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Early Non-Response to Antipsychotic Treatment in Schizophrenia: A Systematic Review and Meta-Analysis of Evidence-Based Management Options
Early Non-Response to Antipsychotic Treatment in Schizophrenia: A Systematic Review and Meta-Analysis of Evidence-Based Management Options
Early non-response is a well-established prognostic marker but evidence-based and consistent recommendations to manage it ...
Calcitonin in the Treatment of Phantom Limb Pain: A Systematic Review
Calcitonin in the Treatment of Phantom Limb Pain: A Systematic Review
Phantom limb pain (PLP) refers to pain perceived in a part of the body removed by amputation or trauma. Despite the high p...
Pharmacological Management of Borderline Personality Disorder and Common Comorbidities
Pharmacological Management of Borderline Personality Disorder and Common Comorbidities
Comorbidity between borderline personality disorder (BPD) and other mental disorders is common. Although no specific pharm...
A Retrospective Real-Life Multicenter Study on Concurrent Oral Preventive Treatments in Patients with Chronic Migraine Treated with OnabotulinumtoxinA
A Retrospective Real-Life Multicenter Study on Concurrent Oral Preventive Treatments in Patients with Chronic Migraine Treated with OnabotulinumtoxinA
OnabotulinumtoxinA (BoNTA) is a relatively safe and effective treatment for chronic migraine. The local mode of action of ...
Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders
Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders
The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure. The sigma-2 receptor is a gene...
Nonstimulant Medications for Attention-Deficit/Hyperactivity Disorder (ADHD) in Adults: Systematic Review and Meta-analysis
Nonstimulant Medications for Attention-Deficit/Hyperactivity Disorder (ADHD) in Adults: Systematic Review and Meta-analysis
For some adults with Attention-Deficit/Hyperactivity Disorder (ADHD), nonstimulants need to be considered either as a mono...
New Pharmacological Approaches to the Management of Premenstrual Dysphoric Disorder
New Pharmacological Approaches to the Management of Premenstrual Dysphoric Disorder
Premenstrual symptoms are experienced by many female individuals during their fertile age. Premenstrual dysphoric disorder...
Idiopathic Hypersomnia: Neurobiology, Diagnosis, and Management
Idiopathic Hypersomnia: Neurobiology, Diagnosis, and Management
Idiopathic hypersomnia is a chronic neurologic sleep disorder that manifests as excessive daytime sleepiness despite norma...
Pharmacologic Management of Cognitive Disengagement Syndrome (CDS) and Implications for Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment: Emerging Treatments and Recommendations for Future Research
Pharmacologic Management of Cognitive Disengagement Syndrome (CDS) and Implications for Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment: Emerging Treatments and Recommendations for Future Research
Although the study of cognitive disengagement syndrome (CDS; previously called sluggish cognitive tempo) first emerged in ...
Sex Differences in Outcomes of Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Preadmission Use of Antiplatelets
Sex Differences in Outcomes of Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Preadmission Use of Antiplatelets
To compare safety and functional outcomes of intravenous thrombolysis (IVT) between females and males with acute ischaemic...
Efgartigimod Alfa in Generalised Myasthenia Gravis: A Profile of Its Use
Efgartigimod Alfa in Generalised Myasthenia Gravis: A Profile of Its Use
Intravenous efgartigimod alfa (also known as efgartigimod alfa-fcab in the USA; Vyvgart®) is the first neonatal Fc re...
Long-Term Safety and Tolerability During a Clinical Trial and Open-Label Extension of Low-Sodium Oxybate in Participants with Narcolepsy with Cataplexy
Long-Term Safety and Tolerability During a Clinical Trial and Open-Label Extension of Low-Sodium Oxybate in Participants with Narcolepsy with Cataplexy
The safety and efficacy of low-sodium oxybate (LXB; Xywav®) were established in a randomized, double-blind, placebo-c...
A Randomized, Open-Label, Multiple-Dose, Parallel-Arm, Pivotal Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Aripiprazole 2-Month Long-Acting Injectable in Adults With Schizophrenia or Bipolar I Disorder
A Randomized, Open-Label, Multiple-Dose, Parallel-Arm, Pivotal Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Aripiprazole 2-Month Long-Acting Injectable in Adults With Schizophrenia or Bipolar I Disorder
Aripiprazole 2-month ready-to-use 960 mg (Ari 2MRTU 960) is a new long-acting injectable antipsychotic formulation for glu...
Satralizumab: A Review in Neuromyelitis Optica Spectrum Disorder
Satralizumab: A Review in Neuromyelitis Optica Spectrum Disorder
Satralizumab (Enspryng®) is a monoclonal antibody that blocks the interleukin-6 (IL-6) receptor and is approved for t...
Immunoregulatory and/or Anti-inflammatory Agents for the Management of Core and Associated Symptoms in Individuals with Autism Spectrum Disorder: A Narrative Review of Randomized, Placebo-Controlled Trials
Immunoregulatory and/or Anti-inflammatory Agents for the Management of Core and Associated Symptoms in Individuals with Autism Spectrum Disorder: A Narrative Review of Randomized, Placebo-Controlled Trials
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with a so far poorly understood underlying ...
