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Cardioprotective potential of mitochondria-targeted antioxidant, mito-TEMPO, in 5-fluorouracil-induced cardiotoxicity
Cardioprotective potential of mitochondria-targeted antioxidant, mito-TEMPO, in 5-fluorouracil-induced cardiotoxicity
The mitochondria-targeted antioxidants (MTAs) are known to offer protection against mitochondrial oxidative stress. The re...
Olaparib in an ovarian cancer patient with end-stage renal disease and hemodialysis
Olaparib in an ovarian cancer patient with end-stage renal disease and hemodialysis
For patients with severe renal impairment (CrCl ≤ 30 ml/min) or end-stage renal disease (ESRD),...
Exposure–response analyses of BRAF- and MEK-inhibitors dabrafenib plus trametinib in melanoma patients
Exposure–response analyses of BRAF- and MEK-inhibitors dabrafenib plus trametinib in melanoma patients
Dabrafenib and trametinib are currently administered at fixed doses, at which interpatient variability in exposure is high...
A three-marker signature identifies senescence in human breast cancer exposed to neoadjuvant chemotherapy
A three-marker signature identifies senescence in human breast cancer exposed to neoadjuvant chemotherapy
Despite the beneficial effects of chemotherapy, therapy-induced senescence (TIS) manifests itself as an undesirable byprod...
Progressive erythrocytosis under lenvatinib treatment in patients with advanced hepatocellular carcinoma
Progressive erythrocytosis under lenvatinib treatment in patients with advanced hepatocellular carcinoma
This manuscript reports on the occurrence of early and frequent erythrocytosis in advanced hepatocellular carcinoma (HCC) ...
Synergistic action of lactoferrin in enhancing the safety and effectiveness of docetaxel treatment against prostate cancer
Synergistic action of lactoferrin in enhancing the safety and effectiveness of docetaxel treatment against prostate cancer
Tumor metastasis is promoted by an immunosuppressive environment. Lactoferrin (Lf) is known to regulate immunological acti...
Assay performance and stability of uracil and dihydrouracil in clinical practice
Assay performance and stability of uracil and dihydrouracil in clinical practice
Measurement of endogenous uracil (U) is increasingly being used as a dose-individualization method in the treatment of can...
Systemic exposure to cisplatin and paclitaxel after intraperitoneal chemotherapy in ovarian cancer
Systemic exposure to cisplatin and paclitaxel after intraperitoneal chemotherapy in ovarian cancer
To determine the systemic exposure to cisplatin and paclitaxel after adjuvant intraperitoneal administration in patients w...
Entrectinib dose confirmation in pediatric oncology patients: pharmacokinetic considerations
Entrectinib dose confirmation in pediatric oncology patients: pharmacokinetic considerations
Entrectinib is a central nervous system-active potent inhibitor of tropomyosin receptor kinase (TRK), with anti-t...
Precision fluoropyrimidines dosing in a compound heterozygous variant carrier of the DPYD gene: a case report
Precision fluoropyrimidines dosing in a compound heterozygous variant carrier of the DPYD gene: a case report
Fluoropyrimidines (FPs) form still nowadays the backbone of chemotherapic schemes in colorectal cancer (CRC). Inter-patien...
Clinical results of the EVESOR trial, a multiparameter phase I trial of everolimus and sorafenib combination in solid tumors
Clinical results of the EVESOR trial, a multiparameter phase I trial of everolimus and sorafenib combination in solid tumors
Everolimus (EVE) and sorafenib (SOR) combination was associated with synergistic activity in preclinical models. However, ...
Phase 1 study of belinostat and adavosertib in patients with relapsed or refractory myeloid malignancies
Phase 1 study of belinostat and adavosertib in patients with relapsed or refractory myeloid malignancies
Belinostat is an intravenous histone deacetylase inhibitor with approval for T-cell lymphomas. Adavosertib is a first in c...
Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance
Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance
Natural products, also referred to as dietary supplements, complementary and alternative medicines, and health or food sup...
The CNS-penetrating taxane drug TPI 287 potentiates antiglioma activity of the AURKA inhibitor alisertib in vivo
The CNS-penetrating taxane drug TPI 287 potentiates antiglioma activity of the AURKA inhibitor alisertib in vivo
Glioblastoma (GBM) has a very poor prognosis despite current treatment. We previously found cytotoxic synergy between the ...
The impact of single nucleotide polymorphisms on return-to-work after taxane-based chemotherapy in breast cancer
The impact of single nucleotide polymorphisms on return-to-work after taxane-based chemotherapy in breast cancer
Breast cancer treatment is associated with adverse effects, which may delay return-to-work. Single nucleotide polymorphism...