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Unique Properties of Thalamocortical Projections to the Gustatory Cortex
Unique Properties of Thalamocortical Projections to the Gustatory Cortex
First-order thalamic nuclei play a crucial role in relaying sensory information from the periphery to the primary sensory ...
Age-Related Brain Atrophy and the Positive Effects of Behavioral Enrichment in Middle-Aged Beagles
Age-Related Brain Atrophy and the Positive Effects of Behavioral Enrichment in Middle-Aged Beagles
Aging dogs serve as a valuable preclinical model for Alzheimer's disease (AD) due to their natural age-related development...
Optogenetic Determination of Dynamic and Cell-Type-Specific Inhibitory Reversal Potentials
Optogenetic Determination of Dynamic and Cell-Type-Specific Inhibitory Reversal Potentials
The reversal potential refers to the membrane potential at which the net current flow through a channel reverses direction...
Biophysical Modeling of Frontocentral ERP Generation Links Circuit-Level Mechanisms of Action-Stopping to a Behavioral Race Model
Biophysical Modeling of Frontocentral ERP Generation Links Circuit-Level Mechanisms of Action-Stopping to a Behavioral Race Model
Human frontocentral event-related potentials (FC-ERPs) are ubiquitous neural correlates of cognition and control, but thei...
Multisensory Integration Underlies the Distinct Representation of Odor-Taste Mixtures in the Gustatory Cortex of Behaving Rats
Multisensory Integration Underlies the Distinct Representation of Odor-Taste Mixtures in the Gustatory Cortex of Behaving Rats
The perception of food relies on the integration of olfactory and gustatory signals originating from the mouth. This multi...
Ultrahigh Field fMRI Reveals Different Roles of the Temporal and Frontoparietal Cortices in Subjective Awareness
Ultrahigh Field fMRI Reveals Different Roles of the Temporal and Frontoparietal Cortices in Subjective Awareness
A central question in consciousness theories is whether one is dealing with a dichotomous (“all-or-none”) or a gradual phe...
Erratum: Doehler et al., "The 3D Structural Architecture of the Human Hand Area Is Nontopographic"
Erratum: Doehler et al., "The 3D Structural Architecture of the Human Hand Area Is Nontopographic"
In the article “The 3D Structural Architecture of the Human Hand Area Is Nontopographic” by Juliane Doehler, Alicia Northa...
Cholinergic Neurotransmission Controls Orexigenic Endocannabinoid Signaling in the Gut in Diet-Induced Obesity
Cholinergic Neurotransmission Controls Orexigenic Endocannabinoid Signaling in the Gut in Diet-Induced Obesity
The brain bidirectionally communicates with the gut to control food intake and energy balance, which becomes dysregulated ...
Impairment of the Glial Phagolysosomal System Drives Prion-Like Propagation in a Drosophila Model of Huntington's Disease
Impairment of the Glial Phagolysosomal System Drives Prion-Like Propagation in a Drosophila Model of Huntington's Disease
Protein misfolding, aggregation, and spread through the brain are primary drivers of neurodegenerative disease pathogenesi...
Identifying Distinct Neural Features between the Initial and Corrective Phases of Precise Reaching Using AutoLFADS
Identifying Distinct Neural Features between the Initial and Corrective Phases of Precise Reaching Using AutoLFADS
Many initial movements require subsequent corrective movements, but how the motor cortex transitions to make corrections a...
Imbalance in Glucose Metabolism Regulates the Transition of Microglia from Homeostasis to Disease-Associated Microglia Stage 1
Imbalance in Glucose Metabolism Regulates the Transition of Microglia from Homeostasis to Disease-Associated Microglia Stage 1
Microglia undergo two-stage activation in neurodegenerative diseases, known as disease-associated microglia (DAM). TREM2 m...
Encoding Manual Dexterity through Modulation of Intrinsic {alpha} Band Connectivity
Encoding Manual Dexterity through Modulation of Intrinsic {alpha} Band Connectivity
IntroductionHealthy individuals differ in their manual dexterity. This ability is fundamental to efficiently interact with...
