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From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling
Volume 76, June 2024, 102458Author links open overlay panel, , , , Abstractβ-blockers are a solid pillar in the treatment ...
The complement pathway as a therapeutic target for neovascular age-related macular degeneration-mediated subretinal fibrosis
The complement pathway as a therapeutic target for neovascular age-related macular degeneration-mediated subretinal fibrosis
Volume 76, June 2024, 102448Author links open overlay panel, , AbstractNeovascular age-related macular degeneration (nAMD)...
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside
Volume 75, April 2024, 102447Author links open overlay panel, , , AbstractSeveral decades of research support the involvem...
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration
Age-related macular degeneration (AMD) is a neurodegenerative blinding disease affecting the elderly. The lack of treatmen...
Targeting the endocannabinoid system for the management of low back pain
Targeting the endocannabinoid system for the management of low back pain
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Gastrointestinal issue: Advances in gastrointestinal oncology
Gastrointestinal issue: Advances in gastrointestinal oncology
Dr Angelica Petrillo is a consultant in Medical Oncology at the Medical Oncology Unit of Ospedale del Mare in Naples (Ital...
Lipid raft disruption as an opportunity for peripheral analgesia
Lipid raft disruption as an opportunity for peripheral analgesia
Volume 75, April 2024, 102432Author links open overlay panel, , , AbstractChronic pain conditions are unmet medical needs,...
Editorial overview: Endocrine and metabolic diseases (2023)
Editorial overview: Endocrine and metabolic diseases (2023)
Dr. Stephanie Constantin received a Ph.D. in Life Sciences from the University of Tours in 2004. She joined the lab of Dr....
Analgesic potential of voltage gated sodium channel modulators for the management of pain
Analgesic potential of voltage gated sodium channel modulators for the management of pain
Volume 75, April 2024, 102433Author links open overlay panel, AbstractNeuronal electrochemical signals involve the flux of...
Novel treatments for dry eye syndrome
Novel treatments for dry eye syndrome
Dry eye syndrome (DES) is a common reason for ophthalmological consultations that can significantly impact patients' quali...
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”
Wolfgang Junger, a professor of surgery at the University of California San Diego, Harvard Medical School, and a visiting ...
Editorial overview: New and revitalized old targets in metabolic disease
Editorial overview: New and revitalized old targets in metabolic disease
Ivana Novak is professor at the Department of Biology, University of Copenhagen, and coordinator of the Center for Advance...
Targeting ferroptosis in the maintenance of mitochondrial homeostasis in the realm of septic cardiomyopathy
Targeting ferroptosis in the maintenance of mitochondrial homeostasis in the realm of septic cardiomyopathy
Sepsis is a systematic inflammatory response syndrome (SIRS) provoked by host infection and represents a major cause of th...
AI-driven GPCR analysis, engineering, and targeting
AI-driven GPCR analysis, engineering, and targeting
Volume 74, February 2024, 102427Author links open overlay panel, , , AbstractThis article investigates the role of recent ...
Integrating network pharmacology: The next-generation approach in ocular drug discovery
Integrating network pharmacology: The next-generation approach in ocular drug discovery
With the spread of the “omics” sciences, the approaches of systems biology can be considered as new paradigms of pharmacol...
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction
Vision is routinely ranked as one of the most important features of healthy aging, often ranked above other senses, or eve...
Optic nerve regeneration: Potential treatment approaches
Optic nerve regeneration: Potential treatment approaches
Like other axons in the central nervous system (CNS), axons of the optic nerve have limited regenerative capacity due to t...
Human experience and efficacy of omidenepag isopropyl (Eybelis®; Omlonti®): Discovery to approval of the novel non-prostaglandin EP2-receptor-selective agonist ocular hypotensive drug
Human experience and efficacy of omidenepag isopropyl (Eybelis®; Omlonti®): Discovery to approval of the novel non-prostaglandin EP2-receptor-selective agonist ocular hypotensive drug
The neurodegenerative retinal-optic nerve-brain eye diseases currently grouped together as glaucoma are among the leading ...
Currently available prostanoids for the treatment of glaucoma and ocular hypertension: A review
Currently available prostanoids for the treatment of glaucoma and ocular hypertension: A review
Glaucoma, a progressive optic neuropathy resulting in the degeneration of retinal ganglion cells and subsequent visual fie...
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation
Volume 73, December 2023, 102415Author links open overlay panel, , Highlights•Preclinical to clinical translation for nove...
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe
Volume 73, December 2023, 102414Author links open overlay panel, , AbstractWith technical progress of gastrointestinal fun...
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2
Pathogens, including viruses, have evolved to use host-encoded proteins to infect, replicate, and persist in the host [1]....
Pharmacologic treatment of gastroparesis: What is (still) on the horizon?
Pharmacologic treatment of gastroparesis: What is (still) on the horizon?
Volume 72, October 2023, 102395Author links open overlay panel, AbstractGastroparesis is a neuromuscular disorder of the u...
Discerning conformational dynamics and binding kinetics of GPCRs by 19F NMR
Discerning conformational dynamics and binding kinetics of GPCRs by 19F NMR
Available online 21 August 2023, 102377Author links open overlay panel, Abstract19F NMR provides a way of monitoring confo...
Illuminating GPCR signaling mechanisms by NMR spectroscopy with stable-isotope labeled receptors
Illuminating GPCR signaling mechanisms by NMR spectroscopy with stable-isotope labeled receptors
G protein-coupled receptors (GPCRs) are sensory integral membrane proteins that recognize an enormous range of extracellul...
Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle
SBMA is caused by the expansion of a CAG/glutamine (polyQ) tract in the androgen receptor (AR) gene [1]. The glutamine tra...
Adenosine signaling as target in cardiovascular pharmacology
Cardiovascular diseases (CVDs) are the prominent cause of death globally, taking an estimated 17.9 million lives each year...
Targeting cAMP signaling compartments in iPSC-derived models of cardiovascular disease
Cardiovascular diseases (CVD) are diverse. They include amongst others ischemic heart disease, heart failure, many other h...
Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors
G protein-coupled receptors (GPCRs) form the largest class of cell membrane receptors and belong to the most important dru...
Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors
Volume 71, August 2023, 102382Author links open overlay panel, , , AbstractGonadotropin-releasing hormone (GnRH) neurons a...
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