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The Role of the Rat Prefrontal Cortex and Sex Differences in Decision-Making
The Role of the Rat Prefrontal Cortex and Sex Differences in Decision-Making
The prefrontal cortex is critical for decision-making across species, with its activity linked to choosing between options...
Deciphering Peripheral Taste Neuron Diversity: Using Genetic Identity to Bridge Taste Bud Innervation Patterns and Functional Responses
Deciphering Peripheral Taste Neuron Diversity: Using Genetic Identity to Bridge Taste Bud Innervation Patterns and Functional Responses
Peripheral taste neurons exhibit functional, genetic, and morphological diversity, yet understanding how or if these attri...
A Prefrontal->Periaqueductal Gray Pathway Differentially Engages Autonomic, Hormonal, and Behavioral Features of the Stress-Coping Response
A Prefrontal->Periaqueductal Gray Pathway Differentially Engages Autonomic, Hormonal, and Behavioral Features of the Stress-Coping Response
The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjust...
Dynamics of Saccade Trajectory Modulation by Distractors: Neural Activity Patterns in the Frontal Eye Field
Dynamics of Saccade Trajectory Modulation by Distractors: Neural Activity Patterns in the Frontal Eye Field
The sudden appearance of a visual distractor shortly before saccade initiation can capture spatial attention and modulate ...
Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin
Encoding of Vibrotactile Stimuli by Mechanoreceptors in Rodent Glabrous Skin
Somatosensory coding in rodents has been mostly studied in the whisker system and hairy skin, whereas the function of low-...
Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States
Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States
Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA d...
Monocyte Invasion into the Retina Restricts the Regeneration of Neurons from Müller Glia
Monocyte Invasion into the Retina Restricts the Regeneration of Neurons from Müller Glia
Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using l...
Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons
Monosynaptic Inputs to Ventral Tegmental Area Glutamate and GABA Co-transmitting Neurons
A unique population of ventral tegmental area (VTA) neurons co-transmits glutamate and GABA. However, the circuit inputs t...
Behavioral and Neural Mechanisms of Face-Specific Attention during Goal-Directed Visual Search
Behavioral and Neural Mechanisms of Face-Specific Attention during Goal-Directed Visual Search
Goal-directed visual attention is a fundamental cognitive process that enables animals to selectively focus on specific re...
Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain
Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain
Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here, we report...
A Novel Directed Seed-Based Connectivity Analysis Toolbox Applied to Human and Marmoset Resting-State FMRI
A Novel Directed Seed-Based Connectivity Analysis Toolbox Applied to Human and Marmoset Resting-State FMRI
Estimating the direction of functional connectivity (FC) can help further elucidate complex brain function. However, the e...
G-Protein Signaling in Alzheimer's Disease: Spatial Expression Validation of Semi-supervised Deep Learning-Based Computational Framework
G-Protein Signaling in Alzheimer's Disease: Spatial Expression Validation of Semi-supervised Deep Learning-Based Computational Framework
Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) fac...
EphB2 Signaling Is Implicated in Astrocyte-Mediated Parvalbumin Inhibitory Synapse Development
EphB2 Signaling Is Implicated in Astrocyte-Mediated Parvalbumin Inhibitory Synapse Development
Ethics statementAll mouse studies were done according to National Institutes of Health and Institutional Animal Care and ...
Glucocorticoids Rapidly Modulate CaV1.2-Mediated Calcium Signals through Kv2.1 Channel Clusters in Hippocampal Neurons
Glucocorticoids Rapidly Modulate CaV1.2-Mediated Calcium Signals through Kv2.1 Channel Clusters in Hippocampal Neurons
The precise regulation of Ca2+ signals plays a crucial role in the physiological functions of neurons. Here, we investigat...
Spatiotemporal Neural Network for Sublexical Information Processing: An Intracranial SEEG Study
Spatiotemporal Neural Network for Sublexical Information Processing: An Intracranial SEEG Study
ParticipantsThirty-nine epilepsy patients (11 females) were recruited from Sanbo Brain Hospital, Capital Medical Universit...
Erratum: McCosh et al., "Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice"
Erratum: McCosh et al., "Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice"
In the article “Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Fema...
The Hippocampus Preorders Movements for Skilled Action Sequences
The Hippocampus Preorders Movements for Skilled Action Sequences
ParticipantsTwenty-four participants (14 females and 10 males; mean age, 21.00 years; SD, 1.64 years) completed the 3 d ex...
