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Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
Selective Serotonin Reuptake Inhibitors within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane
Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed treatment for individuals experiencing major depre...
Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3
Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3
Substance use disorder is a chronic disease and a leading cause of disability around the world. The NAc is a major brain h...
Innexin-Mediated Adhesion between Glia Is Required for Axon Ensheathment in the Peripheral Nervous System
Innexin-Mediated Adhesion between Glia Is Required for Axon Ensheathment in the Peripheral Nervous System
Glia are essential to protecting and enabling nervous system function and a key glial function is the formation of the gli...
A Role for KCNQ Channels on Cell Type-Specific Plasticity in Mouse Auditory Cortex after Peripheral Damage
A Role for KCNQ Channels on Cell Type-Specific Plasticity in Mouse Auditory Cortex after Peripheral Damage
Damage to sensory organs triggers compensatory plasticity mechanisms in sensory cortices. These plasticity mechanisms resu...
A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition
A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition
IntroductionCholecystokinin (CCK), the most abundant and widely distributed neuropeptide in the CNS (Crawley and Corwin, 1...
Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated Na+ Channel Isoforms
Transient and Sustained Ganglion Cell Light Responses Are Differentially Modulated by Intrinsically Produced Reactive Oxygen Species Acting upon Specific Voltage-Gated Na+ Channel Isoforms
Increasing spike rates drive greater neuronal energy demand. In turn, mitochondrial ATP production leads to the generation...
In Vivo Photoadduction of Anesthetic Ligands in Mouse Brain Markedly Extends Sedation and Hypnosis
In Vivo Photoadduction of Anesthetic Ligands in Mouse Brain Markedly Extends Sedation and Hypnosis
AbstractPhotoaffinity ligands are best known as tools used to identify the specific binding sites of drugs to their molecu...
Vestibular Contributions to Primate Neck Postural Muscle Activity during Natural Motion
Vestibular Contributions to Primate Neck Postural Muscle Activity during Natural Motion
To maintain stable posture of the head and body during our everyday activities, the brain integrates information across mu...
Neural Substrates of Body Ownership and Agency during Voluntary Movement
Neural Substrates of Body Ownership and Agency during Voluntary Movement
AbstractBody ownership and the sense of agency are two central aspects of bodily self-consciousness. While multiple neuroi...
Genetic Disruption of System xc-Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat
Genetic Disruption of System xc-Mediated Glutamate Release from Astrocytes Increases Negative-Outcome Behaviors While Preserving Basic Brain Function in Rat
The importance of neuronal glutamate to synaptic transmission throughout the brain illustrates the immense therapeutic pot...
Tip60's Novel RNA-Binding Function Modulates Alternative Splicing of Pre-mRNA Targets Implicated in Alzheimer's Disease
Tip60's Novel RNA-Binding Function Modulates Alternative Splicing of Pre-mRNA Targets Implicated in Alzheimer's Disease
The severity of Alzheimer's disease (AD) progression involves a complex interplay of genetics, age, and environmental fact...
GluA1 Degradation by Autophagy Contributes to Circadian Rhythm Effects on Cerebral Ischemia Injury
GluA1 Degradation by Autophagy Contributes to Circadian Rhythm Effects on Cerebral Ischemia Injury
The mechanisms of many diseases, including central nervous system disorders, are regulated by circadian rhythms. The devel...
Severely Attenuated Visual Feedback Processing in Children on the Autism Spectrum
Severely Attenuated Visual Feedback Processing in Children on the Autism Spectrum
IntroductionIndividuals on the autism spectrum demonstrate atypicality in sensory processing across multiple domains. Give...
A Role for Second Messengers in Axodendritic Neuronal Polarity
A Role for Second Messengers in Axodendritic Neuronal Polarity
Neuronal polarization is a complex molecular process regulated by intrinsic and extrinsic mechanisms. Nerve cells integrat...
Coupling between the Stereocilia of Rat Sensory Inner-Hair-Cell Hair Bundles Is Weak, Shaping Their Sensitivity to Stimulation
Coupling between the Stereocilia of Rat Sensory Inner-Hair-Cell Hair Bundles Is Weak, Shaping Their Sensitivity to Stimulation
The hair bundle is the universal mechanosensory organelle of auditory, vestibular, and lateral-line systems. A bundle comp...
Macrophages Promote Repair of Inner Hair Cell Ribbon Synapses following Noise-Induced Cochlear Synaptopathy
Macrophages Promote Repair of Inner Hair Cell Ribbon Synapses following Noise-Induced Cochlear Synaptopathy
Resident cochlear macrophages rapidly migrate into the inner hair cell synaptic region and directly contact the damaged sy...
