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The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regenerat...
Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies
Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in c...
Recent advances in therapeutic strategies for triple-negative breast cancer
Recent advances in therapeutic strategies for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC) with a poor prognosis. Current tr...
Posttranslational control of lipogenesis in the tumor microenvironment
Posttranslational control of lipogenesis in the tumor microenvironment
Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutrit...
Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)
Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)
The vast majority of our knowledge regarding cancer radiobiology and the activation of radioresistance mechanisms emerged ...
CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR
CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR
Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stab...
Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy
Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy
Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-ligand 1, and cytotoxic T-lymphoc...
Targeting macrophages in hematological malignancies: recent advances and future directions
Targeting macrophages in hematological malignancies: recent advances and future directions
Emerging evidence indicates that the detection and clearance of cancer cells via phagocytosis induced by innate immune che...
Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry
Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome caused by pathogenic TP53 variants. The condition represent...
Oral eltanexor treatment of patients with higher-risk myelodysplastic syndrome refractory to hypomethylating agents
Oral eltanexor treatment of patients with higher-risk myelodysplastic syndrome refractory to hypomethylating agents
Patients with higher-risk myelodysplastic syndromes (MDS) refractory to hypomethylating agents (HMAs) have limited therape...
Correction: hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
Correction: hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
Yan Su and Xueyan Sun have contributed equally to this workPeking University People’s Hospital, Peking University Institut...
NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis
NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH), particularly primary HLH (pHLH), is a rare, life-threatening disease. Germline g...
hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
Both extracellular vesicles from mesenchymal stromal cell-derived human umbilical cords (hUC-EVs) and arsenic trioxides (A...
The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer
The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer
Mitochondria are essential for tumor growth and progression. However, the heavy demand for mitochondrial activity in cance...
Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms underlying stress adaptation of cance...