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Unravelling the Association Between Uncertainties in Model-based Economic Analysis and Funding Recommendations of Medicines in Australia
Unravelling the Association Between Uncertainties in Model-based Economic Analysis and Funding Recommendations of Medicines in Australia
Health technology assessment is used extensively by the Pharmaceutical Benefits Advisory Committee (PBAC) to inform medici...
Cost Effectiveness of Tremelimumab Plus Durvalumab for Unresectable Hepatocellular Carcinoma in the USA
Cost Effectiveness of Tremelimumab Plus Durvalumab for Unresectable Hepatocellular Carcinoma in the USA
Treating unresectable hepatocellular carcinoma (uHCC) is challenging. Clinical trials have shown that Single Tremelimumab ...
Value-Based Healthcare in Practice: IDEATE, a Collaboration to Design and Test an Outcomes-Based Agreement for a Medicine in Wales
Value-Based Healthcare in Practice: IDEATE, a Collaboration to Design and Test an Outcomes-Based Agreement for a Medicine in Wales
To develop a sustainable, scalable methodology for the design of outcome-based agreements (OBAs) that works on the ground ...
Comparison of EQ-5D-Y-3L Utility Scores Using Nine Country-Specific Value Sets in Chinese Adolescents
Comparison of EQ-5D-Y-3L Utility Scores Using Nine Country-Specific Value Sets in Chinese Adolescents
This study aimed to assess and compare the measurement properties of EQ-5D-Y-3L utilities derived from available countries...
The Use of Real-World Data for Estimating Relative Treatment Effects in NICE Health Technology Assessment Submissions: A Review
The Use of Real-World Data for Estimating Relative Treatment Effects in NICE Health Technology Assessment Submissions: A Review
This paper investigates the current use of real-world data (RWD) for estimating relative treatment effects in National Ins...
Recurrence of Cardiovascular Events After an Acute Myocardial Infarction in Patients with Multivessel Disease and Associated Healthcare Costs: A German Claims Data Analysis
Recurrence of Cardiovascular Events After an Acute Myocardial Infarction in Patients with Multivessel Disease and Associated Healthcare Costs: A German Claims Data Analysis
This study sought to quantify the healthcare costs of multivessel disease (MVD) and determine the prevalence and incidence...
Costs of Care in Relation to Alzheimer’s Disease Severity in Sweden: A National Registry-Based Cohort Study
Costs of Care in Relation to Alzheimer’s Disease Severity in Sweden: A National Registry-Based Cohort Study
The advancement of diagnostic and therapeutic interventions in early Alzheimer’s disease (AD) has demanded the econo...
A Systematic Literature Review of Modelling Approaches to Evaluate the Cost Effectiveness of PET/CT for Therapy Response Monitoring in Oncology
A Systematic Literature Review of Modelling Approaches to Evaluate the Cost Effectiveness of PET/CT for Therapy Response Monitoring in Oncology
This systematic literature review addresses model-based cost-effectiveness studies for therapy response monitoring with po...
Estimating the Incremental Cost Per QALY Produced by the Spanish NHS: A Fixed-Effect Econometric Approach
Estimating the Incremental Cost Per QALY Produced by the Spanish NHS: A Fixed-Effect Econometric Approach
Knowing the health opportunity costs of funding decisions is crucial to assess whether the health gains associated with ne...
Universal Health Coverage of Opioid Agonist Treatment in Norway: An Equity-Adjusted Economic Evaluation
Universal Health Coverage of Opioid Agonist Treatment in Norway: An Equity-Adjusted Economic Evaluation
Detailed information on the efficiency of health services targeting opioid use disorder (OUD) and treatment with opioid ag...
Design and Features of Pricing and Payment Schemes for Health Technologies: A Scoping Review and a Proposal for a Flexible Need-Driven Classification
Design and Features of Pricing and Payment Schemes for Health Technologies: A Scoping Review and a Proposal for a Flexible Need-Driven Classification
In a context of growing clinical and financial uncertainty, pricing and payment schemes can act as possible solutions to t...
Economic Burden Associated with Pulmonary Arterial Hypertension in the United States
Economic Burden Associated with Pulmonary Arterial Hypertension in the United States
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pressure in the pulmonary arterie...
The Impact of Tocilizumab Coverage on Health Equity for Inpatients with COVID-19 in the USA: A Distributional Cost-Effectiveness Analysis
The Impact of Tocilizumab Coverage on Health Equity for Inpatients with COVID-19 in the USA: A Distributional Cost-Effectiveness Analysis
We conducted a distributional cost-effectiveness analysis to evaluate how coverage of tocilizumab for inpatients with COVI...
How Much Better is Faster? Empirical Tests of QALY Assumptions in Health-Outcome Sequences
How Much Better is Faster? Empirical Tests of QALY Assumptions in Health-Outcome Sequences
This study was designed to test hypotheses regarding the path dependence of health-outcome values in the form of linear ad...
Managed Entry Agreements for High-Cost, One-Off Potentially Curative Therapies: A Framework and Calculation Tool to Determine Their Suitability
Managed Entry Agreements for High-Cost, One-Off Potentially Curative Therapies: A Framework and Calculation Tool to Determine Their Suitability
To construct a framework and calculation tool to compare the consequences of implementing different payment models for hig...
