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Evaluating immunotherapeutic outcomes in triple-negative breast cancer with a cholesterol radiotracer in mice
T cells from ICI-responsive tumors show greater cholesterol uptake. To study cholesterol uptake and the immunotherapy res...
Integrated plasma proteomics identifies tuberculosis-specific diagnostic biomarkers
Clinical MedicineInfectious diseasePulmonology Open Access | 10.1172/jci.insight.173273 Hannah ...
Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP
Loss of atrogin-1 results in contraction-dependent fiber failure. To determine the role of atrogin-1 in skeletal muscle, ...
Myosin folding boosts solubility in cardiac muscle sarcomeres
Sex as a biological variable. Our study examined male and female FVB WT mice purchased from The Jackson Laboratory, and s...
HIPK2 C-terminal domain inhibits NF-κB signaling and renal inflammation in kidney injury
Sex as a biological variable. Our study examined male mice, because male animals exhibited less variability in phenotype....
Dysregulated fibrinolysis and plasmin activation promote the pathogenesis of osteoarthritis
Key molecules in the fibrinolysis pathway are dysregulated in human OA joints. To gain insight into the role of fibrinoly...
Natural antibodies drive type 2 immunity in response to damage-associated molecular patterns
DAMP-induced airway eosinophilia and antigen-specific CD4+ T cell priming is impaired in B cell–deficient mice. To probe ...
CETP inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia–associated mortality in mice
CETP inhibition improves Streptococcus pneumoniae–induced sepsis mortality in APOE*3-Leiden.CETP mice. Previously, we dem...
Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity
Sex as a biological variable As Fabry disease is an X-linked genetic disorder predominantly affecting males and our Fabry...
OGDH and Bcl-xL loss causes synthetic lethality in glioblastoma
Research ArticleOncology Open Access | 10.1172/jci.insight.172565 Trang T.T. Nguyen,1 Consu...
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models
Research ArticleAgingMetabolism Open Access | 10.1172/jci.insight.175462 Hoa T.T. Ha,1 SiYi...
In utero and postnatal ivacaftor/lumacaftor therapy rescues multiorgan disease in CFTR-F508del ferrets
Research ArticlePulmonologyTherapeutics Open Access | 10.1172/jci.insight.157229 Idil Apak Evan...
Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia
Research ArticleOncologyTherapeutics Open Access | 10.1172/jci.insight.173646 Ola A. Elgamal,1,...
Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction
Research ArticleOphthalmologyStem cells Open Access | 10.1172/jci.insight.174179 Yuki Otsuka,1,...
A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer
Single-cell expression atlas of PTC and ATC. We performed scRNA-Seq analysis to profile the cellular landscape of 48 samp...
Phase separation of SHP2E76K promotes malignant transformation of mesenchymal stem cells by activating mitochondrial complexes
MSCs harboring the SHP2E76K mutation undergo malignant transformation and initiate sarcomagenesis in mice. To better unde...
DDIT4L regulates mitochondrial and innate immune activities in early life
Research ArticleImmunology Open Access | 10.1172/jci.insight.172312 Christina Michalski,1,2 ...
Right ventricular cardiomyocyte expansion accompanies cardiac regeneration in newborn mice after large left ventricular infarcts
Functional recovery from LV ischemic heart injury involves a prominent adaptive response of the RV. In order to create co...
Activator protein transcription factors coordinate human IL-33 expression from noncanonical promoters in chronic airway disease
IL-33 is expressed from multiple promoters in chronic airway disease. We have previously shown that total IL33 and the tr...
GNAS AS2 methylation status enables mechanism-based categorization of pseudohypoparathyroidism type 1B
Methylation levels upstream of the XL exon are differentially affected according to underlying defects in patients with P...
Loss of T follicular regulatory cell–derived IL-1R2 augments germinal center reactions via increased IL-1
Cre-mediated excision of Il1r2 exon 3 results in loss of IL-1R2 protein. IL-1R2 is the first identified example of a deco...
Purine nucleoside phosphorylase inhibition is an effective approach for the treatment of chemical hemorrhagic cystitis
Sex as a biological variable. This study employed female young (3 months) Harlan Sprague-Dawley rats from Envigo. The CYP...
Tregs from human blood differentiate into nonlymphoid tissue–resident effector cells upon TNFR2 costimulation
Human tTreg characteristics are conserved after TNFR2 or CD28 costimulation. For this study, naive CD4+ Tconvs and Tregs ...
Modeling skeletal dysplasia in Hurler syndrome using patient-derived bone marrow osteoprogenitor cells
Technical AdvanceBone biologyStem cells Open Access | 10.1172/jci.insight.173449 Samantha Donsa...
Interventions to support fellowship application success among predoctoral physician-scientists
NIH investment in predoctoral physician-scientist training. The NRSA F30 awards (current NIH-funding opportunity announce...