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DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration
Subcutaneous DG9-PMO administration enhances survival and improves motor function and muscle strength. To examine whether...
Origin, prospective identification, and function of circulating endothelial colony-forming cells in mice and humans
Research ArticleVascular biology Open Access | 10.1172/jci.insight.164781 Yang Lin,1,2 Kimi...
Collectin-11 promotes cancer cell proliferation and tumor growth
Research ArticleImmunologyOncology Open Access | 10.1172/jci.insight.159452 Jia-Xing Wang,1 ...
Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx
Research ArticleEndocrinologyNephrology Open Access | 10.1172/jci.insight.154164 Michael Crompt...
CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling
Research ArticlePulmonology Open Access | 10.1172/jci.insight.161487 Marta Bueno,1 Jazmin C...
Parathyroid hormone 1 receptor signaling mediates breast cancer metastasis to bone in mice
Loss of PTH1R signaling in osteoblasts increases migration of 4T1 breast cancer cells in vitro. To determine whether migr...
CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque
Research ArticleCell biologyVascular biology Open Access | 10.1172/jci.insight.154922 Atsushi S...
An extended interval between vaccination and infection enhances hybrid immunity against SARS-CoV-2 variants
A longitudinal cohort of vaccinees with previous COVID-19 displayed improved SARS-CoV-2 neutralization compared with thos...
Effect of host factors and COVID-19 infection on the humoral immune repertoire in treated HIV
Research ArticleAIDS/HIVCOVID-19 Open Access | 10.1172/jci.insight.166848 Samuel R. Schnittman,...
Sialylation regulates neutrophil transepithelial migration, CD11b/CD18 activation, and intestinal mucosal inflammatory function
Sialylation-dependent regulation of intestinal PMN TEpM in vitro and in vivo. Given the heavily sialylated nature of PMN ...
A specific molecular signature in SARS-CoV-2–infected kidney biopsies
Research ArticleCOVID-19Nephrology Open Access | 10.1172/jci.insight.165192 Pierre Isnard,1,2 ...
Adipose-targeted SWELL1 deletion exacerbates obesity- and age-related nonalcoholic fatty liver disease
Adipose SWELL1 deletion limits adipose depot expansion with overnutrition. We showed previously that mice with adipose SW...
Malat1 deficiency prevents neonatal heart regeneration by inducing cardiomyocyte binucleation
Mouse strains. Malat1–/– and Malat1fl/fl mouse lines were described previously (38). Wild-type littermates were used as c...
Defective jagged-1 signaling affects GnRH development and contributes to congenital hypogonadotropic hypogonadism
Research ArticleDevelopmentGenetics Open Access | 10.1172/jci.insight.161998 Ludovica Cotelless...
Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility
Prdm6 interacts with MRTF-A. In an attempt to uncover novel mechanisms that regulate SMC-specific gene expression, we use...
The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease
Research ArticleImmunologyTransplantation Open Access | 10.1172/jci.insight.154440 Erica Dander...
Murine cytomegalovirus reactivation concomitant with acute graft-versus-host disease is controlled by antibodies
Research ArticleHematologyImmunology Open Access | 10.1172/jci.insight.149648 Martina Seefried,...
The different natural estrogens promote endothelial healing through distinct cell targets
Research ArticleEndocrinologyVascular biology Open Access | 10.1172/jci.insight.161284 Morgane ...
mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer
mTORis synergize with BETis in vitro. We first examined the combination of JQ1 (a prototype BETi) and a Mechanism Interro...
Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation
Research ArticleAngiogenesisVascular biology Open Access | 10.1172/jci.insight.160372 Xi Yang,1...
Insulin-like growth factor 1 reduces coronary atherosclerosis in pigs with familial hypercholesterolemia
Phenotype of FH pigs. We used 14-month-old FH noncastrated males (n = 5/group) and gilt (never been used for breeding) fe...
PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease
Research Article Open Access | 10.1172/jci.insight.166107 Dhruti P. Chen,1 Claudia P. Aiell...
SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis
Research ArticleOncology Open Access | 10.1172/jci.insight.154120 Yuchen Xie,1,2 Merve Sahi...
Targeting activin receptor–like kinase 7 ameliorates adiposity and associated metabolic disorders
ALK7-neutralizing Ab reduces adiposity in mouse models of genetic and dietary obesity. Previous mouse and human genetic f...
T follicular helper cells contribute to pathophysiology in a model of neuromyelitis optica spectrum disorders
In vivo electroporation induces AQP4 overexpression in skeletal muscle. The M23 isoform of AQP4 exists in the plasma memb...
Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma
Corrigendum Open Access | 10.1172/jci.insight.169136 Stephen M.F. Jamieson, Peter Tsai, ...
High-fat diet–induced vagal afferent dysfunction via upregulation of 2-pore domain potassium TRESK channel
Published in Volume 8, Issue 4 on February 22, 2023 JCI Insight. 2023;8(4):e169516. https://doi.org/10.1172/jci.insigh...
Effect of mechanical unloading on genome-wide DNA methylation profile of the failing human heart
Research ArticleCardiology Open Access | 10.1172/jci.insight.161788 Xianghai Liao,1 Peter J...
Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques
Research ArticleCOVID-19 Open Access | 10.1172/jci.insight.166485 Kyle Rosenke,1 Matt C. Le...
Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4
Research ArticleEndocrinologyMicrobiology Open Access | 10.1172/jci.insight.166655 Zhuang Li,1,...
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