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Elraglusib (9-ING-41), a selective small-molecule inhibitor of glycogen synthase kinase-3 beta, reduces expression of immune checkpoint molecules PD-1, TIGIT and LAG-3 and enhances CD8+ T cell cytolytic killing of melanoma cells
Elraglusib (9-ING-41), a selective small-molecule inhibitor of glycogen synthase kinase-3 beta, reduces expression of immune checkpoint molecules PD-1, TIGIT and LAG-3 and enhances CD8+ T cell cytolytic killing of melanoma cells
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase with multiple roles in tumour growth, cell invasion and me...
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regenerat...
Correction to: A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety
Correction to: A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies
Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in c...
Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients
Somatic copy number alteration and fragmentation analysis in circulating tumor DNA for cancer screening and treatment monitoring in colorectal cancer patients
Analysis of circulating free DNA (cfDNA) is a promising tool for personalized management of colorectal cancer (CRC) patien...
Recent advances in therapeutic strategies for triple-negative breast cancer
Recent advances in therapeutic strategies for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer (BC) with a poor prognosis. Current tr...
Posttranslational control of lipogenesis in the tumor microenvironment
Posttranslational control of lipogenesis in the tumor microenvironment
Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutrit...
Treatment of myelodysplastic syndromes in the era of precision medicine and immunomodulatory drugs: a focus on higher-risk disease
Treatment of myelodysplastic syndromes in the era of precision medicine and immunomodulatory drugs: a focus on higher-risk disease
Myelodysplastic syndromes (MDS) are a heterogeneous clonal disease of myeloid neoplasms characterized by ineffective&n...
Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)
Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)
The vast majority of our knowledge regarding cancer radiobiology and the activation of radioresistance mechanisms emerged ...
CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR
CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR
Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stab...
Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thro...
Connecting telomere maintenance and regulation to the developmental origin and differentiation states of neuroblastoma tumor cells
Connecting telomere maintenance and regulation to the developmental origin and differentiation states of neuroblastoma tumor cells
A cardinal feature that distinguishes clinically high-risk neuroblastoma from low-risk tumors is telomere maintenance. Spe...
Osteosarcoma with cell-cycle and fibroblast growth factor genomic alterations: case report of Molecular Tumor Board combination strategy resulting in long-term exceptional response
Osteosarcoma with cell-cycle and fibroblast growth factor genomic alterations: case report of Molecular Tumor Board combination strategy resulting in long-term exceptional response
There is a paucity of information about molecularly driven therapy in osteosarcomas. We report a 31-year-old woman with ch...
Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy
Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy
Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-ligand 1, and cytotoxic T-lymphoc...
Triple MAPK inhibition salvaged a relapsed post-BCMA CAR-T cell therapy multiple myeloma patient with a BRAF V600E subclonal mutation
Triple MAPK inhibition salvaged a relapsed post-BCMA CAR-T cell therapy multiple myeloma patient with a BRAF V600E subclonal mutation
Multiple Myeloma (MM) is a progressive plasma cell neoplasm characterized by heterogeneous clonal expansion. Despite promi...
Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway
Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway
Lung adenocarcinoma (LUAD) is the leading cause of death worldwide. However, the roles of long noncoding RNAs (lncRNAs) hi...
Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial
Olverembatinib (HQP1351), a well-tolerated and effective tyrosine kinase inhibitor for patients with T315I-mutated chronic myeloid leukemia: results of an open-label, multicenter phase 1/2 trial
BCR-ABL1T315I mutations confer resistance to tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML). Olveremb...
Revealing the evolution of the tumor immune microenvironment in follicular lymphoma patients progressing within 24 months using single-cell imaging mass cytometry
Revealing the evolution of the tumor immune microenvironment in follicular lymphoma patients progressing within 24 months using single-cell imaging mass cytometry
Patients with follicular lymphoma (FL) who experience disease progression within 24 months (POD24) have inferior ...
Targeting macrophages in hematological malignancies: recent advances and future directions
Targeting macrophages in hematological malignancies: recent advances and future directions
Emerging evidence indicates that the detection and clearance of cancer cells via phagocytosis induced by innate immune che...
Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity
Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity
Characterized by the expression of the critical transcription factor forkhead box protein P3, regulatory T (Treg) cells ar...
Matched related transplantation versus immunosuppressive therapy plus eltrombopag for first-line treatment of severe aplastic anemia: a multicenter, prospective study
Matched related transplantation versus immunosuppressive therapy plus eltrombopag for first-line treatment of severe aplastic anemia: a multicenter, prospective study
This study prospectively compared the efficacy and safety between matched related donor-hematopoietic stem cell transplant...
Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry
Genotype–phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome caused by pathogenic TP53 variants. The condition represent...
Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma
Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma
Multiple myeloma (MM) and its precursors monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma ...
Oral eltanexor treatment of patients with higher-risk myelodysplastic syndrome refractory to hypomethylating agents
Oral eltanexor treatment of patients with higher-risk myelodysplastic syndrome refractory to hypomethylating agents
Patients with higher-risk myelodysplastic syndromes (MDS) refractory to hypomethylating agents (HMAs) have limited therape...
Correction: hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
Correction: hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
Yan Su and Xueyan Sun have contributed equally to this workPeking University People’s Hospital, Peking University Institut...
NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis
NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH), particularly primary HLH (pHLH), is a rare, life-threatening disease. Germline g...
Correction: Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer
Correction: Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whic...
hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
Both extracellular vesicles from mesenchymal stromal cell-derived human umbilical cords (hUC-EVs) and arsenic trioxides (A...
The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer
The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer
Mitochondria are essential for tumor growth and progression. However, the heavy demand for mitochondrial activity in cance...
Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms underlying stress adaptation of cance...
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