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Muscle: an independent contributor to the neuromuscular spinal muscular atrophy disease phenotype
SMA is commonly referred to as a spinal motor neuron disease (16). Consequently, muscle atrophy in the disease is often p...
MicroRNA-1 protects the endothelium in acute lung injury
Research ArticlePulmonologyVascular biology Open Access | 10.1172/jci.insight.164816 Asawari Ko...
Role of succinate in airway epithelial cell regulation following traumatic lung injury
Upregulated glycolysis in the presence of HIF-1α following LC. In our previous studies, we confirmed that doxycycline wil...
Regulation of human and mouse bystander T cell activation responses by PD-1
Research ArticleImmunology Open Access | 10.1172/jci.insight.173287 Catherine T. Le,1 Logan...
Cardiac gene therapy treats diabetic cardiomyopathy and lowers blood glucose
Animals and ethical approvals. Equal amount of male and female C57BLKS/J genetic background BKS.Cg-Dock7m +/+ Leprdb/J mi...
ACOT1 deficiency attenuates high-fat diet–induced fat mass gain by increasing energy expenditure
ACOT1KO attenuates HFD-induced weight gain. Mice with whole body ACOT1KO were purchased from the NIH Knockout Mouse Proje...
Modulating the polyamine/hypusine axis controls generation of CD8+ tissue-resident memory T cells
Research ArticleImmunologyMetabolism Open Access | 10.1172/jci.insight.169308 Aya G. Elmarsafaw...
A hybrid breast cancer/mesenchymal stem cell population enhances chemoresistance and metastasis
Research ArticleCell biologyOncology Open Access | 10.1172/jci.insight.164216 Giuseppina Augime...
Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation
Research ArticleBone biology Open Access | 10.1172/jci.insight.167790 Qiang Fu,1,2 Nancy C....
Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease
Loss of SERCA2 in human keratinocytes impairs cytosolic calcium handling and reduces intercellular adhesive strength. DD,...
Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections
Research ArticleCOVID-19 Open Access | 10.1172/jci.insight.172470 Kevin J. Selva,1 Pradhipa...
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas
Research ArticleMetabolismReproductive biology Open Access | 10.1172/jci.insight.171305 Azna Zu...
Ginger intake suppresses neutrophil extracellular trap formation in autoimmune mice and healthy humans
Ginger extract. A ginger extract (Ginactiv) was provided to us for research purposes by Aurea Biolabs (Kerala, India) in ...
TRAF4 is crucial for ST2+ memory Th2 cell expansion in IL-33–driven airway inflammation
Mice. B6. OT-II TCR-transgenic mice (stock no: 004194) and CD4-Cre–transgenic mice (stock no: 022071) were purchased from...
A phase I study of autologous mesenchymal stromal cells for severe steroid-dependent nephrotic syndrome
Clinical MedicineClinical trialsNephrology Open Access | 10.1172/jci.insight.169424 Marina Viva...
Muscle: to the neuromuscular disease phenotype in spinal muscular atrophy
SMA is commonly referred to as a spinal motor neuron disease (16). Consequently, muscle atrophy in the disease is often p...
SETD1A drives stemness by reprogramming the epigenetic landscape in hepatocellular carcinoma stem cells
A genome-wide CRISPR screening for factors contributing to HCC stemness. We used a pooled genome-wide CRISPR/Cas9 knockou...
Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis
Among the genes with shortened 3′UTRs in KIRC, UCK2 and MORC2 gain oncogenic potential. APA has emerged as a participator...
Maternal acellular pertussis vaccination in mice impairs cellular immunity to Bordetella pertussis infection in offspring
Maternal aP immunization prolongs nasal carriage of B. pertussis in infected neonatal mice. To investigate the influence ...
The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells
Research ArticleAIDS/HIVImmunology Open Access | 10.1172/jci.insight.169028 Dennis C. Copertino...
Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation
Research ArticleOncology Open Access | 10.1172/jci.insight.168445 Pan-Yu Chen,1 Benjamin J....
Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells
Decidual CD8+ T cells contain distinct Trm clusters not found in peripheral blood. To determine decidual CD8+ T cell dive...
Mocetinostat activates Krüppel-like factor 4 and protects against tissue destruction and inflammation in osteoarthritis
HTS of small molecules activating endogenous KLF4 expression. We established a KLF4 reporter cell line from SW1353 human ...
Single-cell profiling reveals inflammatory polarization of human carotid versus femoral plaque leukocytes
Technical AdvanceCardiologyInflammation Open Access | 10.1172/jci.insight.171359 Joshua Slysz,1...
DNASE1L3 enhances antitumor immunity and suppresses tumor progression in colon cancer
Research ArticleOncology Open Access | 10.1172/jci.insight.168161 Wenling Li,1,2 Hideki Nak...
Impaired 1,25-dihydroxyvitamin D3 action underlies enthesopathy development in the Hyp mouse model of X-linked hypophosphatemia
Impaired 1,25D action in mice leads to enhanced BMP and IHH signaling in Achilles entheses. Our previous studies demonstr...
Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta
Research ArticleCell biologyVascular biology Open Access | 10.1172/jci.insight.170845 Marycarme...
Argininosuccinate lyase deficiency causes blood-brain barrier disruption via nitric oxide–mediated dysregulation of claudin expression
Research ArticleGeneticsNeuroscience Open Access | 10.1172/jci.insight.168475 Jordan Kho,1 ...
The minichromosome maintenance complex drives esophageal basal zone hyperplasia
Participant inclusion criteria and biopsy sample acquisition Biopsies were acquired from individuals who were having an e...
Mitochondrial metabolites predict adverse cardiovascular events in individuals with diabetes
Research ArticleCardiologyMetabolism Open Access | 10.1172/jci.insight.168563 Jessica A. Regan,...
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