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A sub-pharmacological test dose does not predict individual docetaxel exposure in prostate cancer patients
A sub-pharmacological test dose does not predict individual docetaxel exposure in prostate cancer patients
Docetaxel is a cytotoxic drug used for first-line treatment of various malignancies. It has a narrow therapeutic index and...
Aclarubicin: contemporary insights into its mechanism of action, toxicity, pharmacokinetics, and clinical standing
Aclarubicin: contemporary insights into its mechanism of action, toxicity, pharmacokinetics, and clinical standing
Aclarubicin (aclacinomycin A) is one of the anthracycline antineoplastic antibiotics with a multifaceted mechanism of anti...
Regorafenib plus FOLFIRINOX as first-line treatment for patients with RAS-mutant metastatic colorectal cancer (FOLFIRINOX-R trial): a dose-escalation study
Regorafenib plus FOLFIRINOX as first-line treatment for patients with RAS-mutant metastatic colorectal cancer (FOLFIRINOX-R trial): a dose-escalation study
The combination of bevacizumab and FOLFIRINOX is used in patients with RAS-mutant metastatic colorectal cancer (RASm-mCRC)...
A joint model of longitudinal pharmacokinetic and time-to-event data to study exposure–response relationships: a proof-of-concept study with alectinib
A joint model of longitudinal pharmacokinetic and time-to-event data to study exposure–response relationships: a proof-of-concept study with alectinib
In exposure–response analyses of oral targeted anticancer agents, longitudinal plasma trough concentrations are ofte...
Systematic review: genetic polymorphisms in the pharmacokinetics of high-dose methotrexate in pediatric acute lymphoblastic leukemia patients
Systematic review: genetic polymorphisms in the pharmacokinetics of high-dose methotrexate in pediatric acute lymphoblastic leukemia patients
Variations in pharmacokinetic responses to high-dose methotrexate are essential for the prognosis and management of toxici...
Role of renin angiotensin system inhibitors and metformin in Glioblastoma Therapy: a review
Role of renin angiotensin system inhibitors and metformin in Glioblastoma Therapy: a review
Glioblastoma multiforme (GBM) is a highly aggressive and incurable disease accounting for about 10,000 deaths in the USA e...
Quantitative characterization of the effects of fulvestrant alone or in combination with taselisib (PI3Kinase inhibitor) on longitudinal tumor growth in patients with estrogen receptor-positive, HER2-negative, PIK3CA-mutant, advanced or metastatic breast cancer
Quantitative characterization of the effects of fulvestrant alone or in combination with taselisib (PI3Kinase inhibitor) on longitudinal tumor growth in patients with estrogen receptor-positive, HER2-negative, PIK3CA-mutant, advanced or metastatic breast cancer
Among cases of breast cancer, estrogen receptor-positive (ER +), PIK3CA-mutant, HER2- advanced breast cancer stands ...
Immunoregulatory cyclophilin a improves low-dose chemotherapy with a modulation of the immune tumor microenvironment in experimental models of melanoma B16 and lymphoma EL4 in vivo
Immunoregulatory cyclophilin a improves low-dose chemotherapy with a modulation of the immune tumor microenvironment in experimental models of melanoma B16 and lymphoma EL4 in vivo
Different regimens of low-dose chemotherapy (LDC) are currently being actively developed and introduced into clinical prac...
Alterations in pharmacogenetic genes and their implications for imatinib resistance in Chronic Myeloid Leukemia patients from an admixed population
Alterations in pharmacogenetic genes and their implications for imatinib resistance in Chronic Myeloid Leukemia patients from an admixed population
Imatinib is the tyrosine kinase inhibitor used as the gold standard for the treatment of Chronic Myeloid Leukemia. However...
Development of a novel nomogram for predicting delayed methotrexate excretion following high-dose methotrexate in adult patients with hematologic malignancies
Development of a novel nomogram for predicting delayed methotrexate excretion following high-dose methotrexate in adult patients with hematologic malignancies
High-dose methotrexate (HDMTX) is integral in treating hematologic malignancies but carries risks of severe toxicities due...
AKR1C4 regulates the sensitivity of colorectal cancer cells to chemotherapy through ferroptosis modulation
AKR1C4 regulates the sensitivity of colorectal cancer cells to chemotherapy through ferroptosis modulation
Colorectal cancer (CRC) remains a major global health concern, necessitating innovative therapeutic strategies to enhance ...
Evaluation of the effect of modafinil on the pharmacokinetics of encorafenib and binimetinib in patients with BRAF V600-mutant advanced solid tumors
Evaluation of the effect of modafinil on the pharmacokinetics of encorafenib and binimetinib in patients with BRAF V600-mutant advanced solid tumors
A clinical drug-drug interaction (DDI) study was designed to evaluate the effect of multiple doses of modafinil, a moderat...
Population pharmacokinetics of TLD-1, a novel liposomal doxorubicin, in a phase I trial
Population pharmacokinetics of TLD-1, a novel liposomal doxorubicin, in a phase I trial
TLD-1 is a novel pegylated liposomal doxorubicin (PLD) formulation aiming to optimise the PLD efficacy-toxicity ratio. We ...
Comparable efficacy of oral bendamustine versus intravenous administration in treating hematologic malignancies
Comparable efficacy of oral bendamustine versus intravenous administration in treating hematologic malignancies
The purpose of this study was to analyze potential differences in antitumor efficacy and pharmacokinetics between intraven...
