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Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy
Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy
Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours are known as tumour-associate...
Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia
Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia
Neutrophils play a crucial role in inflammation and in the increased thrombotic risk in myeloproliferative neoplasms (MPNs...
Impact of extramedullary multiple myeloma on outcomes with idecabtagene vicleucel
Impact of extramedullary multiple myeloma on outcomes with idecabtagene vicleucel
Idecabtagene vicleucel (Ide-cel) has demonstrated excellent efficacy and durable responses in patients with relapsed/refra...
Ferroptosis: principles and significance in health and disease
Ferroptosis: principles and significance in health and disease
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecul...
Current and future immunotherapeutic approaches in pancreatic cancer treatment
Current and future immunotherapeutic approaches in pancreatic cancer treatment
Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook and prognosis for this resistant...
Targeting FGFR for cancer therapy
Targeting FGFR for cancer therapy
The FGFR signaling pathway is integral to cellular activities, including proliferation, differentiation, and survival. Dys...
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Peripheral T cell lymphoma (PTCL) represents a group of heterogeneous hematological malignancies, which are notoriously ch...
Advances in targeting histone deacetylase for treatment of solid tumors
Advances in targeting histone deacetylase for treatment of solid tumors
Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have g...
Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening
Identification of restrictive molecules involved in oncolytic virotherapy using genome-wide CRISPR screening
Oncolytic viruses (OVs) offer a novel approach to treat solid tumors; however, their efficacy is frequently suboptimal due...
Generation of sarconoids from angiosarcoma patients as a systematic-based rational approach to treatment
Generation of sarconoids from angiosarcoma patients as a systematic-based rational approach to treatment
Angiosarcoma is a rare subtype of malignant neoplasm originating from vascular or lymphatic endothelial cells; its low inc...
Critical role of the gut microbiota in immune responses and cancer immunotherapy
Critical role of the gut microbiota in immune responses and cancer immunotherapy
The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there...
Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immu...
Small molecule inhibitors targeting m6A regulators
Small molecule inhibitors targeting m6A regulators
As the most common form of epigenetic regulation by RNA, N6 methyladenosine (m6A) modification is closely involved in phys...
ChatGPT’s ability to generate realistic experimental images poses a new challenge to academic integrity
ChatGPT’s ability to generate realistic experimental images poses a new challenge to academic integrity
The rapid advancements in large language models (LLMs) such as ChatGPT have raised concerns about their potential impact o...
Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives
Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives
Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited therapeutic options and poor prognosis. I...
Germline biallelic BRCA2 pathogenic variants and medulloblastoma: an international cohort study
Germline biallelic BRCA2 pathogenic variants and medulloblastoma: an international cohort study
Constitutional heterozygous pathogenic variants in genes coding for some components of the Fanconi anemia-BRCA signaling p...
Conventional and novel [18F]FDG PET/CT features as predictors of CAR-T cell therapy outcome in large B-cell lymphoma
Conventional and novel [18F]FDG PET/CT features as predictors of CAR-T cell therapy outcome in large B-cell lymphoma
Relapse and toxicity limit the effectiveness of chimeric antigen receptor T-cell (CAR-T) therapy for large B-cell lymphoma...
Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
Heterodimerization of T cell engaging bispecific antibodies to enhance specificity against pancreatic ductal adenocarcinoma
EGFR and/or HER2 expression in pancreatic cancers is correlated with poor prognoses. We generated homodimeric (EGFRxEGFR o...
Efficacy and safety of bendamustine for lymphodepletion before lisocabtagene maraleucel
Efficacy and safety of bendamustine for lymphodepletion before lisocabtagene maraleucel
Bendamustine has been retrospectively shown to be an effective and safe lymphodepletion regimen prior to the anti-CD19 chi...
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy
Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancem...
Identification of SARS-CoV-2-specific T cell and its receptor
Identification of SARS-CoV-2-specific T cell and its receptor
The T-cell receptor (TCR) repertoires exhibits distinct signatures associated with COVID-19 severity. However, the precise...
Targeting inflammation as cancer therapy
Targeting inflammation as cancer therapy
Inflammation has accompanied human beings since the emergence of wounds and infections. In the past decades, numerous effo...