamphetamine For Idiopathic Hypersomnia and Narcolepsy Type 2: A Randomized, Blinded, Non-inferiority Trial
Modafinil Versus Amphetamine-Dextroamphetamine For Idiopathic Hypersomnia and Narcolepsy Type 2: A Randomized, Blinded, Non-inferiority Trial
Although there are several treatments for narcolepsy type 2 and idiopathic hypersomnia, studies that assess amphetamines, ...
Current Landscape of NTRK Inhibition for Pediatric CNS Tumors
Current Landscape of NTRK Inhibition for Pediatric CNS Tumors
Over the last decade, as molecular platforms have permitted the characterization of the genomic landscape of pediatric cen...
Early Disease-Modifying Treatments for Presymptomatic Multiple Sclerosis
Early Disease-Modifying Treatments for Presymptomatic Multiple Sclerosis
Radiologically isolated syndrome (RIS) is the earliest stage in the disease continuum of multiple sclerosis (MS). RIS is d...
Effectiveness of Disease-Modifying Treatment on Spinal Cord Lesion Formation in Relapse-Onset Multiple Sclerosis: An MSBase Registry Study
Effectiveness of Disease-Modifying Treatment on Spinal Cord Lesion Formation in Relapse-Onset Multiple Sclerosis: An MSBase Registry Study
Spinal cord lesions in multiple sclerosis (MS) have considerable impact on disability. High-efficacy disease-modifying tre...
Glutamatergic Modulators for Major Depression from Theory to Clinical Use
Glutamatergic Modulators for Major Depression from Theory to Clinical Use
Major depressive disorder (MDD) is a chronic, burdensome, highly prevalent disease that is characterized by depressed mood...
Effects of Trazodone on Sleep: A Systematic Review and Meta-analysis
Effects of Trazodone on Sleep: A Systematic Review and Meta-analysis
Sleep problems and insomnia are common, challenging to treat, and transcend specific diagnoses. Although trazodone is a po...
Antiseizure Medications and Sudden Unexpected Death in Epilepsy: An Updated Review
Antiseizure Medications and Sudden Unexpected Death in Epilepsy: An Updated Review
Sudden unexpected death in epilepsy (SUDEP) is responsible for most epilepsy-related deaths. It is mainly related to unwit...
Incident Benzodiazepine and Z-Drug Use and Subsequent Risk of Serious Infections
Incident Benzodiazepine and Z-Drug Use and Subsequent Risk of Serious Infections
Animal studies have suggested a link between benzodiazepine and related Z-drug (BZDR) use and immune dysfunction. Correspo...
Psychotropic Drugs Reemerging as Headache Medicines
Psychotropic Drugs Reemerging as Headache Medicines
Scientific and public attention on the therapeutic effects of psychedelics and other psychoactive compounds in headache di...
Caregiver Perspective of Benefits and Side Effects of Anti-Seizure Medications in CDKL5 Deficiency Disorder from an International Database
Caregiver Perspective of Benefits and Side Effects of Anti-Seizure Medications in CDKL5 Deficiency Disorder from an International Database
CDKL5 deficiency disorder presents as a challenging condition with early-onset refractory seizures, severe developmental d...
When, Why and How to Re-challenge Clozapine in Schizophrenia Following Myocarditis
When, Why and How to Re-challenge Clozapine in Schizophrenia Following Myocarditis
Clozapine-induced myocarditis (CIM) is among the most important adverse events limiting the use of clozapine as the most e...
Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022
Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022
In recent years, pregabalin has received growing attention due to its abuse liability. The aim of this study was to furthe...
A Long-Term Safety and Tolerability Study of TV-46000 for Subcutaneous Use in Patients with Schizophrenia: A Phase 3, Randomized, Double-Blinded Clinical Trial
A Long-Term Safety and Tolerability Study of TV-46000 for Subcutaneous Use in Patients with Schizophrenia: A Phase 3, Randomized, Double-Blinded Clinical Trial
TV-46000 is a long-acting subcutaneous antipsychotic (LASCA) formulation of risperidone that is approved by the United Sta...
The State of Synthetic Cannabinoid Medications for the Treatment of Pain
The State of Synthetic Cannabinoid Medications for the Treatment of Pain
Synthetic cannabinoids are compounds made in the laboratory to structurally and functionally mimic phytocannabinoids from ...
Alzheimer’s Disease: Combination Therapies and Clinical Trials for Combination Therapy Development
Alzheimer’s Disease: Combination Therapies and Clinical Trials for Combination Therapy Development
Alzheimer’s disease (AD) is a complex multifaceted disease. Recently approved anti-amyloid monoclonal antibodies slo...
The Use of Ketamine for the Treatment of Anhedonia in Depression
The Use of Ketamine for the Treatment of Anhedonia in Depression
Anhedonia, a complex symptom rooted in deficits across reward processes, is primarily linked to depression and schizophren...
Semi-physiological Pharmacokinetic Model of Clozapine and Norclozapine in Healthy, Non-smoking Volunteers: The Impact of Race and Genetics
Semi-physiological Pharmacokinetic Model of Clozapine and Norclozapine in Healthy, Non-smoking Volunteers: The Impact of Race and Genetics
Clozapine is the medication of choice for treatment-resistant schizophrenia. However, it has a complex metabolism and unex...
A Framework for the Administration of Anti-amyloid Monoclonal Antibody Treatments in Early-Stage Alzheimer’s Disease
A Framework for the Administration of Anti-amyloid Monoclonal Antibody Treatments in Early-Stage Alzheimer’s Disease
The US Food and Drug Administration (FDA) approval of lecanemab for early-stage Alzheimer’s disease (AD) represents ...
Targeting Biometals in Alzheimer’s Disease with Metal Chelating Agents Including Coumarin Derivatives
Targeting Biometals in Alzheimer’s Disease with Metal Chelating Agents Including Coumarin Derivatives
Numerous physiological processes happening in the human body, including cerebral development and function, require the par...
Intervening in the Premonitory Phase to Prevent Migraine: Prospects for Pharmacotherapy
Intervening in the Premonitory Phase to Prevent Migraine: Prospects for Pharmacotherapy
Migraine is a common brain condition characterised by disabling attacks of headache with sensory sensitivities. Despite in...
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