ZNF384 transcriptionally activated MGST1 to confer TMZ resistance of glioma cells by negatively regulating ferroptosis
ZNF384 transcriptionally activated MGST1 to confer TMZ resistance of glioma cells by negatively regulating ferroptosis
Drug resistance is one of the major reasons of the poor prognosis and recurs frequently in glioma. Ferroptosis is consider...
Pre-treatment amino acids and risk of paclitaxel-induced peripheral neuropathy in SWOG S0221
Pre-treatment amino acids and risk of paclitaxel-induced peripheral neuropathy in SWOG S0221
Chemotherapy-induced peripheral neuropathy (CIPN) is a treatment-limiting and debilitating neurotoxicity of many commonly ...
Oral docetaxel plus encequidar – a phase 1 clinical trial
Oral docetaxel plus encequidar – a phase 1 clinical trial
To determine the bioavailability, safety, and tolerability of a single dose of oral docetaxel plus encequidar (oDox ...
Physiologically-based pharmacokinetic models versus allometric scaling for prediction of tyrosine-kinase inhibitor exposure from adults to children
Physiologically-based pharmacokinetic models versus allometric scaling for prediction of tyrosine-kinase inhibitor exposure from adults to children
Model-based methods can predict pediatric exposure and support initial dose selection. The aim of this study was to evalua...
Overexposure to venetoclax is associated with prolonged-duration of neutropenia during venetoclax and azacitidine therapy in Japanese patients with acute myeloid leukemia
Overexposure to venetoclax is associated with prolonged-duration of neutropenia during venetoclax and azacitidine therapy in Japanese patients with acute myeloid leukemia
An observational study was conducted to evaluate the pharmacokinetics of venetoclax and its impact on the efficacy and saf...
Using maximum plasma concentration (Cmax) to personalize taxane treatment and reduce toxicity
Using maximum plasma concentration (Cmax) to personalize taxane treatment and reduce toxicity
Taxanes are a widely used class of anticancer agents that play a vital role in the treatment of a variety of cancers. Howe...
Non-linear IV pharmacokinetics of the ATR inhibitor berzosertib (M6620) in mice
Non-linear IV pharmacokinetics of the ATR inhibitor berzosertib (M6620) in mice
The Ataxia Telangiectasia and Rad3-related (ATR) protein complex is an apical initiator of DNA damage response pathways. S...
Effect of food on the pharmacokinetics and safety profiles of a new PARP inhibitor fuzuloparib capsules in healthy volunteers
Effect of food on the pharmacokinetics and safety profiles of a new PARP inhibitor fuzuloparib capsules in healthy volunteers
This study assessed effect of food on pharmacokinetics (PK) and safety of fuzuloparib capsules. A randomized, open-label, ...
Combined treatment of All-trans retinoic acid with Tamoxifen suppresses ovarian cancer
Combined treatment of All-trans retinoic acid with Tamoxifen suppresses ovarian cancer
Ovarian cancer is a malignant tumor of the female reproductive system, and its mortality rate is as high as 70%. Estrogen ...
Gene polymorphisms of TACR1 serve as the potential pharmacogenetic predictors of response to the neurokinin-1 receptor antagonist-based antiemetic regimens: a candidate-gene association study in breast cancer patients
Gene polymorphisms of TACR1 serve as the potential pharmacogenetic predictors of response to the neurokinin-1 receptor antagonist-based antiemetic regimens: a candidate-gene association study in breast cancer patients
The current candidate gene association study aims to investigate tag SNPs from the TACR1 gene as pharmacogenetic predictor...
Preventive effect of free radical scavenger edaravone lotion on cyclophosphamide chemotherapy-induced alopecia
Preventive effect of free radical scavenger edaravone lotion on cyclophosphamide chemotherapy-induced alopecia
We investigated the inhibitory effect of edaravone (EDR) lotion on chemotherapy-induced alopecia (CIA) to improve the qual...
Pharmacokinetic study of capivasertib and the CYP3A4 substrate midazolam in patients with advanced solid tumors
Pharmacokinetic study of capivasertib and the CYP3A4 substrate midazolam in patients with advanced solid tumors
Capivasertib, a potent, selective inhibitor of all three AKT serine/threonine kinase (AKT) isoforms, is being evaluated in...
PARP1 promotes EGFR-TKI drug-resistance via PI3K/AKT pathway in non-small-cell lung cancer
PARP1 promotes EGFR-TKI drug-resistance via PI3K/AKT pathway in non-small-cell lung cancer
Tyrosine kinase inhibitor (TKI) resistance is the main type of drug resistance in lung cancer patients with epidermal grow...
Prognostic impact of concomitant pH-regulating drugs in patients with non-small cell lung cancer receiving epidermal growth factor receptor tyrosine kinase inhibitors: the Tokushukai REAl-world Data project 01-S1
Prognostic impact of concomitant pH-regulating drugs in patients with non-small cell lung cancer receiving epidermal growth factor receptor tyrosine kinase inhibitors: the Tokushukai REAl-world Data project 01-S1
This study aimed to examine the prognostic impact of concomitant pH-regulating drug use in patients with epidermal growth ...
A polo-like kinase 1 inhibitor enhances erastin sensitivity in head and neck squamous cell carcinoma cells in vitro
A polo-like kinase 1 inhibitor enhances erastin sensitivity in head and neck squamous cell carcinoma cells in vitro
Polo-like kinase 1 (PLK1) is a critical therapeutic target in the treatment of head and neck squamous cell carcinoma (HNSC...
Pharmacology and pharmacokinetics of tazemetostat
Pharmacology and pharmacokinetics of tazemetostat
Tazemetostat, a novel oral selective inhibitor of enhancer of zeste homolog 2 (EZH2), was approved by the Food and Drug Ad...
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