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Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via {alpha}2{delta}-1 in Spinal Excitatory Neurons
Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via {alpha}2{delta}-1 in Spinal Excitatory Neurons
Calcineurin inhibitors, such as cyclosporine and tacrolimus (FK506), are commonly used immunosuppressants for preserving t...
Development of the Fetal Brain Corticocortical Structural Network during the Second-to-Third Trimester Based on Diffusion MRI
Development of the Fetal Brain Corticocortical Structural Network during the Second-to-Third Trimester Based on Diffusion MRI
During the second-to-third trimester, the neuronal pathways of the fetal brain experience rapid development, resulting in ...
Computation on Demand: Action-Specific Representations of Visual Task Features Arise during Distinct Movement Phases
Computation on Demand: Action-Specific Representations of Visual Task Features Arise during Distinct Movement Phases
The intention to act influences the computations of various task-relevant features. However, little is known about the tim...
The Small G-Protein Rac1 in the Dorsomedial Striatum Promotes Alcohol-Dependent Structural Plasticity and Goal-Directed Learning in Mice
The Small G-Protein Rac1 in the Dorsomedial Striatum Promotes Alcohol-Dependent Structural Plasticity and Goal-Directed Learning in Mice
The small G-protein Ras–related C3 botulinum toxin substrate 1 (Rac1) promotes the formation of filamentous actin (F-actin...
Neuronal Coupling Modes Show Differential Development in the Early Cortical Activity Networks of Human Newborns
Neuronal Coupling Modes Show Differential Development in the Early Cortical Activity Networks of Human Newborns
The third trimester is a critical period for the development of functional networks that support the lifelong neurocogniti...
Impact of Extracellular Current Flow on Action Potential Propagation in Myelinated Axons
Impact of Extracellular Current Flow on Action Potential Propagation in Myelinated Axons
Myelinated axons conduct action potentials, or spikes, in a saltatory manner. Inward current caused by a spike occurring a...
The Time-Course of Food Representation in the Human Brain
The Time-Course of Food Representation in the Human Brain
Humans make decisions about food every day. The visual system provides important information that forms a basis for these ...
Transient Attention Gates Access Consciousness: Coupling N2pc and P3 Latencies Using Dynamic Time Warping
Transient Attention Gates Access Consciousness: Coupling N2pc and P3 Latencies Using Dynamic Time Warping
AbstractThe N2pc and P3 event-related potentials (ERPs), used to index selective attention and access to working memory an...
Biophysics of Frequency-Dependent Variation in Paresthesia and Pain Relief during Spinal Cord Stimulation
Biophysics of Frequency-Dependent Variation in Paresthesia and Pain Relief during Spinal Cord Stimulation
The neurophysiological effects of spinal cord stimulation (SCS) for chronic pain are poorly understood, resulting in ineff...
Striatal Dopamine Contributions to Skilled Motor Learning
Striatal Dopamine Contributions to Skilled Motor Learning
Coordinated multijoint limb and digit movements—“manual dexterity”—underlie both specialized skills (e.g., playing the pia...
Suspending the Embodied Self in Meditation Attenuates Beta Oscillations in the Posterior Medial Cortex
Suspending the Embodied Self in Meditation Attenuates Beta Oscillations in the Posterior Medial Cortex
Human experience is imbued by the sense of being an embodied agent. The investigation of such basic self-consciousness has...
Seven Tesla Evidence for Columnar and Rostral-Caudal Organization of the Human Periaqueductal Gray Response in the Absence of Threat: A Working Memory Study
Seven Tesla Evidence for Columnar and Rostral-Caudal Organization of the Human Periaqueductal Gray Response in the Absence of Threat: A Working Memory Study
AbstractThe periaqueductal gray (PAG) is a small midbrain structure that surrounds the cerebral aqueduct, regulates brain–...
Separate Cue- and Alpha-Related Mechanisms for Distractor Suppression
Separate Cue- and Alpha-Related Mechanisms for Distractor Suppression
Research on selective attention has largely focused on the enhancement of behaviorally important information, with less fo...
Inhibitory Subpopulations in preBötzinger Complex Play Distinct Roles in Modulating Inspiratory Rhythm and Pattern
Inhibitory Subpopulations in preBötzinger Complex Play Distinct Roles in Modulating Inspiratory Rhythm and Pattern
Inhibitory neurons embedded within mammalian neural circuits shape breathing, walking, and other rhythmic motor behaviors....