The Effect of Congruent versus Incongruent Distractor Positioning on Electrophysiological Signals during Perceptual Decision-Making
The Effect of Congruent versus Incongruent Distractor Positioning on Electrophysiological Signals during Perceptual Decision-Making
Key event-related potentials (ERPs) of perceptual decision-making such as centroparietal positivity (CPP) elucidate how ev...
Pre- and Postsynaptic MEF2C Promotes Experience-Dependent, Input-Specific Development of Cortical Layer 4 to Layer 2/3 Excitatory Synapses and Regulates Activity-Dependent Expression of Synaptic Cell Adhesion Molecules
Pre- and Postsynaptic MEF2C Promotes Experience-Dependent, Input-Specific Development of Cortical Layer 4 to Layer 2/3 Excitatory Synapses and Regulates Activity-Dependent Expression of Synaptic Cell Adhesion Molecules
Experience- and activity-dependent transcription is a candidate mechanism to mediate development and refinement of specifi...
Multiple Intrinsic Timescales Govern Distinct Brain States in Human Sleep
Multiple Intrinsic Timescales Govern Distinct Brain States in Human Sleep
Human sleep exhibits multiple, recurrent temporal regularities, ranging from circadian rhythms to sleep stage cycles and n...
GABAergic Inhibition Underpins Hidden Hearing Loss
GABAergic Inhibition Underpins Hidden Hearing Loss
Hearing involves both peripheral and central processing mechanisms that range from simple detection of sounds to complex p...
TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation
TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation
Vertebrate nervous systems use the axon initial segment (AIS) to initiate action potentials and maintain neuronal polarity...
A Virtual In Vivo Dissection and Analysis of Socioaffective Symptoms Related to Cerebellum-Midbrain Reward Circuitry in Humans
A Virtual In Vivo Dissection and Analysis of Socioaffective Symptoms Related to Cerebellum-Midbrain Reward Circuitry in Humans
Emerging research in nonhuman animals implicates cerebellar projections to the ventral tegmental area (VTA) in appetitive ...
The Role of the Hippocampus in Consolidating Motor Learning during Wakefulness
The Role of the Hippocampus in Consolidating Motor Learning during Wakefulness
Learning processes continue well beyond the time when the information to be learned is presented. Some offline gains are r...
Recent Visual Experience Reshapes V4 Neuronal Activity and Improves Perceptual Performance
Recent Visual Experience Reshapes V4 Neuronal Activity and Improves Perceptual Performance
Recent visual experience heavily influences our visual perception, but how neuronal activity is reshaped to alter and impr...
Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?
Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?
Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD? Joia K. C...
A Systematic Structure-Function Characterization of a Human Mutation in Neurexin-3{alpha} Reveals an Extracellular Modulatory Sequence That Stabilizes Neuroligin-1 Binding to Enhance the Postsynaptic Properties of Excitatory Synapses
A Systematic Structure-Function Characterization of a Human Mutation in Neurexin-3{alpha} Reveals an Extracellular Modulatory Sequence That Stabilizes Neuroligin-1 Binding to Enhance the Postsynaptic Properties of Excitatory Synapses
α-Neurexins are essential and highly expressed presynaptic cell-adhesion molecules that are frequently linked to neuropsyc...
Dense and Persistent Odor Representations in the Olfactory Bulb of Awake Mice
Dense and Persistent Odor Representations in the Olfactory Bulb of Awake Mice
Recording and analysis of neural activity are often biased toward detecting sparse subsets of highly active neurons, maski...
The Transcription Factor Tbx5-Dependent Epigenetic Modification Contributes to Neuropathic Allodynia by Activating TRPV1 Expression in the Dorsal Horn
The Transcription Factor Tbx5-Dependent Epigenetic Modification Contributes to Neuropathic Allodynia by Activating TRPV1 Expression in the Dorsal Horn
Nerve injury can induce aberrant changes in the spine; these changes are due to, or at least partly governed by, transcrip...
Medial Prefrontal Cortex Stimulation Reduces Retrieval-Induced Forgetting via Fronto-parietal Beta Desynchronization
Medial Prefrontal Cortex Stimulation Reduces Retrieval-Induced Forgetting via Fronto-parietal Beta Desynchronization
AbstractThe act of recalling memories can paradoxically lead to the forgetting of other associated memories, a phenomenon ...
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