Comparative Analysis of Traditional and Pharmacometric-Based Pharmacoeconomic Modeling in the Cost-Utility Evaluation of Sunitinib Therapy
Comparative Analysis of Traditional and Pharmacometric-Based Pharmacoeconomic Modeling in the Cost-Utility Evaluation of Sunitinib Therapy
Cost-utility analyses (CUAs) increasingly use models to predict long-term outcomes and translate trial data to real-world ...
Valuation of the EORTC Quality of Life Utility Core 10 Dimensions (QLU-C10D) in a Multi-ethnic Asian Setting: How Does Having Cancer Matter?
Valuation of the EORTC Quality of Life Utility Core 10 Dimensions (QLU-C10D) in a Multi-ethnic Asian Setting: How Does Having Cancer Matter?
The aim of the study was to develop and compare utility value sets for the EORTC QLU-C10D, a cancer-specific utility instr...
An Evaluation of an Algorithm for the Selection of Flexible Survival Models for Cancer Immunotherapies: Pass or Fail?
An Evaluation of an Algorithm for the Selection of Flexible Survival Models for Cancer Immunotherapies: Pass or Fail?
Accurately extrapolating survival beyond trial follow-up is essential in a health technology assessment where model choice...
Evidence Following Conditional NICE Technology Appraisal Recommendations: A Critical Analysis of Methods, Quality and Risk of Bias
Evidence Following Conditional NICE Technology Appraisal Recommendations: A Critical Analysis of Methods, Quality and Risk of Bias
The National Institute for Health and Care Excellence (NICE) may approve health technologies on condition of more evidence...
Different Models, Same Results: Considerations When Choosing Between Approaches to Model Cost Effectiveness of Chimeric-Antigen Receptor T-Cell Therapy Versus Standard of Care
Different Models, Same Results: Considerations When Choosing Between Approaches to Model Cost Effectiveness of Chimeric-Antigen Receptor T-Cell Therapy Versus Standard of Care
Chimeric antigen-receptor T-cell therapy (CAR-T) is characterised by early phase data at the time of registration, high up...
A Reporting Checklist for Discrete Choice Experiments in Health: The DIRECT Checklist
A Reporting Checklist for Discrete Choice Experiments in Health: The DIRECT Checklist
Reporting standards of discrete choice experiments (DCEs) in health have not kept pace with the growth of this method, wit...
Effects and Costs of Hepatitis C Virus Elimination for the Whole Population in China: A Modelling Study
Effects and Costs of Hepatitis C Virus Elimination for the Whole Population in China: A Modelling Study
China has the highest number of hepatitis C virus (HCV) infections in the world. However, it is unclear what levels of scr...
MPES-R: Multi-Parameter Evidence Synthesis in R for Survival Extrapolation—A Tutorial
MPES-R: Multi-Parameter Evidence Synthesis in R for Survival Extrapolation—A Tutorial
Survival extrapolation often plays an important role in health technology assessment (HTA), and there are a range of diffe...
A Systematic Review of Modeling Approaches to Evaluate Treatments for Relapsed Refractory Multiple Myeloma: Critical Review and Considerations for Future Health Economic Models
A Systematic Review of Modeling Approaches to Evaluate Treatments for Relapsed Refractory Multiple Myeloma: Critical Review and Considerations for Future Health Economic Models
Multiple myeloma is a rare incurable hematological cancer in which most patients relapse or become refractory to treatment...
Treatment Effect Waning in Immuno-oncology Health Technology Assessments: A Review of Assumptions and Supporting Evidence with Proposals to Guide Modelling
Treatment Effect Waning in Immuno-oncology Health Technology Assessments: A Review of Assumptions and Supporting Evidence with Proposals to Guide Modelling
Treatment effect waning (TEW) refers to the attenuation of treatment effects over time. Assumptions of a sustained immuno-...
Bring Out Your Dead: A Review of the Cost Minimisation Approach in Health Technology Assessment Submissions to the Australian Pharmaceutical Benefits Advisory Committee
Bring Out Your Dead: A Review of the Cost Minimisation Approach in Health Technology Assessment Submissions to the Australian Pharmaceutical Benefits Advisory Committee
Published literature has levied criticism against the cost-minimisation analysis (CMA) approach to economic evaluation ove...
Estimating Risk Factor Time Paths Among People with Type 2 Diabetes and QALY Gains from Risk Factor Management
Estimating Risk Factor Time Paths Among People with Type 2 Diabetes and QALY Gains from Risk Factor Management
Most type 2 diabetes simulation models utilise equations mapping out lifetime trajectories of risk factors [e.g. glycated ...
Cost and Cost Effectiveness of Treatments for Psoriatic Arthritis: An Updated Systematic Literature Review
Cost and Cost Effectiveness of Treatments for Psoriatic Arthritis: An Updated Systematic Literature Review
Psoriatic arthritis (PsA) is an inflammatory disease characterised by a variety of clinical manifestations. Considering th...
Drug Pricing Stewardship from Mark Cuban’s Cost Plus Generic Drug Program
Drug Pricing Stewardship from Mark Cuban’s Cost Plus Generic Drug Program
The exceedingly high US spending per capita on prescription medications is mediated, at least in part, by the inefficienci...
Considerations Around the Inclusion of Children and Young People’s Time in Economic Evaluation: Findings from an International Delphi Study
Considerations Around the Inclusion of Children and Young People’s Time in Economic Evaluation: Findings from an International Delphi Study
People’s time is a finite resource and a valuable input that ought to be considered in economic evaluations taking a...
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