SCI时时刷

search
Pathogenicity and impact of HLA class I alleles in aplastic anemia patients of different ethnicities
Research ArticleHematology Open Access | 10.1172/jci.insight.163040 Timothy S. Olson,1,2 Be...
Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
Research ArticleOncologyTherapeutics Open Access | 10.1172/jci.insight.160606 Jinmei Jin,1 ...
Targeting TNF-α–producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling
Diverse TAMs coexist in human PDA. Analysis of transcriptome data demonstrated that human PDA is characterized by excessi...
IL-6–targeted therapies to block the cytokine or its receptor drive distinct alterations in T cell function
Study approach and pharmacokinetics. In 2 independent single-arm, open-label clinical studies, a single dose of either an...
Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains
Research ArticleCardiology Open Access | 10.1172/jci.insight.162602 Lu Ren,1,2 Phung N. Tha...
Autophagy inducer rapamycin treatment reduces IFN-I–mediated Inflammation and improves anti–HIV-1 T cell response in vivo
Inhibition of autophagy by ATG5 disruption or bafilomycin A1 leads to increased IFN-I signaling in THP-1 cells. Monocytes...
Severe acute respiratory disease in American mink experimentally infected with SARS-CoV-2
Research ArticleCOVID-19 Open Access | 10.1172/jci.insight.159573 Danielle R. Adney,1,2 Jam...
A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy
Generation and flow cytometry screening of anti–human FSHR antibodies. FSHR is a tumor-associated antigen present in OC (...
Augmenting chemotherapy with low-dose decitabine through an immune-independent mechanism
Research ArticleOncology Open Access | 10.1172/jci.insight.159419 Wade R. Gutierrez,1,2,3,4 ...
Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells
Research ArticleCOVID-19Vaccines Open Access | 10.1172/jci.insight.163347 Yuta Yamaguchi,1,2 ...
Activated cholesterol metabolism is integral for innate macrophage responses by amplifying Myd88 signaling
Cellular cholesterol accumulates in response to TLR4 activation in macrophages. To begin investigating the potential inte...
Neoadjuvant chemotherapy drives intratumoral T cells toward a proinflammatory profile in pancreatic cancer
Clinical MedicineImmunologyOncology Open Access | 10.1172/jci.insight.152761 Max Heiduk,1,2 ...
Liposomal UHRF1 siRNA shows lung fibrosis treatment potential through regulation of fibroblast activation
Upregulation of UHRF1 in TGF-β1–stimulated fibroblasts and fibrotic lungs. First, we examined UHRF1 expression in fibrobl...
NLRC4-mediated activation of CD1c+ DC contributes to perpetuation of synovitis in rheumatoid arthritis
Research ArticleCell biology Open Access | 10.1172/jci.insight.152886 Cristina Delgado-Arévalo,...
The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
Loss of Phd1 but not Phd2 or Phd3 selectively protects mice against chronic colitis. Several studies have shown that loss...
Aberrant amino acid metabolism promotes neurovascular reactivity in rosacea
Patient information and sample collection. A total of 57 rosacea patients before and after treatment with doxycycline of ...
mTOR–neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.159247 Lunhao Chen,1 Yaling ...
Metabolites enhance innate resistance to human Mycobacterium tuberculosis infection
Research ArticleImmunology Open Access | 10.1172/jci.insight.152357 Deepak Tripathi,1 Kamak...
Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells
Research ArticleHematologyTransplantation Open Access | 10.1172/jci.insight.154250 Haroon Shaik...
Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia
Research ArticleCell biologyImmunology Open Access | 10.1172/jci.insight.154948 Matilde I. Cont...
Dicarbonyl-modified lipoproteins contribute to proteinuric kidney injury
Research ArticleNephrology Open Access | 10.1172/jci.insight.161878 Jianyong Zhong,1,2 Hai-...
Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment
Melanoma in Braf/Pten mice is associated with induction of TSLP in epidermis. To examine the role of TSLP in melanoma, we...
Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature
Resource availability Lead contact. Further information and requests for resources and reagents should be directed to and...
Deficiency of inhibitory TLR4 homolog RP105 exacerbates fibrosis
Cell culture and reagents. Primary cultures of fibroblasts were established by explanations from SSc and healthy adult sk...
Constitutive bone marrow adipocytes suppress local bone formation
Research ArticleBone biology Open Access | 10.1172/jci.insight.160915 Ziru Li,1 Devika P. B...
SARA suppresses myofibroblast precursor transdifferentiation in fibrogenesis in a mouse model of scleroderma
Effects of SARA overexpression in PDGFR-β+ cells on histological changes in a mouse SSc model. Pericytes are defined by t...