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Sensitivity Analyses for Means or Proportions with Missing Outcome Data
Sensitivity Analyses for Means or Proportions with Missing Outcome Data
We describe an approach to sensitivity analysis introduced by Robins et al (1999), for the setting w
The Prevalent New-user Design for Studies With no Active Comparator: The Example of Statins and Cancer
The Prevalent New-user Design for Studies With no Active Comparator: The Example of Statins and Cancer
Background: Observational studies evaluating the effect of a drug versus “non-use” are challengin
Evaluating Metformin Strategies for Cancer Prevention: A Target Trial Emulation Using Electronic Health Records
Evaluating Metformin Strategies for Cancer Prevention: A Target Trial Emulation Using Electronic Health Records
Background: Metformin users appear to have a substantially lower risk of cancer than nonusers in
Wildfire Exposure and Health Care Use Among People Who Use Durable Medical Equipment in Southern California
Wildfire Exposure and Health Care Use Among People Who Use Durable Medical Equipment in Southern California
Background: People using electricity-dependent durable medical equipment (DME) may be vulnerable
An Overview of Current Methods for Real-world Applications to Generalize or Transport Clinical Trial Findings to Target Populations of Interest
An Overview of Current Methods for Real-world Applications to Generalize or Transport Clinical Trial Findings to Target Populations of Interest
It has been well established that randomized clinical trials have poor external validity, resulting
Misclassification Bias in the Assessment of Gene-by-Environment Interactions
Misclassification Bias in the Assessment of Gene-by-Environment Interactions
Background: Misclassification bias is a common concern in epidemiologic studies. Despite strong b
The Causal Effects of Causal Inference Pedagogy
The Causal Effects of Causal Inference Pedagogy
This issue includes three commentaries on the target trial framework. At its core, this framework begins any causal effect...
Start with the Target Trial Protocol, Then Follow the Roadmap for Causal Inference
Start with the Target Trial Protocol, Then Follow the Roadmap for Causal Inference
Before taking flight, pilots complete a preflight checklist. Before starting surgery, operating room staff complete a pres...
Transparency and Rigor: Target Trial Emulation Aims to Achieve Both
Transparency and Rigor: Target Trial Emulation Aims to Achieve Both
Pearce and Vanderbroucke argue in their commentary1 that the target trial emulation framework is being hyped as a new gold...
Are Target Trial Emulations the Gold Standard for Observational Studies?
Are Target Trial Emulations the Gold Standard for Observational Studies?
There has been considerable debate in epidemiology about whether the randomized controlled trial (RCT) is the gold standar...
Using Balancing Weights to Target the Treatment Effect on the Treated when Overlap is Poor
Using Balancing Weights to Target the Treatment Effect on the Treated when Overlap is Poor
Inverse probability weights are commonly used in epidemiology to estimate causal effects in observat
Visualizing the (Causal) Effect of a Continuous Variable on a Time-To-Event Outcome
Visualizing the (Causal) Effect of a Continuous Variable on a Time-To-Event Outcome
Visualization is a key aspect of communicating the results of any study aiming to estimate causal ef
The Effect of Mobile Stroke Unit Care on Functional Outcomes: An Application of the Front-door Formula
The Effect of Mobile Stroke Unit Care on Functional Outcomes: An Application of the Front-door Formula
Background: The Berlin-based B_PROUD study was designed to assess the effect of mobile stroke uni
The Author Responds
The Author Responds
To the Editor: Prof. Doi1 is under the impression that the relative risk always varies with the baseline risk, ...
The Relationship of Preconception and Early Pregnancy Isoprostanes with Fecundability and Pregnancy Loss
The Relationship of Preconception and Early Pregnancy Isoprostanes with Fecundability and Pregnancy Loss
Background: Although redox stress likely plays an important role in reproductive health, the util
Effect Measure Modification by Covariates in Mediation: Extending Regression-based Causal Mediation Analysis
Effect Measure Modification by Covariates in Mediation: Extending Regression-based Causal Mediation Analysis
Existing methods for regression-based mediation analysis assume that the exposure-mediator effect, e
Response to Mindel C. Sheps: Counted, Dead or Alive
Response to Mindel C. Sheps: Counted, Dead or Alive
To the Editor: It is true that when decision-making in medicine proceeds (e.g., drug A to prevent outcome Y), c...
