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The Relationship between White Matter Architecture and Language Lateralization in the Healthy Brain
The Relationship between White Matter Architecture and Language Lateralization in the Healthy Brain
Study data and participantsAll data were acquired from the Human Connectome Project (HCP; http://www.humanconnectome.org/)...
Restoring Compromised Cl- in D2 Neurons of a Huntingtons Disease Mouse Model Rescues Motor Disability
Restoring Compromised Cl- in D2 Neurons of a Huntingtons Disease Mouse Model Rescues Motor Disability
Figure 3. KCC2 function is altered specifically in D2 MSNs of R6/2 mice. A, Image showing infection site of AAV5-mCherry i...
Disruption of the Autism-Associated Pcdh9 Gene Leads to Transcriptional Alterations, Synapse Overgrowth, and Defective Network Activity in the CA1
Disruption of the Autism-Associated Pcdh9 Gene Leads to Transcriptional Alterations, Synapse Overgrowth, and Defective Network Activity in the CA1
Protocadherins, a family of adhesion molecules with a crucial role in cell–cell interactions, have emerged as key players ...
Metabotropic NMDAR Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory
Metabotropic NMDAR Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory
NMDA receptor (NMDAR)-mediated calcium influx triggers the induction and initial expression of long-term potentiation (LTP...
Defects in Exosome Biogenesis Are Associated with Sensorimotor Defects in Zebrafish vps4a Mutants
Defects in Exosome Biogenesis Are Associated with Sensorimotor Defects in Zebrafish vps4a Mutants
Mutations in human VPS4A are associated with neurodevelopmental defects, including motor delays and defective muscle tone....
Alpha Traveling Waves during Working Memory: Disentangling Bottom-Up Gating and Top-Down Gain Control
Alpha Traveling Waves during Working Memory: Disentangling Bottom-Up Gating and Top-Down Gain Control
AbstractWhile previous works established the inhibitory role of alpha oscillations during working memory maintenance, it r...
Auditory Competition and Stimulus Selection across Spatial Locations from Midbrain to Forebrain in Barn Owls
Auditory Competition and Stimulus Selection across Spatial Locations from Midbrain to Forebrain in Barn Owls
Barn owls enable investigation of neural mechanisms underlying stimulus selection of concurrent stimuli. The audiovisual s...
Effects of Ketamine on Frontoparietal Interactions in a Rule-Based Antisaccade Task in Macaque Monkeys
Effects of Ketamine on Frontoparietal Interactions in a Rule-Based Antisaccade Task in Macaque Monkeys
Cognitive control is engaged by working memory processes and high-demand situations like antisaccade, where one must suppr...
The Challenges of Modulating Neuroinflammation in Alzheimer's Disease and Multiple Sclerosis with TREM2 Agonistic Antibodies
The Challenges of Modulating Neuroinflammation in Alzheimer's Disease and Multiple Sclerosis with TREM2 Agonistic Antibodies
Alzheimer's disease (AD) and multiple sclerosis (MS) are neurodegenerative diseases in which aberrant inflammatory process...
Dendritic Spines of Layer 5 Pyramidal Neurons of the Aging Somatosensory Cortex Exhibit Reduced Volumetric Remodeling
Dendritic Spines of Layer 5 Pyramidal Neurons of the Aging Somatosensory Cortex Exhibit Reduced Volumetric Remodeling
Impairments in synaptic dynamics and stability are observed both in neurodegenerative disorders and in the healthy aging c...
It Takes Three: Parental Hostility, Brain Morphology, and Child Externalizing Problems in a Parent-Offspring Neuroimaging Trio Design
It Takes Three: Parental Hostility, Brain Morphology, and Child Externalizing Problems in a Parent-Offspring Neuroimaging Trio Design
Hostility often co-occurs in parents and associates with increased aggression and inattention problems in children. In thi...
Critical Involvement of Actin Stabilizer TMOD2 in Cocaine-Induced Neuroadaptations
Critical Involvement of Actin Stabilizer TMOD2 in Cocaine-Induced Neuroadaptations
Repeated exposure to addictive drugs leads to the increase in drug-seeking behavior (the effort to obtain a drug when it i...
Optogenetic Stimulation Recruits Cortical Neurons in a Morphology-Dependent Manner
Optogenetic Stimulation Recruits Cortical Neurons in a Morphology-Dependent Manner
Single-photon optogenetics enables precise, cell-type–specific modulation of neuronal circuits, making it a crucial tool i...
The Excessive Tonic Inhibition of the Peri-infarct Cortex Depresses Low Gamma Rhythm Power During Poststroke Recovery
The Excessive Tonic Inhibition of the Peri-infarct Cortex Depresses Low Gamma Rhythm Power During Poststroke Recovery
The cortex immediately surrounding a brain ischemic lesion, the peri-infarct cortex (PIC), harbors a large part of the pot...
Neural Correlates of Category Learning in Monkey Inferior Temporal Cortex
Neural Correlates of Category Learning in Monkey Inferior Temporal Cortex
Neural Correlates of Category Learning in Monkey Inferior Temporal Cortex Jonah E. Pearl, Narihi...
