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Physiological regulation of leptin as an integrative signal of reproductive readiness
Species survival depends on successful reproduction, which in turn is influenced by both environmental and physiological f...
Anabolic–androgenic steroid abuse and testicular function in men; recent insights
Anabolic steroids comprise a group of compounds that are structurally similar to testosterone and have similar actions whe...
Novel therapeutic avenues for kisspeptin
Volume 67, December 2022, 102319Author links open overlay panelAbstractKisspeptin is a hypothalamic neuropeptide that acts...
RAD51 paralogs: Expanding roles in replication stress responses and repair
Volume 67, December 2022, 102313AbstractMammalian RAD51 paralogs are essential for cell survival and are critical for RAD5...
Targeting KNDy neurons to control GnRH pulses
Volume 67, December 2022, 102316AbstractGonadotropin-releasing hormone (GnRH) is the final output of the central nervous s...
Current treatment and molecular targets for axial spondyloarthritis: Evidence from randomized controlled trials
Volume 67, December 2022, 102307AbstractAxial spondyloarthritis (axSpA) is a chronic inflammatory disease that predominant...
Environmental toxicants, brown adipose tissue, and potential links to obesity and metabolic disease
Volume 67, December 2022, 102314AbstractRates of human obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NA...
Reprogramming cell fates towards novel cancer immunotherapies
Volume 67, December 2022, 102312AbstractRecent advances in our understanding of host immune and cancer cells interactions ...
The emerging role of immunotherapy in the treatment of anal cancer
Volume 67, December 2022, 102309AbstractFor decades, chemoradiotherapy for early-stage disease and systemic chemotherapy f...
Ubiquitin proteasome system in immune regulation and therapeutics
Volume 67, December 2022, 102310AbstractThe ubiquitin proteasome system (UPS) is a proteolytic machinery for the degradati...
Tapering biologic DMARDs in rheumatoid arthritis
Volume 67, December 2022, 102308AbstractWith the arrival of biologics and the shift toward treat-to-target therapy, the po...
Hormonal drugs for the treatment of endometriosis
In the past, the primary approach for the treatment of endometriosis was represented by surgery; however, after the introd...
Editorial overview: Introduction to the musculoskeletal section of current opinion in pharmacology
Dr. Cardozo is professor of medicine and of rehabilitation medicine and human performance at Icahn School of Medicine at M...
Current and emerging biologic and small molecule systemic treatment options for psoriasis and psoriatic arthritis
Volume 67, December 2022, 102292AbstractPsoriasis and psoriatic arthritis are chronic inflammatory diseases affecting the ...
Targeting fibroblast-like synoviocytes in rheumatoid arthritis
Volume 67, December 2022, 102304AbstractFibroblast-like synoviocytes (FLS) are mesenchymal-derived cells that play an impo...
Routine neoadjuvant chemotherapy for all patients with resectable pancreatic ductal adenocarcinoma? A review of the evidence
Volume 67, December 2022, 102305AbstractPancreatic ductal adenocarcinoma is an aggressive malignancy that carries a poor p...
Systemic inflammation after spinal cord injury: A review of biological evidence, related health risks, and potential therapies
Volume 67, December 2022, 102303Highlights•Chronic SCI results in persistent systemic inflammation.•Unresolved inflammatio...
Remyelinating strategies: What can be learned from normal brain development
Volume 67, December 2022, 102290AbstractMultiple sclerosis (MS) is a neuroinflammatory demyelinating and neurodegenerative...
PRRT for higher-grade neuroendocrine neoplasms: What is still acceptable?
Volume 67, December 2022, 102293AbstractPeptide receptor radionuclide therapy (PRRT) is a widely accepted treatment for pr...
New players of the adipose secretome: Therapeutic opportunities and challenges
Volume 67, December 2022, 102302Highlights•Adipose tissue-secreted factors can regulate both local and systemic metabolism...
Advances in lupus therapeutics: Achieving sustained control of the type I interferon pathway
Volume 67, December 2022, 102291AbstractAchieving sustained control of disease activity in patients with systemic lupus er...
Metabokines in the regulation of systemic energy metabolism
Volume 67, December 2022, 102286AbstractMetabolism consists of life-sustaining chemical reactions involving metabolites. H...
Editorial overview – 2022 respiratory issue: Cystic fibrosis pathophysiology, models, and novel therapies
Carla M. P. Ribeiro, PhD, Dr. Ribeiro is a professor of medicine, a joint professor of physiology and cell biology, and a ...
Stress, kisspeptin, and functional hypothalamic amenorrhea
Volume 67, December 2022, 102288AbstractFunctional hypothalamic amenorrhea (FHA) is the most common cause of secondary ame...
Treatments targeting the luminal gut microbiota in patients with irritable bowel syndrome
Volume 66, October 2022, 102284Highlights•Some patients with irritable bowel syndrome have gut microbiota alterations.•Var...
Impact of amino acids on microglial activation and CNS remyelination
Volume 66, October 2022, 102287AbstractAmino acids and their derivatives function as building blocks as well as signaling ...
Immune-mediated food reactions in irritable bowel syndrome
Volume 66, October 2022, 102285AbstractIrritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder ch...
Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond?
Volume 66, October 2022, 102283AbstractAtherosclerosis is a lipid-driven disease of the artery characterized by chronic no...
Oligonucleotide-based therapies for cystic fibrosis
Volume 66, October 2022, 102271AbstractIn the clinically successful era of CFTR modulators and Theratyping, 10–20% of indi...
Pituitary gonadotroph-specific patterns of gene expression and hormone secretion
Volume 66, October 2022, 102274AbstractPituitary gonadotrophs play a key role in reproductive functions by secreting lutei...