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“The State of the Science” of Childhood, Adolescent and Young Adult Non Hodgkin Lymphoma (NHL)
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Targeted cellular therapy for treatment of relapsed or refractory leukemia
While the mainstay of treatment for high-risk or relapsed, refractory (r/r) hematologic malignancies (including leukemias)...
Reducing barriers of access and care related to hematopoietic cell transplantation and cellular therapy: The mission-driven role of the national marrow donor program
Hematopoietic cell transplantation and cellular therapies (TCT) are potentially curative treatments for malignant and non-...
Endpoint selection and evaluation in hematology studies
Observational studies and clinical trials in hematology aim to examine an array of treatments for blood disorders includin...
The analysis of multiple outcomes, multiple variables and variables selection in hematopoietic cell transplantation studies
Time-to-event data are common in cancer research such as hematopoietic cell transplantation (HCT) for leukemia. In time-to...
Handling missing covariate data in clinical studies in haematology
Available online 22 May 2023, 101477Author links open overlay panel, , , AbstractMissing data are frequently encountered a...
Designing and conducting a clinical trial in blood and marrow transplantation
Clinical trials form the cornerstone of the science-based approach to improving patient outcomes. They provide the highest...
Immunopathogenic mechanisms and modulatory approaches to graft-versus-host disease prevention in acute myeloid leukaemia
The application of allogeneic haematopoietic stem cell transplantation (HSCT) in human was first reported in 1957 after nu...
What should be done and what should be avoided when comparing two treatments?
The gold-standard approach to compare two treatments, or more generally to assess the efficacy and safety of an interventi...
What is relative survival and what is its role in haematology?
Available online 8 May 2023, 101474Author links open overlay panel, , AbstractIn many haematological diseases, the surviva...
The presentation of results from studies in clinical haematology
Research is based on trying to find answers to specific questions or to test hypotheses. Studies are thus undertaken to ge...
Pharmacogenomics in allogeneic hematopoietic stem cell transplantation: Implications on supportive therapies and conditioning regimens
Allogeneic HSCT mortality has declined substantially largely due to improvements in managing post-transplant complications...
Measurable residual disease in patients undergoing allogeneic transplant for acute myeloid leukemia
Allogeneic hematopoietic cell transplant (alloHCT) is a well-established and effective anti-cancer cellular immunotherapy,...
Take a spin: Apheresis in the care of adult leukaemia patients
Apheresis is the use of an automated instrument to separate whole blood followed by the removal of a specific blood compon...
Financial toxicity in patients with leukemia undergoing hematopoietic stem cell transplantation: A systematic review
Although the physical toxicity of many cancer regimens has improved with the use of targeted therapies and advancements in...
Cardio-oncology and transplantation for acute myeloid leukemia
Acute Myeloid Leukemia (AML) includes a spectrum of aggressive hematologic malignancies with considerable heterogeneity in...
Dermatologic complications in transplantation and cellular therapy for acute leukemia
Available online 6 April 2023, 101464Author links open overlay panel, , , AbstractAdoptive cellular immunotherapy, mainly ...
Allogeneic hematopoietic cell transplantation in acute myeloid leukemia
Dr. E. Donnall Thomas pioneered the field of hematopoietic cell transplantation (HCT), reporting the first infusion of all...
Diagnosis and management of mature B-cell lymphomas in children, adolescents, and young adults
In resource rich countries mature B-cell lymphoma has an expected cure rate of greater than 90% making it one of the most ...
Worldwide sources of data in haematology: Importance of clinician-biostatistician collaboration
Observational studies using registry-based data have contributed much to the understanding and care of patients with hemat...
Diagnosis and management of lymphoblastic lymphoma in children, Adolescents and young Adults
Available online 16 February 2023, 101449Author links open overlay panel, , , AbstractLymphoblastic lymphoma (LBL) is the ...
Diagnosis and management of cutaneous lymphomas and lymphoid proliferations in children, adolescents and young adults (CAYA)
Available online 10 February 2023, 101448Author links open overlay panel, , , AbstractCutaneous lymphomas and lymphoid pro...
Biopathology of childhood, adolescent and young adult non-Hodgkin lymphoma
Mature lymphomas in childhood, adolescent and young adult (CAYA) population are rare and exhibit unique clinical, immunoph...
Principles of cost-effectiveness studies and their use in haematology
Available online 2 February 2023, 101441Author links open overlay panelAbstractHealth economics is about providing the pop...
Diagnosis and management of ALK-positive anaplastic large cell lymphoma in children and adolescents
A 9-year-old boy presented with fever, lymphadenopathy, lung nodules and skin lesions. ALK-positive anaplastic large cell ...
Cellular and humoral immunotherapy in children, adolescents and young adults with non-Hodgkin lymphoma
The prognosis is dismal for childhood, adolescent, and young adult (CAYA) relapsed and/or refractory (R/R) non-Hodgkin lym...
Late effects and frontline treatment selection for children with non-Hodgkin lymphoma
Survivors of childhood cancer comprise approximately 500,000 individuals among the United States population [1], a number ...
Diagnosis and management of Hodgkin lymphoma in children, adolescents, and young adults
Classic Hodgkin lymphoma (HL) is the most common cancer in adolescent young adult (AYA) patients between ages 15 and 19, a...
Diagnosis and management of post-transplant lymphoproliferative disease following solid organ transplantation in children, adolescents, and young adults
Solid organ transplantation (SOT) is an effective treatment modality for children and young adults with end-stage organ fa...
Diagnosis and management of rare paediatric Non-Hodgkin lymphoma
It has long been recognised that effective cancer care is not possible without multi-professional team working. Collaborat...
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