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Quantitative assessment of skin disorders induced by panitumumab: a prospective observational study
Quantitative assessment of skin disorders induced by panitumumab: a prospective observational study
Acneiform rash is frequently observed in patients undergoing cancer treatment with anti-epidermal growth factor receptor (...
Pharmacokinetics and immunogenicity of eftozanermin alfa in subjects with previously-treated solid tumors or hematologic malignancies: results from a phase 1 first-in-human study
Pharmacokinetics and immunogenicity of eftozanermin alfa in subjects with previously-treated solid tumors or hematologic malignancies: results from a phase 1 first-in-human study
Eftozanermin alfa is a second-generation tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor agonist ...
Pharmacodynamic effects of the PARP inhibitor talazoparib (MDV3800, BMN 673) in patients with BRCA-mutated advanced solid tumors
Pharmacodynamic effects of the PARP inhibitor talazoparib (MDV3800, BMN 673) in patients with BRCA-mutated advanced solid tumors
Talazoparib is an inhibitor of the poly (ADP-ribose) polymerase (PARP) family of enzymes and is FDA-approved for patients ...
Pharmacokinetic drug–drug interaction between olaparib and apixaban: a case report
Pharmacokinetic drug–drug interaction between olaparib and apixaban: a case report
Farge D, Frere C, Connors JM, Khorana A, Kakkar A, Ay C et al (2022) 2022 international clinical practice guidelines for t...
The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis
The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis
Peripheral T-cell lymphoma (PTCL) is an aggressive disease with a poor prognosis. Brentuximab vedotin (BV), an anti-CD30 m...
Association between chemotherapy-induced myelosuppression and curative efficacy of 2-cycle chemotherapy in small cell lung cancer
Association between chemotherapy-induced myelosuppression and curative efficacy of 2-cycle chemotherapy in small cell lung cancer
The association of chemotherapy-induced myelosuppression with tumor response and overall survival remained controversial. ...
Effect of vitamin E on doxorubicin and paclitaxel-induced memory impairments in male rats
Effect of vitamin E on doxorubicin and paclitaxel-induced memory impairments in male rats
In addition to peripheral neuronal dysfunction, conventional chemotherapy can be associated with other neurological treatm...
A phase-II study based on dose adjustment according to UGT1A1 polymorphism: is irinotecan underdosed in first-line FOLFIRI regimen for mCRC?
A phase-II study based on dose adjustment according to UGT1A1 polymorphism: is irinotecan underdosed in first-line FOLFIRI regimen for mCRC?
Irinotecan has considerable importance in the treatment of metastatic colorectal cancer (mCRC). UDP-glucoronyltransferase ...
Platinum-based chemotherapy in metastatic prostate cancer: what possibilities?
Platinum-based chemotherapy in metastatic prostate cancer: what possibilities?
Metastatic prostate cancer is a major health burden worldwide, necessitating the continuous development of effective treat...
CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms
CUDC-907 exhibits potent antitumor effects against ovarian cancer through multiple in vivo and in vitro mechanisms
CUDC-907 is a promising dual-target inhibitor of the HDAC and PI3K signaling pathways, with demonstrated therapeutic effec...
Retraction Note: Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis
Retraction Note: Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis
Cite this articleNigam, N., George, J., Srivastava, S. et al. Retraction Note: Induction of apoptosis by [6]-gingerol asso...
Relative bioavailability of fedratinib through various alternative oral administration methods in healthy adults
Relative bioavailability of fedratinib through various alternative oral administration methods in healthy adults
Fedratinib is an oral Janus kinase 2-selective inhibitor for the treatment of adult patients with intermediate-2 or high-r...
Life-threatening toxicities upon Pembrolizumab intake: could pharmacokinetics be the bad guy?
Life-threatening toxicities upon Pembrolizumab intake: could pharmacokinetics be the bad guy?
We report the case of an adult patient diagnosed with Hodgkin’s lymphoma who was scheduled for Pembrolizumab after f...
Azithromycin in cancer treatment: envisioning the probable link of mitochondrial dysfunction and necroptosis
Azithromycin in cancer treatment: envisioning the probable link of mitochondrial dysfunction and necroptosis
Zhang X, Xu H (2023) Azithromycin inhibits glioblastoma angiogenesis in mice via inducing mitochondrial dysfunction and ox...
Prediction of ROS1 and TRKA/B/C occupancy in plasma and cerebrospinal fluid for entrectinib alone and in DDIs using physiologically based pharmacokinetic (PBPK) modeling approach
Prediction of ROS1 and TRKA/B/C occupancy in plasma and cerebrospinal fluid for entrectinib alone and in DDIs using physiologically based pharmacokinetic (PBPK) modeling approach
Entrectinib (ENT) is a potent c-ros oncogene 1(ROS1) and neurotrophic tyrosine receptor kinase (NTRKA/B/C) inhibitor. To d...
Prospective validation of an equation based on plasma cystatin C for monitoring the glomerular filtration rate in children treated with cisplatin or ifosfamide for cancer
Prospective validation of an equation based on plasma cystatin C for monitoring the glomerular filtration rate in children treated with cisplatin or ifosfamide for cancer
We recently proposed an equation to estimate the glomerular filtration rate (GFR) in children with cancer based on plasma ...
