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Lipid-based nanosystems: the next generation of cancer immune therapy
Lipid-based nanosystems: the next generation of cancer immune therapy
Immunotherapy has become an important part of the oncotherapy arsenal. Its applicability in various cancer types is impres...
Advances in CAR-T-cell therapy in T-cell malignancies
Advances in CAR-T-cell therapy in T-cell malignancies
Significant advances have been made in chimeric antigen receptor T (CAR-T)-cell therapy for the treatment of recurrent or ...
Individualized dynamic frailty-tailored therapy (DynaFiT) in elderly patients with newly diagnosed multiple myeloma: a prospective study
Individualized dynamic frailty-tailored therapy (DynaFiT) in elderly patients with newly diagnosed multiple myeloma: a prospective study
It remains a substantial challenge to balance treatment efficacy and toxicity in geriatric patients with multiple myeloma ...
Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial
Memory T-cell enriched haploidentical transplantation with NK cell addback results in promising long-term outcomes: a phase II trial
Relapse remains a challenge after transplantation in pediatric patients with hematological malignancies. Myeloablative reg...
Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study
Non-invasive diagnosis of esophageal cancer by a simplified circulating cell-free DNA methylation assay targeting OTOP2 and KCNA3: a double-blinded, multicenter, prospective study
Esophageal cancer (EC) is a highly lethal disease lacking early detection approaches. We previously identified that OTOP2 ...
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development...
Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant
Remodeling of anti-tumor immunity with antibodies targeting a p53 mutant
p53, the most frequently mutated gene in cancer, lacks effective targeted drugs. We developed monoclonal antibodies (mAbs)...
Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy
Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy
Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours are known as tumour-associate...
Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia
Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia
Neutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs...
Impact of extramedullary multiple myeloma on outcomes with idecabtagene vicleucel
Impact of extramedullary multiple myeloma on outcomes with idecabtagene vicleucel
Idecabtagene vicleucel (Ide-cel) has demonstrated excellent efficacy and durable responses in patients with relapsed/refra...
Ferroptosis: principles and significance in health and disease
Ferroptosis: principles and significance in health and disease
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecul...
Current and future immunotherapeutic approaches in pancreatic cancer treatment
Current and future immunotherapeutic approaches in pancreatic cancer treatment
Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook and prognosis for this resistant...
Targeting FGFR for cancer therapy
Targeting FGFR for cancer therapy
The FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dys...
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Peripheral T cell lymphoma (PTCL) represents a group of heterogeneous hematological malignancies, which are notoriously ch...
Advances in targeting histone deacetylase for treatment of solid tumors
Advances in targeting histone deacetylase for treatment of solid tumors
Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have g...
Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening
Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening
Oncolytic viruses (OVs) offer a novel approach to treat solid tumors; however, their efficacy is frequently suboptimal due...
Generation of sarconoids from angiosarcoma patients as a systematic-based rational approach to treatment
Generation of sarconoids from angiosarcoma patients as a systematic-based rational approach to treatment
Angiosarcoma is a rare subtype of malignant neoplasm originating from vascular or lymphatic endothelial cells; its low inc...
PD-1 blockade immunotherapy as a successful rescue treatment for disseminated adenovirus infection after allogeneic hematopoietic stem cell transplantation
PD-1 blockade immunotherapy as a successful rescue treatment for disseminated adenovirus infection after allogeneic hematopoietic stem cell transplantation
Disseminated adenovirus infection is a complication with a relatively high mortality rate among patients undergoing hemato...
Critical role of the gut microbiota in immune responses and cancer immunotherapy
Critical role of the gut microbiota in immune responses and cancer immunotherapy
The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there...
Inotuzumab ozogamicin for the treatment of adult acute lymphoblastic leukemia: past progress, current research and future directions
Inotuzumab ozogamicin for the treatment of adult acute lymphoblastic leukemia: past progress, current research and future directions
Inotuzumab ozogamicin (INO) is an anti-CD22 antibody-drug conjugate that was first evaluated in B-cell lymphomas but was s...
Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immu...
Small molecule inhibitors targeting m6A regulators
Small molecule inhibitors targeting m6A regulators
As the most common form of epigenetic regulation by RNA, N6 methyladenosine (m6A) modification is closely involved in phys...
Identifying long-term survivors and those at higher or lower risk of relapse among patients with cytogenetically normal acute myeloid leukemia using a high-dimensional mixture cure model
Identifying long-term survivors and those at higher or lower risk of relapse among patients with cytogenetically normal acute myeloid leukemia using a high-dimensional mixture cure model
Patients with cytogenetically normal acute myeloid leukemia (CN-AML) may harbor prognostically relevant gene mutations and...
ChatGPT’s ability to generate realistic experimental images poses a new challenge to academic integrity
ChatGPT’s ability to generate realistic experimental images poses a new challenge to academic integrity
The rapid advancements in large language models (LLMs) such as ChatGPT have raised concerns about their potential impact o...
Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives
Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives
Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited therapeutic options and poor prognosis. I...
Germline biallelic BRCA2 pathogenic variants and medulloblastoma: an international cohort study
Germline biallelic BRCA2 pathogenic variants and medulloblastoma: an international cohort study
Constitutional heterozygous pathogenic variants in genes coding for some components of the Fanconi anemia-BRCA signaling p...
A higher CD34 + cell dose correlates with better event-free survival after KIR-ligand mismatched cord blood transplantation for childhood acute myeloid leukemia
A higher CD34 + cell dose correlates with better event-free survival after KIR-ligand mismatched cord blood transplantation for childhood acute myeloid leukemia
Although killer Ig-like receptor ligands (KIR-L) mismatch has been associated with alloreactive natural killer cell activi...
Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis
Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis
Tumor is a local tissue hyperplasia resulted from cancerous transformation of normal cells under the action of various phy...
Conventional and novel [18F]FDG PET/CT features as predictors of CAR-T cell therapy outcome in large B-cell lymphoma
Conventional and novel [18F]FDG PET/CT features as predictors of CAR-T cell therapy outcome in large B-cell lymphoma
Relapse and toxicity limit the effectiveness of chimeric antigen receptor T-cell (CAR-T) therapy for large B-cell lymphoma...
Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
EGFR and/or HER2 expression in pancreatic cancers is correlated with poor prognoses. We generated homodimeric (EGFRxEGFR o...
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