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IFN-signaling gene expression as a diagnostic biomarker for monogenic interferonopathies
Research ArticleInflammationNeuroscience Open Access | 10.1172/jci.insight.178456 Laura A. Adan...
Preclinical spheroid models identify BMX as a therapeutic target for metastatic MYCN nonamplified neuroblastoma
Research ArticleTherapeutics Open Access | 10.1172/jci.insight.169647 Santhoshkumar Sundaramoor...
Immunotoxin-mediated depletion of Gag-specific CD8+ T cells undermines natural control of SIV
Research ArticleAIDS/HIV Open Access | 10.1172/jci.insight.174168 Jennifer Simpson,1 Carly ...
Enhancing radiotherapy response via intratumoral injection of a TLR9 agonist in autochthonous murine sarcomas
Research ArticleImmunologyOncology Open Access | 10.1172/jci.insight.178767 Chang Su,1,2 Co...
Myocardial infarction causes sex-dependent dysfunction in vagal sensory glutamatergic neurotransmission that is mitigated by 17β-estradiol
BRS testing in mice after MI. The arterial baroreflex is critical for the regulation of BP and HR. Rises in BP led to act...
Treg and neutrophil extracellular trap interaction contributes to the development of immunosuppression in sepsis
Sex as a biological variable. For human participants, sex was not considered as a biological variable. Male mice were use...
Epithelial responses to CFTR modulators are improved by inflammatory cytokines and impaired by antiinflammatory drugs
Individual versus combined TNF-α and IL-17 differentially modulate CFTR modulator–evoked anion secretion. Transepithelial...
A dual-acting DNASE1/DNASE1L3 biologic prevents autoimmunity and death in genetic and induced lupus models
Research ArticleTherapeutics Open Access | 10.1172/jci.insight.177003 Paul R. Stabach,1 Dom...
Three-dimensional imaging of upper tract urothelial carcinoma improves diagnostic yield and accuracy
Research ArticleOncology Open Access | 10.1172/jci.insight.175751 Keishiro Fukumoto,1,2 Kan...
Chlorination of epithelial tight junction proteins by neutrophil myeloperoxidase promotes barrier dysfunction and mucosal inflammation
Loss of MPO attenuates acute DSS colitis severity. As an initial series of experiments to define the contribution of MPO ...
Protein kinase G2 activation restores Wnt signaling and bone mass in glucocorticoid-induced osteoporosis in mice
Cinaciguat prevents dexamethasone-induced inhibition of osteoblast proliferation, survival, and differentiation. Based on...
Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGF-β
scRNA-Seq analysis reveals AG immune response to physiological stressors. Macrophages are remarkably diverse immune cells...
Distinct glutamatergic projections of the posteroventral medial amygdala play different roles in arousal and anxiety
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.176329 Ying Li,1 Yuchen Deng...
4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer
Research ArticleOncologyTherapeutics Open Access | 10.1172/jci.insight.177857 Jiaxin Yin,1 ...
DRA involvement in linaclotide-stimulated bicarbonate secretion during loss of CFTR function
Linaclotide stimulates bicarbonate secretion in mouse and human duodenum. To determine linaclotide’s ability to stimulate...
FDXR variants cause adrenal insufficiency and atypical sexual development
Research ArticleEndocrinologyGenetics Open Access | 10.1172/jci.insight.179071 Emanuele Pignatt...
Preservation of naive-phenotype CD4+ T cells after vaccination contributes to durable immunity
Detection of naive-like CD4+ T cells after YFV vaccination. We had previously performed a longitudinal study of YFV-speci...
PM2.5 triggers tau aggregation in a mouse model of tauopathy
Sex as a biological variable. Our study examined male and female animals, and similar findings were reported for both sex...
Prenatal SARS-CoV-2 infection results in neurodevelopmental and behavioral outcomes in mice
Sex as a biological variable Mice of both sexes were used to account for sex as a biological variable. Study design The o...
IL-10 inhibition during immunization improves vaccine-induced protection against Staphylococcus aureus infection
IL-10 expression is upregulated in the nasal cavity of S. aureus persistently colonized individuals, and this is associat...
Pregnancy dedifferentiates memory CD8+ T cells into hypofunctional cells with exhaustion-enriched programs
Pregnancy successfully constrains immunological memory. To test whether semiallogeneic pregnancy is possible in females h...
HIV infection and ART exposure affect tumor TCR repertoire of diffuse large B cell lymphoma
Research ArticleAIDS/HIVHematology Open Access | 10.1172/jci.insight.180771 Sophia M. Roush,1 ...
IFN-λ uniquely promotes CD8 T cell immunity against SARS-CoV-2 relative to type I IFN
IFN-λ restricts SARS-CoV-2 replication in vivo. To assess the effects of IFN-λ on SARS-CoV-2 replication and pathogenesis...
PFKFB3 controls acinar IP3R-mediated Ca2+ overload to regulate acute pancreatitis severity
Research ArticleInflammationMetabolism Open Access | 10.1172/jci.insight.169481 Tan Zhang,1,2 ...
Factors associated with immune responses to SARS-CoV-2 vaccination in individuals with autoimmune diseases
Research Article Open Access | 10.1172/jci.insight.180750 Erik Anderson,1,2 Michael Powell,...
Protein biomarker signature in patients with spinal and bulbar muscular atrophy
Discovery of SBMA proteomic signature from patient cohorts. The outline of our study is shown in Figure 1. Briefly, we in...
ISG15/GRAIL1/CD3 axis influences survival of patients with esophageal adenocarcinoma
Lower CD3-ε expression within the tumor and the surrounding stroma is associated with BE progression to EAC. Utilizing mu...
Urinary cytokeratin 20 as a predictor for chronic kidney disease following acute kidney injury
Sex as a biological variable Similar findings are reported for both sexes (22, 23), but our study examined male mice beca...
Downregulation of adipose LPL by PAR2 contributes to the development of hypertriglyceridemia
Research ArticleMetabolism Open Access | 10.1172/jci.insight.173240 Yiheng Huang,1 Liujun C...
ADAM17 variant causes hair loss via ubiquitin ligase TRIM47–mediated degradation
Research ArticleDermatologyGenetics Open Access | 10.1172/jci.insight.177588 Xiaoxiao Wang,1,2 ...
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