Sensory and Choice Responses in MT Distinct from Motion Encoding
Sensory and Choice Responses in MT Distinct from Motion Encoding
IntroductionPrimate middle temporal (MT) area plays a critical role in the perception of visual motion. A long line of stu...
A Short Route for Reach Planning between Human V6A and the Motor Cortex
A Short Route for Reach Planning between Human V6A and the Motor Cortex
In the macaque monkey, area V6A, located in the medial posterior parietal cortex, contains cells that encode the spatial p...
The Basolateral Amygdala Sends a Mixed (GABAergic and Glutamatergic) Projection to the Mediodorsal Thalamic Nucleus
The Basolateral Amygdala Sends a Mixed (GABAergic and Glutamatergic) Projection to the Mediodorsal Thalamic Nucleus
The medial prefrontal cortex receives converging inputs from the mediodorsal thalamic nucleus (MD) and basolateral amygdal...
Hindbrain Adenosine 5-Triphosphate (ATP)-Purinergic Signaling Triggers LH Surge and Ovulation via Activation of AVPV Kisspeptin Neurons in Rats
Hindbrain Adenosine 5-Triphosphate (ATP)-Purinergic Signaling Triggers LH Surge and Ovulation via Activation of AVPV Kisspeptin Neurons in Rats
AbstractOvulation disorders are a serious problem for humans and livestock. In female rodents, kisspeptin neurons in the a...
Dorsolateral Striatum is a Bottleneck for Responding to Task-Relevant Stimuli in a Learned Whisker Detection Task in Mice
Dorsolateral Striatum is a Bottleneck for Responding to Task-Relevant Stimuli in a Learned Whisker Detection Task in Mice
A learned sensory-motor behavior engages multiple brain regions, including the neocortex and the basal ganglia. How a targ...
Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults
Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults
Sleep loss pervasively affects the human brain at multiple levels. Age-related changes in several sleep characteristics in...
Enhanced Reactivation of Remapping Place Cells during Aversive Learning
Enhanced Reactivation of Remapping Place Cells during Aversive Learning
IntroductionEpisodic memories include details about salient experiences from our past as well as information about the loc...
Statistical Learning of Distractor Suppression Downregulates Prestimulus Neural Excitability in Early Visual Cortex
Statistical Learning of Distractor Suppression Downregulates Prestimulus Neural Excitability in Early Visual Cortex
Visual attention is highly influenced by past experiences. Recent behavioral research has shown that expectations about th...
Cortical Grey Matter Mediates Increases in Model-Based Control and Learning from Positive Feedback from Adolescence to Adulthood
Cortical Grey Matter Mediates Increases in Model-Based Control and Learning from Positive Feedback from Adolescence to Adulthood
Cognition and brain structure undergo significant maturation from adolescence into adulthood. Model-based (MB) control is ...
Rapid and Chronic Ethanol Tolerance Are Composed of Distinct Memory-Like States in Drosophila
Rapid and Chronic Ethanol Tolerance Are Composed of Distinct Memory-Like States in Drosophila
Ethanol tolerance is the first type of behavioral plasticity and neural plasticity that is induced by ethanol intake, and ...
Retinal Dysfunction in a Mouse Model of HCN1 Genetic Epilepsy
Retinal Dysfunction in a Mouse Model of HCN1 Genetic Epilepsy
Pathogenic variants in HCN1 are associated with a range of epilepsy syndromes including a developmental and epileptic ence...
Insufficient Oligodendrocyte Turnover in Optic Nerve Contributes to Age-Related Axon Loss and Visual Deficits
Insufficient Oligodendrocyte Turnover in Optic Nerve Contributes to Age-Related Axon Loss and Visual Deficits
Age-related decline in visual functions is a prevalent health problem among elderly people, and no effective therapies are...
Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically toward Thoraco-Lumbar Spinal Cord
Cbln1 Directs Axon Targeting by Corticospinal Neurons Specifically toward Thoraco-Lumbar Spinal Cord
IntroductionFor skilled motor control, the cerebral cortex must precisely and accurately connect with specific spinal segm...
Neurons in Primate Area MSTd Signal Eye Movement Direction Inferred from Dynamic Perspective Cues in Optic Flow
Neurons in Primate Area MSTd Signal Eye Movement Direction Inferred from Dynamic Perspective Cues in Optic Flow
Smooth eye movements are common during natural viewing; we frequently rotate our eyes to track moving objects or to mainta...
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