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Antitumor and antioxidant activity of some metal complex compounds
Antitumor and antioxidant activity of some metal complex compounds
In the last few years, interest in platinum drugs has increased. Successful treatment depends to a large extent on complex...
Pharmaco-epigenetics: Histone modification and personalized medicine
Pharmaco-epigenetics: Histone modification and personalized medicine
Epigenetic changes have a major effect in both normal and disease cases of organism. Multiple types of epigenetic changes ...
Antecedents and consequence of patients’ satisfaction with pharmaceutical service in hospitals: A multidimensional approach
Antecedents and consequence of patients’ satisfaction with pharmaceutical service in hospitals: A multidimensional approach
Measuring patient satisfaction and trust across various dimensions poses a challenge in the economic dynamics and service ...
Memantine and its role in parkinsonism, seizure, depression, migraine headache, and Alzheimer’s disease
Memantine and its role in parkinsonism, seizure, depression, migraine headache, and Alzheimer’s disease
Alzheimer’s disease (AD) is a neurological disorder characterized by mental and behavioral changes that develop progressiv...
Validated ion exchange HPLC method for the quantification of levothyroxine – a narrow therapeutic index drug – used for the treatment of hypothyroidism
Validated ion exchange HPLC method for the quantification of levothyroxine – a narrow therapeutic index drug – used for the treatment of hypothyroidism
Drugs with narrow therapeutic index (NTI-drugs) have been defined by the FDA as drugs with small differences between thera...
Study of the influence of armed conflict on the reimbursement of oral glucose lowering drugs in Ukraine
Study of the influence of armed conflict on the reimbursement of oral glucose lowering drugs in Ukraine
The humanitarian crisis significantly affects the provision of medical and pharmaceutical care to PWD, and makes it diffic...
The discovery of potential tumor necrosis factor alpha converting enzyme inhibitors via implementation of K Nearest Neighbor QSAR analysis
The discovery of potential tumor necrosis factor alpha converting enzyme inhibitors via implementation of K Nearest Neighbor QSAR analysis
Tumor necrosis factor-alpha converting enzyme (TACE) is considered as a pro-inflammatory cytokine which catalyzes the form...
Development and characterization of clove oil microemulsion
Development and characterization of clove oil microemulsion
Clove oil is one type of essential oil from clove flower buds (Syzygium aromaticum) which contains eugenol compounds. Clov...
Physical stability and dissolution of ketoprofen nanosuspension formulation: Polyvinylpyrrolidone and Tween 80 as stabilizers
Physical stability and dissolution of ketoprofen nanosuspension formulation: Polyvinylpyrrolidone and Tween 80 as stabilizers
This study was conducted to improve the dissolution of ketoprofen in nanosuspensions. Ketoprofen nanosuspensions were prep...
Biofilm formation by E. coli and S. aureus on cellphone cover: sensitivity to commercially available sanitizers
Biofilm formation by E. coli and S. aureus on cellphone cover: sensitivity to commercially available sanitizers
Presence of pathogens on the cellphones and their accessories poses a significant risk for public health. This study aimed...
Logistical challenges with an emphasis on organizing specialized triage in the conditions of a newly emerging, epidemiologically significant infectious pathogen for humans – SARS-CoV2
Logistical challenges with an emphasis on organizing specialized triage in the conditions of a newly emerging, epidemiologically significant infectious pathogen for humans – SARS-CoV2
Background: UMHATEM „N.I. Pirogov“ Sofia, is one of the largest and busiest hospitals for emergency medical care in Bulgar...
How to create an experimental diabetes mellitus model?
How to create an experimental diabetes mellitus model?
Diabetes is a metabolic disorder characterized by chronic hyperglycemia. Early treatment is very important in terms of pre...
Drug delivery to the brain – lipid nanoparticles-based approach
Drug delivery to the brain – lipid nanoparticles-based approach
The complex structure of the human brain defines it as one of the most inaccessible organs in terms of drug delivery. The ...
Antioxidant, cholesterol lowering activity, and analysis of Caesalpinia bonducella seeds extract
Antioxidant, cholesterol lowering activity, and analysis of Caesalpinia bonducella seeds extract
Tombili plant (Caesalpinia bonducella) belongs to the family of Fabaceae. The seed extract of tombili has been empirically...
Production of rare cycloartane saponins from Astragalus thracicus (Griseb) compared to Astragalus membranaceus (Fisch.) Bunge – native and biotechnological sources
Production of rare cycloartane saponins from Astragalus thracicus (Griseb) compared to Astragalus membranaceus (Fisch.) Bunge – native and biotechnological sources
The aim of this study is a comparative metabolomic analysis between the endangered species Astragalus membranaceus and end...
Comparative study of the chemical composition of Trigonella foenum-graecum L. essential oil
Comparative study of the chemical composition of Trigonella foenum-graecum L. essential oil
Fenugreek is a well-known aromatic plant. Its leaves and seeds are commonly used for their many health benefits and the sp...