Transformation of Motion Pattern Selectivity from Retina to Superior Colliculus
Transformation of Motion Pattern Selectivity from Retina to Superior Colliculus
The superior colliculus (SC) is a prominent and conserved visual center in all vertebrates. In mice, the most superficial ...
Distinctive and Complementary Roles of Default Mode Network Subsystems in Semantic Cognition
Distinctive and Complementary Roles of Default Mode Network Subsystems in Semantic Cognition
AbstractThe default mode network (DMN) typically deactivates to external tasks, yet supports semantic cognition. It compri...
Optogenetic Inhibition of Rat Anterior Cingulate Cortex Impairs the Ability to Initiate and Stay on Task
Optogenetic Inhibition of Rat Anterior Cingulate Cortex Impairs the Ability to Initiate and Stay on Task
IntroductionThe anterior cingulate cortex (ACC) has been implicated across a plethora of cognitive functions—including att...
Neural Representations of Observed Interpersonal Synchrony/Asynchrony in the Social Perception Network
Neural Representations of Observed Interpersonal Synchrony/Asynchrony in the Social Perception Network
The present study employed MVPA to identify visual regions that underlie the perception of interpersonal synchrony/asynchr...
Topographical Representation of Saliency in the Human Visual and Temporo-occipital Cortex
Topographical Representation of Saliency in the Human Visual and Temporo-occipital Cortex
Visual search is a fundamental process in everyday life, and it has received extensive attention throughout the decades. N...
Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements
Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements
Animals must distinguish the sensory consequences of self-generated movements (reafference) from those of other-generated ...
Spinal Glycine Receptor Alpha 3 Cells Communicate Sensations of Chemical Itch in Hairy Skin
Spinal Glycine Receptor Alpha 3 Cells Communicate Sensations of Chemical Itch in Hairy Skin
AnimalsProcedures related to the mice used in this study were approved by the local animal research ethical committee (Upp...
Dopamine D2 Receptor Modulates Exercise Related Effect on Cortical Excitation/Inhibition and Motor Skill Acquisition
Dopamine D2 Receptor Modulates Exercise Related Effect on Cortical Excitation/Inhibition and Motor Skill Acquisition
Exercise is known to benefit motor skill learning in health and neurological disease. Evidence from brain stimulation, gen...
Visual Deprivation during Mouse Critical Period Reorganizes Network-Level Functional Connectivity
Visual Deprivation during Mouse Critical Period Reorganizes Network-Level Functional Connectivity
A classic example of experience-dependent plasticity is ocular dominance (OD) shift, in which the responsiveness of neuron...
Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine
Rare GPR37L1 Variants Reveal Potential Association between GPR37L1 and Disorders of Anxiety and Migraine
GPR37L1 is an orphan receptor that couples through heterotrimeric G-proteins to regulate physiological functions. Since it...
A Neural Decision Signal during Internal Sampling from Working Memory in Humans
A Neural Decision Signal during Internal Sampling from Working Memory in Humans
AbstractHow humans transform sensory information into decisions that steer purposeful behavior is a central question in ps...
The Intellectual Disability Risk Gene Kdm5b Regulates Long-Term Memory Consolidation in the Hippocampus
The Intellectual Disability Risk Gene Kdm5b Regulates Long-Term Memory Consolidation in the Hippocampus
AnimalsExperiments with mice carrying the Kdm5btm1Jtpu, referred to as the Kdm5bΔARID allele (Catchpole et al., 2011), we...
TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia
TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia
Excitotoxicity and the concurrent loss of inhibition are well-defined mechanisms driving acute elevation in excitatory/inh...
Basic Properties of Coordinated Neuronal Ensembles in the Auditory Thalamus
Basic Properties of Coordinated Neuronal Ensembles in the Auditory Thalamus
Coordinated neuronal activity has been identified to play an important role in information processing and transmission in ...
Double Dissociation of Spontaneous Alpha-Band Activity and Pupil-Linked Arousal on Additive and Multiplicative Perceptual Gain
Double Dissociation of Spontaneous Alpha-Band Activity and Pupil-Linked Arousal on Additive and Multiplicative Perceptual Gain
Perception is a probabilistic process dependent on external stimulus properties and one's internal state. However, which i...