SCI时时刷

search
+
In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis
In vitro cytotoxic and genotoxic effects of Phyllanthus niruri extract loaded chitosan nanoparticles in TM4 cells and their influence on spermatogenesis
Purpose: This paper introduces a complete in vitro investigation of cytotoxic and genotoxic effects of Phyllanthus niruri ...
Formulation and validation of Candesartan cilexetil-loaded nanosuspension to enhance solubility
Formulation and validation of Candesartan cilexetil-loaded nanosuspension to enhance solubility
The following research aimed to enhance solubility by loading candesartan cilexetil into nanosuspension. Candesartan cilex...
Study of the antitumor activity of the combination baicalin and epigallocatechin gallate in a murine model of vincristine-resistant breast cancer
Study of the antitumor activity of the combination baicalin and epigallocatechin gallate in a murine model of vincristine-resistant breast cancer
Background: Breast cancer is one of the primary causes of death in women worldwide. Yearly, a quarter of cancer cases in w...
Preparation and characterization of vemurafenib microemulsion based hydrogel using surface active ionic liquid
Preparation and characterization of vemurafenib microemulsion based hydrogel using surface active ionic liquid
Cancer is considered the second leading cause of death worldwide. Skin melanomas account for the highest mortality rate am...
Nanostructured lipid carriers: A prospective dermal drug delivery system for natural active ingredients
Nanostructured lipid carriers: A prospective dermal drug delivery system for natural active ingredients
Nanostructured lipid carriers (NLCs) are versatile tools used for several purposes, including drug release modification, a...
The impact of DME treatment on diabetic patients
The impact of DME treatment on diabetic patients
Background: Both type 1 and type 2 diabetics can potentially develop nephropathy, neuropathy, and retinopathy. Diabetic ma...
Targeting cisplatin resistance in breast cancer using a combination of Thymoquinone and Silymarin: an in vitro and in vivo study
Targeting cisplatin resistance in breast cancer using a combination of Thymoquinone and Silymarin: an in vitro and in vivo study
Background: Breast cancer (BC) is considered the most diagnosed cancer among women globally. This is because of its high p...
Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings
Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings
Aim: investigate the possible anti-psoriatic effect of ivermectin in mice based on observational and histopathological out...
Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides
Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides
According to the recent studies bezylcarboxamide fragment attached to the thiophene ring of thieno[2,3-d]pyrimidine is ben...
Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds
Anticancer potential of garlic bioactive constituents: Allicin, Z-ajoene, and organosulfur compounds
Cancer, a formidable disease with a significant mortality rate, continues to claim the lives of thousands of individuals a...
Docking, synthesis, and anticancer assessment of novel quinoline-amidrazone hybrids
Docking, synthesis, and anticancer assessment of novel quinoline-amidrazone hybrids
A group of new amidrazone compounds that include a quinoline component was produced through the reaction of hydrazonyl chl...
Microneedle and drug delivery across the skin: An overview
Microneedle and drug delivery across the skin: An overview
The skin offers a route of administration with numerous advantages. However, one of the major limitations of this route is...
Morphological, teratogenic and behavioral evaluations of Gelidium spinosum methanol extract on zebrafish embryos
Morphological, teratogenic and behavioral evaluations of Gelidium spinosum methanol extract on zebrafish embryos
Gelidium spinosum is an edible red seaweed from the family Gelidiaceae with possibility to be developed. The potential med...
Regulation and control of the use of Cannabis and Cannabidiol in „novel foods”
Regulation and control of the use of Cannabis and Cannabidiol in „novel foods”
Cannabis sativa L. is a medicinal plant from family Cannabaceae with many pharmacological activities. The recent appearanc...
Separation and analysis of triazole antifungal in biological matrices by liquid chromatography: a review
Separation and analysis of triazole antifungal in biological matrices by liquid chromatography: a review
Invasive fungal infections cause serious illness and death worldwide. Long-term therapeutic and preventative use of antifu...
Comparison of treatment of COVID-19 with inhaled bromhexine, higher doses of colchicine and hymecromone with WHO-recommended paxlovid, molnupiravir, remdesivir, anti-IL-6 receptor antibodies and baricitinib
Comparison of treatment of COVID-19 with inhaled bromhexine, higher doses of colchicine and hymecromone with WHO-recommended paxlovid, molnupiravir, remdesivir, anti-IL-6 receptor antibodies and baricitinib
Millions of publications and thousands of clinical trials have not led to the discovery of an effective treatment for COVI...
In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues
In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues
In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activi...