Essential oil in Phlomis tuberosa
Essential oil in Phlomis tuberosa
Phlomis tuberosa L. (Lamiaceae) is a flowering perennial plant, native to Eurasia, and sparsely distributed in Bulgaria. T...
GC-MS analysis of bioactive compounds and antibacterial activity of nangka leaves (Artocarpus heterophyllus Lam)
GC-MS analysis of bioactive compounds and antibacterial activity of nangka leaves (Artocarpus heterophyllus Lam)
Nangka is a plant that has various kinds of potential both because of the nutritional content provided through the fruit a...
Analytical quality by design-based RP-HPLC method for quantification of pioglitazone and candesartan cilexetil in bilayer tablet and its forced degradation studies
Analytical quality by design-based RP-HPLC method for quantification of pioglitazone and candesartan cilexetil in bilayer tablet and its forced degradation studies
Aim: The current project involves developing an RP-HPLC method for simultaneous quantification of Candesartan Cilexetil an...
Antidiabetic activity of Anredera cordifolia (Ten.) Stennis extracts with different ethanol percentages: an evaluation based on in vitro, in vivo, and molecular studies
Antidiabetic activity of Anredera cordifolia (Ten.) Stennis extracts with different ethanol percentages: an evaluation based on in vitro, in vivo, and molecular studies
Anredera cordifolia (Ten.) Stennis, also known as Binahong (B), is an Indonesian plant used to treat diabetes. The purpose...
The effect of excessive coffee consumption, in relation to diterpenes levels of medium-roasted coffee, on non-high-density lipoprotein cholesterol level in healthy men
The effect of excessive coffee consumption, in relation to diterpenes levels of medium-roasted coffee, on non-high-density lipoprotein cholesterol level in healthy men
This study was designed to determine the levels of coffee oil and diterpenes and evaluate the correlation between the effe...
Investigation of the nephroprotective activity of Moringa peregrina leaves aqueous extract in mice
Investigation of the nephroprotective activity of Moringa peregrina leaves aqueous extract in mice
Traditional remedies for Moringa peregrina leaves have a variety of uses with confirmed biological and therapeutic effects...
Acute toxicity test nanoherbal mahkota dewa fruit (Phaleria macrocarpa)
Acute toxicity test nanoherbal mahkota dewa fruit (Phaleria macrocarpa)
A common plant from Papua, Indonesia, called Phaleria macrocarpa (mahkota dewa), has potent therapeutic components. The ai...
Phytochemical screening, antibacterial, antioxidant, and anticancer activity of Coffee parasite acetone extract (Loranthus ferrugineus Roxb)
Phytochemical screening, antibacterial, antioxidant, and anticancer activity of Coffee parasite acetone extract (Loranthus ferrugineus Roxb)
This study aimed to perform a phytochemical screening and test the antibacterial, antioxidant, and anticancer activities o...
Molecular docking-based virtual screening: Challenges in hits identification for Anti-SARS-Cov-2 activity
Molecular docking-based virtual screening: Challenges in hits identification for Anti-SARS-Cov-2 activity
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) requires finding new drugs or repurposing dr...
Rapid LC-MS/MS method for determination of scopolamine in human plasma
Rapid LC-MS/MS method for determination of scopolamine in human plasma
Sensitive, simple, and fast LC-MS/MS method for the determination of Scopolamine in human plasma was developed and validat...
Study of phytochemical compounds of Plantago major leaves grown in Kazakhstan
Study of phytochemical compounds of Plantago major leaves grown in Kazakhstan
Leaves of Plantago major have been used for centuries to treat diseases relating to skin, digestive organs and blood circu...
Design, synthesis and anti-diabetic activity of piperazine sulphonamide derivatives as dipeptidyl peptidase-4 inhibitors
Design, synthesis and anti-diabetic activity of piperazine sulphonamide derivatives as dipeptidyl peptidase-4 inhibitors
Type II diabetes (T2DM) is considered one of the most prevalent metabolic disorders in the world. It is known as insulin r...
Synthesis and evaluation of inhibitory potentials of microbial biofilms and quorum-sensing by 3-(1,3-dithian-2-ylidene) pentane-2,4-dione and ethyl-2-cyano-2-(1,3-dithian-2-ylidene) acetate
Synthesis and evaluation of inhibitory potentials of microbial biofilms and quorum-sensing by 3-(1,3-dithian-2-ylidene) pentane-2,4-dione and ethyl-2-cyano-2-(1,3-dithian-2-ylidene) acetate
The virulence and resistance of pathogenic microorganisms are promoted by quorum-sensing (QS) mediated traits and biofilms...
Conjugation of a WOW Peptide with silver nanoparticles to face the increase of antimicrobial resistance during COVID 19 pandemic
Conjugation of a WOW Peptide with silver nanoparticles to face the increase of antimicrobial resistance during COVID 19 pandemic
Bacterial resistance is a difficult limitation in the treatment of infections. The potential antibacterial activity of WOW...
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