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Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells
Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells
Abstract Mechanical stimulation plays in an important role in regulating stem cell differentiation and their release of ex...
Novel Anion Exchange Membrane Chromatography Method for the Separation of Empty and Full Adeno‐Associated Virus
Novel Anion Exchange Membrane Chromatography Method for the Separation of Empty and Full Adeno‐Associated Virus
Abstract A challenge in the production of recombinant Adeno-Associated Virus (AAV) for gene therapies is the presence of c...
Bacteriophage carriers localize in the brain of a rat model of neonatal hypoxic‐ischemic encephalopathy
Bacteriophage carriers localize in the brain of a rat model of neonatal hypoxic‐ischemic encephalopathy
Abstract Background Neonatal hypoxic-ischemic encephalopathy arises from a reduction of oxygen and blood supply to the inf...
Unravelling the promise and limitations of CRISPR/Cas system in natural product research: Approaches and challenges
Unravelling the promise and limitations of CRISPR/Cas system in natural product research: Approaches and challenges
Abstract An incredible array of natural products are produced by plants that serve several ecological functions, including...
Advancements in nucleic acids‐based techniques for bone regeneration
Advancements in nucleic acids‐based techniques for bone regeneration
Abstract The dynamic biology of bone involving an enormous magnitude of cellular interactions and signaling transduction p...
Improving genomically recoded Escherichia coli to produce proteins containing non‐canonical amino acids
Improving genomically recoded Escherichia coli to produce proteins containing non‐canonical amino acids
Abstract A genomically recoded Escherichia coli strain that lacks all amber codons and release factor 1 (C321.∆A) e...
Dinucleotide tag‐based parallel reporter gene assay method enables efficient identification of regulatory mutations
Dinucleotide tag‐based parallel reporter gene assay method enables efficient identification of regulatory mutations
Abstract Background : The causal single nucleotide polymorphisms (SNPs) leading to increased cancer predisposition mainly ...
An integrative multiomics approach to characterize anti‐adipogenic and anti‐lipogenic effects of Akkermansia muciniphila in adipocytes
An integrative multiomics approach to characterize anti‐adipogenic and anti‐lipogenic effects of Akkermansia muciniphila in adipocytes
Abstract The cellular components of Akkermansia muciniphila are considered potential biotherapeutics for the improvement o...
Curcumin biosynthesis from ferulic acid by engineered Saccharomyces cerevisiae
Curcumin biosynthesis from ferulic acid by engineered Saccharomyces cerevisiae
Abstract Background and Goal : Curcumin is a polyphenolic compound found in Curcuma longa. This bioactive molecule has sev...
Rational hinge engineering of carboxylic acid reductase from Mycobacterium smegmatis enhances its catalytic efficiency in biocatalysis
Rational hinge engineering of carboxylic acid reductase from Mycobacterium smegmatis enhances its catalytic efficiency in biocatalysis
Abstract Background: Carboxylic acid reductases (CARs) represent useful tools for the production of aldehydes from ubiquit...
Improvement of acetyl‐CoA supply and glucose utilization increases l‐leucine production in Corynebacterium glutamicum
Improvement of acetyl‐CoA supply and glucose utilization increases l‐leucine production in Corynebacterium glutamicum
Abstract Background l-Leucine is one of important essential amino acids with multiple industrial applications, whose marke...
Deletion analysis of Pichia pastoris alcohol dehydrogenase 2 (ADH2) promoter and development of synthetic promoters
Deletion analysis of Pichia pastoris alcohol dehydrogenase 2 (ADH2) promoter and development of synthetic promoters
Abstract Pichia pastoris (Komagataella phaffii) is a non-conventional Crabtree-negative yeast with the capability of reach...
The Economic Value of Genetically Engineered Mosquitoes as a Malaria Control Strategy Depends on Local Transmission Rates
The Economic Value of Genetically Engineered Mosquitoes as a Malaria Control Strategy Depends on Local Transmission Rates
Abstract Aim: This paper assesses the economic value of genetically engineered (GE) Anopheles gambiae mosquitoes as a mala...
Virus Inactivation at Moderately Low pH Varies with Virus and Buffer Properties
Virus Inactivation at Moderately Low pH Varies with Virus and Buffer Properties
Abstract Background Virus inactivation is a critical operation in therapeutic protein manufacturing. Low pH buffers are a ...
Outside Front Cover: (Biotechnology Journal 12/2021)
Outside Front Cover: (Biotechnology Journal 12/2021)
The cover image is based on the Review Rational engineering and applications of functional bioadhesives in biomedical engi...
Editorial Board: Biotechnology Journal 12/2021
Editorial Board: Biotechnology Journal 12/2021
Volume 16, Issue 12 2170122 PDF ShareShare Pl...
