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From a bispecific monoclonal antibody to gene therapy: A new era in the treatment of hemophilia A
The treatment of hemophilia A has progressed amazingly in recent years. Emicizumab, a bispecific-humanized monoclonal anti...
Complete revascularization of multivessel coronary artery disease in patients with ST elevation acute coronary syndrome - for whom and when? A comprehensive review
Atherosclerosis is the most common cause of coronary steno-occlusive disease and acute myocardial infarction is the leadin...
Blood urea nitrogen - independent marker of mortality in sepsis
Background. This retrospective study examines the relationship between admission Blood Urea Nitrogen (BUN) levels and clin...
Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis
Aim. The aim of this study was to identify whether NfL and CXCL13 cerebrospinal fluid (CSF) concentrations at diagnostic l...
Detection of galanin receptors in the spinal cord in experimental autoimmune encephalomyelitis
Aims. The neuropeptide galanin is a widely distributed neurotransmitter/neuromodulator that regulates a variety of physiol...
Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury
Aim. Currently available medicines have little to offer in terms of supporting the regeneration of injured hepatic cells. ...
Global DNA methylation and increased DNMT3A expression in multiple myeloma patients
Aims. The aim of this study was to compare the expression profile of selected DNA methyltransferases and global DNA methyl...
Administration of mucolytic solution before upper endoscopy - double-blind, monocentric, randomized study
Aims. Sufficient visibility of the mucosa during upper endoscopy is crucial for successful diagnosis, especially for early...
Total thyroidectomy can still remain the method of choice in some Bethesda III cases
Background. The latest WHO classification of tumours of endocrine organs defines new units of borderline thyroid tumours (...
Periradicular corticosteroid infiltration for radicular pain - comparison of Diprophos and Depomedrone and ozone effects
Objectives. To determine the treatment effect of corticosteroids in periradicular therapy (PRT) for radicular pain and to ...
Diabetic macular edema treatment with subthreshold micropulse laser - five-year long monitoring
Aim. The objective of this study was to evaluate the efficacy of diabetic macular edema (DME) therapy using subthreshold m...
Floppy iris syndrome associated with specific medication intake: A narrative review
Intraoperative floppy iris syndrome (IFIS) is a cataract surgery complication that remains a challenge for eye surgeons. I...
Is high accuracy of Vesical Imaging-Reporting and Data System (VI-RADS) sufficient for its implementation in the urological practice?
Aims. Currently, the only method used to differentiate between MIBC and NMIBC is transurethral resection of the bladder tu...
Letter to the Editor Regarding: "Modern diagnostic and therapeutic approaches in familial maculopathy with reference to North Carolina macular dystrophy" by Jana Nekolova et al.
Small, K.W. (2023). Letter to the Editor Regarding: "Modern diagnostic and therapeutic approaches in familial maculop...
Tension pneumopericardium in a polytrauma patient
Introduction. Tension pneumopericardium is a life-threatening condition, manifesting most commonly as hemodynamic instabil...
The use of biomarkers in the diagnosis and treatment of obstruction of the upper urinary tract in children
Antenatal hydronephrosis, dilatation of the upper urinary tract (UUTD), is a common finding on prenatal ultrasound. One of...
Visual neuroprosthesis: present and future perspectives
The purpose of this study is to provide an overview of the replacements used in lost vision in the form of the bionic eye,...
Sudden cardiac death - a known unknown?
Sudden cardiac death (SCD) is a major medical, economic and social problem. The estimated annual number of SCDs is approxi...
The anti-inflammatory role of placental Hofbauer cells is altered in patients with chorioamnionitis: Are CYP2C8 and soluble epoxide hydrolase involved in immunomodulation?
Aims. Hofbauer cells (HBCs) are placental macrophages playing various roles during normal and complicated pregnancies, and...
A rare epidermal growth factor receptor (EGFR) gene mutation in small cell lung carcinoma patients
Aim. Activating mutations in the epidermal growth factor receptor (EGFR) are predominantly detected in pulmonary adenocarc...
Surgical treatment of duodenal adenocarcinoma: ampullary vs. non-ampullary, short- and long-term outcomes
Background. The aim of this study was to evaluate symptoms, diagnostic methods, short- and long-term outcomes of surgical ...
Construction of the miRNA-mRNA regulatory network and analysis of hub genes in oral squamous cell carcinoma
Background. Oral squamous cell carcinoma (OSCC) severely affects the quality of life and the 5-year survival rate is low. ...
Associations between neurofilament light chain levels, disease activity and brain atrophy in progressive multiple sclerosis
Background. Neurofilament light chain is a promising biomarker of disease activity and treatment response in relapsing-rem...
Predictive value of tissue calprotectin for disease recurrence after ileocecal resection in pediatric Crohn's disease
Aim. Detection of possible predictive factors of endoscopic recurrence after ileocecal resection in Crohn's disease could ...
Angiotensin-converting enzyme inhibitors, angiotensin-II-receptor antagonists and angiotensin-receptor blocker/neprilysin inhibitor utilization in heart failure patients: Sub-analysis of a nation-wide population-based study in the Czech Republic
Aims. Sub-analysis of a retrospective nation-wide observational analysis of heart failure (HF) epidemiology reported to th...
The prognosis and therapeutic management of patients hospitalized for heart failure in 2010-2020
Aims. We analyzed the mortality risk and its predictors in patients hospitalized for heart failure (HF). Methods. Patients...
Lapidus arthrodesis in combination with arthrodesis of the first metatarsophalangeal joint-biomechanical cadaver study comparing two methods of fixation
Aims. To assess the results of a biomechanical test of cadaveric specimens, comparing 2 methods of fixation of modified La...
Elasticity of neck muscles in cervicogenic headache
Aim. To compare the elasticity of the sternocleidomastoid and trapezius muscles in patients with cervicogenic headache and...
Hearing improvement after vestibular schwannoma surgery in the era of the hearing preservation rule - case report and literature review
Objectives. Hearing preservation after vestibular schwannoma (VS) surgery remains a surgical challenge. In some patients w...
Transnasal endoscopic surgery of sphenoid meningocele associated with pituitary adenoma. A case report
Background. Transsphenoid meningoencephalocele is a congenital anomaly formed by herniation of an ependyma delimited sac t...
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