Structural Connectivity between Olfactory Tubercle and Ventrolateral Periaqueductal Gray Implicated in Human Feeding Behavior
Structural Connectivity between Olfactory Tubercle and Ventrolateral Periaqueductal Gray Implicated in Human Feeding Behavior
The olfactory tubercle (TUB), also called the tubular striatum, receives direct input from the olfactory bulb and, along w...
Erroneous Compensation for Long-Latency Feedback Delays as Origin of Essential Tremor
Erroneous Compensation for Long-Latency Feedback Delays as Origin of Essential Tremor
Essential tremor (ET), a movement disorder characterized by involuntary oscillations of the limbs during movement, remains...
Superagers Resist Typical Age-Related White Matter Structural Changes
Superagers Resist Typical Age-Related White Matter Structural Changes
AbstractSuperagers are elderly individuals with the memory ability of people 30 years younger and provide evidence that ag...
Cortical Networks Relating to Arousal Are Differentially Coupled to Neural Activity and Hemodynamics
Cortical Networks Relating to Arousal Are Differentially Coupled to Neural Activity and Hemodynamics
IntroductionThe cerebral cortex shows constant activity even in the absence of overt behaviors. This spontaneous resting-s...
Edge-Community Entropy Is a Novel Neural Correlate of Aging and Moderator of Fluid Cognition
Edge-Community Entropy Is a Novel Neural Correlate of Aging and Moderator of Fluid Cognition
Decreased neuronal specificity of the brain in response to cognitive demands (i.e., neural dedifferentiation) has been imp...
Transcranial Alternating Current Stimulation over Frontal Eye Fields Mimics Attentional Modulation of Visual Processing
Transcranial Alternating Current Stimulation over Frontal Eye Fields Mimics Attentional Modulation of Visual Processing
Attentional control over sensory processing has been linked to neural alpha oscillations and related inhibition of cerebra...
Thalamocortical Dynamics during Rapid Eye Movement Sleep in the Mouse Somatosensory Pathway
Thalamocortical Dynamics during Rapid Eye Movement Sleep in the Mouse Somatosensory Pathway
Rapid eye movement (REM) sleep, also referred to as paradoxical sleep for the striking resemblance of its electroencephalo...
The Molecular Logic of Synaptic Specificity in the Retinocollicular Pathway
The Molecular Logic of Synaptic Specificity in the Retinocollicular Pathway
Vision is vital for many animals to interact with the world around them. Visual perception commences within the retina, wh...
Altered Hierarchical Gradients of Intrinsic Neural Timescales in Mild Cognitive Impairment and Alzheimer's Disease
Altered Hierarchical Gradients of Intrinsic Neural Timescales in Mild Cognitive Impairment and Alzheimer's Disease
Alzheimer's disease (AD) is a devastating neurodegenerative disease that affects millions of seniors in the United States....
Memory Reactivation during Sleep Does Not Act Holistically on Object Memory
Memory Reactivation during Sleep Does Not Act Holistically on Object Memory
Memory reactivation during sleep is thought to facilitate memory consolidation. Most sleep reactivation research has exami...
A Reconsideration of the Core and Matrix Classification of Thalamocortical Projections
A Reconsideration of the Core and Matrix Classification of Thalamocortical Projections
In 1998, Jones suggested a classification of thalamocortical projections into core and matrix divisions (Jones, 1998). In ...
Differences in Neural Activation between Actual Tool Use and Pantomime: Evidence for Two Different Streams?
Differences in Neural Activation between Actual Tool Use and Pantomime: Evidence for Two Different Streams?
Using tools is an extraordinarily refined motor skill in humans (Vaesen, 2012). The neural correlates of tool use have bee...
Synapse-Specific Trapping of SNARE Machinery Proteins in the Anesthetized Drosophila Brain
Synapse-Specific Trapping of SNARE Machinery Proteins in the Anesthetized Drosophila Brain
General anesthetics disrupt brain network dynamics through multiple pathways, in part through postsynaptic potentiation of...
Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials
Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials
Laboratory animalsCortical astrocytes were prepared using C57BL/6N mice of either sex at postnatal day (P) 0–3. Mixed cult...
Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex
Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex
Acetylcholine is a robust neuromodulator of the limbic system and a critical regulator of arousal and emotions. The anteri...
Novel Electrophysiological Signatures of Learning and Forgetting in Human Rapid Eye Movement Sleep
Novel Electrophysiological Signatures of Learning and Forgetting in Human Rapid Eye Movement Sleep
Despite the known behavioral benefits of rapid eye movement (REM) sleep, discrete neural oscillatory events in human scalp...
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