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DDIT4L regulates mitochondrial and innate immune activities in early life
Research ArticleImmunology Open Access | 10.1172/jci.insight.172312 Christina Michalski,1,2 ...
Right ventricular cardiomyocyte expansion accompanies cardiac regeneration in newborn mice after large left ventricular infarcts
Functional recovery from LV ischemic heart injury involves a prominent adaptive response of the RV. In order to create co...
Activator protein transcription factors coordinate human IL-33 expression from noncanonical promoters in chronic airway disease
IL-33 is expressed from multiple promoters in chronic airway disease. We have previously shown that total IL33 and the tr...
GNAS AS2 methylation status enables mechanism-based categorization of pseudohypoparathyroidism type 1B
Methylation levels upstream of the XL exon are differentially affected according to underlying defects in patients with P...
Loss of T follicular regulatory cell–derived IL-1R2 augments germinal center reactions via increased IL-1
Cre-mediated excision of Il1r2 exon 3 results in loss of IL-1R2 protein. IL-1R2 is the first identified example of a deco...
Purine nucleoside phosphorylase inhibition is an effective approach for the treatment of chemical hemorrhagic cystitis
Sex as a biological variable. This study employed female young (3 months) Harlan Sprague-Dawley rats from Envigo. The CYP...
Tregs from human blood differentiate into nonlymphoid tissue–resident effector cells upon TNFR2 costimulation
Human tTreg characteristics are conserved after TNFR2 or CD28 costimulation. For this study, naive CD4+ Tconvs and Tregs ...
Modeling skeletal dysplasia in Hurler syndrome using patient-derived bone marrow osteoprogenitor cells
Technical AdvanceBone biologyStem cells Open Access | 10.1172/jci.insight.173449 Samantha Donsa...
Interventions to support fellowship application success among predoctoral physician-scientists
NIH investment in predoctoral physician-scientist training. The NRSA F30 awards (current NIH-funding opportunity announce...
A T cell–based SARS-CoV-2 spike protein vaccine provides protection without antibodies
Research ArticleCOVID-19Vaccines Open Access | 10.1172/jci.insight.155789 Juan Shi,1 Jian Z...
CDK1 inhibition reduces osteogenesis in endothelial cells in vascular calcification
CDK inhibitor AT7519 prevents endothelial lineage cells from undergoing osteogenic differentiation and reduces arterial c...
Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury
The expression of Sectm1a, a cardiac macrophage–enriched gene, is dynamically altered in macrophages upon myocardial I/R ...
PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age
Sex as biological variable. Our study examined male and female participants, and similar findings were obtained for both ...
Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells
Research ArticleCell biologyOncology Open Access | 10.1172/jci.insight.170961 Hunter D. Reavis,...
ADAMTSL2 mutations determine the phenotypic severity in geleophysic dysplasia
Technical AdvanceGenetics Open Access | 10.1172/jci.insight.174417 Vladimir Camarena,1 Moni...
Human MAIT cells inhibit alloreactive T cell responses and protect against acute graft-versus-host disease
Research ArticleImmunologyTransplantation Open Access | 10.1172/jci.insight.166310 Nana Talvard...
Adverse outcomes and an immunosuppressed endotype in septic patients with reduced IFN-γ ELISpot
Clinical MedicineImmunology Open Access | 10.1172/jci.insight.175785 Evan L. Barrios,1 Mont...
Integrin β1–rich extracellular vesicles of kidney recruit Fn1+ macrophages to aggravate ischemia-reperfusion–induced inflammation
Induction of AKI by IRI. To evaluate the degree of kidney injury at 24 hours after IRI, changes in renal function and pat...
Treatment of advanced atherosclerotic mice with ABT-263 reduced indices of plaque stability and increased mortality
Klf4 KO in SMC resulted in reduced overall lesion senescence. As an initial test of our hypothesis that the multiple bene...
IL-13 promotes functional recovery after myocardial infarction via direct signaling to macrophages
Macrophage deletion of IL-4Rα impairs cardiac functional recovery following neonatal MI. We previously demonstrated that ...
Spatial transcriptomics identifies candidate stromal drivers of benign prostatic hyperplasia
Spatial transcriptomics identifies factors secreted by presumptive inductive BPH stroma. McNeal observed that tangent duc...
Farnesoid X receptor mediates macrophage-intrinsic responses to suppress colitis-induced colon cancer progression
Animal experiments. C57BL/6J (WT; catalog 000664) mice were purchased from Jackson Laboratory. FXR whole-body KO mice (FX...
Schwann cells modulate nociception in neurofibromatosis 1
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.171275 Namrata G.R. Raut,1 L...
Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegeneration
Research ArticleAgingNeuroscience Open Access | 10.1172/jci.insight.162771 Michael K. Kanan,1 ...