Bidirectional pharmacokinetic drug interactions between olaparib and metformin
Bidirectional pharmacokinetic drug interactions between olaparib and metformin
Olaparib is a PARP (poly-ADP-ribose polymerase) inhibitor used for maintenance therapy in BRCA-mutated cancers. Metformin ...
Correction to: An IQ consortium analysis of starting dose selection for oncology small molecule first‑in‑patient trials suggests an alternative NOAEL‑based method can be safe while reducing time to the recommended phase 2 dose
Correction to: An IQ consortium analysis of starting dose selection for oncology small molecule first‑in‑patient trials suggests an alternative NOAEL‑based method can be safe while reducing time to the recommended phase 2 dose
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Predictive significance of inflammatory markers and mGPS in metastatic castration-resistant prostate cancer treated with abiraterone or enzalutamide
Predictive significance of inflammatory markers and mGPS in metastatic castration-resistant prostate cancer treated with abiraterone or enzalutamide
Prostate cancer is a prevalent cancer in men worldwide, and castration-resistant prostate cancer (CRPC) is characterized b...
Sodium orthovanadate exhibits anti-angiogenic, antiapoptotic and blood glucose-lowering effect on colon cancer associated with diabetes
Sodium orthovanadate exhibits anti-angiogenic, antiapoptotic and blood glucose-lowering effect on colon cancer associated with diabetes
The presence of type 2 diabetes mellitus increases the risk of developing the colon cancer. The main objective of this stu...
Long non-coding RNAs: controversial roles in drug resistance of solid tumors mediated by autophagy
Long non-coding RNAs: controversial roles in drug resistance of solid tumors mediated by autophagy
Current genome-wide studies have indicated that a great number of long non-coding RNAs (lncRNAs) are transcribed from the ...
Correlation analysis between camrelizumab trough concentration levels and efficacy or safety in East Asian patients with advanced lung cancer
Correlation analysis between camrelizumab trough concentration levels and efficacy or safety in East Asian patients with advanced lung cancer
Camrelizumab combined with chemotherapy is approved across tumor types. However, only a fraction of patients benefits from...
Polatuzumab vedotin pharmacokinetics in a hemodialysis patient with diffuse large B-cell lymphoma
Polatuzumab vedotin pharmacokinetics in a hemodialysis patient with diffuse large B-cell lymphoma
Chemotherapy for the hemodialysis (HD) patient is a challenging situation because it requires special considerations inclu...
Clinical outcomes and response to chemotherapy in a cohort of pancreatic cancer patients with germline variants of unknown significance (VUS) in BRCA1 and BRCA2 genes
Clinical outcomes and response to chemotherapy in a cohort of pancreatic cancer patients with germline variants of unknown significance (VUS) in BRCA1 and BRCA2 genes
The clinical outcome and the efficacy of chemotherapy in pancreatic cancer patients with BRCA1/2 Variants of Unknown Signi...
The Beta2-adrenergic agonist salbutamol synergizes with paclitaxel on cell proliferation and tumor growth in triple negative breast cancer models
The Beta2-adrenergic agonist salbutamol synergizes with paclitaxel on cell proliferation and tumor growth in triple negative breast cancer models
Globally breast cancer accounts for 24.5% in incidence and 15.5% in cancer deaths in women. The triple-negative subtype la...
TMEM120A-mediated regulation of chemotherapy sensitivity in colorectal cancer cells
TMEM120A-mediated regulation of chemotherapy sensitivity in colorectal cancer cells
Enhancing chemotherapy sensitivity in colorectal cancer (CRC) is critical for improving treatment outcomes. TMEM120A has b...
Retraction Note: Effectiveness and safety of sorafenib for renal cell, hepatocellular and thyroid carcinoma: pooled analysis in patients with renal impairment
Retraction Note: Effectiveness and safety of sorafenib for renal cell, hepatocellular and thyroid carcinoma: pooled analysis in patients with renal impairment
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Pharmacokinetics and pharmacodynamics of Rh2 and aPPD ginsenosides in prostate cancer: a drug interaction perspective
Pharmacokinetics and pharmacodynamics of Rh2 and aPPD ginsenosides in prostate cancer: a drug interaction perspective
Ginsenoside Rh2 and its aglycon (aPPD) are one of the major metabolites from Panax ginseng. Preclinical studies suggest th...
Cytidine deaminase enzyme activity is a predictive biomarker in gemcitabine-treated cancer patients
Cytidine deaminase enzyme activity is a predictive biomarker in gemcitabine-treated cancer patients
Gemcitabine is a chemotherapeutic agent, widely used for the treatment of many types of cancer. Cytidine deaminas...
A polymorphism in ABCA2 is associated with neutropenia induced by capecitabine in Japanese patients with colorectal cancer
A polymorphism in ABCA2 is associated with neutropenia induced by capecitabine in Japanese patients with colorectal cancer
Capecitabine is a prodrug that converts to 5-fluorouracil (5-FU) in three steps. A previous study showed that ABCA2 rs2271...
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