Single‐strand annealing: Molecular mechanisms and potential applications in CRISPR‐Cas‐based precision genome editing
Single‐strand annealing: Molecular mechanisms and potential applications in CRISPR‐Cas‐based precision genome editing
Abstract Background Spontaneous double-stranded DNA breaks (DSBs) frequently occur within the genome of all living organis...
CRISPRa/i with adaptive single guide assisted regulation DNA (ASGARD) mediated control of Chlorella sorokiniana to enhance lipid and protein production
CRISPRa/i with adaptive single guide assisted regulation DNA (ASGARD) mediated control of Chlorella sorokiniana to enhance lipid and protein production
Abstract Chlorella species are indispensable microalgae for biorefinery but are hardly in DNA manipulation due to the high...
Key Criteria for Engineering Mycotoxin Binding Aptamers via Computational Simulations: Aflatoxin B1 as a Case Study
Key Criteria for Engineering Mycotoxin Binding Aptamers via Computational Simulations: Aflatoxin B1 as a Case Study
Abstract Due to the difficulties in monoclonal antibody production specific to mycotoxins, aptameric probes have been cons...
Designing microfluidic devices for behavioral screening of multiple zebrafish larvae
Designing microfluidic devices for behavioral screening of multiple zebrafish larvae
Abstract Background Microfluidic devices are being used for phenotypic screening of zebrafish larvae in fundamental and pr...
Ultrasound assisted in‐situ separation of sophorolipids in multi‐phase fermentation system to achieve efficient production by Candida bombicola
Ultrasound assisted in‐situ separation of sophorolipids in multi‐phase fermentation system to achieve efficient production by Candida bombicola
Abstract Background Sophorolipids (SLs) are regarded as one of the most promising biosurfactants. However, high production...
Massively parallel DNA target capture using long adapter single stranded oligonucleotide (LASSO) probes assembled through a novel DNA recombinase mediated methodology
Massively parallel DNA target capture using long adapter single stranded oligonucleotide (LASSO) probes assembled through a novel DNA recombinase mediated methodology
Abstract In the attempt to bridge the widening gap from DNA sequence to biological function, we developed a novel methodol...
T‐cell surface generation of dual bivalent, bispecific T‐cell engaging, RNA duplex cross‐linked antibodies (dbBiTERs) for re‐directed tumor cell lysis
T‐cell surface generation of dual bivalent, bispecific T‐cell engaging, RNA duplex cross‐linked antibodies (dbBiTERs) for re‐directed tumor cell lysis
Abstract Background Genetic engineered Bispecific T-cell engagers (BiTEs) generate potent cytotoxic effects. Methods Alter...
Antimicrobial and antiviral activities with molecular docking study of chitosan/carrageenan@clove oil beads
Antimicrobial and antiviral activities with molecular docking study of chitosan/carrageenan@clove oil beads
Abstract Background : Biopolymers are promising candidates that can be fabricated into hydrophilic matrices and used for m...
Green and ecofriendly biosynthesis of selenium nanoparticles using Urtica dioica (Stinging nettle) leaf extract: Antimicrobial and anticancer activity
Green and ecofriendly biosynthesis of selenium nanoparticles using Urtica dioica (Stinging nettle) leaf extract: Antimicrobial and anticancer activity
Abstract Background/goal/aim Plant extract is affordable and does not require any particular conditions; rapid production ...
Epitope Screening Using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX‐MS): An Accelerated Workflow for Evaluation of Lead Monoclonal Antibodies
Epitope Screening Using Hydrogen/Deuterium Exchange Mass Spectrometry (HDX‐MS): An Accelerated Workflow for Evaluation of Lead Monoclonal Antibodies
Abstract Background : Epitope mapping is an increasingly important aspect of biotherapeutic and vaccine development. Recen...
Mechanistic discoveries and simulation‐guided assay optimization of portable hormone biosensors with cell‐free protein synthesis
Mechanistic discoveries and simulation‐guided assay optimization of portable hormone biosensors with cell‐free protein synthesis
Abstract Nuclear receptors influence nearly every system of the body and our lives depend on correct nuclear receptor sign...
Editorial Board: Biotechnology Journal 11/2021
Editorial Board: Biotechnology Journal 11/2021
Volume 16, Issue 11 2170112 PDF ShareShare Pl...
Outside Front Cover: (Biotechnology Journal 11/2021)
Outside Front Cover: (Biotechnology Journal 11/2021)
Cover Image © Kateryna Kon/Science Photo Library/Getty Images.
A BioBricks® toolbox for metabolic engineering of the tetracenomycin pathway
A BioBricks® toolbox for metabolic engineering of the tetracenomycin pathway
Abstract Background/Goal/Aim The tetracenomycins are aromatic anticancer polyketides that inhibit peptide translation via ...
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