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Effect of youthful blood environment and its key factor SCF on renal interstitial fibrosis in elderly mice
Effect of youthful blood environment and its key factor SCF on renal interstitial fibrosis in elderly mice
Introduction: Youthful blood environment was shown to decelerate the aging process of kidney and to attenuate senile renal...
Using minimal clinically important differences to measure long-term transitions of osteosarcopenia: The New Mexico Aging Process Study
Background/objectiveBy having a better understanding of transitions in osteosarcopenia, interventions to reduce morbidity ...
Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals
Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals
Frailty, a clinical syndrome commencing at midlife, is a risk for morbidity and mortality. Little is known about the facto...
Probable Sarcopenia, Obesity, and Risk of All-Cause Mortality: A Pooled Analysis of 4,612 Participants
Probable Sarcopenia, Obesity, and Risk of All-Cause Mortality: A Pooled Analysis of 4,612 Participants
<b><i>Introduction:</i></b> Conflicting evidence exists concerning whether having sarcopenic obesi...
Centrally Acting ACE Inhibitor Use and Physical Performance in Older Adults
Centrally Acting ACE Inhibitor Use and Physical Performance in Older Adults
There is conflicting evidence regarding the role of angiotensin-converting enzyme inhibitors and physical function. While ...
Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice
Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice
Frailty is an age-related condition characterized by a multisystem functional decline, increased vulnerability to stressor...
Efficient representations of binarized health deficit data: the frailty index and beyond
Efficient representations of binarized health deficit data: the frailty index and beyond
We investigated efficient representations of binarized health deficit data using the 2001–2002 National Health and N...
Health Trajectories of Older Chinese Adults: Gender Disparities and Cohort Differences
Health Trajectories of Older Chinese Adults: Gender Disparities and Cohort Differences
This study investigates the gender disparities and cohort differences in the health trajectories of older Chinese adults. ...
Role of NADPH Oxidases in Renal Aging
Role of NADPH Oxidases in Renal Aging
Introduction: Aging of the kidney is associated with complex molecular, histological, and functional changes. Although the...
Exercise based reduction of falls in communitydwelling older adults: a network meta-analysis
Exercise based reduction of falls in communitydwelling older adults: a network meta-analysis
Traditional meta-analyses with pairwise direct comparison revealed that a variety of exercise-based training interventions...
Modifiable healthy behaviours and incident disability in older adults: Analysis of combined data from two cohort studies in Japan
Healthy behaviours reduce the risk of incident disability; however, their components require further consideration. Specif...
Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status
IntroductionThe effect of androgens on the cardiovascular system in humans is ambiguous. Moreover, still little is known a...
Differences in mitochondrial function between brain and heart of senile rats exposed to acute hypobaric hypoxia. Role of nitric oxide
Rat brain and heart display different endogenous protective responses against hypobaric hypoxia in an age-dependent way. T...
Effects of aging and type 2 diabetes on cardiac structure and function: Underlying mechanisms
Volume 173, March 2023, 112108Author links open overlay panelHighlights•Aging leads to detrimental changes in heart struct...
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice
There is increasing concern that cancer and cancer treatment accelerate aging and the associated cognitive decline. We sho...
CCA identifies a neurophysiological marker of adaptation capacity that is reliably linked to internal locus of control of cognition in amnestic MCI
CCA identifies a neurophysiological marker of adaptation capacity that is reliably linked to internal locus of control of cognition in amnestic MCI
Locus of control (LOC) describes whether an individual thinks that they themselves (internal LOC) or external factors (ext...
Study of Alzheimer's disease- and frontotemporal dementia-associated genes in the Cretan Aging Cohort
In addition to age, a major risk factor for Alzheimer's disease (AD; the commonest form of dementia in the elderly) is pos...
Age-related changes in midfrontal theta activity during steering control: A driving simulator study
As a result of population aging and its associated socioeconomic implications, it is important that older adults remain in...
Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice
Over 6.2 million Americans are currently living with Alzheimer's disease (AD), a neurodegenerative disease manifesting as ...
Pathogenicity classification of SOD1 variants of uncertain significance by in vitro aggregation propensity
Volume 123, March 2023, Pages 182-190Author links open overlay panelHighlights•We reclassify the pathogenicity of all the ...
Genetic and clinical characteristics of ALS patients with NEK1 gene variants
Volume 123, March 2023, Pages 191-199Author links open overlay panelAbstractNIMA-related kinase 1(NEK1) gene was related t...
Genome-wide association study of executive function in a multi-ethnic cohort implicates LINC01362: Results from the northern Manhattan study
Cognition is a complex human trait comprised of several domains including executive function. Executive function is an umb...
Single-neuron whole genome sequencing identifies increased somatic mutation burden in Alzheimer's disease related genes
Alzheimer's disease (AD) is the most common neurodegenerative disorder, affecting over 30 million people worldwide(Brookme...
Linking early-life bilingualism and cognitive advantage in older adulthood
According to a growing body of research, bilingualism could help counteract cognitive and brain aging, as well as help del...
Older rats show slow modulation of hippocampal theta rhythm during voluntary running
Aging causes brain function degeneration and slows many motor and behavioural responses. The hippocampal theta rhythm (4–1...
Osteocalcin inhibits myocyte aging through promotion of starvation-induced autophagy via IL-6/STAT3 signaling
This study aimed to investigate the effects and mechanisms of osteocalcin on autophagy in myoblasts, as well as its possib...