Correction to: Daridorexant in Insomnia Disorder: A Profile of Its Use
Correction to: Daridorexant in Insomnia Disorder: A Profile of Its Use
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International L...
Safety, Tolerability, Pharmacokinetics, and Immunogenicity of a Novel Recombination Human Nerve Growth Factor in Healthy Chinese Subjects
Safety, Tolerability, Pharmacokinetics, and Immunogenicity of a Novel Recombination Human Nerve Growth Factor in Healthy Chinese Subjects
Nerve growth factor (NGF), the first-discovered member of the neurotrophin family, has long been regarded as a potential d...
Correction to: Improvements in Cognitive Processing Speed, Disability, and Patient‑Reported Outcomes in Patients with Early Relapsing‑Remitting Multiple Sclerosis Treated with Natalizumab: Results of a 4‑year, Real‑World, Open‑Label Study
Correction to: Improvements in Cognitive Processing Speed, Disability, and Patient‑Reported Outcomes in Patients with Early Relapsing‑Remitting Multiple Sclerosis Treated with Natalizumab: Results of a 4‑year, Real‑World, Open‑Label Study
STRIVE was a prospective, 4-year, multicenter, observational, open-label, single-arm study of natalizumab treatment in ant...
Rimegepant: A Review in the Acute Treatment and Preventive Treatment of Migraine
Rimegepant: A Review in the Acute Treatment and Preventive Treatment of Migraine
Rimegepant [Nurtec® ODT (USA); Vydura® (EU)] is a calcitonin gene-related peptide (CGRP) receptor antagonist app...
Teriflunomide Concentrations in Cerebrospinal Fluid and Plasma in Patients with Multiple Sclerosis: A Pharmacokinetic Study
Teriflunomide Concentrations in Cerebrospinal Fluid and Plasma in Patients with Multiple Sclerosis: A Pharmacokinetic Study
Teriflunomide is a disease modifying treatment (DMT) approved for relapsing-remitting multiple sclerosis (RRMS) in adults ...
Switching OnabotulinumtoxinA to Monoclonal Anti-CGRP Antibodies in Drug-Resistant Chronic Migraine
Switching OnabotulinumtoxinA to Monoclonal Anti-CGRP Antibodies in Drug-Resistant Chronic Migraine
OnabotulinumtoxinA (BTX-A) and anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (anti-CGRP mAbs) are appr...
Ketamine and Zinc: Treatment of Anorexia Nervosa Via Dual NMDA Receptor Modulation
Ketamine and Zinc: Treatment of Anorexia Nervosa Via Dual NMDA Receptor Modulation
Anorexia nervosa is a disorder associated with serious adverse health outcomes, for which there is currently considerable ...
Treatment of Patients with Multiple Sclerosis Transitioning Between Relapsing and Progressive Disease
Treatment of Patients with Multiple Sclerosis Transitioning Between Relapsing and Progressive Disease
Multiple sclerosis (MS) is a chronic autoimmune demyelinating and neurodegenerative disease of the central nervous system ...
Treatment Outcomes of Newly Diagnosed Epilepsy: A Systematic Review and Meta-analysis
Treatment Outcomes of Newly Diagnosed Epilepsy: A Systematic Review and Meta-analysis
Understanding the multi-faceted treatment outcomes of newly diagnosed epilepsy is critical for developing rational therape...
Early Morning ADHD Symptoms and Functional Impairment: Impact on Patients and Caregivers, and Pharmacological Approaches to Management
Early Morning ADHD Symptoms and Functional Impairment: Impact on Patients and Caregivers, and Pharmacological Approaches to Management
Attention-deficit/hyperactivity disorder (ADHD) is a common and impairing mental disorder. Individuals with ADHD typically...
Estimating Risk of Antidepressant Withdrawal from a Review of Published Data
Estimating Risk of Antidepressant Withdrawal from a Review of Published Data
Adaptation of the brain to the presence of a drug predicts withdrawal on cessation. The outcome of adaptation is often ref...
A 10-Year Observational Study of the Use, Acceptability and Effectiveness of Long-Acting Paliperidone Palmitate: Implications for Clinical Decision Making
A 10-Year Observational Study of the Use, Acceptability and Effectiveness of Long-Acting Paliperidone Palmitate: Implications for Clinical Decision Making
Long-acting injectable antipsychotics (LAIs) have been shown to improve adherence and prevent relapse in the trea...
Long-Term Safety and Tolerability of Daridorexant in Patients with Insomnia Disorder
Long-Term Safety and Tolerability of Daridorexant in Patients with Insomnia Disorder
Daridorexant is a dual orexin receptor antagonist for the treatment of insomnia. In two phase III, 12-week studies in pati...
Leveraging Molecular and Immune-Based Therapies in Leptomeningeal Metastases
Leveraging Molecular and Immune-Based Therapies in Leptomeningeal Metastases
Leptomeningeal metastases represent an aggressive stage of cancer with few durable treatment options. Improved understandi...
Orexin Receptor Antagonists in the Treatment of Depression: A Leading Article Summarising Pre-clinical and Clinical Studies
Orexin Receptor Antagonists in the Treatment of Depression: A Leading Article Summarising Pre-clinical and Clinical Studies
The orexin (hypocretin) system comprises two neuropeptides (orexin-A and orexin-B) and two G-protein coupled receptors (th...
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