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Modulating regulatory T cell migration in the treatment of autoimmunity and autoinflammation
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Pharmacological regulation of HIF-1α, RGC death, and glaucoma
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Biased signalling in analgesic research and development
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Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration
Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration
Volume 76, June 2024, 102463Author links open overlay panel, , , Highlights•Age-related macular degeneration (AMD) is an i...
Effects of protein glycation and protective mechanisms against glycative stress
Effects of protein glycation and protective mechanisms against glycative stress
In regards to informational content, the proteome is more complex than the transcriptome and genome [1]. As such, the regu...
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer
DNA damage response (DDR) senses and resolves DNA damage to preserve the integrity of the genome through a multi-complex p...
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”
Editorial overview: Special issue on “Rheumatology: Therapeutic advances for autoimmune and musculoskeletal diseases”
Kristi Kuhn, MD, PhD, is the Scoville Endowed Chair and Head of the Division of Rheumatology and an associate professor of...
In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF)
In the heart and beyond: Mitochondrial dysfunction in heart failure with preserved ejection fraction (HFpEF)
Volume 76, June 2024, 102461Author links open overlay panel, AbstractHeart failure with preserved ejection fraction (HFpEF...
Advanced therapeutic approaches in sarcoglycanopathies
Advanced therapeutic approaches in sarcoglycanopathies
Volume 76, June 2024, 102459Author links open overlay panel, , , Highlights•Sarcoglycanopathies are due to the loss of fun...
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling
From “contraindicated” to “first line” – Current mechanistic insights beyond canonical β-receptor signaling
Volume 76, June 2024, 102458Author links open overlay panel, , , , Abstractβ-blockers are a solid pillar in the treatment ...
The complement pathway as a therapeutic target for neovascular age-related macular degeneration-mediated subretinal fibrosis
The complement pathway as a therapeutic target for neovascular age-related macular degeneration-mediated subretinal fibrosis
Volume 76, June 2024, 102448Author links open overlay panel, , AbstractNeovascular age-related macular degeneration (nAMD)...
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside
Volume 75, April 2024, 102447Author links open overlay panel, , , AbstractSeveral decades of research support the involvem...
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration
Estrogen related receptor alpha: Potential modulator of age-related macular degeneration
Age-related macular degeneration (AMD) is a neurodegenerative blinding disease affecting the elderly. The lack of treatmen...
Targeting the endocannabinoid system for the management of low back pain
Targeting the endocannabinoid system for the management of low back pain
Cookies are used by this site. Cookie SettingsAll content on this site: Copyright © 2024 Elsevier B.V., its licensors, an...
Gastrointestinal issue: Advances in gastrointestinal oncology
Gastrointestinal issue: Advances in gastrointestinal oncology
Dr Angelica Petrillo is a consultant in Medical Oncology at the Medical Oncology Unit of Ospedale del Mare in Naples (Ital...
Lipid raft disruption as an opportunity for peripheral analgesia
Lipid raft disruption as an opportunity for peripheral analgesia
Volume 75, April 2024, 102432Author links open overlay panel, , , AbstractChronic pain conditions are unmet medical needs,...
Editorial overview: Endocrine and metabolic diseases (2023)
Editorial overview: Endocrine and metabolic diseases (2023)
Dr. Stephanie Constantin received a Ph.D. in Life Sciences from the University of Tours in 2004. She joined the lab of Dr....
Analgesic potential of voltage gated sodium channel modulators for the management of pain
Analgesic potential of voltage gated sodium channel modulators for the management of pain
Volume 75, April 2024, 102433Author links open overlay panel, AbstractNeuronal electrochemical signals involve the flux of...
Novel treatments for dry eye syndrome
Novel treatments for dry eye syndrome
Dry eye syndrome (DES) is a common reason for ophthalmological consultations that can significantly impact patients' quali...
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”
Editorial overview: “Purinergic immune cell regulation reveals novel pharmacological targets”
Wolfgang Junger, a professor of surgery at the University of California San Diego, Harvard Medical School, and a visiting ...
Editorial overview: New and revitalized old targets in metabolic disease
Editorial overview: New and revitalized old targets in metabolic disease
Ivana Novak is professor at the Department of Biology, University of Copenhagen, and coordinator of the Center for Advance...
Targeting ferroptosis in the maintenance of mitochondrial homeostasis in the realm of septic cardiomyopathy
Targeting ferroptosis in the maintenance of mitochondrial homeostasis in the realm of septic cardiomyopathy
Sepsis is a systematic inflammatory response syndrome (SIRS) provoked by host infection and represents a major cause of th...
AI-driven GPCR analysis, engineering, and targeting
AI-driven GPCR analysis, engineering, and targeting
Volume 74, February 2024, 102427Author links open overlay panel, , , AbstractThis article investigates the role of recent ...
Integrating network pharmacology: The next-generation approach in ocular drug discovery
Integrating network pharmacology: The next-generation approach in ocular drug discovery
With the spread of the “omics” sciences, the approaches of systems biology can be considered as new paradigms of pharmacol...
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction
Targeting the NRF2 pathway: A promising approach for corneal endothelial dysfunction
Vision is routinely ranked as one of the most important features of healthy aging, often ranked above other senses, or eve...
Optic nerve regeneration: Potential treatment approaches
Optic nerve regeneration: Potential treatment approaches
Like other axons in the central nervous system (CNS), axons of the optic nerve have limited regenerative capacity due to t...
Human experience and efficacy of omidenepag isopropyl (Eybelis®; Omlonti®): Discovery to approval of the novel non-prostaglandin EP2-receptor-selective agonist ocular hypotensive drug
Human experience and efficacy of omidenepag isopropyl (Eybelis®; Omlonti®): Discovery to approval of the novel non-prostaglandin EP2-receptor-selective agonist ocular hypotensive drug
The neurodegenerative retinal-optic nerve-brain eye diseases currently grouped together as glaucoma are among the leading ...
Currently available prostanoids for the treatment of glaucoma and ocular hypertension: A review
Currently available prostanoids for the treatment of glaucoma and ocular hypertension: A review
Glaucoma, a progressive optic neuropathy resulting in the degeneration of retinal ganglion cells and subsequent visual fie...
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation
Angiotensin II type 2 receptor signalling as a pain target: Bench, bedside and back-translation
Volume 73, December 2023, 102415Author links open overlay panel, , Highlights•Preclinical to clinical translation for nove...
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe
Interventional functional diagnostics in gastrointestinal endoscopy: Combining diagnostic and therapeutic tools in the endoscopy suite with the functional lumen imaging probe
Volume 73, December 2023, 102414Author links open overlay panel, , AbstractWith technical progress of gastrointestinal fun...
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