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Hepatic arterial infusion chemotherapy for patients with hepatocellular carcinoma: Applicability in Western countries
FOLFOX-HAIC is effective in early-, intermediate-, and advanced-stage hepatocellular carcinoma [2∗, 3∗, 4∗, 5∗, 6, 7, 8, 9...
The blood pressure lowering effects of glucagon-like peptide-1 receptor agonists: A mini-review of the potential mechanisms
Type 2 diabetes (T2D) accelerates progression of chronic liver disease to cirrhosis, yet the effects of most glucose-lower...
Editorial overview: Immune regulation and cancers
Professor Carlotta Giorgi is full professor of general pathology in the Dept. of Medical Sciences, University of Ferrara P...
Pharmacology of pannexin channels
Available online 28 February 2023, 102359Author links open overlay panel, , AbstractPannexin channels play fundamental rol...
The role of extracellular ATP and P2X receptors in the pathogenesis of HIV-1
Volume 69, April 2023, 102358Author links open overlay panel, , , AbstractHuman Immunodeficiency Virus Type 1 (HIV-1) caus...
How organoids can improve personalized treatment in patients with gastro-esophageal tumors
Gastric cancer (GC) is still a big killer, being fifth for incidence and fourth for mortality globally [1]. About 90% of g...
The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies
Volume 69, April 2023, 102357Author links open overlay panel, Highlights•Loss of dystrophin and/or sarcoglycans reduces eA...
Drug development for the treatment of RyR1-related skeletal muscle diseases
In skeletal muscles, the action potential of transverse tubule membranes triggers Ca2+ release from the sarcoplasmic retic...
KRAS inhibition in metastatic colorectal cancer: An update
KRASG12C is present in about 3% of metastatic CRC [16]. The potential to target KRAS has been revolutionized with selectiv...
Purinergic signalling in graft-versus-host disease
Allogeneic hematopoietic stem cell transplantation (HSCT) is used to treat blood cancers and other blood disorders. In abo...
Recent advances in emerging PCOS therapies
Intraoperative joint condition is different from preoperative CT/MR due to the motion applied during surgery, inducing an ...
Store-operated calcium entry: From physiology to tubular aggregate myopathy
Volume 68, February 2023, 102347Author links open overlay panelAbstractStore-Operated Ca2+ entry (SOCE) is recognized as a...
Non-hereditary early onset gastric cancer: An unmet medical need
Gastric cancer (GC) is a major health problem worldwide, ranking the 6th place in incidence with new 30000 cases expected ...
Is there still a place for radiotherapy in gastric cancer?
Gastric cancer represents the second most common cause of cancer death worldwide [1]. Most patients relapse after curative...
The use of hormone stimulation in male infertility
Volume 68, February 2023, 102333Author links open overlay panelHighlights•GnRH and Gonadotropins are an effective treatmen...
Pharmacological strategies for mitigating anti-TNF biologic immunogenicity in rheumatoid arthritis patients
Volume 68, February 2023, 102320Author links open overlay panelAbstractTumor necrosis factor alpha (TNFα) inhibitors are a...
Update on anti-fibrotic pharmacotherapies in skeletal muscle disease
Volume 68, February 2023, 102332Author links open overlay panelAbstractFibrosis, defined as an excessive accumulation of e...
The role of extracellular ATP in homeostatic immune cell migration
Volume 68, February 2023, 102331Author links open overlay panelHighlights•The non-lytic release of ATP occurs in lymphoid ...
Gene therapies for RyR1-related myopathies
Type 1 ryanodine receptor (RyR1) is the main intracellular calcium channel in skeletal muscle. In association with the vol...
Pharmacotherapy of male hypogonadism
The function of the male gonad, the testis, is devoted to androgens and spermatozoa production and is tightly regulated by...
Antibiotics, the microbiome and gastrointestinal cancers: A causal interference?
The human gut microbiome (GM) is a complex community made of approximately 500 different species of bacteria, archaea, vir...
Helpful inflammation turned harmful in non-communicable diseases
Lucy V. Norling obtained her PhD at Queen Mary University of London. Her career to date has been shaped by the generous su...
Newly identified tumor suppressor functions of ING proteins
Volume 68, February 2023, 102324Author links open overlay panelHighlights•The INhibitor of Growth (ING) proteins are a fam...
Three-dimensional perspective on ryanodine receptor mutations causing skeletal and cardiac muscle-related diseases
Ryanodine receptors (RyRs) are large intracellular calcium channels with a well-documented role in excitation-contraction ...
Making myelin regenerate: Factors to consider
Jeffrey Huang, PhD, is a Provost's Distinguished Associate Professor at Georgetown University, in the Department of Biolog...
Drug repurposing in skeletal muscle ion channelopathies
Volume 68, February 2023, 102329Author links open overlay panelAbstractSkeletal muscle ion channelopathies are rare geneti...
Therapeutic approaches in different congenital myopathies
Volume 68, February 2023, 102328Author links open overlay panelAbstractCongenital myopathies are rare and severe genetic d...
Metabolic crosstalk between thermogenic adipocyte and cancer cell: Dysfunction and therapeutics
Volume 68, February 2023, 102322Author links open overlay panelAbstractAs one of the largest endocrine organs with a wide ...
Physiological regulation of leptin as an integrative signal of reproductive readiness
Species survival depends on successful reproduction, which in turn is influenced by both environmental and physiological f...
Anabolic–androgenic steroid abuse and testicular function in men; recent insights
Anabolic steroids comprise a group of compounds that are structurally similar to testosterone and have similar actions whe...
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