SCI时时刷

search
+
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2
Pathogens, including viruses, have evolved to use host-encoded proteins to infect, replicate, and persist in the host [1]....
Pharmacologic treatment of gastroparesis: What is (still) on the horizon?
Pharmacologic treatment of gastroparesis: What is (still) on the horizon?
Volume 72, October 2023, 102395Author links open overlay panel, AbstractGastroparesis is a neuromuscular disorder of the u...
Discerning conformational dynamics and binding kinetics of GPCRs by 19F NMR
Discerning conformational dynamics and binding kinetics of GPCRs by 19F NMR
Available online 21 August 2023, 102377Author links open overlay panel, Abstract19F NMR provides a way of monitoring confo...
Illuminating GPCR signaling mechanisms by NMR spectroscopy with stable-isotope labeled receptors
Illuminating GPCR signaling mechanisms by NMR spectroscopy with stable-isotope labeled receptors
G protein-coupled receptors (GPCRs) are sensory integral membrane proteins that recognize an enormous range of extracellul...
Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle
SBMA is caused by the expansion of a CAG/glutamine (polyQ) tract in the androgen receptor (AR) gene [1]. The glutamine tra...
Adenosine signaling as target in cardiovascular pharmacology
Cardiovascular diseases (CVDs) are the prominent cause of death globally, taking an estimated 17.9 million lives each year...
Targeting cAMP signaling compartments in iPSC-derived models of cardiovascular disease
Cardiovascular diseases (CVD) are diverse. They include amongst others ischemic heart disease, heart failure, many other h...
Spatiotemporal GPCR signaling illuminated by genetically encoded fluorescent biosensors
G protein-coupled receptors (GPCRs) form the largest class of cell membrane receptors and belong to the most important dru...
Central and peripheral mechanisms involved in the control of GnRH neuronal function by metabolic factors
Volume 71, August 2023, 102382Author links open overlay panel, , , AbstractGonadotropin-releasing hormone (GnRH) neurons a...
Corrigendum to “Antihypertensive effect of soybean bioactive peptides: A review” [Curr Opin Pharmacol (62) (2022) 74–81]
Volume 71, August 2023, 102383Author links open overlay panelTingna Li 1 a, Xiaorui Zhang 1 a, Yuanyuan Ren 1, Yijia Zeng ...
Highlighting vulnerabilities in the alternative lengthening of telomeres pathway
Human chromosomes end in telomeres, 5–15 kilobases of double-stranded (TTAGGG)n repeats that culminate in a 3′ single-stra...
Targeting DNA damage repair precision medicine strategies in cancer
Volume 70, June 2023, 102381Author links open overlay panel, , , , , , AbstractDNA repair targeted therapeutics is a promi...
Extracellular adenosine signaling in bone health and disease
Bone is a dynamic tissue which continuously undergoes remodeling primarily through osteoblast-mediated bone formation and ...
NMR applications to GPCR recognition by peptide ligands
G-protein coupled receptors (GPCR) are the largest superfamily of membrane proteins with more than 800 members that transd...
Considerations for individualized first-line systemic treatment in advanced hepatocellular carcinoma
In 2020, primary liver cancer was the sixth most commonly diagnosed cancer and the third most common cause of cancer-relat...
Purinergic signaling pathway in severe COVID-19
Available online 23 March 2023, 102379Author links open overlay panel, , , , AbstractSubstantial efforts have been made to...
Targeting the altered duodenal microenvironment in functional dyspepsia
Functional dyspepsia (FD) is a chronic upper gastrointestinal (GI) disorder affecting over 7% of the population worldwide ...
Hepatic arterial infusion chemotherapy for patients with hepatocellular carcinoma: Applicability in Western countries
FOLFOX-HAIC is effective in early-, intermediate-, and advanced-stage hepatocellular carcinoma [2∗, 3∗, 4∗, 5∗, 6, 7, 8, 9...
The blood pressure lowering effects of glucagon-like peptide-1 receptor agonists: A mini-review of the potential mechanisms
Type 2 diabetes (T2D) accelerates progression of chronic liver disease to cirrhosis, yet the effects of most glucose-lower...
Editorial overview: Immune regulation and cancers
Professor Carlotta Giorgi is full professor of general pathology in the Dept. of Medical Sciences, University of Ferrara P...
Pharmacology of pannexin channels
Available online 28 February 2023, 102359Author links open overlay panel, , AbstractPannexin channels play fundamental rol...
The role of extracellular ATP and P2X receptors in the pathogenesis of HIV-1
Volume 69, April 2023, 102358Author links open overlay panel, , , AbstractHuman Immunodeficiency Virus Type 1 (HIV-1) caus...
How organoids can improve personalized treatment in patients with gastro-esophageal tumors
Gastric cancer (GC) is still a big killer, being fifth for incidence and fourth for mortality globally [1]. About 90% of g...
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies
Volume 69, April 2023, 102357Author links open overlay panel, Highlights•Loss of dystrophin and/or sarcoglycans reduces eA...
Drug development for the treatment of RyR1-related skeletal muscle diseases
In skeletal muscles, the action potential of transverse tubule membranes triggers Ca2+ release from the sarcoplasmic retic...
KRAS inhibition in metastatic colorectal cancer: An update
KRASG12C is present in about 3% of metastatic CRC [16]. The potential to target KRAS has been revolutionized with selectiv...
Purinergic signalling in graft-versus-host disease
Allogeneic hematopoietic stem cell transplantation (HSCT) is used to treat blood cancers and other blood disorders. In abo...
Recent advances in emerging PCOS therapies
Intraoperative joint condition is different from preoperative CT/MR due to the motion applied during surgery, inducing an ...
Store-operated calcium entry: From physiology to tubular aggregate myopathy
Volume 68, February 2023, 102347Author links open overlay panelAbstractStore-Operated Ca2+ entry (SOCE) is recognized as a...
Non-hereditary early onset gastric cancer: An unmet medical need
Gastric cancer (GC) is a major health problem worldwide, ranking the 6th place in incidence with new 30000 cases expected ...
阅读更多
format_indent_increase