Differential Employment Quality and Educational Inequities in Mental Health: A Causal Mediation Analysis
Differential Employment Quality and Educational Inequities in Mental Health: A Causal Mediation Analysis
Background: In the United States, inequities in mental distress between those more and less educa
Estimation of SARS-CoV-2 Seroprevalence in Central North Carolina: Accounting for Outcome Misclassification in Complex Sample Designs
Estimation of SARS-CoV-2 Seroprevalence in Central North Carolina: Accounting for Outcome Misclassification in Complex Sample Designs
Background: Population-based seroprevalence studies are crucial to understand community transmiss
Disparities in Fatal Occupational Injury Rates in North Carolina, 1978–2017: Comparing Nonmanagerial Employees to Managers
Disparities in Fatal Occupational Injury Rates in North Carolina, 1978–2017: Comparing Nonmanagerial Employees to Managers
Background: We examined fatal occupational injuries among private-sector workers in North Carolin
Comparative Safety of Gout Treatment Strategies on Cardiovascular Outcomes Using Observational Data: Clone-censor-weight Target Trial Emulation Approach
Comparative Safety of Gout Treatment Strategies on Cardiovascular Outcomes Using Observational Data: Clone-censor-weight Target Trial Emulation Approach
Background: We sought to examine the cardiovascular safety of intensive treat-to-target serum ura
Comparing Two-way Fixed Effects and New Estimators for Difference-in-Differences: A Simulation Study and Empirical Example
Comparing Two-way Fixed Effects and New Estimators for Difference-in-Differences: A Simulation Study and Empirical Example
Background: Two-way fixed effects methods have been used to estimate effects of policies adopted
Early Life Anti-Müllerian Hormone Trajectories in Infant Girls
Early Life Anti-Müllerian Hormone Trajectories in Infant Girls
Background: Minipuberty is a period of increased reproductive axis activity in infancy, but the i
Changes in Opioid and Benzodiazepine Poisoning Deaths After Cannabis Legalization in the US: A County-level Analysis, 2002–2020
Changes in Opioid and Benzodiazepine Poisoning Deaths After Cannabis Legalization in the US: A County-level Analysis, 2002–2020
Background: Cannabis legalization for medical and recreational purposes has been suggested as an
Prenatal Antidepressant Exposure and the Risk of Attention-Deficit/Hyperactivity Disorder in Childhood: Accounting for Misclassification of Exposure
Prenatal Antidepressant Exposure and the Risk of Attention-Deficit/Hyperactivity Disorder in Childhood: Accounting for Misclassification of Exposure
Background: Many studies of prenatal antidepressant exposure and the risk of attention-deficit/hy
Complexity Epidemiology in Practice: A Tale of Two Simplicities
Complexity Epidemiology in Practice: A Tale of Two Simplicities
From the aSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology, and Research (A*STAR), ...
Kara E. Rudolph, Winner of 2023 Rothman Epidemiology Prize
Kara E. Rudolph, Winner of 2023 Rothman Epidemiology Prize
The Editors and Editorial Board of Epidemiology are pleased to announce the selection of Kara E. Rudolph as the winner of ...
Role of Air Pollution in the Development of Asthma Among Children with a History of Bronchiolitis in Infancy
Role of Air Pollution in the Development of Asthma Among Children with a History of Bronchiolitis in Infancy
Background: Infants experiencing bronchiolitis are at increased risk for asthma, but few studies
Inverse Probability of Treatment Weighting and Confounder Missingness in Electronic Health Record-based Analyses: A Comparison of Approaches Using Plasmode Simulation
Inverse Probability of Treatment Weighting and Confounder Missingness in Electronic Health Record-based Analyses: A Comparison of Approaches Using Plasmode Simulation
Background: Electronic health record (EHR) data represent a critical resource for comparative eff
Uneven Resources Threaten Causal Consistency in Randomized Trials
Uneven Resources Threaten Causal Consistency in Randomized Trials
From the aDepartment of Medical Education, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mex...
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