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miR-515-5p suppresses trophoblast cell invasion and proliferation through XIAP regulation in preeclampsia
MicroRNAs (miRNAs) are non-coding small RNA molecules that can be secreted into the circulation and which exist in remarka...
Maternal adaptations of the pancreas and glucose homeostasis in lactation and after lactation
During lactation, the maternal physiology adapts to bear the nutritional requirements of the offspring. The exocrine and e...
Functional alterations of two novel MC4R mutations found in Argentinian pediatric patients with early onset obesity
Loss-of-function mutations in melanocortin-4 receptor (MC4R) are the most common cause of monogenic obesity, a severe type...
High-refined carbohydrate diet alters different metabolic functions in female rats
A diet containing refined carbohydrate (HCD) caused obesity and white adipose tissue (WAT) abnormalities, but it is unclea...
Overexpression of estrogen receptor GPER1 and G1 treatment reduces SARS-CoV-2 infection in BEAS-2B bronchial cells
Gender-bias in COVID-19 severity has been suggested by clinical data. Experimental data in cell and animal models have dem...
Prior aerobic physical training modulates neuropeptide expression and central thermoregulation after ovariectomy in the rat
This study compared the effects of aerobic physical training and estradiol (E2) replacement on central pathways involved w...
Heat stress upregulates aromatases expression through nuclear DAX-1 deficiency in R2C Leydig tumor cells
An appropriate balance between testicular testosterone and estradiol is required for spermatogenesis. Excess estradiol is ...
Vitamin D receptor activation is a feasible therapeutic target to impair adrenocortical tumorigenesis
ObjectiveTo evaluate the therapeutic potential of vitamin D receptor (VDR) signaling in adrenocortical carcinoma (ACC) cel...
Totipotency of miR-184 in porcine granulosa cells
Estradiol (E2) synthesis, cell proliferation and the apoptosis of porcine granulosa cells (GCs) affect follicular growth a...
Combined therapy of GABA and sitagliptin prevents high-fat diet impairment of beta-cell function
We recently demonstrated that combined therapy of GABA and sitagliptin promoted beta-cell proliferation, and decreased bet...
Vasopressin regulation of maternal body fluid balance in pregnancy and lactation: A role for TRPV channels?
Available online 28 August 2022, 111764AbstractRenal water reabsorption increases in pregnancy and lactation to expand mat...
Alpha4 contributes to the dysfunction of the pancreatic beta cell under metabolic stress
The current study examined the roles of Alpha4, a non-canonical subunit of protein phosphatase 2A, in the regulation of ac...
Oleate restores altered autophagic flux to rescue palmitate lipotoxicity in hypothalamic neurons
Accumulation of excess lipids in non-adipose tissues, such as the hypothalamus, is termed lipotoxicity and causative of fr...
How does apelin affect LH levels? An investigation at the level of GnRH and KNDy neurons
Hypothalamic control of reproduction relies on GnRH and kisspeptin (KP) secretions. KP neurons are sensitive to sex steroi...
Transcriptional networks underlying a primary ovarian insufficiency disorder in alligators naturally exposed to EDCs
Available online 11 August 2022, 111751AbstractInteractions between the endocrine system and environmental contaminants ar...
Effects of selective inhibition of prostaglandin E2 receptors EP2 and EP4 on the miRNA profile in endometriosis
Endometriosis is an estrogen-dependent, progesterone-resistant, chronic inflammatory gynecological disease of reproductive...
Comparative proteomic analysis of insulin receptor isoform A and B signaling
The insulin receptor (IR) gene undergoes differential splicing generating two IR isoforms, IR-A and IR-B. The roles of IR-...
Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes
Dysregulation of adipose tissue involves increased cellular hypoxia, ER stress, and inflammation and altered adipokine pro...
DCAF13 is essential for the pathogenesis of preeclampsia through its involvement in endometrial decidualization
Preeclampsia (PE) is a syndrome that occurs during pregnancy and affects more than 8 million mother-infant pairs each year...
Sitagliptin reduces FAP-activity and increases intact FGF21 levels in patients with newly detected glucose abnormalities
IntroductionFibroblast growth factor 21 (FGF21), a hormone with pleiotropic metabolic effects, is inactivated by fibroblas...
Interactive effects of anthropogenic environmental drivers on endocrine responses in wildlife
Anthropogenic activity has created unique environmental drivers, which may interact to produce unexpected effects. My aim ...
Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in mouse liver
Available online 30 July 2022, 111722Highlights•3930402G23Rik (G23Rik) is a liver-enriched lncRNA.•G23Rik is a PPARA targe...
CXCL13 and CXCR5 are upregulated in PCOS mice ovaries but downregulated following metformin administration
Polycystic ovary syndrome (PCOS) is becoming a common pathology among women, yet its pathogenesis remains enigmatic. The c...
Synaptophysin and chromogranin A expression analysis in human tumors
Available online 31 July 2022, 111726Highlights•Neuroendocrine markers chromogranin A and synaptophysin were analyzed in 1...
Origin of circulating 18-oxocortisol in the normal human adrenal
18-Oxocortisol is the product of the metabolism of 11-deoxycortisol by the mitochondrial enzyme aldosterone synthase (CYP1...