Glutamate Signaling and Neuroligin/Neurexin Adhesion Play Opposing Roles That Are Mediated by Major Histocompatibility Complex I Molecules in Cortical Synapse Formation
Glutamate Signaling and Neuroligin/Neurexin Adhesion Play Opposing Roles That Are Mediated by Major Histocompatibility Complex I Molecules in Cortical Synapse Formation
Although neurons release neurotransmitter before contact, the role for this release in synapse formation remains unclear. ...
Fast Feature- and Category-Related Parafoveal Previewing Support Free Visual Exploration
Fast Feature- and Category-Related Parafoveal Previewing Support Free Visual Exploration
AbstractWhile humans typically saccade every ∼250 ms in natural settings, studies on vision tend to prevent or restrict ey...
Involvement of Neurons in the Nonhuman Primate Anterior Striatum in Proactive Inhibition
Involvement of Neurons in the Nonhuman Primate Anterior Striatum in Proactive Inhibition
All behavioral and neurophysiological data were preprocessed with MATLAB 2022b (MathWorks).BehaviorIn the choice task, sac...
Prevalent Harmonic Interaction in the Bat Inferior Colliculus
Prevalent Harmonic Interaction in the Bat Inferior Colliculus
Animal vocalizations and human speech are typically characterized by a complex spectrotemporal structure, composed of mult...
Distinct Functional Classes of CA1 Hippocampal Interneurons Are Modulated by Cerebellar Stimulation in a Coordinated Manner
Distinct Functional Classes of CA1 Hippocampal Interneurons Are Modulated by Cerebellar Stimulation in a Coordinated Manner
There is mounting evidence that the cerebellum impacts hippocampal functioning, but the impact of the cerebellum on hippoc...
Direct Piriform-to-Auditory Cortical Projections Shape Auditory-Olfactory Integration
Direct Piriform-to-Auditory Cortical Projections Shape Auditory-Olfactory Integration
In a real-world environment, the brain must integrate information from multiple sensory modalities, including the auditory...
Developmental Syngap1 Haploinsufficiency in Medial Ganglionic Eminence-Derived Interneurons Impairs Auditory Cortex Activity, Social Behavior, and Extinction of Fear Memory
Developmental Syngap1 Haploinsufficiency in Medial Ganglionic Eminence-Derived Interneurons Impairs Auditory Cortex Activity, Social Behavior, and Extinction of Fear Memory
AbstractMutations in SYNGAP1, a protein enriched at glutamatergic synapses, cause intellectual disability associated with ...
Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread
Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread
The transmission of tau pathology has been proposed as one of the major mechanisms for the spatiotemporal spreading of tau...
A "Conscious" Loss of Balance: Directing Attention to Movement Can Impair the Cortical Response to Postural Perturbations
A "Conscious" Loss of Balance: Directing Attention to Movement Can Impair the Cortical Response to Postural Perturbations
Abstract“Trying too hard” can interfere with skilled movement, such as sports and music playing. Postural control can simi...
Estrous Cycle-Dependent Modulation of Sexual Receptivity in Female Mice by Estrogen Receptor Beta-Expressing Cells in the Dorsal Raphe Nucleus
Estrous Cycle-Dependent Modulation of Sexual Receptivity in Female Mice by Estrogen Receptor Beta-Expressing Cells in the Dorsal Raphe Nucleus
The sexual receptivity of female mice, shown as lordosis response, is mainly regulated by estradiol action on estrogen rec...
Neural Transformation from Retinotopic to Background-Centric Coordinates in the Macaque Precuneus
Neural Transformation from Retinotopic to Background-Centric Coordinates in the Macaque Precuneus
IntroductionThere has been accumulated psychophysical evidence since a seminal report by Melcher and Morrone (2003) that v...
More Than a Small Brain: The Importance of Studying Neural Function during Development
More Than a Small Brain: The Importance of Studying Neural Function during Development
AbstractThe nervous system contains complex circuits comprising thousands of cell types and trillions of connections. Here...
Haploinsufficiency of Syngap1 in Striatal Indirect Pathway Neurons Alters Motor and Goal-Directed Behaviors in Mice
Haploinsufficiency of Syngap1 in Striatal Indirect Pathway Neurons Alters Motor and Goal-Directed Behaviors in Mice
IntroductionMutations in the SYNGAP1 gene lead to a neurodevelopmental disorder (NDD) that presents with intellectual disa...
Guidelines for Inclusive and Diverse Human Neuroscience Research Practices
Guidelines for Inclusive and Diverse Human Neuroscience Research Practices
Although neurosciences have made notable progress in theory and technology, a significant methodological issue persists wi...
The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin
The Alzheimer's Disease Risk Gene CD2AP Functions in Dendritic Spines by Remodeling F-Actin
CD2-associated protein (CD2AP) was identified as a genetic risk factor for late-onset Alzheimer's disease (LOAD). However,...
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