INNs granted with specific storage requirements in Bulgarian pharmacies. Part 2: Antineoplastic and immunomodulating agents
INNs granted with specific storage requirements in Bulgarian pharmacies. Part 2: Antineoplastic and immunomodulating agents
There are drugs that require special storage in Bulgarian pharmacies as well as extra caution during the dispensing proces...
Molecular docking analysis of ginger (Zingiber officinale) on dopamine compare to bupropion as smoking cessation
Molecular docking analysis of ginger (Zingiber officinale) on dopamine compare to bupropion as smoking cessation
Tobacco use continues to be the leading cause of preventable death worldwide. Smoking is highly addictive because nicotine...
Phytochemical profiling and cardioprotective activity of Vernonia amygdalina ethanol extract (VAEE) against ISO-induced cardiotoxicity in rats
Phytochemical profiling and cardioprotective activity of Vernonia amygdalina ethanol extract (VAEE) against ISO-induced cardiotoxicity in rats
Cardiovascular disorder is the leading cause death in the world, one of them are acute myocardial infarction (AMI) which a...
Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights
Vernonia amygdalina protects against doxorubicin-induced hepatic and renal damage in rats: mechanistic insights
The use of the chemotherapeutic agent doxorubicin is limited due to its potential to cause signifi-cant hepatorenal damage...
The complex mechanism of developing trust in pharmacy
The complex mechanism of developing trust in pharmacy
Indicators of the success in pharmaceutical services at pharmacy can be seen from customer satisfaction which is influence...
Update review: Etnopharmacological, bioactivity and phytochemical of Allium cepa L.
Update review: Etnopharmacological, bioactivity and phytochemical of Allium cepa L.
Allium cepa L. is commonly used as a vegetable, spice, and in traditional medicine. In traditional medicine, A. cepa is ap...
INNs granted with specific storage requirements in Bulgarian pharmacies. Part 1: Medicines acting on cardiovascular and nervous system
INNs granted with specific storage requirements in Bulgarian pharmacies. Part 1: Medicines acting on cardiovascular and nervous system
Some medicines require special storage in Bulgarian pharmacies due to serious adverse reactions that may be even life-thre...
Development and validation of analytical procedure for analysis of Amoxiciline, Metronidazole and Omeprazole, used as anti- Helicobacter pylori agents alone and in mixture
Development and validation of analytical procedure for analysis of Amoxiciline, Metronidazole and Omeprazole, used as anti- Helicobacter pylori agents alone and in mixture
Background: The contemporary treatment of ulcerogenic diseases and gastroesophageal reflux disease is related usually to a...
An updated review of Typhonium flagelliforme: phytochemical compound, pharmacological activities and the use of vitexin and isovitexin as flavonoid compound in cosmetics development
An updated review of Typhonium flagelliforme: phytochemical compound, pharmacological activities and the use of vitexin and isovitexin as flavonoid compound in cosmetics development
Typhonium flagelliforme, a plant known for its medicinal properties, has numerous benefits in the treatment of certain dis...
The effect of a small polyphenolic and terpenoids phytochemical constituent on curing and preventing of Covid-19 infections
The effect of a small polyphenolic and terpenoids phytochemical constituent on curing and preventing of Covid-19 infections
Covid-19 spreading have caused millions of deaths worldwide and caused sever economic shrinking resulted in high levels of...
Pharmacogenetic variants of CYP2C9 and CYP2C19 associated with adverse reactions induced by antiepileptic drugs used in Peru
Pharmacogenetic variants of CYP2C9 and CYP2C19 associated with adverse reactions induced by antiepileptic drugs used in Peru
Epilepsy is the most common neurological disorder with a worldwide incidence of 20% and a treatment failure rate of 25–30%...
Synthesis, characterization, and antimicrobial evaluation of new Schiff bases derived from vanillic acid conjugated to heterocyclic 4H-1,2,4-triazole-3-thiol
Synthesis, characterization, and antimicrobial evaluation of new Schiff bases derived from vanillic acid conjugated to heterocyclic 4H-1,2,4-triazole-3-thiol
A multistep synthesis was established for the preparation of a new vanillic acid-1, 2, 4-1triazole-3-thiol conjugate (4). ...
Astragalus glycyphyllos L.: Phytochemical constituents, pharmacology, and biotechnology
Astragalus glycyphyllos L.: Phytochemical constituents, pharmacology, and biotechnology
Astragalus glycyphyllos is a widely distributed plant found in Bulgaria that has been used in the folk medicine of the cou...
阅读更多
format_indent_increase